JP2009526780A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009526780A5 JP2009526780A5 JP2008554443A JP2008554443A JP2009526780A5 JP 2009526780 A5 JP2009526780 A5 JP 2009526780A5 JP 2008554443 A JP2008554443 A JP 2008554443A JP 2008554443 A JP2008554443 A JP 2008554443A JP 2009526780 A5 JP2009526780 A5 JP 2009526780A5
- Authority
- JP
- Japan
- Prior art keywords
- derived
- hpv16
- hpv18
- hpv
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 58
- 241000701806 Human papillomavirus Species 0.000 claims 54
- 239000012634 fragment Substances 0.000 claims 42
- 102000036639 antigens Human genes 0.000 claims 36
- 108091007433 antigens Proteins 0.000 claims 36
- 239000000203 mixture Substances 0.000 claims 36
- 239000000427 antigen Substances 0.000 claims 29
- 150000007523 nucleic acids Chemical class 0.000 claims 26
- 229960005486 vaccine Drugs 0.000 claims 23
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 108010076363 licheninase Proteins 0.000 claims 20
- 241000196324 Embryophyta Species 0.000 claims 19
- 238000000034 method Methods 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 12
- 210000004899 c-terminal region Anatomy 0.000 claims 8
- 230000004927 fusion Effects 0.000 claims 8
- 230000028993 immune response Effects 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 241000219198 Brassica Species 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 4
- 240000007377 Petunia x hybrida Species 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 238000003780 insertion Methods 0.000 claims 4
- 230000037431 insertion Effects 0.000 claims 4
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 3
- 235000003351 Brassica cretica Nutrition 0.000 claims 3
- 240000007124 Brassica oleracea Species 0.000 claims 3
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims 3
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims 3
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 claims 3
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims 3
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 claims 3
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims 3
- 235000003343 Brassica rupestris Nutrition 0.000 claims 3
- 235000010469 Glycine max Nutrition 0.000 claims 3
- 244000020551 Helianthus annuus Species 0.000 claims 3
- 235000003222 Helianthus annuus Nutrition 0.000 claims 3
- 235000014647 Lens culinaris subsp culinaris Nutrition 0.000 claims 3
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 3
- 240000004658 Medicago sativa Species 0.000 claims 3
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims 3
- 244000088415 Raphanus sativus Species 0.000 claims 3
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims 3
- 240000003768 Solanum lycopersicum Species 0.000 claims 3
- 244000061456 Solanum tuberosum Species 0.000 claims 3
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 3
- 235000009337 Spinacia oleracea Nutrition 0.000 claims 3
- 244000300264 Spinacia oleracea Species 0.000 claims 3
- 241000219793 Trifolium Species 0.000 claims 3
- 241000209140 Triticum Species 0.000 claims 3
- 235000021307 Triticum Nutrition 0.000 claims 3
- 240000004922 Vigna radiata Species 0.000 claims 3
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims 3
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims 3
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 3
- 235000010460 mustard Nutrition 0.000 claims 3
- 229960002715 nicotine Drugs 0.000 claims 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 3
- 235000002566 Capsicum Nutrition 0.000 claims 2
- 244000068988 Glycine max Species 0.000 claims 2
- 240000004322 Lens culinaris Species 0.000 claims 2
- 239000006002 Pepper Substances 0.000 claims 2
- 235000016761 Piper aduncum Nutrition 0.000 claims 2
- 235000017804 Piper guineense Nutrition 0.000 claims 2
- 244000203593 Piper nigrum Species 0.000 claims 2
- 235000008184 Piper nigrum Nutrition 0.000 claims 2
- 108010067390 Viral Proteins Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 235000011331 Brassica Nutrition 0.000 claims 1
- 206010011732 Cyst Diseases 0.000 claims 1
