JP2009527572A5 - - Google Patents
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- Publication number
- JP2009527572A5 JP2009527572A5 JP2008556452A JP2008556452A JP2009527572A5 JP 2009527572 A5 JP2009527572 A5 JP 2009527572A5 JP 2008556452 A JP2008556452 A JP 2008556452A JP 2008556452 A JP2008556452 A JP 2008556452A JP 2009527572 A5 JP2009527572 A5 JP 2009527572A5
- Authority
- JP
- Japan
- Prior art keywords
- cationic polysaccharide
- immunogenic composition
- composition according
- immunogenic
- microparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 28
- 230000002163 immunogen Effects 0.000 claims 21
- -1 cationic polysaccharide Chemical class 0.000 claims 18
- 229920001282 polysaccharide Polymers 0.000 claims 18
- 239000005017 polysaccharide Substances 0.000 claims 18
- 239000011859 microparticle Substances 0.000 claims 14
- 230000001900 immune effect Effects 0.000 claims 11
- 241000894007 species Species 0.000 claims 11
- 229920002988 biodegradable polymer Polymers 0.000 claims 10
- 239000004621 biodegradable polymer Substances 0.000 claims 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 3
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000007762 w/o emulsion Substances 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000013626 chemical specie Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 230000001571 immunoadjuvant effect Effects 0.000 claims 1
- 239000000568 immunological adjuvant Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77675706P | 2006-02-24 | 2006-02-24 | |
| PCT/US2007/004798 WO2007100699A2 (en) | 2006-02-24 | 2007-02-24 | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013080151A Division JP2013136641A (ja) | 2006-02-24 | 2013-04-08 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009527572A JP2009527572A (ja) | 2009-07-30 |
| JP2009527572A5 true JP2009527572A5 (https=) | 2011-04-14 |
Family
ID=38326215
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556452A Withdrawn JP2009527572A (ja) | 2006-02-24 | 2007-02-24 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2013080151A Pending JP2013136641A (ja) | 2006-02-24 | 2013-04-08 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2015047973A Withdrawn JP2015110661A (ja) | 2006-02-24 | 2015-03-11 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2016254929A Pending JP2017057227A (ja) | 2006-02-24 | 2016-12-28 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013080151A Pending JP2013136641A (ja) | 2006-02-24 | 2013-04-08 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2015047973A Withdrawn JP2015110661A (ja) | 2006-02-24 | 2015-03-11 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2016254929A Pending JP2017057227A (ja) | 2006-02-24 | 2016-12-28 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8431160B2 (https=) |
| EP (1) | EP1991204A2 (https=) |
| JP (4) | JP2009527572A (https=) |
| AU (1) | AU2007221154A1 (https=) |
| CA (1) | CA2643322C (https=) |
| WO (1) | WO2007100699A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR011700A0 (en) | 2000-09-14 | 2000-10-05 | Austin Research Institute, The | Composition comprising immunogenic virus sized particles (VSP) |
| EP1333858B8 (en) | 2000-11-07 | 2006-06-14 | Immunovaccine Technologies Inc. | Vaccines with enhanced immune response and methods for their preparation |
| WO2006081576A2 (en) | 2005-01-28 | 2006-08-03 | Galenbio, Inc. | Immunologically active compositions |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| CA2700808C (en) | 2007-09-27 | 2017-11-14 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
| US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
| AU2013204315B2 (en) * | 2007-10-19 | 2016-02-18 | Glaxosmithkline Biologicals Sa | Meningococcal vaccine formulations |
| WO2009050586A1 (en) * | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| EP3067048B1 (en) * | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| CA2722765C (en) * | 2008-04-28 | 2016-10-04 | Novartis Ag | Nanoparticles for use in pharmaceutical compositions |
| ES2524699T3 (es) * | 2008-06-05 | 2014-12-11 | Immunovaccine Technologies Inc. | Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba |
| TWI351288B (en) * | 2008-07-04 | 2011-11-01 | Univ Nat Pingtung Sci & Tech | Cpg dna adjuvant in avian vaccines |
| JP5804453B2 (ja) * | 2009-05-14 | 2015-11-04 | 国立大学法人 東京大学 | 結晶性ポリオール微粒子及びその調製方法 |
| CA2762653A1 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Immunomodulatory agent-polymeric compounds |
| BR112012001077A2 (pt) * | 2009-07-16 | 2020-08-11 | The General Hospital Corporation | extração de ácido nucleico, métodos para avaliar a qualidade de uma extração de ácido nucleico e de uma amostra biológica, para ober ácido nucleico a partir de uma amostra biológica, para analisar rna de microvesículas e para diagnosticar e monitorar um indivíduo, e, kit |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| WO2011031877A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| GB0922066D0 (en) | 2009-12-17 | 2010-02-03 | Univ Belfast | Modulator |
| ES2536429T3 (es) * | 2010-01-24 | 2015-05-25 | Novartis Ag | Micropartículas de polímero biodegradables irradiadas |
| US8994811B2 (en) * | 2010-01-27 | 2015-03-31 | National University Corporation Hokkaido University | Diffraction microscopy |
| WO2011117844A2 (en) * | 2010-03-26 | 2011-09-29 | Serum Institute Of India Ltd. | Method for evaluation of multiple antibodies or multiple antigens in a single sample |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| MX350927B (es) | 2010-08-26 | 2017-09-26 | Toray Ind Inc Star | Composicion inmunogenica. |
| US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| JP6219721B2 (ja) | 2010-11-10 | 2017-10-25 | エキソソーム ダイアグノスティックス インコーポレイテッド | 核酸含有粒子の単離および該粒子からの核酸の抽出のための方法 |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| KR20140041505A (ko) | 2011-04-29 | 2014-04-04 | 셀렉타 바이오사이언시즈, 인크. | 조절 b 세포 유도를 위한 관용원성 합성 나노운반체 |
| JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| JP6240077B2 (ja) | 2011-10-06 | 2017-11-29 | イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用 |
| US20130142878A1 (en) * | 2011-12-01 | 2013-06-06 | Flow Pharma, Inc. | Peptide particle formulation |
| US20140105970A1 (en) * | 2011-12-01 | 2014-04-17 | Flow Pharma, Inc. | Adjuvant and antigen particle formulation |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013192532A2 (en) * | 2012-06-21 | 2013-12-27 | Northwestern University | Peptide conjugated particles |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| SI3116887T1 (sl) | 2014-03-13 | 2021-06-30 | Universitaet Basel | Ogljikohidratni ligandi, ki se vežejo na protitelesa img proti glikoproteinu, ki je povezan z mielinom |
| US11091591B2 (en) | 2015-09-16 | 2021-08-17 | Universität Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
| WO2018025926A1 (ja) * | 2016-08-04 | 2018-02-08 | ゼノアックリソース株式会社 | 免疫賦活剤、医薬組成物および飲食品 |
| TWI654993B (zh) * | 2016-11-04 | 2019-04-01 | National Health Research Institutes | 陽離子型生物可降解性陶瓷聚合物微粒子用以遞送疫苗之用途 |
| US12257294B2 (en) | 2018-02-02 | 2025-03-25 | Danmarks Tekniske Universitet | Therapeutics for autoimmune disease: synthetic antigens |
| US11771761B2 (en) | 2019-06-12 | 2023-10-03 | Wisconsin Alumni Research Foundation | Adjuvant for animal and human vaccines |
| US12233177B2 (en) | 2019-09-16 | 2025-02-25 | Amgen Inc. | Method for external sterilization of drug delivery device |
| CN111728955A (zh) * | 2020-06-19 | 2020-10-02 | 中山大学 | 一种用于乙肝治疗的纳米颗粒及其制备方法和治疗性疫苗 |
| US20220160822A1 (en) * | 2020-11-23 | 2022-05-26 | Wisconsin Alumni Research Foundation | Neutralizing vaccines against human coronavirus |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT991403E (pt) | 1997-01-30 | 2003-08-29 | Chiron Corp | Uso de microparticulas com antigenio adsorvido para estimular respostas imunes |
| US6884435B1 (en) | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| US6514522B2 (en) * | 1998-04-08 | 2003-02-04 | Chondros, Inc. | Polymer constructs |
| AU763975B2 (en) | 1998-07-29 | 2003-08-07 | Novartis Vaccines And Diagnostics, Inc. | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
| NZ514323A (en) | 1999-03-24 | 2003-03-28 | Secr Defence | A immunostimulant containing an acitive agent and an adjuvant which increases the effect of the active agent |
| GB9914412D0 (en) * | 1999-06-22 | 1999-08-18 | Worrall Eric E | Method for the preservation of viruses,bacteria and biomolecules |
| JP5597335B2 (ja) | 1999-11-19 | 2014-10-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 樹状細胞の微粒子ベースのトランスフェクションおよび活性化 |
| US7838015B2 (en) | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| WO2003086454A1 (en) * | 2002-04-18 | 2003-10-23 | Akzo Nobel N.V. | Antigen-loaded chitosan microparticles for oral vaccination |
| ATE426412T1 (de) | 2003-01-30 | 2009-04-15 | Novartis Vaccines & Diagnostic | Adjuvante influenza-vakzine |
| US20050244505A1 (en) * | 2003-12-11 | 2005-11-03 | Higbee Russell G | Immunotherapy compositions, method of making and method of use thereof |
| ES2434029T3 (es) | 2004-11-15 | 2013-12-13 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido |
-
2007
- 2007-02-24 WO PCT/US2007/004798 patent/WO2007100699A2/en not_active Ceased
- 2007-02-24 CA CA2643322A patent/CA2643322C/en not_active Expired - Fee Related
- 2007-02-24 US US11/710,250 patent/US8431160B2/en not_active Expired - Fee Related
- 2007-02-24 EP EP20070751550 patent/EP1991204A2/en not_active Ceased
- 2007-02-24 JP JP2008556452A patent/JP2009527572A/ja not_active Withdrawn
- 2007-02-24 AU AU2007221154A patent/AU2007221154A1/en not_active Abandoned
-
2013
- 2013-04-08 JP JP2013080151A patent/JP2013136641A/ja active Pending
-
2015
- 2015-03-11 JP JP2015047973A patent/JP2015110661A/ja not_active Withdrawn
-
2016
- 2016-12-28 JP JP2016254929A patent/JP2017057227A/ja active Pending
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