JP2009534634A - バイオリアクターからの機械的に敏感な物質の滅菌サンプリングを備えた工程分析システム - Google Patents

バイオリアクターからの機械的に敏感な物質の滅菌サンプリングを備えた工程分析システム Download PDF

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Publication number
JP2009534634A
JP2009534634A JP2009505763A JP2009505763A JP2009534634A JP 2009534634 A JP2009534634 A JP 2009534634A JP 2009505763 A JP2009505763 A JP 2009505763A JP 2009505763 A JP2009505763 A JP 2009505763A JP 2009534634 A JP2009534634 A JP 2009534634A
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Japan
Prior art keywords
sample
transport
sampling valve
analysis system
burette
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Pending
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JP2009505763A
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English (en)
Japanese (ja)
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JP2009534634A5 (enExample
Inventor
シュテファン・シュタイヒミラー
ハンス・トゥップス
カルステン・ゾンマー
ゾニア・ダンシュテット
マルティン・シーフハウアー
ゼバスティアン・シュミット
イェルク・カウリング
アルント・ブラウン
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Bayer AG
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Bayer Technology Services GmbH
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Publication of JP2009534634A publication Critical patent/JP2009534634A/ja
Publication of JP2009534634A5 publication Critical patent/JP2009534634A5/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
    • G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hydrology & Water Resources (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2009505763A 2006-04-21 2007-04-17 バイオリアクターからの機械的に敏感な物質の滅菌サンプリングを備えた工程分析システム Pending JP2009534634A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006019242A DE102006019242A1 (de) 2006-04-21 2006-04-21 Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
PCT/EP2007/003341 WO2007121887A2 (de) 2006-04-21 2007-04-17 Prozessanalysensystem mit steriler probenahme von mechanisch empfindlichem material aus einem bioreaktor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012203358A Division JP5693537B2 (ja) 2006-04-21 2012-09-14 バイオリアクターからの機械的に敏感な物質の滅菌サンプリングを備えた工程分析システム

Publications (2)

Publication Number Publication Date
JP2009534634A true JP2009534634A (ja) 2009-09-24
JP2009534634A5 JP2009534634A5 (enExample) 2010-06-03

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ID=38324151

Family Applications (2)

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JP2009505763A Pending JP2009534634A (ja) 2006-04-21 2007-04-17 バイオリアクターからの機械的に敏感な物質の滅菌サンプリングを備えた工程分析システム
JP2012203358A Expired - Fee Related JP5693537B2 (ja) 2006-04-21 2012-09-14 バイオリアクターからの機械的に敏感な物質の滅菌サンプリングを備えた工程分析システム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012203358A Expired - Fee Related JP5693537B2 (ja) 2006-04-21 2012-09-14 バイオリアクターからの機械的に敏感な物質の滅菌サンプリングを備えた工程分析システム

Country Status (10)

Country Link
US (2) US8431089B2 (enExample)
EP (1) EP2013328A2 (enExample)
JP (2) JP2009534634A (enExample)
CN (1) CN101426897B (enExample)
CA (1) CA2649554C (enExample)
DE (1) DE102006019242A1 (enExample)
IL (1) IL194643A (enExample)
NO (1) NO20084455L (enExample)
SG (2) SG171597A1 (enExample)
WO (1) WO2007121887A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020166436A1 (ja) * 2019-02-12 2020-08-20 株式会社エンプラス 流体取扱システムおよびこれに用いるカートリッジ

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US7824905B2 (en) * 2009-03-04 2010-11-02 Oleg Shvabsky Biological reactor
PL2576758T3 (pl) * 2010-06-07 2018-01-31 Roux Dit Buisson Jean Louis Fotobioreaktor o przepływie ciągłym lub półciągłym i sposób jego użycia
US12227734B2 (en) 2011-03-08 2025-02-18 University Of Maryland, Baltimore County Microscale bioprocessing system and method for protein manufacturing from human blood
US10774304B2 (en) 2011-03-08 2020-09-15 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
US9982227B2 (en) 2011-03-08 2018-05-29 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
WO2012122413A1 (en) * 2011-03-08 2012-09-13 University Of Maryland Baltimore County Microscale bioprocessing system and method for protein manufacturing
EP2705137B1 (en) 2011-05-06 2022-11-02 EMD Millipore Corporation Automatic aseptic sampling valve for sampling from enclosed containers
JP2014527456A (ja) 2011-05-13 2014-10-16 ノボマー， インコーポレイテッド 触媒的カルボニル化用触媒および方法
FR2978131B1 (fr) * 2011-07-19 2013-09-13 Sartorius Stedim Biotech Sa Perfectionnement au raccordement d'un accessoire a un recipient.
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EP2771449A1 (en) 2011-10-24 2014-09-03 Bend Research, Inc. Systems and methods for producing bioproducts
DE102012003113A1 (de) * 2012-02-16 2013-08-22 Forschungszentrum Jülich GmbH Probeentnahmevorrichtung und Verfahren zur Entnahme einer Probe aus einem Bioreaktor
CN104812888A (zh) * 2012-09-18 2015-07-29 拜耳技术服务有限公司 一次性瓶式反应罐
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US9322749B2 (en) 2012-11-05 2016-04-26 Bend Research, Inc. Automatic sampling system for sampling from enclosed containers
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WO2015171372A1 (en) 2014-05-05 2015-11-12 Novomer, Inc. Catalyst recycle methods
CN106488899B (zh) 2014-05-30 2020-08-18 诺沃梅尔公司 用于化学合成的综合方法
JP6670011B2 (ja) 2014-07-25 2020-03-18 ノボマー， インコーポレイテッド 金属錯体の合成およびその使用
MA41513A (fr) 2015-02-13 2017-12-19 Novomer Inc Procédé de distillation pour la production d'acide acrylique
KR20170129735A (ko) * 2015-02-13 2017-11-27 노보머, 인코포레이티드 유연한 화학 제조 플랫폼
CA2976253A1 (en) 2015-02-13 2016-08-18 Novomer, Inc. Continuous carbonylation processes
MA41514A (fr) 2015-02-13 2017-12-19 Novomer Inc Procédés intégrés de synthèse chimique
MA41510A (fr) 2015-02-13 2017-12-19 Novomer Inc Procédé de production d'acide acrylique
EP3088006A1 (de) 2015-04-28 2016-11-02 Bayer Technology Services GmbH Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor
KR101863427B1 (ko) * 2016-02-02 2018-06-01 한국수력원자력 주식회사 배관 내 축적된 공기 포집 장치
US9976946B2 (en) * 2016-04-21 2018-05-22 Instrumentation Laboratory Company Optical flow cell and test head apparatus
US10288556B2 (en) 2016-04-21 2019-05-14 Instrumentation Laboratory Company Optical flow cell apparatus and method for reducing deflection of sample chamber
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CN107603855A (zh) * 2017-10-23 2018-01-19 江苏棉海园林工程有限公司 一种可泄压的生物发酵设备
DE102017011263B3 (de) 2017-12-06 2019-05-02 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur Untersuchung eines Mediums
EA202190053A1 (ru) * 2018-06-18 2021-03-22 Баксалта Инкорпорейтед Нижняя секция для соединения со сборкой с тарельчатым сепаратором и сборка с тарельчатым сепаратором
CN110042052B (zh) * 2019-04-26 2022-05-31 中国农业大学烟台研究院 一种沼气工程厌氧发酵系统的智能监控装置
CN110129186B (zh) * 2019-05-29 2022-08-16 浙江美森细胞科技有限公司 一种细胞培养无菌采样装置
CN110411788B (zh) * 2019-08-14 2022-06-10 安徽金联地矿科技有限公司 一种多深度水样取样装置及使用方法
CN110411789B (zh) * 2019-08-14 2022-03-15 安徽金联地矿科技有限公司 一种水样的取样装置及使用方法
DE102019135275A1 (de) 2019-12-19 2021-06-24 Endress+Hauser (Deutschland) Gmbh+Co. Kg Transportables Probennahmebehältnis, Probennahmesystem und Verfahren zur Probennahme
DE102020004956A1 (de) * 2020-08-14 2022-02-17 Forschungszentrum Jülich GmbH Vorrichtung zum sterilen Flüssigkeitstransfer
EP4026889A1 (de) * 2021-01-11 2022-07-13 Eppendorf AG Sterilschutz-aufsatz für spitzen von liquid-handling-einrichtungen
CN112924237B (zh) * 2021-01-26 2022-11-22 安徽金三隆再生资源有限公司 一种钕铁硼废料加工用污水处理装置
CN113567699A (zh) * 2021-08-24 2021-10-29 中国科学院上海微系统与信息技术研究所 一种新型液滴采样枪头、包括其的采样系统以及一种高通量采样方法
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CN115372077B (zh) * 2022-09-15 2024-11-12 聊城好佳一生物乳业有限公司 一种乳酸菌发酵取样器
CN117004479B (zh) * 2023-08-10 2024-01-26 河北蔺氏盛泰药业有限公司 一种麦芽加工用原料融合均匀发酵设备
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JPS5865549U (ja) * 1981-10-28 1983-05-04 大明金属工業株式会社 定量抜き取り用サンプリングバルブ
WO2004044119A1 (de) * 2002-11-11 2004-05-27 Sartorius Ag Probenahmeventil und damit durchführbares verfahren zur sterilen entnahme von proben aus fermentern oder bioreaktoren

Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2020166436A1 (ja) * 2019-02-12 2020-08-20 株式会社エンプラス 流体取扱システムおよびこれに用いるカートリッジ

Also Published As

Publication number Publication date
US8647592B2 (en) 2014-02-11
WO2007121887A3 (de) 2007-12-21
CN101426897A (zh) 2009-05-06
CN101426897B (zh) 2012-05-30
DE102006019242A1 (de) 2007-10-25
US20090178495A1 (en) 2009-07-16
SG10201508150WA (en) 2015-10-29
NO20084455L (no) 2008-11-19
WO2007121887A2 (de) 2007-11-01
JP5693537B2 (ja) 2015-04-01
US20130295600A1 (en) 2013-11-07
JP2013011618A (ja) 2013-01-17
EP2013328A2 (de) 2009-01-14
IL194643A (en) 2013-03-24
SG171597A1 (en) 2011-06-29
US8431089B2 (en) 2013-04-30
CA2649554A1 (en) 2007-11-01
CA2649554C (en) 2019-01-22

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