- 101100540311 Human papillomavirus type 16 E6 gene Proteins 0.000 claims 1
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 claims 1
- 244000043158 Lens esculenta Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 235000017879 Nasturtium officinale Nutrition 0.000 claims 1
- 240000005407 Nasturtium officinale Species 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229940037003 alum Drugs 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 208000031513 cyst Diseases 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 108010051618 macrophage stimulatory lipopeptide 2 Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229960002566 papillomavirus vaccine Drugs 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229930182490 saponin Natural products 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77337406P | 2006-02-13 | 2006-02-13 | |
| PCT/US2007/003973 WO2007095320A2 (en) | 2006-02-13 | 2007-02-13 | Hpv antigens, vaccine compositions, and related methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526780A JP2009526780A (ja) | 2009-07-23 |
| JP2009526780A5 true JP2009526780A5 (OSRAM) | 2009-09-03 |
Family
ID=38372130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554443A Withdrawn JP2009526780A (ja) | 2006-02-13 | 2007-02-13 | Ｈｐｖ抗原、ワクチン組成物、および関連する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080279877A1 (OSRAM) |
| EP (1) | EP1984388B1 (OSRAM) |
| JP (1) | JP2009526780A (OSRAM) |
| KR (1) | KR20080106434A (OSRAM) |
| CN (1) | CN101395174B (OSRAM) |
| AU (1) | AU2007215082B2 (OSRAM) |
| BR (1) | BRPI0707779B8 (OSRAM) |
| CA (1) | CA2642056A1 (OSRAM) |
| IL (1) | IL193397A0 (OSRAM) |
| WO (1) | WO2007095320A2 (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005026375A2 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| CN101378781B (zh) * | 2005-08-03 | 2013-08-07 | 美国弗劳恩霍夫股份有限公司 | 制造免疫球蛋白的组合物和方法 |
| BRPI0707733B1 (pt) * | 2006-02-13 | 2019-12-31 | Ibio, Inc. | antígeno isolado, composição de vacina, uso da referida composição e método para produção de uma proteína de antígeno |
| US8968995B2 (en) | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
| US8859218B2 (en) | 2008-06-13 | 2014-10-14 | Oncohealth Corp. | In situ detection of early stages and late stages HPV infection |
| US8778348B2 (en) * | 2007-04-28 | 2014-07-15 | Ibio Inc. | Trypanosoma antigens, vaccine compositions, and related methods |
| WO2009009759A2 (en) | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| BRPI0818154A2 (pt) * | 2007-11-02 | 2020-10-06 | The Johns Hopkins University | composições de peptídeo de hpv de multitipo e métodos para o tratamento ou prevenção de infecção por papilomavírus humano |
| EP2288380B1 (en) * | 2008-06-09 | 2020-06-03 | Bharat Biotech International Limited | Vaccine composition useful for hpv and hepatitis b infections and a method for preparing the same |
| WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
| CN102449479B (zh) | 2009-05-07 | 2015-11-25 | 安科健康公司 | 鉴别高度或≥cin2用于人乳头瘤病毒(hpv)与hpv相关癌症的早期及晚期检测、筛检和诊断 |
| CA2776144C (en) | 2009-09-29 | 2020-10-27 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
| WO2011084598A1 (en) | 2010-01-08 | 2011-07-14 | Oncohealth Corporation | High throughput cell-based hpv immunoassays for diagnosis and screening of hpv-associated cancers |
| US10160789B2 (en) * | 2011-03-14 | 2018-12-25 | University Of Louisville Research Foundation, Inc. | Polypeptides having immunoactivating activity and methods of producing the same |
| EA033242B1 (ru) * | 2011-10-12 | 2019-09-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Усовершенствованные нуклеиновые кислоты и белки вируса человеческой папилломы, вакцины и композиции на их основе и способы индукции иммунного ответа против впч с их применением |
| EA034056B1 (ru) | 2013-03-12 | 2019-12-23 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Усовершенствованные вакцины против вируса папилломы человека и способы их применения |
| CN107249627B (zh) * | 2015-01-30 | 2021-06-29 | 国立大学法人东京大学 | 含有来自hpv e7蛋白质的多肽的乳酸菌的组合物 |
