JP2009529561A5 - - Google Patents
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- JP2009529561A5 JP2009529561A5 JP2008558730A JP2008558730A JP2009529561A5 JP 2009529561 A5 JP2009529561 A5 JP 2009529561A5 JP 2008558730 A JP2008558730 A JP 2008558730A JP 2008558730 A JP2008558730 A JP 2008558730A JP 2009529561 A5 JP2009529561 A5 JP 2009529561A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- use according
- composition
- cellulose
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 35
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 23
- 229960002715 nicotine Drugs 0.000 claims 23
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 23
- 239000001913 cellulose Substances 0.000 claims 20
- 229920002678 cellulose Polymers 0.000 claims 20
- 235000010980 cellulose Nutrition 0.000 claims 11
- 239000002585 base Substances 0.000 claims 7
- -1 alkali metal citrate Chemical class 0.000 claims 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 239000006172 buffering agent Substances 0.000 claims 4
- 239000007937 lozenge Substances 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 235000006708 antioxidants Nutrition 0.000 claims 3
- 235000003599 food sweetener Nutrition 0.000 claims 3
- 239000003205 fragrance Substances 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 239000003765 sweetening agent Substances 0.000 claims 3
- 238000012360 testing method Methods 0.000 claims 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 2
- 230000000181 anti-adherent effect Effects 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 238000007925 in vitro drug release testing Methods 0.000 claims 2
- 235000019359 magnesium stearate Nutrition 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims 1
- QLDPCHZQQIASHX-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.CN1CCCC1C1=CC=CN=C1 QLDPCHZQQIASHX-UHFFFAOYSA-N 0.000 claims 1
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 claims 1
- IRJNJBIOUYJBHG-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.CN1CCCC1C1=CC=CN=C1 IRJNJBIOUYJBHG-UHFFFAOYSA-N 0.000 claims 1
- MQWJVKLIBZWVEL-XRIOVQLTSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;dihydrochloride Chemical compound Cl.Cl.CN1CCC[C@H]1C1=CC=CN=C1 MQWJVKLIBZWVEL-XRIOVQLTSA-N 0.000 claims 1
- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 claims 1
- YHBIGBYIUMCLJS-UHFFFAOYSA-N 5-fluoro-1,3-benzothiazol-2-amine Chemical compound FC1=CC=C2SC(N)=NC2=C1 YHBIGBYIUMCLJS-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims 1
- 108010011485 Aspartame Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 241000195493 Cryptophyta Species 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 244000166124 Eucalyptus globulus Species 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 claims 1
- 229960005164 acesulfame Drugs 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 239000008122 artificial sweetener Substances 0.000 claims 1
- 235000021311 artificial sweeteners Nutrition 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 239000000605 aspartame Substances 0.000 claims 1
- 235000010357 aspartame Nutrition 0.000 claims 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 1
- 229960003438 aspartame Drugs 0.000 claims 1
- 235000013734 beta-carotene Nutrition 0.000 claims 1
- 239000011648 beta-carotene Substances 0.000 claims 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 1
- 229960002747 betacarotene Drugs 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940112822 chewing gum Drugs 0.000 claims 1
- 235000015218 chewing gum Nutrition 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 238000007922 dissolution test Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000007888 film coating Substances 0.000 claims 1
- 238000009501 film coating Methods 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000003630 glycyl group Chemical class [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000905 isomalt Substances 0.000 claims 1
- 235000010439 isomalt Nutrition 0.000 claims 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 239000008368 mint flavor Substances 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 229940069688 nicotine bitartrate Drugs 0.000 claims 1
