JP2009528309A5 - - Google Patents
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- Publication number
- JP2009528309A5 JP2009528309A5 JP2008556686A JP2008556686A JP2009528309A5 JP 2009528309 A5 JP2009528309 A5 JP 2009528309A5 JP 2008556686 A JP2008556686 A JP 2008556686A JP 2008556686 A JP2008556686 A JP 2008556686A JP 2009528309 A5 JP2009528309 A5 JP 2009528309A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl adamantane
- formamide
- dimethyl
- memantine
- refluxed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 description 2
- RTPQXHZLCUUIJP-UHFFFAOYSA-N 1,2-dimethyladamantane Chemical compound C1C(C2)CC3CC1C(C)C2(C)C3 RTPQXHZLCUUIJP-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229960004640 memantine Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006009279.1 | 2006-03-01 | ||
| DE102006009279A DE102006009279A1 (de) | 2006-03-01 | 2006-03-01 | Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan |
| PCT/EP2007/001433 WO2007101536A1 (de) | 2006-03-01 | 2007-02-20 | Verfahren zur herstellung von 1-formamido-3,5-dimethyladamantan |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528309A JP2009528309A (ja) | 2009-08-06 |
| JP2009528309A5 true JP2009528309A5 (https=) | 2010-04-08 |
| JP5345403B2 JP5345403B2 (ja) | 2013-11-20 |
Family
ID=38197988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556686A Active JP5345403B2 (ja) | 2006-03-01 | 2007-02-20 | １−ホルムアミド−３，５−ジメチルアダマンタンの製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8138375B2 (https=) |
| EP (1) | EP1989175B1 (https=) |
| JP (1) | JP5345403B2 (https=) |
| DE (1) | DE102006009279A1 (https=) |
| ES (1) | ES2392550T3 (https=) |
| RU (1) | RU2455281C2 (https=) |
| WO (1) | WO2007101536A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2103597A1 (en) * | 2008-03-20 | 2009-09-23 | Merz Pharma GmbH & Co.KGaA | Process for the manufacture of memantine and intermediate product |
| ES2507085T3 (es) * | 2008-03-20 | 2014-10-14 | Merz Pharma Gmbh & Co. Kgaa | Proceso para la fabricación de Memantina y producto intermedio |
| EP2373612B1 (en) | 2008-12-17 | 2013-04-17 | Merz Pharma GmbH & Co. KGaA | Method for producing memantine |
| EP2389351A1 (en) * | 2009-01-21 | 2011-11-30 | Merz Pharma GmbH & Co. KGaA | A process for preparing memantine |
| WO2011015265A2 (en) | 2009-08-04 | 2011-02-10 | Merck Patent Gmbh | Electronic devices comprising multi cyclic hydrocarbons |
| JP2013180983A (ja) * | 2012-03-01 | 2013-09-12 | Tokyo Univ Of Agriculture & Technology | Ｎ置換アミド化合物の製造方法 |
| RU2549901C1 (ru) * | 2013-12-30 | 2015-05-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") | Способ получения n-адамантилированных амидов |
| EP4005565A1 (en) | 2020-11-30 | 2022-06-01 | Merz Pharmaceuticals GmbH | Novel uses of adamantane derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2318461A1 (de) | 1973-04-12 | 1974-10-31 | Merz & Co | Verfahren zur herstellung von 1,3,5trisubstituierten adamanta-verbindungen |
| JPS63159330A (ja) * | 1986-12-23 | 1988-07-02 | Kawasaki Steel Corp | １，３−ジメチルアダマンタンの製造方法 |
| JPS63295519A (ja) * | 1987-05-27 | 1988-12-01 | Kawasaki Steel Corp | １，３−ジメチルアダマンタンの製造方法 |
| SU1643528A1 (ru) * | 1988-10-03 | 1991-04-23 | Научно-производственное объединение "Комплекс" | Способ получени 1-ацетаминоадамантана |
| ES2059602T3 (es) * | 1989-04-14 | 1994-11-16 | Merz & Co Gmbh & Co | Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral. |
| US5117056A (en) | 1990-12-21 | 1992-05-26 | Air Products And Chemicals, Inc. | Preparation of N-(1-alkoxyalkyl)formamide and bis formamides |
| RU2246482C2 (ru) * | 2002-12-25 | 2005-02-20 | ООО "Циклан" | Способ получения гидрохлорида 1-амино-3,5-диметиладамантана |
| CN100345819C (zh) * | 2003-07-01 | 2007-10-31 | 北京德众万全药物技术开发有限公司 | 一种取代的金刚烷胺类化合物或其盐的制备方法 |
| EP1789380A1 (de) | 2004-07-23 | 2007-05-30 | Justus-Liebig-Universität Giessen | Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung |
-
2006
- 2006-03-01 DE DE102006009279A patent/DE102006009279A1/de not_active Ceased
-
2007
- 2007-02-20 JP JP2008556686A patent/JP5345403B2/ja active Active
- 2007-02-20 US US12/224,575 patent/US8138375B2/en active Active
- 2007-02-20 ES ES07722859T patent/ES2392550T3/es active Active
- 2007-02-20 EP EP07722859A patent/EP1989175B1/de active Active
- 2007-02-20 WO PCT/EP2007/001433 patent/WO2007101536A1/de not_active Ceased
- 2007-02-20 RU RU2008138891/04A patent/RU2455281C2/ru active
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