| EP3313866B1 (en) | 2015-06-29 | 2024-11-20 | University Of Louisville Research Foundation, Inc. | Compositions and methods for treating cancer and promoting wound healing |
| US12343375B2 (en) | 2021-02-09 | 2025-07-01 | University Of Louisville Research Foundation, Inc. | Spray dried formulation of a cholera toxin B subunit variant |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4270537A (en) * | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPS61176721A (ja) * | 1985-01-31 | 1986-08-08 | Mochizuki Motor Kk | マンホ−ル蓋の開閉運搬装置 |
| CA1288073C (en) * | 1985-03-07 | 1991-08-27 | Paul G. Ahlquist | Rna transformation vector |
| US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4886499A (en) * | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) * | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4790824A (en) * | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4940460A (en) * | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4941880A (en) * | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5316931A (en) * | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5339163A (en) * | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| FR2638359A1 (fr) * | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5312335A (en) * | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) * | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5190521A (en) * | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| JP2938569B2 (ja) * | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル，インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5698426A (en) * | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| CZ282603B6 (cs) * | 1991-03-06 | 1997-08-13 | Merck Patent Gesellschaft Mit Beschränkter Haftun G | Humanizované a chimerické monoklonální protilátky |
| EP1471142B1 (en) * | 1991-04-10 | 2008-11-19 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
| MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| GB9118204D0 (en) * | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) * | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| GB9125979D0 (en) * | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
| US5667988A (en) * | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5863537A (en) * | 1992-02-19 | 1999-01-26 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US5328483A (en) * | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| AU3737893A (en) * | 1992-03-05 | 1993-10-05 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
| US6093399A (en) * | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US5733743A (en) * | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5383851A (en) * | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5569189A (en) * | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) * | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5693506A (en) * | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
| WO1995024176A1 (en) * | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) * | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) * | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US5702892A (en) * | 1995-05-09 | 1997-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Phage-display of immunoglobulin heavy chain libraries |
| US5893397A (en) * | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| US6042832A (en) * | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| US6103511A (en) * | 1996-10-04 | 2000-08-15 | University Of Georgia Research Foundation, Inc. | Lichenase and coding sequences |
| US5993412A (en) * | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| CA2298840A1 (en) * | 1997-08-05 | 1999-02-18 | Stressgen Biotechnologies Corporation | Immune responses against hpv antigens elicited by compositions comprising an hpv antigen and a stress protein or an expression vector capable of expression of these proteins |
| US6037456A (en) * | 1998-03-10 | 2000-03-14 | Biosource Technologies, Inc. | Process for isolating and purifying viruses, soluble proteins and peptides from plant sources |
| US6044555A (en) * | 1998-05-04 | 2000-04-04 | Keystone Powered Metal Company | Method for producing fully dense powdered metal helical gear |