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical compound O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 235000010388 propyl gallate Nutrition 0.000 claims 1
- 239000000473 propyl gallate Substances 0.000 claims 1
- 229940075579 propyl gallate Drugs 0.000 claims 1
- 235000019204 saccharin Nutrition 0.000 claims 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- 229940081974 saccharin Drugs 0.000 claims 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- 229960005055 sodium ascorbate Drugs 0.000 claims 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000011343 solid material Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 239000006068 taste-masking agent Substances 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims 1
- FGAFEHZTRRYNDF-UHFFFAOYSA-L zinc;3-(1-methylpyrrolidin-2-yl)pyridine;dichloride Chemical compound [Cl-].[Cl-].[Zn+2].CN1CCCC1C1=CC=CN=C1 FGAFEHZTRRYNDF-UHFFFAOYSA-L 0.000 claims 1
- BRTHFWPGJMGHIV-UHFFFAOYSA-L zinc;3-(1-methylpyrrolidin-2-yl)pyridine;dichloride;hydrate Chemical compound O.[Cl-].[Cl-].[Zn+2].CN1CCCC1C1=CC=CN=C1 BRTHFWPGJMGHIV-UHFFFAOYSA-L 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78290306P | 2006-03-16 | 2006-03-16 | |
| DKPA200600375 | 2006-03-16 | ||
| PCT/EP2007/002345 WO2007104575A2 (en) | 2006-03-16 | 2007-03-16 | Stable lozenge compositions providing rapid release of nicotine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009529561A JP2009529561A (ja) | 2009-08-20 |
| JP2009529561A5 true JP2009529561A5 (cg-RX-API-DMAC7.html) | 2010-05-06 |
Family
ID=38357118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008558729A Pending JP2009529343A (ja) | 2006-03-16 | 2007-03-16 | ニコチンの迅速放出を提供するチューインガム組成物 |
| JP2008558730A Withdrawn JP2009529561A (ja) | 2006-03-16 | 2007-03-16 | ニコチンの速やかな放出をもたらす安定なロゼンジ組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008558729A Pending JP2009529343A (ja) | 2006-03-16 | 2007-03-16 | ニコチンの迅速放出を提供するチューインガム組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20100061940A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1998754A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2009529343A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2007224586A1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2657932A1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2007104574A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI3473251T3 (fi) | 2002-12-20 | 2024-01-09 | Niconovum Ab | Nikotiini-selluloosa-kombinaatio |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| AU2007224584A1 (en) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Improved snuff composition |
| US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| GB2468424B (en) * | 2007-04-02 | 2011-11-09 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
| ES2521494T3 (es) * | 2007-04-02 | 2014-11-12 | Parkinson's Institute | Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos |
| WO2009037319A2 (en) * | 2007-09-18 | 2009-03-26 | Niconovum Ab | Stable chewing gum compositions comprising maltitol and providing rapid release of nicotine |
| MX2010010607A (es) | 2008-03-26 | 2011-03-29 | Stichting Sanammad | Composiciones para goma de mascar que comprenden canabinoides. |
| CL2009001025A1 (es) | 2008-05-01 | 2010-09-24 | Smithkline Beecham Corp | Composicion de pastilla para chupar que comprende: a) un granulo patron con al menos: un agente tampon alcalino, un modificador de la disolucion y una carga, b) un principio activo de nicotina definido extragranular y al menos un agente tampon alcalino; procedimiento de preparacion; util para eliminar o reducir el uso de tabaco. |
| ES2529297T3 (es) * | 2008-05-21 | 2015-02-18 | Novartis Ag | Chicles prensables que comprenden nicotina y un agente tamponador |
| US8833378B2 (en) | 2008-09-17 | 2014-09-16 | Niconovum Ab | Process for preparing snuff composition |
| US8807979B2 (en) * | 2009-09-24 | 2014-08-19 | Mcneil-Ppc, Inc. | Machine for the manufacture of dosage forms utilizing radiofrequency energy |
| MX2012009586A (es) * | 2010-02-18 | 2012-09-12 | Jatin Vasant Thakkar | Patillas de gelatina blanda con nicotina. |
| US8952038B2 (en) | 2010-03-26 | 2015-02-10 | Philip Morris Usa Inc. | Inhibition of undesired sensory effects by the compound camphor |
| US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| EP2729148A4 (en) | 2011-07-06 | 2015-04-22 | Parkinson S Inst | COMPOSITIONS AND METHOD FOR THE TREATMENT OF SYMPTOMS IN PATIENTS WITH MORBUS PARKINSON |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| EP2804897B1 (en) * | 2012-01-20 | 2016-07-13 | Altria Client Services LLC | Oral product |
| CN102754907B (zh) | 2012-01-20 | 2015-06-24 | 奥驰亚客户服务公司 | 口腔用产品 |
| CN102754908B (zh) | 2012-01-20 | 2015-06-10 | 奥驰亚客户服务公司 | 口腔用烟草产品 |
| US9854831B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral product |
| CN103040090B (zh) | 2012-01-20 | 2016-03-30 | 奥驰亚客户服务公司 | 脱除烟草的口腔用产品 |
| CN103039688B (zh) | 2012-01-20 | 2016-01-06 | 奥驰亚客户服务公司 | 口腔用产品 |
| US12285025B2 (en) | 2012-02-10 | 2025-04-29 | R.J. Reynolds Tobacco Company | Multi-layer smokeless tobacco composition |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| SE536491C2 (sv) * | 2012-03-26 | 2013-12-27 | Bionicotine Ab | Påse innehållande nikotin och en tuggummikomposition |
| US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| US9339058B2 (en) | 2012-04-19 | 2016-05-17 | R. J. Reynolds Tobacco Company | Method for producing microcrystalline cellulose from tobacco and related tobacco product |
| US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
| US9445971B2 (en) | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
| US20140255452A1 (en) | 2013-03-11 | 2014-09-11 | Niconovum Usa, Inc. | Method and apparatus for differentiating oral pouch products |
| AR096223A1 (es) | 2013-05-10 | 2015-12-16 | Glaxosmithkline Llc | Pastilla de nicotina para administración oral |
| CN105530916B (zh) | 2013-07-11 | 2020-04-07 | 艾利斯达医药品公司 | 与间水杨酸形成的烟碱盐 |
| CA2918271C (en) | 2013-07-19 | 2022-10-18 | Altria Client Services Llc | Methods and systems for incorporating nicotine into oral products |
| US11503853B2 (en) | 2013-09-09 | 2022-11-22 | R.J. Reynolds Tobacco Company | Smokeless tobacco composition incorporating a botanical material |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| CN103549646B (zh) * | 2013-11-11 | 2016-03-02 | 云南烟草科学研究院 | 含烟草超微粉末的口崩片型无烟烟草制品及其制备方法 |
| BR112016015944A8 (pt) | 2014-01-10 | 2020-06-09 | Johnson & Johnson Consumer Inc | processo para produzir comprimido, que usa radiofrequência e partículas revestidas dissipadoras de energia |
| PL3871515T3 (pl) | 2014-05-27 | 2025-06-16 | R. J. Reynolds Tobacco Company | Sole nikotyny, ko-kryształy i kompleksy ko-kryształów soli |
| JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 薬剤送達方法及びシステム |
| US10679516B2 (en) | 2015-03-12 | 2020-06-09 | Morningside Venture Investments Limited | Craving input and support system |
| US10881133B2 (en) | 2015-04-16 | 2021-01-05 | R.J. Reynolds Tobacco Company | Tobacco-derived cellulosic sugar |
| US20170172995A1 (en) * | 2015-09-08 | 2017-06-22 | Venkateswara Rao Repaka | Pharmaceutical compositions of Nicotine and process for preparation thereof |
| US10869497B2 (en) | 2015-09-08 | 2020-12-22 | R.J. Reynolds Tobacco Company | High-pressure cold pasteurization of tobacco material |
| CA3000770A1 (en) | 2015-10-07 | 2017-04-13 | Fertin Pharma A/S | Chewing gum comprising nicotine |
| CN114656446A (zh) | 2015-11-25 | 2022-06-24 | R.J.雷诺兹烟草公司 | 烟碱盐、共晶体和盐共晶体配合物 |
| US10532046B2 (en) | 2015-12-03 | 2020-01-14 | Niconovum Usa, Inc. | Multi-phase delivery compositions and products incorporating such compositions |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| US10499684B2 (en) | 2016-01-28 | 2019-12-10 | R.J. Reynolds Tobacco Company | Tobacco-derived flavorants |
| US11154087B2 (en) | 2016-02-02 | 2021-10-26 | R.J. Reynolds Tobacco Company | Method for preparing flavorful compounds isolated from black liquor and products incorporating the flavorful compounds |
| EP4424190A3 (en) | 2016-12-30 | 2024-11-06 | Philip Morris Products S.A. | Nicotine and cellulose containing sheet |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| US11091446B2 (en) | 2017-03-24 | 2021-08-17 | R.J. Reynolds Tobacco Company | Methods of selectively forming substituted pyrazines |
| EP3681865B1 (en) | 2017-09-05 | 2025-09-17 | R. J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| US20190307082A1 (en) | 2018-04-05 | 2019-10-10 | R.J. Reynolds Tobacco Company | Oriental tobacco production methods |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| DK3807260T3 (da) | 2018-06-15 | 2024-10-14 | Reynolds Tobacco Co R | Oprensning af nikotin |
| CA3119992A1 (en) | 2018-11-16 | 2020-05-22 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| US12213510B2 (en) | 2019-09-11 | 2025-02-04 | Nicoventures Trading Limited | Pouched products with enhanced flavor stability |
| US12342847B2 (en) | 2019-09-11 | 2025-07-01 | Nicoventures Trading Limited | Oral product with cellulosic flavor stabilizer |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
| CA3160750A1 (en) | 2019-12-09 | 2021-06-17 | Anthony Richard Gerardi | Oral product comprising a cannabinoid |
| WO2021116865A1 (en) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Agents for oral composition |
| US12151023B2 (en) | 2019-12-09 | 2024-11-26 | Nicoventures Trading Limited | Oral composition with beet material |
| US12137723B2 (en) | 2019-12-09 | 2024-11-12 | Nicoventures Trading Limited | Oral products with active ingredient combinations |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| WO2021116855A1 (en) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Oral compositions and methods of manufacture |
| EP4072338A1 (en) | 2019-12-09 | 2022-10-19 | Nicoventures Trading Limited | Agents for oral composition |
| US12433321B2 (en) | 2019-12-09 | 2025-10-07 | Nicoventures Trading Limited | Oral composition with beet material |
| US12310959B2 (en) | 2019-12-09 | 2025-05-27 | Nicoventures Trading Limited | Oral compositions with reduced water content |
| US12439949B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Oral compositions with reduced water activity |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| US11672862B2 (en) | 2019-12-09 | 2023-06-13 | Nicoventures Trading Limited | Oral products with reduced irritation |
| US12171872B2 (en) | 2019-12-09 | 2024-12-24 | Nicoventures Trading Limited | Oral compositions and methods of manufacture |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| US12491250B2 (en) | 2019-12-09 | 2025-12-09 | Nicoventures Trading Limited | Oral composition with nanocrystalline cellulose |
| US11617744B2 (en) | 2019-12-09 | 2023-04-04 | Nico Ventures Trading Limited | Moist oral compositions |
| US11883527B2 (en) | 2019-12-09 | 2024-01-30 | Nicoventures Trading Limited | Oral composition and method of manufacture |
| US11889856B2 (en) | 2019-12-09 | 2024-02-06 | Nicoventures Trading Limited | Oral foam composition |
| SE544672C2 (en) | 2020-05-07 | 2022-10-11 | Liw Innovation Ab | New compositions for oral or nasal use |
| AU2021289162A1 (en) | 2020-06-08 | 2023-02-09 | Nicoventures Trading Limited | Effervescent oral composition comprising an active ingredient |
| US11839602B2 (en) | 2020-11-25 | 2023-12-12 | Nicoventures Trading Limited | Oral cannabinoid product with lipid component |
| EP4304568A1 (en) | 2021-03-09 | 2024-01-17 | Nicoventures Trading Limited | Oral products and methods of manufacture |
| US20220354785A1 (en) | 2021-04-22 | 2022-11-10 | Nicoventures Trading Limited | Oral lozenge products |
| EP4333650A1 (en) | 2021-05-06 | 2024-03-13 | Nicoventures Trading Limited | Oral compositions and related methods for reducing throat irritation |
| JP2024523520A (ja) | 2021-06-25 | 2024-06-28 | ニコベンチャーズ トレーディング リミテッド | 経口製品及び製造方法 |
| CN119789793A (zh) | 2021-07-30 | 2025-04-08 | 尼科凡图尔斯贸易有限公司 | 包含微晶纤维素的气溶胶发生基材 |
| CA3233375A1 (en) | 2021-09-30 | 2023-04-06 | Michael Zawadzki | Oral product with a basic amine and an ion pairing agent |
| WO2023084499A1 (en) | 2021-11-15 | 2023-05-19 | Nicoventures Trading Limited | Products with enhanced sensory characteristics |
| US12295412B2 (en) | 2022-01-28 | 2025-05-13 | Altria Client Services Llc | Oral pouch product |
