IL194643A - Process analysis system with sterile sampling of mechanically-sensitive material from a bioreactor - Google Patents

Process analysis system with sterile sampling of mechanically-sensitive material from a bioreactor

Info

Publication number
IL194643A
IL194643A IL194643A IL19464308A IL194643A IL 194643 A IL194643 A IL 194643A IL 194643 A IL194643 A IL 194643A IL 19464308 A IL19464308 A IL 19464308A IL 194643 A IL194643 A IL 194643A
Authority
IL
Israel
Prior art keywords
sample
transport
sampling valve
analysis system
sampling
Prior art date
Application number
IL194643A
Other languages
English (en)
Original Assignee
Bayer Ip Gmbh
Bayer Technology Services Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh, Bayer Technology Services Gmbh filed Critical Bayer Ip Gmbh
Publication of IL194643A publication Critical patent/IL194643A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
    • G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hydrology & Water Resources (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL194643A 2006-04-21 2008-10-07 Process analysis system with sterile sampling of mechanically-sensitive material from a bioreactor IL194643A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006019242A DE102006019242A1 (de) 2006-04-21 2006-04-21 Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
PCT/EP2007/003341 WO2007121887A2 (de) 2006-04-21 2007-04-17 Prozessanalysensystem mit steriler probenahme von mechanisch empfindlichem material aus einem bioreaktor

Publications (1)

Publication Number Publication Date
IL194643A true IL194643A (en) 2013-03-24

Family

ID=38324151

Family Applications (1)

Application Number Title Priority Date Filing Date
IL194643A IL194643A (en) 2006-04-21 2008-10-07 Process analysis system with sterile sampling of mechanically-sensitive material from a bioreactor

Country Status (10)

