JP2009529498A5 - - Google Patents
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- JP2009529498A5 JP2009529498A5 JP2008556626A JP2008556626A JP2009529498A5 JP 2009529498 A5 JP2009529498 A5 JP 2009529498A5 JP 2008556626 A JP2008556626 A JP 2008556626A JP 2008556626 A JP2008556626 A JP 2008556626A JP 2009529498 A5 JP2009529498 A5 JP 2009529498A5
- Authority
- JP
- Japan
- Prior art keywords
- sod1
- antibody
- seq
- substance
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008221 Superoxide Dismutase-1 Human genes 0.000 claims 40
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 claims 40
- 239000000126 substance Substances 0.000 claims 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 230000002163 immunogen Effects 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 201000010099 disease Diseases 0.000 claims 11
- 239000000178 monomer Substances 0.000 claims 11
- 239000000539 dimer Substances 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 5
- 210000004408 hybridoma Anatomy 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 3
- 108010012715 Superoxide dismutase Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 230000000626 neurodegenerative effect Effects 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000012631 diagnostic technique Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77837906P | 2006-03-03 | 2006-03-03 | |
| US11/367,609 US7439324B2 (en) | 2003-08-20 | 2006-03-03 | ALS-specific peptide composition |
| US60/778,379 | 2006-03-03 | ||
| US11/367,609 | 2006-03-03 | ||
| US79872806P | 2006-05-09 | 2006-05-09 | |
| US79872706P | 2006-05-09 | 2006-05-09 | |
| US60/798,727 | 2006-05-09 | ||
| US60/798,728 | 2006-05-09 | ||
| US11/565,967 | 2006-12-01 | ||
| US11/565,967 US7794692B2 (en) | 2005-12-02 | 2006-12-01 | Methods and compositions for detecting amyotrophic lateral sclerosis |
| PCT/CA2007/000346 WO2007098607A1 (en) | 2006-03-03 | 2007-03-05 | Methods and compositions to treat and detect misfolded-sod1 mediated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012275632A Division JP2013091648A (ja) | 2006-03-03 | 2012-12-18 | ミスフォールドｓｏｄ１媒介疾患を処置および検出するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529498A JP2009529498A (ja) | 2009-08-20 |
| JP2009529498A5 true JP2009529498A5 (enExample) | 2010-04-22 |
| JP5823663B2 JP5823663B2 (ja) | 2015-11-25 |
Family
ID=38460601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556626A Expired - Fee Related JP5823663B2 (ja) | 2006-03-03 | 2007-03-05 | ミスフォールドｓｏｄ１媒介疾患を処置および検出するための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7977314B2 (enExample) |
| EP (5) | EP2514824A3 (enExample) |
| JP (1) | JP5823663B2 (enExample) |
| AU (1) | AU2007219615B2 (enExample) |
| CA (1) | CA2642848C (enExample) |
| DK (2) | DK2495327T3 (enExample) |
| WO (1) | WO2007098607A1 (enExample) |
Families Citing this family (72)
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| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
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| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| PL1976877T5 (pl) | 2005-11-30 | 2017-09-29 | Abbvie Inc | Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania |
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| EP2514824A3 (en) | 2006-03-03 | 2013-01-23 | Amorfix Life Sciences Ltd. | Methods and compositions to treat and detect misfolded-SOD1 mediated diseases |
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| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
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| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| US20130115622A1 (en) * | 2009-12-14 | 2013-05-09 | Kyoto University | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis |
| WO2011130377A2 (en) | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Amyloid-beta binding proteins |