| CA3259894A1 (en) | 2022-06-24 | 2023-12-28 | Nicoventures Trading Limited | ORAL COMPOSITION INCLUDING A RECEIVER MODULATOR |
| GB202214775D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| GB202214771D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| AU2023357713A1 (en) | 2022-10-07 | 2025-04-17 | Nicoventures Trading Limited | Oral product |
| JP2025533129A (ja) | 2022-10-07 | 2025-10-03 | ニコベンチャーズ トレーディング リミテッド | 経口製品 |
| JP2025533087A (ja) | 2022-10-07 | 2025-10-03 | ニコベンチャーズ トレーディング リミテッド | 経口製剤 |
| GB202214803D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| WO2024095163A1 (en) | 2022-11-01 | 2024-05-10 | Nicoventures Trading Limited | Oral composition comprising encapsulated ph adjusting agent |
| GB202216465D0 (en) | 2022-11-04 | 2022-12-21 | Nicoventures Trading Ltd | Oral product |
| EP4611557A1 (en) | 2022-11-04 | 2025-09-10 | Nicoventures Trading Limited | Oral product |
| CN115997965A (zh) * | 2023-02-09 | 2023-04-25 | 东莞市吉纯生物技术有限公司 | 一种尼古丁缓释型口含烟及其制备方法 |
| WO2024180481A1 (en) | 2023-02-28 | 2024-09-06 | Nicoventures Trading Limited | Caffeine-containing oral product |
| GB202304445D0 (en) | 2023-03-27 | 2023-05-10 | Nicoventures Trading Ltd | Oral product |
| GB202307279D0 (en) | 2023-05-16 | 2023-06-28 | Nicoventures Trading Ltd | Oral product |
| GB202307278D0 (en) | 2023-05-16 | 2023-06-28 | Nicoventures Holdings Ltd | Oral product |
| EP4585055A1 (en) | 2024-01-12 | 2025-07-16 | Nicoventures Trading Limited | Oral product with probiotic component |
| EP4599698A1 (en) | 2024-02-07 | 2025-08-13 | Nicoventures Trading Limited | Products comprising sensory agents |
| EP4602929A1 (en) | 2024-02-19 | 2025-08-20 | Nicoventures Trading Limited | Oral product with powder coating |
| EP4623708A1 (en) | 2024-03-26 | 2025-10-01 | Nicoventures Trading Limited | Sweetener composition for pouched oral products |
| EP4623702A1 (en) | 2024-03-27 | 2025-10-01 | Nicoventures Trading Limited | Oral product |
| EP4631502A1 (en) | 2024-04-12 | 2025-10-15 | Nicoventures Trading Limited | Use of flavones such as quercetin to increase cognitive function and to reduce jitterness |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
| GB8615676D0 (en) * | 1986-06-26 | 1986-07-30 | Stoppers Co Ltd | Nicotine containing lozenge |
| US5488962A (en) * | 1990-10-10 | 1996-02-06 | Perfetti, S.P.A. | Chewing gum which is a substitute for tobacco smoke |
| US5549906A (en) * | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US5362496A (en) * | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| SE0102197D0 (sv) * | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| US20040101543A1 (en) * | 2002-03-22 | 2004-05-27 | John Liu | Nicotine-containing oral dosage form |
| FI3473251T3 (fi) * | 2002-12-20 | 2024-01-09 | Niconovum Ab | Nikotiini-selluloosa-kombinaatio |
| EA012306B1 (ru) * | 2003-01-24 | 2009-08-28 | Магле Холдинг Аб | Композиционный материал для доставки через слизистые оболочки |
| JP4604034B2 (ja) * | 2003-09-08 | 2010-12-22 | マクニール・アクチェボラーグ | ニコチン製剤およびその使用 |
| ATE439839T1 (de) * | 2003-12-02 | 2009-09-15 | Fertin Pharma As | Nikotin-abgabeprodukt und herstellungsverfahren |
| JP5437574B2 (ja) * | 2004-06-29 | 2014-03-12 | フェルティン ファルマ アー／エス | タバコアルカロイド放出チューインガム |
-
2007
- 2007-03-16 WO PCT/EP2007/002344 patent/WO2007104574A2/en not_active Ceased
- 2007-03-16 US US12/225,260 patent/US20100061940A1/en not_active Abandoned
- 2007-03-16 AU AU2007224586A patent/AU2007224586A1/en not_active Abandoned
- 2007-03-16 JP JP2008558729A patent/JP2009529343A/ja active Pending
- 2007-03-16 JP JP2008558730A patent/JP2009529561A/ja not_active Withdrawn
- 2007-03-16 AU AU2007224585A patent/AU2007224585A1/en not_active Abandoned
- 2007-03-16 CA CA002657932A patent/CA2657932A1/en not_active Abandoned
- 2007-03-16 WO PCT/EP2007/002345 patent/WO2007104575A2/en not_active Ceased
- 2007-03-16 CA CA002646230A patent/CA2646230A1/en not_active Abandoned
- 2007-03-16 EP EP07711967A patent/EP1998754A2/en not_active Withdrawn
- 2007-03-16 EP EP07723324A patent/EP1998755A2/en not_active Withdrawn
- 2007-09-16 US US12/226,273 patent/US20100004294A1/en not_active Abandoned
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