Country Link
US (2) US8431089B2 (enExample)
EP (1) EP2013328A2 (enExample)
JP (2) JP2009534634A (enExample)
CN (1) CN101426897B (enExample)
CA (1) CA2649554C (enExample)
DE (1) DE102006019242A1 (enExample)
IL (1) IL194643A (enExample)
NO (1) NO20084455L (enExample)
SG (2) SG171597A1 (enExample)
WO (1) WO2007121887A2 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200430121Y1 (ko) * 2006-07-13 2006-11-02 주식회사 이엠따블유안테나 내장형 안테나 일체형 스피커의 조립구조
US7824905B2 (en) * 2009-03-04 2010-11-02 Oleg Shvabsky Biological reactor
PL2576758T3 (pl) * 2010-06-07 2018-01-31 Roux Dit Buisson Jean Louis Fotobioreaktor o przepływie ciągłym lub półciągłym i sposób jego użycia
US12227734B2 (en) 2011-03-08 2025-02-18 University Of Maryland, Baltimore County Microscale bioprocessing system and method for protein manufacturing from human blood
US10774304B2 (en) 2011-03-08 2020-09-15 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
US9982227B2 (en) 2011-03-08 2018-05-29 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
WO2012122413A1 (en) * 2011-03-08 2012-09-13 University Of Maryland Baltimore County Microscale bioprocessing system and method for protein manufacturing
EP2705137B1 (en) 2011-05-06 2022-11-02 EMD Millipore Corporation Automatic aseptic sampling valve for sampling from enclosed containers
JP2014527456A (ja) 2011-05-13 2014-10-16 ノボマー， インコーポレイテッド 触媒的カルボニル化用触媒および方法
FR2978131B1 (fr) * 2011-07-19 2013-09-13 Sartorius Stedim Biotech Sa Perfectionnement au raccordement d'un accessoire a un recipient.
EP2570167A1 (de) 2011-09-13 2013-03-20 Bayer Intellectual Property GmbH Gerät und Verfahren zur diskontinuierlichen Filtration
EP2771449A1 (en) 2011-10-24 2014-09-03 Bend Research, Inc. Systems and methods for producing bioproducts
DE102012003113A1 (de) * 2012-02-16 2013-08-22 Forschungszentrum Jülich GmbH Probeentnahmevorrichtung und Verfahren zur Entnahme einer Probe aus einem Bioreaktor
CN104812888A (zh) * 2012-09-18 2015-07-29 拜耳技术服务有限公司 一次性瓶式反应罐
US9389151B2 (en) 2012-11-05 2016-07-12 Bend Research, Inc. Fixed volume aseptic sampling valve for sampling from enclosed containers
US9322749B2 (en) 2012-11-05 2016-04-26 Bend Research, Inc. Automatic sampling system for sampling from enclosed containers
DE102014102600B4 (de) 2013-03-05 2015-09-03 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung und Verfahren zur Entnahme einer Flüssigkeit aus einem Prozessbehälter
WO2015171372A1 (en) 2014-05-05 2015-11-12 Novomer, Inc. Catalyst recycle methods
CN106488899B (zh) 2014-05-30 2020-08-18 诺沃梅尔公司 用于化学合成的综合方法
JP6670011B2 (ja) 2014-07-25 2020-03-18 ノボマー， インコーポレイテッド 金属錯体の合成およびその使用
MA41513A (fr) 2015-02-13 2017-12-19 Novomer Inc Procédé de distillation pour la production d'acide acrylique
KR20170129735A (ko) * 2015-02-13 2017-11-27 노보머, 인코포레이티드 유연한 화학 제조 플랫폼
CA2976253A1 (en) 2015-02-13 2016-08-18 Novomer, Inc. Continuous carbonylation processes
MA41514A (fr) 2015-02-13 2017-12-19 Novomer Inc Procédés intégrés de synthèse chimique
MA41510A (fr) 2015-02-13 2017-12-19 Novomer Inc Procédé de production d'acide acrylique
EP3088006A1 (de) 2015-04-28 2016-11-02 Bayer Technology Services GmbH Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor
KR101863427B1 (ko) * 2016-02-02 2018-06-01 한국수력원자력 주식회사 배관 내 축적된 공기 포집 장치
US9976946B2 (en) * 2016-04-21 2018-05-22 Instrumentation Laboratory Company Optical flow cell and test head apparatus
US10288556B2 (en) 2016-04-21 2019-05-14 Instrumentation Laboratory Company Optical flow cell apparatus and method for reducing deflection of sample chamber
WO2018061035A1 (en) * 2016-09-30 2018-04-05 Council Of Scientific & Industrial Research A device for collecting water sample to concentrate diversified bacteria from different water depth
EP3460036B1 (en) * 2017-09-22 2020-02-12 Sartorius Stedim Biotech GmbH Sterile probe sampling for a single-use vessel
CN107603855A (zh) * 2017-10-23 2018-01-19 江苏棉海园林工程有限公司 一种可泄压的生物发酵设备
DE102017011263B3 (de) 2017-12-06 2019-05-02 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur Untersuchung eines Mediums
EA202190053A1 (ru) * 2018-06-18 2021-03-22 Баксалта Инкорпорейтед Нижняя секция для соединения со сборкой с тарельчатым сепаратором и сборка с тарельчатым сепаратором
JP2020128963A (ja) * 2019-02-12 2020-08-27 株式会社エンプラス 流体取扱システムおよびこれに用いるカートリッジ
CN110042052B (zh) * 2019-04-26 2022-05-31 中国农业大学烟台研究院 一种沼气工程厌氧发酵系统的智能监控装置
CN110129186B (zh) * 2019-05-29 2022-08-16 浙江美森细胞科技有限公司 一种细胞培养无菌采样装置
CN110411788B (zh) * 2019-08-14 2022-06-10 安徽金联地矿科技有限公司 一种多深度水样取样装置及使用方法
CN110411789B (zh) * 2019-08-14 2022-03-15 安徽金联地矿科技有限公司 一种水样的取样装置及使用方法
DE102019135275A1 (de) 2019-12-19 2021-06-24 Endress+Hauser (Deutschland) Gmbh+Co. Kg Transportables Probennahmebehältnis, Probennahmesystem und Verfahren zur Probennahme
DE102020004956A1 (de) * 2020-08-14 2022-02-17 Forschungszentrum Jülich GmbH Vorrichtung zum sterilen Flüssigkeitstransfer
EP4026889A1 (de) * 2021-01-11 2022-07-13 Eppendorf AG Sterilschutz-aufsatz für spitzen von liquid-handling-einrichtungen
CN112924237B (zh) * 2021-01-26 2022-11-22 安徽金三隆再生资源有限公司 一种钕铁硼废料加工用污水处理装置
CN113567699A (zh) * 2021-08-24 2021-10-29 中国科学院上海微系统与信息技术研究所 一种新型液滴采样枪头、包括其的采样系统以及一种高通量采样方法
DE102021127134A1 (de) 2021-10-19 2023-04-20 TRI Thinking Research Instruments GmbH Bilderfassungsvorrichtung für einen transparenten Bioreaktor
CN115372077B (zh) * 2022-09-15 2024-11-12 聊城好佳一生物乳业有限公司 一种乳酸菌发酵取样器
CN117004479B (zh) * 2023-08-10 2024-01-26 河北蔺氏盛泰药业有限公司 一种麦芽加工用原料融合均匀发酵设备
EP4574961A1 (en) * 2023-12-20 2025-06-25 Sartorius Stedim Biotech GmbH Bioprocess assembly with integrated filtration and sampling systems
CN119198790B (zh) * 2024-12-02 2025-04-08 上海邦林生物科技有限公司 一种对羟基苯甘氨酸发酵酶样本检测装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56161493A (en) 1980-05-19 1981-12-11 Mitsui Cokes Kogyo Kk Hydrogenolysis of heavy oil
JPS5865549U (ja) * 1981-10-28 1983-05-04 大明金属工業株式会社 定量抜き取り用サンプリングバルブ
FR2617286B1 (fr) * 1987-06-26 1991-08-30 Commissariat Energie Atomique Dispositif de prelevement comportant une tete de prelevement sterilisable en position montee sur un bioreacteur
DE68915785T2 (de) 1989-04-24 1995-01-05 Keofitt A/S, Fredericia Ventil zur musternahme.
JPH03110435A (ja) 1989-09-25 1991-05-10 Fuji Electric Co Ltd 半導体圧覚センサ及びその製造方法
US5591344A (en) * 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US6162400A (en) * 1998-08-12 2000-12-19 Agilent Technologies, Inc. Apparatus for controlling reactions
DE10023582A1 (de) * 2000-05-13 2001-11-15 Bosch Gmbh Robert Ventil mit elastischen Dichtelementen
ATE380859T1 (de) * 2001-03-16 2007-12-15 Colder Prod Co Sterilisierende baugruppe für biologische geräte und kupplungsverfahren
DE10252217B4 (de) * 2002-11-11 2005-06-09 Sartorius Ag Probenahmeventil und damit durchführbares Verfahren zur sterilen Entnahme von Proben aus Fermentern oder Bioreaktoren
DE10301421A1 (de) 2003-01-16 2004-07-29 Bayer Ag Prozessanalysensysteme mit automatischer Flüssigprobenvorbereitung und Anbindung zu Prozessleitsystemen
US7169599B2 (en) 2003-06-20 2007-01-30 Groton Biosystems, Llc Fluid interface for bioprocessor systems

