JP2009534294A5 - - Google Patents
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- Publication number
- JP2009534294A5 JP2009534294A5 JP2008550095A JP2008550095A JP2009534294A5 JP 2009534294 A5 JP2009534294 A5 JP 2009534294A5 JP 2008550095 A JP2008550095 A JP 2008550095A JP 2008550095 A JP2008550095 A JP 2008550095A JP 2009534294 A5 JP2009534294 A5 JP 2009534294A5
- Authority
- JP
- Japan
- Prior art keywords
- pioglitazone
- salt
- formulation
- coating layer
- excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 16
- 239000011247 coating layer Substances 0.000 claims description 10
- 229960005095 pioglitazone Drugs 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- 239000007771 core particle Substances 0.000 claims description 6
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000007884 disintegrant Substances 0.000 claims description 2
- 235000003599 food sweetener Nutrition 0.000 claims description 2
- 239000003765 sweetening agent Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- -1 acetal diethylaminoacetate Chemical class 0.000 claims 4
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- GHUUBYQTCDQWRA-UHFFFAOYSA-N Pioglitazone hydrochloride Chemical compound Cl.N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 GHUUBYQTCDQWRA-UHFFFAOYSA-N 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229960002827 pioglitazone hydrochloride Drugs 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 5
- 239000000654 additive Substances 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008550095A JP5276991B2 (ja) | 2006-04-27 | 2007-04-26 | 固形製剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006124456 | 2006-04-27 | ||
| JP2006124456 | 2006-04-27 | ||
| PCT/JP2007/059430 WO2007126136A2 (en) | 2006-04-27 | 2007-04-26 | Mask- tasting solid preparation of pioglitazone |
| JP2008550095A JP5276991B2 (ja) | 2006-04-27 | 2007-04-26 | 固形製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534294A JP2009534294A (ja) | 2009-09-24 |
| JP2009534294A5 true JP2009534294A5 (enExample) | 2010-06-17 |
| JP5276991B2 JP5276991B2 (ja) | 2013-08-28 |
Family
ID=38655916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550095A Expired - Fee Related JP5276991B2 (ja) | 2006-04-27 | 2007-04-26 | 固形製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8632808B2 (enExample) |
| EP (1) | EP2010154A2 (enExample) |
| JP (1) | JP5276991B2 (enExample) |
| AR (1) | AR060662A1 (enExample) |
| CL (1) | CL2007001194A1 (enExample) |
| PE (1) | PE20080249A1 (enExample) |
| TW (1) | TW200810753A (enExample) |
| WO (1) | WO2007126136A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20080180A1 (es) | 2006-05-23 | 2008-04-22 | Takeda Pharmaceutical | Preparacion oral de pioglitazona |
| JP5683058B2 (ja) * | 2007-04-27 | 2015-03-11 | ニプロ株式会社 | 経口固形製剤及びその製造方法 |
| TW200914006A (en) * | 2007-07-12 | 2009-04-01 | Takeda Pharmaceutical | Coated preparation |
| JP4706785B2 (ja) * | 2008-09-30 | 2011-06-22 | アステラス製薬株式会社 | 経口投与用粒子状医薬組成物 |
| JP2010202579A (ja) * | 2009-03-03 | 2010-09-16 | Sawai Pharmaceutical Co Ltd | アカルボースを含有する口腔内崩壊剤 |
| JP5614445B2 (ja) * | 2010-03-29 | 2014-10-29 | アステラス製薬株式会社 | 経口投与用粒子状医薬組成物 |
| JP5534004B2 (ja) * | 2010-03-29 | 2014-06-25 | アステラス製薬株式会社 | 口腔内崩壊錠 |
| JP5566757B2 (ja) * | 2010-04-16 | 2014-08-06 | 大塚製薬株式会社 | 固形製剤 |
| WO2012156997A2 (en) * | 2011-05-16 | 2012-11-22 | Sun Pharma Advanced Research Company Ltd | Multi-particulate pharmaceutical composition |
| EP2814466B1 (en) * | 2012-02-15 | 2018-12-26 | Takeda Pharmaceutical Company Limited | Tablet comprising 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamide or a salt thereof |
| JPWO2013129436A1 (ja) * | 2012-02-29 | 2015-07-30 | 武田薬品工業株式会社 | 経口剤 |
| CA2852042C (en) * | 2012-03-02 | 2018-05-01 | Rhodes Pharmaceuticals L.P. | Tamper resistant immediate release formulations |
| KR101340733B1 (ko) * | 2012-12-31 | 2013-12-12 | (주) 에프엔지리서치 | 신규한 마이크로그래뉼 제형 |
| WO2014152351A1 (en) * | 2013-03-15 | 2014-09-25 | Boston Therapeutics, Inc. | Encapsulation of pharmaceuticals for taste masking in chewable tablets |
| EP3091966B1 (en) * | 2014-01-10 | 2019-07-31 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| JP6147711B2 (ja) * | 2014-05-26 | 2017-06-14 | 富士フイルム株式会社 | 医薬用組成物及びその製造方法、並びに口腔内崩壊錠及びその製造方法 |
| JP5764811B2 (ja) * | 2014-06-18 | 2015-08-19 | 大塚製薬株式会社 | 固形製剤 |
| US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| EA038894B1 (ru) * | 2018-06-08 | 2021-11-03 | Айтен Садиг кызы Шукюрова | Антидиабетическое лекарственное средство |
| WO2025049710A1 (en) * | 2023-08-29 | 2025-03-06 | Aclipse Two Inc. | Pharmaceutical composition for use in the disease treatments |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708867A (en) * | 1983-12-19 | 1987-11-24 | Key Pharmaceuticals, Inc. | Minipellets |
| EP0826376B1 (en) * | 1995-05-02 | 2007-01-24 | Taisho Pharmaceutical Co. Ltd | Composition for oral administration |
| ATE481090T1 (de) | 1998-07-28 | 2010-10-15 | Takeda Pharmaceutical | Leicht zerfallende feste zubereitung |
| JP3718398B2 (ja) | 2000-01-11 | 2005-11-24 | 信越化学工業株式会社 | フィルムコーティング剤及び経口固形製剤 |
| WO2002030400A1 (fr) | 2000-10-06 | 2002-04-18 | Takeda Chemical Industries, Ltd. | Preparations solides |
| CA2492722A1 (en) | 2002-07-11 | 2004-01-22 | Takeda Pharmaceutical Company Limited | Production method of coated preparations |
| IN192749B (enExample) * | 2002-11-15 | 2004-05-15 | Ranbaxy Lab Ltd | |
| US20060182796A1 (en) * | 2005-02-03 | 2006-08-17 | Abrika Pharmaceuticals, Inc. | Taste masked pharmaceutical compositions |
-
2007
- 2007-04-26 JP JP2008550095A patent/JP5276991B2/ja not_active Expired - Fee Related
- 2007-04-26 CL CL2007001194A patent/CL2007001194A1/es unknown
- 2007-04-26 TW TW096114773A patent/TW200810753A/zh unknown
- 2007-04-26 AR ARP070101811A patent/AR060662A1/es not_active Application Discontinuation
- 2007-04-26 WO PCT/JP2007/059430 patent/WO2007126136A2/en not_active Ceased
- 2007-04-26 PE PE2007000521A patent/PE20080249A1/es not_active Application Discontinuation
- 2007-04-26 US US12/298,418 patent/US8632808B2/en not_active Expired - Fee Related
- 2007-04-26 EP EP07742865A patent/EP2010154A2/en not_active Withdrawn
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