JP2009527572A5 - - Google Patents
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- Publication number
- JP2009527572A5 JP2009527572A5 JP2008556452A JP2008556452A JP2009527572A5 JP 2009527572 A5 JP2009527572 A5 JP 2009527572A5 JP 2008556452 A JP2008556452 A JP 2008556452A JP 2008556452 A JP2008556452 A JP 2008556452A JP 2009527572 A5 JP2009527572 A5 JP 2009527572A5
- Authority
- JP
- Japan
- Prior art keywords
- cationic polysaccharide
- immunogenic composition
- composition according
- immunogenic
- microparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 28
- 230000002163 immunogen Effects 0.000 claims 21
- -1 cationic polysaccharide Chemical class 0.000 claims 18
- 229920001282 polysaccharide Polymers 0.000 claims 18
- 239000005017 polysaccharide Substances 0.000 claims 18
- 239000011859 microparticle Substances 0.000 claims 14
- 230000001900 immune effect Effects 0.000 claims 11
- 241000894007 species Species 0.000 claims 11
- 229920002988 biodegradable polymer Polymers 0.000 claims 10
- 239000004621 biodegradable polymer Substances 0.000 claims 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 3
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000007762 w/o emulsion Substances 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000013626 chemical specie Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 230000001571 immunoadjuvant effect Effects 0.000 claims 1
- 239000000568 immunological adjuvant Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77675706P | 2006-02-24 | 2006-02-24 | |
| PCT/US2007/004798 WO2007100699A2 (en) | 2006-02-24 | 2007-02-24 | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013080151A Division JP2013136641A (ja) | 2006-02-24 | 2013-04-08 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009527572A JP2009527572A (ja) | 2009-07-30 |
| JP2009527572A5 true JP2009527572A5 (https=) | 2011-04-14 |
Family
ID=38326215
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556452A Withdrawn JP2009527572A (ja) | 2006-02-24 | 2007-02-24 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2013080151A Pending JP2013136641A (ja) | 2006-02-24 | 2013-04-08 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2015047973A Withdrawn JP2015110661A (ja) | 2006-02-24 | 2015-03-11 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2016254929A Pending JP2017057227A (ja) | 2006-02-24 | 2016-12-28 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013080151A Pending JP2013136641A (ja) | 2006-02-24 | 2013-04-08 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2015047973A Withdrawn JP2015110661A (ja) | 2006-02-24 | 2015-03-11 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
| JP2016254929A Pending JP2017057227A (ja) | 2006-02-24 | 2016-12-28 | 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8431160B2 (https=) |
| EP (1) | EP1991204A2 (https=) |
| JP (4) | JP2009527572A (https=) |
| AU (1) | AU2007221154A1 (https=) |
| CA (1) | CA2643322C (https=) |
| WO (1) | WO2007100699A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR011700A0 (en) * | 2000-09-14 | 2000-10-05 | Austin Research Institute, The | Composition comprising immunogenic virus sized particles (VSP) |
| DE60117164T2 (de) * | 2000-11-07 | 2006-08-03 | Immuno Vaccine Technologies Inc., Halifax | Impfstoffe mit erhöhter immunantwort und verfahren zur deren herstellung |
| RU2461390C2 (ru) | 2005-01-28 | 2012-09-20 | Галенбио, Инк. | Иммунологически активные составы |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| CN106310293A (zh) | 2007-09-27 | 2017-01-11 | 免疫疫苗技术有限公司 | 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 |
| US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
| AU2013204315B2 (en) * | 2007-10-19 | 2016-02-18 | Glaxosmithkline Biologicals Sa | Meningococcal vaccine formulations |
| BR122016015627A2 (pt) * | 2007-10-19 | 2018-10-30 | Novartis Ag | kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica |
| EP3067048B1 (en) * | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| WO2011009104A1 (en) * | 2009-07-16 | 2011-01-20 | The General Hospital Corporation | Nucleic acid analysis |
| EP2282771B1 (en) | 2008-04-28 | 2014-06-25 | Novartis AG | Method for producing nanoparticles |
| WO2009146523A1 (en) * | 2008-06-05 | 2009-12-10 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
| TWI351288B (en) * | 2008-07-04 | 2011-11-01 | Univ Nat Pingtung Sci & Tech | Cpg dna adjuvant in avian vaccines |
| JP5804453B2 (ja) * | 2009-05-14 | 2015-11-04 | 国立大学法人 東京大学 | 結晶性ポリオール微粒子及びその調製方法 |
| BRPI1012036A2 (pt) | 2009-05-27 | 2017-10-10 | Selecta Biosciences Inc | nanocarreadores que possuem componentes com diferentes taxas de liberação |
| US20130029339A1 (en) | 2009-09-09 | 2013-01-31 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