Also Published As

Publication number Publication date
US8647592B2 (en) 2014-02-11
WO2007121887A3 (de) 2007-12-21
CN101426897A (zh) 2009-05-06
CN101426897B (zh) 2012-05-30
DE102006019242A1 (de) 2007-10-25
US20090178495A1 (en) 2009-07-16
SG10201508150WA (en) 2015-10-29
NO20084455L (no) 2008-11-19
WO2007121887A2 (de) 2007-11-01
JP5693537B2 (ja) 2015-04-01
US20130295600A1 (en) 2013-11-07
JP2013011618A (ja) 2013-01-17
JP2009534634A (ja) 2009-09-24
EP2013328A2 (de) 2009-01-14
SG171597A1 (en) 2011-06-29
US8431089B2 (en) 2013-04-30
CA2649554A1 (en) 2007-11-01
CA2649554C (en) 2019-01-22

Similar Documents

Publication Publication Date Title
US8647592B2 (en) Method for transport of suspensions containing mechanically sensitive material
EP1640718B1 (en) Method and apparatus for the detection of substances or analytes from the analysis of one or more samples
US8518246B2 (en) Device for monitoring water for microbial germs
EP3755992B1 (en) Computer-implemented method and system for spectroscopic analysis of biological material
EP2868742B1 (en) Filtering member and filtering method
CN209485753U (zh) 一种用于生物反应过程在线取样检测装置
JP4842796B2 (ja) 微生物検査装置及び微生物検査用計測チップ
US20200009549A1 (en) Device and method for producing individually processed fluid samples
CN111289295A (zh) 一种用于生物反应过程在线取样检测装置及其方法
EP4159836A1 (en) Filtration cartridge and microbial test method
WO2010130302A1 (en) Modular system for the automatic production of three-dimensional tissue structures
WO2017203744A1 (ja) 核酸検査装置
CN211620516U (zh) 一种核酸微流控制检测系统
DE19819857C2 (de) Vorrichtung zur Bestimmung von Biomolekülen und gelösten Stoffen in Flüssigkeiten
JPWO2007055165A1 (ja) 核酸の分離方法、核酸検査用マイクロリアクタ、核酸検査システム
JP4906362B2 (ja) 化学分析前処理装置
CN121160446A (en) Fermentation tank fermentation process regulation and control system and method
Gloes et al. Analyte Tracking for Novel Bio-Applications
WO2023052401A1 (en) On-line biomolecular analysis for monitoring or controlling bioprocesses
Gastrock et al. Protein‐Processing Platform (3P)–a New Concept for the Characterization of Cell Cultures in the mL‐Scale Using Microfluidic Components
Arnold et al. Employing Near-Infrared Spectroscopic Methods of Analysis for Fermentation Monitoring and Control

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed