|
US3654287A
(en)
|
1970-08-26 |
1972-04-04 |
Mead Johnson & Co |
Spiroindanylpiperidines
|
|
US3666764A
(en)
|
1970-08-26 |
1972-05-30 |
Mead Johnson & Co |
Spiroindenylpiperidines
|
|
US3962259A
(en)
|
1973-12-12 |
1976-06-08 |
American Hoechst Corporation |
1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
|
|
US3959475A
(en)
|
1973-12-12 |
1976-05-25 |
American Hoechst Corporation |
Substituted 1,3-dihydrospiro(isobenzofuran)s
|
|
JPS54109983A
(en)
|
1978-02-13 |
1979-08-29 |
Sumitomo Chem Co Ltd |
Novel spiroamine derivative and its preparation
|
|
GB1575800A
(en)
|
1978-05-16 |
1980-10-01 |
Sumitomo Chemical Co |
Spiro amines their production and compositions containing them
|
|
US4349549A
(en)
|
1981-05-18 |
1982-09-14 |
Syntex (U.S.A.) Inc. |
Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s
|
|
JPS5815979A
(ja)
|
1981-07-11 |
1983-01-29 |
Kyowa Hakko Kogyo Co Ltd |
新規なピペリジン誘導体およびその製造法
|
|
US4558049A
(en)
|
1982-11-24 |
1985-12-10 |
Farmitalia Carlo Erba S.P.A. |
Antipsycotic benzoxazines
|
|
SE445649B
(sv)
|
1983-06-08 |
1986-07-07 |
Jorgen Hermansson |
Anvendning av en fast berare med immobiliserad orosomucoid for separation, forfarande for framstellning av separationsmaterial, separationsanordning samt separationsmaterial
|
|
US4524206A
(en)
|
1983-09-12 |
1985-06-18 |
Mead Johnson & Company |
1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
|
|
GB8917069D0
(en)
|
1989-07-26 |
1989-09-13 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CA2037357A1
(en)
|
1990-03-02 |
1991-09-03 |
Ben E. Evans |
Methods for using spirocyclic oxytocin antagonists
|
|
US5091387A
(en)
|
1990-03-02 |
1992-02-25 |
Merck & Co., Inc. |
Spirocyclic oxytocin antagonists
|
|
EP0445974A3
(en)
*
|
1990-03-05 |
1992-04-29 |
Merck Sharp & Dohme Ltd. |
Spirocyclic antipsychotic agents
|
|
IL99957A0
(en)
|
1990-11-13 |
1992-08-18 |
Merck & Co Inc |
Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them
|
|
NZ243065A
(en)
|
1991-06-13 |
1995-07-26 |
Lundbeck & Co As H |
Piperidine derivatives and pharmaceutical compositions
|
|
US5693643A
(en)
|
1991-09-16 |
1997-12-02 |
Merck & Co., Inc. |
Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
|
|
DK78692D0
(da)
|
1992-06-12 |
1992-06-12 |
Lundbeck & Co As H |
Dimere piperidin- og piperazinderivater
|
|
WO1994013696A1
(en)
|
1992-12-11 |
1994-06-23 |
Merck & Co., Inc. |
Spiro piperidines and homologs which promote release of growth hormone
|
|
US5578593A
(en)
|
1992-12-11 |
1996-11-26 |
Merck & Co., Inc. |
Spiro piperidines and homologs promote release of growth hormone
|
|
WO1994022846A1
(en)
|
1993-03-30 |
1994-10-13 |
Pfizer Inc. |
Compounds enhancing antitumor activity of other cytotoxic agents
|
|
US5817679A
(en)
|
1993-04-01 |
1998-10-06 |
University Of Virginia |
7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
|
|
US5457207A
(en)
|
1993-10-05 |
1995-10-10 |
Regents Of The University Of Minnesota |
Spirovesamicols
|
|
HUT75224A
(en)
|
1993-10-19 |
1997-04-28 |
Merck & Co Inc |
Combination of bisphosphonates and growth hormone secretagogues
|
|
WO1995014025A1
(en)
|
1993-11-16 |
1995-05-26 |
Merck & Co., Inc. |
Piperidinylcamphorsulfonyl oxytocin antagonists
|
|
WO1995028389A1
(en)
|
1994-04-15 |
1995-10-26 |
Yamanouchi Pharmaceutical Co., Ltd. |
Spiro compound and medicinal composition thereof
|
|
US5789402A
(en)
|
1995-01-17 |
1998-08-04 |
Eli Lilly Company |
Compounds having effects on serotonin-related systems
|
|
US5576321A
(en)
|
1995-01-17 |
1996-11-19 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
US5614523A
(en)
|
1995-01-17 |
1997-03-25 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
US5741789A
(en)
|
1995-01-17 |
1998-04-21 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
US5627196A
(en)
|
1995-01-17 |
1997-05-06 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
US6130217A
(en)
|
1995-09-20 |
2000-10-10 |
Pfizer Inc |
Compounds enhancing antitumor activity of other cytotoxic agents
|
|
GB2308064A
(en)
|
1995-10-31 |
1997-06-18 |
Merck & Co Inc |
Treatment of congestive heart failure with a growth hormone secretagogue
|
|
US6413961B1
(en)
|
1995-12-12 |
2002-07-02 |
Omeros Medical Systems, Inc. |
Irrigation solution and method for inhibition of pain and inflammation
|
|
GB9601724D0
(en)
|
1996-01-29 |
1996-03-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP0900086A4
(en)
|
1996-05-07 |
2000-01-12 |
Merck & Co Inc |
IMPROVING THE SLEEP BY MEANS OF A SUBSTANCE PROMOTING THE SECRETION OF GROWTH HORMONES
|
|
WO1997041878A1
(en)
|
1996-05-07 |
1997-11-13 |
Merck & Co., Inc. |
Treatment of mood disorders with a growth hormone secretagogue
|
|
BR9812118A
(pt)
|
1997-07-31 |
2000-07-18 |
Elan Pharm Inc |
Compostos do tipo 4-amino-fenilalanina que inibem adesão de leucócito mediada por vla-4
|
|
US6576664B1
(en)
*
|
1997-08-18 |
2003-06-10 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
|
|
US6166037A
(en)
|
1997-08-28 |
2000-12-26 |
Merck & Co., Inc. |
Pyrrolidine and piperidine modulators of chemokine receptor activity
|
|
US6013652A
(en)
|
1997-12-04 |
2000-01-11 |
Merck & Co., Inc. |
Spiro-substituted azacycles as neurokinin antagonists
|
|
WO1999032489A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
GB9810886D0
(en)
|
1998-05-13 |
1998-07-22 |
Lilly Industries Ltd |
Pharmaceutical compounds
|
|
WO1999064002A1
(en)
*
|
1998-06-11 |
1999-12-16 |
Merck & Co., Inc. |
Spiropiperidine derivatives as melanocortin receptor agonists
|
|
US6294534B1
(en)
|
1998-06-11 |
2001-09-25 |
Merck & Co., Inc. |
Spiropiperidine derivatives as melanocortin receptor agonists
|
|
ID29137A
(id)
|
1998-07-27 |
2001-08-02 |
Schering Corp |
Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
|
|
JP2002521436A
(ja)
|
1998-07-28 |
2002-07-16 |
スミスクライン・ビーチャム・コーポレイション |
置換アニリド化合物および方法
|
|
CA2338804A1
(en)
|
1998-07-28 |
2000-02-10 |
Smithkline Beecham Corporation |
Propenamides as ccr5 modulators
|
|
WO2000038720A1
(en)
|
1998-12-24 |
2000-07-06 |
Meiji Seika Kaisha, Ltd. |
Remedies for pain
|
|
US20030082623A1
(en)
|
1998-12-31 |
2003-05-01 |
Beth Borowsky |
DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
|
|
ITMI991452A1
(it)
|
1999-07-01 |
2001-01-01 |
Mediolanum Farmaceutici Srl |
Antagonisti selettivi per i recettori m2 con struttura 5h-dibenzo b,fazepinica
|
|
TWI279402B
(en)
|
1999-08-20 |
2007-04-21 |
Banyu Pharma Co Ltd |
Spiro compounds having NPY antagonistic activities and agents containing the same
|
|
US6803372B2
(en)
|
1999-08-20 |
2004-10-12 |
Banyu Pharmaceutical Co., Ltd. |
Spiro compounds
|
|
GB2355456A
(en)
|
1999-09-30 |
2001-04-25 |
Merck & Co Inc |
Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
|
|
GB2355264A
(en)
|
1999-09-30 |
2001-04-18 |
Merck & Co Inc |
Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
|
|
AU7716600A
(en)
|
1999-09-30 |
2001-04-30 |
Merck & Co., Inc. |
Spiro[bicyclic -azacycloalkyl and -cycloalkyl] derivatives and uses thereof
|
|
WO2001029027A1
(en)
|
1999-10-22 |
2001-04-26 |
Sankyo Company, Limited |
2-alkoxybenzene derivatives
|
|
WO2001045707A1
(en)
|
1999-12-21 |
2001-06-28 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferase
|
|
US20040038855A1
(en)
|
1999-12-30 |
2004-02-26 |
Salon John A. |
DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
|
|
WO2001064213A1
(en)
|
2000-03-02 |
2001-09-07 |
Smithkline Beecham Corporation |
Compounds and methods
|
|
JP2001278886A
(ja)
|
2000-03-28 |
2001-10-10 |
Dai Ichi Seiyaku Co Ltd |
ベンゾオキサジン誘導体及びこれを含有する医薬
|
|
JP2004501896A
(ja)
|
2000-06-29 |
2004-01-22 |
アンステイテユ・ナシオナル・ドウ・ラ・サンテ・エ・ドウ・ラ・ルシエルシユ・メデイカル(アンセルム) |
PPARγアゴニストとしてのFMOC−L−ロイシンおよびその誘導体
|
|
US6720324B2
(en)
|
2000-07-05 |
2004-04-13 |
Synaptic Pharmaceutical Corporation |
Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
|
|
EP1347982B1
(en)
|
2000-12-12 |
2005-11-16 |
Neurogen Corporation |
Spiro isobenzofuran-1,4'-piperidin]-3-ones and 3h-spiroisobenzofuran-1,4'-piperidines
|
|
CA2438272A1
(en)
|
2001-03-02 |
2002-10-10 |
John Macor |
Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same
|
|
JP4489354B2
(ja)
|
2001-04-18 |
2010-06-23 |
ユーロ−セルティーク エス.エイ. |
スピロインデンおよびスピロインダン化合物類
|
|
JP2002316987A
(ja)
|
2001-04-20 |
2002-10-31 |
Sankyo Co Ltd |
2−アルコキシベンゼン誘導体を含有する医薬
|
|
WO2002094825A1
(en)
|
2001-05-22 |
2002-11-28 |
Banyu Pharmaceutical Co., Ltd. |
Novel spiropiperidine derivative
|
|
HUP0401108A2
(hu)
|
2001-08-07 |
2004-09-28 |
Banyu Pharmaceutical Co., Ltd. |
Spirovegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
|
|
WO2003037271A2
(en)
|
2001-10-30 |
2003-05-08 |
Millennium Pharmaceuticals,Inc. |
Compounds, pharmaceutical compositions and methods of use therefor
|
|
US20040050285A1
(en)
|
2002-01-03 |
2004-03-18 |
Zozulya Vladimir Leonidovich |
Cartridge
|
|
BR0307268A
(pt)
|
2002-01-28 |
2004-12-14 |
Pfizer |
Compostos de espiropiperidina n-substituìda como ligantes para o receptor orl-1
|
|
WO2003095427A1
(en)
|
2002-05-10 |
2003-11-20 |
Taisho Pharmaceutical Co.,Ltd. |
Spiro-ring compound
|
|
US7220862B2
(en)
|
2002-06-05 |
2007-05-22 |
Bristol-Myers Squibb Company |
Calcitonin gene related peptide receptor antagonists
|
|
GB0213715D0
(en)
|
2002-06-14 |
2002-07-24 |
Syngenta Ltd |
Chemical compounds
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
UA77814C2
(en)
|
2002-07-03 |
2007-01-15 |
Lundbeck & Co As H |
Spirocyclic piperidines as antagonists of mch1 and use thereof
|
|
WO2004010943A2
(en)
|
2002-07-31 |
2004-02-05 |
Smithkline Beecham Corporation |
Substituted benzanilides as modulators of the ccr5 receptor
|
|
AU2003254177A1
(en)
|
2002-07-31 |
2004-02-16 |
Smithkline Beecham Corporation |
Substituted benzanilides as modulators of the ccr5 receptor
|
|
AU2003256922A1
(en)
|
2002-07-31 |
2004-02-16 |
Smithkline Beecham Corporation |
Substituted heterocyclic compounds as modulators of the ccr5 receptor
|
|
KR101025633B1
(ko)
|
2002-09-19 |
2011-03-30 |
일라이 릴리 앤드 캄파니 |
오피오이드 수용체 안타고니스트로서의 디아릴 에테르
|
|
US7045527B2
(en)
*
|
2002-09-24 |
2006-05-16 |
Amgen Inc. |
Piperidine derivatives
|
|
DE60328035D1
(de)
|
2002-11-29 |
2009-07-30 |
Banyu Pharma Co Ltd |
Neue azolderivate
|
|
US7247628B2
(en)
|
2002-12-12 |
2007-07-24 |
Pfizer, Inc. |
Cannabinoid receptor ligands and uses thereof
|
|
SE0300458D0
(sv)
|
2003-02-19 |
2003-02-19 |
Astrazeneca Ab |
Novel compounds
|
|
AU2004222336B2
(en)
|
2003-03-18 |
2010-06-03 |
Merck Sharp & Dohme Corp. |
Amino cyclobutylamide modulators of chemokine receptor activity
|
|
CN1768041A
(zh)
*
|
2003-04-04 |
2006-05-03 |
麦克公司 |
作为黑皮质素-4受体激动剂的酰化螺哌啶衍生物
|
|
CN1297557C
(zh)
|
2003-04-10 |
2007-01-31 |
上海药明康德新药开发有限公司 |
螺环类模板化合物的制备
|
|
US7268133B2
(en)
|
2003-04-23 |
2007-09-11 |
Pfizer, Inc. Patent Department |
Cannabinoid receptor ligands and uses thereof
|
|
US7414055B2
(en)
|
2003-04-24 |
2008-08-19 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
WO2005016913A1
(en)
|
2003-08-19 |
2005-02-24 |
Pfizer Japan, Inc. |
Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
|
|
RS20060382A
(sr)
|
2003-12-05 |
2008-09-29 |
Bristol-Myers Squibb Company, |
Antagonisti receptora za peptid povezan sa genom za kalcitonin
|
|
PT1696931E
(pt)
|
2003-12-22 |
2009-06-12 |
Acadia Pharm Inc |
Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas
|
|
JP2007516298A
(ja)
|
2003-12-23 |
2007-06-21 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
新規なスピロインドリンまたはスピロイソキノリン化合物、それらの使用方法および組成物
|
|
RU2006132465A
(ru)
|
2004-02-10 |
2008-03-20 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Модуляторы хемокинового рецептора ccr5
|
|
TW200533398A
(en)
|
2004-03-29 |
2005-10-16 |
Bristol Myers Squibb Co |
Novel therapeutic agents for the treatment of migraine
|
|
WO2005097788A2
(en)
|
2004-04-02 |
2005-10-20 |
Elixir Pharmaceuticals, Inc. |
Sulfonamides and uses thereof
|
|
US7279471B2
(en)
|
2004-04-15 |
2007-10-09 |
Boehringer Ingelheim International Gmbh |
Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
|
|
CA2565211A1
(en)
*
|
2004-04-29 |
2005-11-24 |
Abbott Laboratories |
Amino-tetrazoles analogues and methods of use
|
|
WO2006001958A2
(en)
|
2004-05-21 |
2006-01-05 |
Merck & Co., Inc. |
Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
|
|
KR20070034524A
(ko)
|
2004-05-28 |
2007-03-28 |
버텍스 파마슈티칼스 인코포레이티드 |
무스카린 수용체 조정자
|
|
US7786141B2
(en)
|
2004-08-19 |
2010-08-31 |
Vertex Pharmaceuticals Incorporated |
Dihydrospiroindene modulators of muscarinic receptors
|
|
EP2374455A3
(en)
*
|
2004-08-19 |
2012-03-28 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
EP1795527B1
(en)
|
2004-09-07 |
2009-04-22 |
Banyu Pharmaceutical Co., Ltd. |
Carbamoyl-substituted spiro derivative
|
|
US7351706B2
(en)
|
2006-01-05 |
2008-04-01 |
Hoffmann-La Roche Inc. |
Indol-3-yl-carbonyl-spiro-piperidine derivatives
|
|
AU2007221214A1
(en)
|
2006-02-22 |
2007-09-07 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
CN101500565A
(zh)
|
2006-06-29 |
2009-08-05 |
弗特克斯药品有限公司 |
毒蕈碱性受体的调节剂
|