| EP2475988B1 (en) | 2009-09-09 | 2018-11-14 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| GB0922066D0 (en) | 2009-12-17 | 2010-02-03 | Univ Belfast | Modulator |
| EP2525815B1 (en) * | 2010-01-24 | 2015-02-25 | Novartis AG | Irradiated biodegradable polymer microparticles |
| EP2530459A4 (en) * | 2010-01-27 | 2017-05-10 | National University Corporation Hokkaido University | Diffraction microscopy |
| WO2011117844A2 (en) * | 2010-03-26 | 2011-09-29 | Serum Institute Of India Ltd. | Method for evaluation of multiple antibodies or multiple antigens in a single sample |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES2829819T3 (es) * | 2010-08-26 | 2021-06-02 | Toray Industries | Composición inmunogénica |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| CA2817111C (en) | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| MX374963B (es) | 2011-04-29 | 2025-03-06 | Selecta Biosciences Inc | Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos. |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CN113876945A (zh) | 2011-10-06 | 2022-01-04 | 免疫疫苗技术有限公司 | 包括激活或增加tlr2活性的佐剂的脂质体组合物及其应用 |
| US20140105970A1 (en) * | 2011-12-01 | 2014-04-17 | Flow Pharma, Inc. | Adjuvant and antigen particle formulation |
| WO2013082503A1 (en) * | 2011-12-01 | 2013-06-06 | Flow Pharma, Inc. | Peptide particle formulation |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| CN110064049B (zh) | 2012-06-21 | 2024-02-09 | 西北大学 | 肽缀合粒子 |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9994605B2 (en) | 2014-03-13 | 2018-06-12 | Universitaet Basel | Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein |
| CA2996073A1 (en) | 2015-09-16 | 2017-03-23 | Universitat Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
| JP6730744B2 (ja) * | 2016-08-04 | 2020-07-29 | ゼノアックリソース株式会社 | 免疫賦活剤、医薬組成物および飲食品 |
| TWI654993B (zh) * | 2016-11-04 | 2019-04-01 | National Health Research Institutes | 陽離子型生物可降解性陶瓷聚合物微粒子用以遞送疫苗之用途 |
| US12257294B2 (en) | 2018-02-02 | 2025-03-25 | Danmarks Tekniske Universitet | Therapeutics for autoimmune disease: synthetic antigens |
| WO2020252263A1 (en) * | 2019-06-12 | 2020-12-17 | Wisconsin Alumni Research Foundation | Novel adjuvant for animal and human vaccines |
| MX2022002980A (es) | 2019-09-16 | 2022-04-06 | Amgen Inc | Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos. |
| CN111728955A (zh) * | 2020-06-19 | 2020-10-02 | 中山大学 | 一种用于乙肝治疗的纳米颗粒及其制备方法和治疗性疫苗 |
| US20220160822A1 (en) * | 2020-11-23 | 2022-05-26 | Wisconsin Alumni Research Foundation | Neutralizing vaccines against human coronavirus |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884435B1 (en) | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
| ATE235890T1 (de) | 1997-01-30 | 2003-04-15 | Chiron Corp | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| US6514522B2 (en) * | 1998-04-08 | 2003-02-04 | Chondros, Inc. | Polymer constructs |
| DE69930642T2 (de) | 1998-07-29 | 2006-12-28 | Chiron Corp., Emeryville | Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung |
| JP5124066B2 (ja) | 1999-03-24 | 2013-01-23 | イギリス国 | ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 |
| GB9914412D0 (en) | 1999-06-22 | 1999-08-18 | Worrall Eric E | Method for the preservation of viruses,bacteria and biomolecules |
| EP1235900B1 (en) | 1999-11-19 | 2006-07-05 | Chiron Corporation | Microparticle-based transfection and activation of dendritic cells |
| US7838015B2 (en) | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| WO2003086454A1 (en) * | 2002-04-18 | 2003-10-23 | Akzo Nobel N.V. | Antigen-loaded chitosan microparticles for oral vaccination |
| CA2514667C (en) | 2003-01-30 | 2013-01-08 | Chiron Corporation | Adjuvanted influenza vaccine |
| CA2548992A1 (en) * | 2003-12-11 | 2005-08-11 | Vaxdesign Corporation | Immunotherapy compositions, method of making and method of use thereof |
| EP1812056B1 (en) | 2004-11-15 | 2013-08-07 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
-
2007
- 2007-02-24 US US11/710,250 patent/US8431160B2/en not_active Expired - Fee Related
- 2007-02-24 JP JP2008556452A patent/JP2009527572A/ja not_active Withdrawn
- 2007-02-24 WO PCT/US2007/004798 patent/WO2007100699A2/en not_active Ceased
- 2007-02-24 EP EP20070751550 patent/EP1991204A2/en not_active Ceased
- 2007-02-24 AU AU2007221154A patent/AU2007221154A1/en not_active Abandoned
- 2007-02-24 CA CA2643322A patent/CA2643322C/en not_active Expired - Fee Related
-
2013
- 2013-04-08 JP JP2013080151A patent/JP2013136641A/ja active Pending
-
2015
- 2015-03-11 JP JP2015047973A patent/JP2015110661A/ja not_active Withdrawn
-
2016
- 2016-12-28 JP JP2016254929A patent/JP2017057227A/ja active Pending
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