| CA2833912C (en) | 2010-04-23 | 2021-09-21 | University Of Massachusetts | Aav-based treatment of cholesterol-related disorders |
| CA3050894C (en) | 2010-04-23 | 2022-10-18 | University Of Massachusetts | Multicistronic expression constructs |
| DK2561073T3 (en) | 2010-04-23 | 2016-12-12 | Univ Massachusetts | Aav vectors targeted to central nervous system and methods of use thereof |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| US9109037B2 (en) | 2010-10-26 | 2015-08-18 | University Of Massachusetts | Anti-SOD1 antibodies and uses thereof |
| US20120328605A1 (en) * | 2010-10-27 | 2012-12-27 | Daniel Larocque | Compositions and uses |
| CN103380145B (zh) * | 2010-12-17 | 2016-10-12 | 生物控股有限公司 | 人类抗-sod1抗体 |
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| US10689653B2 (en) | 2014-06-03 | 2020-06-23 | University Of Massachusetts | Compositions and methods for modulating dysferlin expression |
| US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
| WO2016065001A1 (en) | 2014-10-21 | 2016-04-28 | University Of Massachusetts | Recombinant aav variants and uses thereof |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
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| US11046955B2 (en) | 2015-04-24 | 2021-06-29 | University Of Massachusetts | Modified AAV constructs and uses thereof |
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| CA3012344A1 (en) | 2016-02-12 | 2017-08-17 | University Of Massachusetts | Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization |
| EP3469093A4 (en) | 2016-06-10 | 2019-12-25 | Saunders, Ann M. | METHOD FOR DETECTING STRUCTURAL VARIANTS IN NEURODEGENERATIVE DISEASES |
| US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
| KR20190075964A (ko) | 2016-10-13 | 2019-07-01 | 유니버시티 오브 매사추세츠 | Aav 캡시드 설계 |
| EP3618839A4 (en) | 2017-05-05 | 2021-06-09 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| AU2018264996A1 (en) | 2017-05-09 | 2019-12-05 | University Of Massachusetts | Methods of treating Amyotrophic Lateral Sclerosis (ALS) |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CN118006607A (zh) | 2017-09-22 | 2024-05-10 | 马萨诸塞大学 | Sod1双表达载体及其用途 |
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| KR102581734B1 (ko) | 2017-10-06 | 2023-09-22 | 네오토프 뉴로사이언스 리미티드 | 트랜스타이레틴의 검출 방법 |
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| WO2019236995A1 (en) | 2018-06-08 | 2019-12-12 | University Of Massachusetts | Antisense oligonucleotides to restore dysferlin protein expression in dysferlinopathy patient cells |
| US20210254103A1 (en) | 2018-07-02 | 2021-08-19 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis and disorders associated with the spinal cord |
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-
2007
- 2007-03-05 EP EP12161568A patent/EP2514824A3/en not_active Withdrawn
- 2007-03-05 DK DK12161575.1T patent/DK2495327T3/da active
- 2007-03-05 EP EP12161564.5A patent/EP2514823B1/en not_active Not-in-force
- 2007-03-05 AU AU2007219615A patent/AU2007219615B2/en not_active Ceased
- 2007-03-05 DK DK12161564.5T patent/DK2514823T3/en active
- 2007-03-05 JP JP2008556626A patent/JP5823663B2/ja not_active Expired - Fee Related
- 2007-03-05 CA CA2642848A patent/CA2642848C/en active Active
- 2007-03-05 EP EP12161575.1A patent/EP2495327B1/en not_active Not-in-force
- 2007-03-05 EP EP12161571A patent/EP2502999A3/en not_active Withdrawn
- 2007-03-05 US US11/682,217 patent/US7977314B2/en active Active
- 2007-03-05 WO PCT/CA2007/000346 patent/WO2007098607A1/en not_active Ceased
- 2007-03-05 EP EP07710682.1A patent/EP1989308B1/en not_active Not-in-force
-
2011
- 2011-06-08 US US13/155,939 patent/US8778885B2/en not_active Expired - Fee Related
-
2014
- 2014-06-10 US US14/300,858 patent/US9637552B2/en not_active Expired - Fee Related
-
2017
- 2017-03-31 US US15/476,440 patent/US20180079825A1/en not_active Abandoned
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