| KR20010072372A (ko) * | 1998-08-11 | 2001-07-31 | 맥기 데이비드 알 | 식물조직의 간질액으로부터 단백질을 추출하는 방법 |
| CN1248631A (zh) * | 1998-09-24 | 2000-03-29 | 周国庆 | 一种免疫预防和免疫治疗性病和癌症的融合蛋白 |
| US6734173B1 (en) * | 1999-10-20 | 2004-05-11 | Johns Hopkins University | HSP DNA vaccines |
| CA2403553A1 (en) * | 2000-03-17 | 2001-09-27 | David Johnson | Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors |
| ES2295175T3 (es) * | 2000-06-23 | 2008-04-16 | Wyeth Holdings Corporation | Ensamblaje de particulas similares al virus (vlp) de la gripe de tipo salvaje y quimericas. |
| IL153474A0 (en) * | 2000-06-26 | 2003-07-06 | Stressgen Biotechnologies Corp | Human papilloma virus treatment |
| WO2002000892A1 (en) * | 2000-06-26 | 2002-01-03 | Glaxosmithkline Biologicals S.A. | Triple fusion proteins comprising ubiquitin fused between thioredoxin and a polypeptide of interest |
| WO2002012281A2 (en) * | 2000-08-03 | 2002-02-14 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| CN1198840C (zh) * | 2000-11-03 | 2005-04-27 | 浙江大学医学院附属第二医院 | 人类乳头瘤病毒11l1－e7重组蛋白及其应用 |
| US20040170606A1 (en) * | 2002-06-07 | 2004-09-02 | Palmer Kenneth E. | Production of peptides in plants as viral coat protein fusions |
| EP1629090B1 (en) * | 2002-11-06 | 2014-03-05 | iBio, Inc. | Expression of foreign sequences in plants using trans-activation system |
| US7683238B2 (en) * | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
| AU2004209660A1 (en) * | 2003-02-03 | 2004-08-19 | Fraunhofer Usa, Inc. | System for expression of genes in plants |
| CN101123871B (zh) * | 2003-05-05 | 2011-05-18 | 美国陶氏益农公司 | 来源于转基因植物细胞的稳定免疫预防性和治疗性组合物及其制备方法 |
| AU2004235813B2 (en) * | 2003-05-05 | 2010-07-29 | Boyce Thompson Institute For Plant Research | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| WO2005026375A2 (en) * | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| WO2005018539A2 (en) * | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| CZ297389B6 (cs) * | 2003-07-03 | 2006-11-15 | Ústav Molekulární Biologie Rostlin Av Cr | Fúzní protein pro vakcinaci proti lidskému papillomaviru a zpusob jeho produkce |
| CA2541294C (en) * | 2003-11-10 | 2013-06-25 | Icon Genetics Ag | Rna virus-derived plant expression system |
| AU2005216133A1 (en) * | 2004-02-20 | 2005-09-09 | Fraunhofer Usa, Inc. | Systems and methods for clonal expression in plants |
| WO2005111622A2 (en) * | 2004-04-23 | 2005-11-24 | The University Of Georgia Research Foundation, Inc. | Diagnostic assay for trypanosoma cruzi infection |
| ES2393492T3 (es) * | 2004-05-25 | 2012-12-21 | Medimmune, Llc | Variantes de hemaglutinina y neuraminidasa de influenza |
| EP1616959A1 (en) * | 2004-07-07 | 2006-01-18 | Icon Genetics AG | Biological safe transient protein expression in plants |
| BRPI0707733B1 (pt) * | 2006-02-13 | 2019-12-31 | Ibio, Inc. | antígeno isolado, composição de vacina, uso da referida composição e método para produção de uma proteína de antígeno |
| WO2008048344A2 (en) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| WO2009009759A2 (en) * | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| CA2696764A1 (en) * | 2007-08-20 | 2009-02-26 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods |
-
2007
- 2007-02-13 EP EP07750787.9A patent/EP1984388B1/en active Active
- 2007-02-13 BR BRPI0707779A patent/BRPI0707779B8/pt not_active IP Right Cessation
- 2007-02-13 JP JP2008554443A patent/JP2009526780A/ja not_active Withdrawn
- 2007-02-13 CN CN200780008072.9A patent/CN101395174B/zh active Active
- 2007-02-13 AU AU2007215082A patent/AU2007215082B2/en not_active Ceased
- 2007-02-13 WO PCT/US2007/003973 patent/WO2007095320A2/en not_active Ceased
- 2007-02-13 KR KR1020087022553A patent/KR20080106434A/ko not_active Ceased
- 2007-02-13 US US11/706,568 patent/US20080279877A1/en not_active Abandoned
- 2007-02-13 CA CA002642056A patent/CA2642056A1/en not_active Abandoned
-
2008
- 2008-08-12 IL IL193397A patent/IL193397A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009526780A5 (OSRAM) | ||
| JP2009526526A5 (OSRAM) | ||
| JP7250878B2 (ja) | 新規多価ナノ粒子に基づくワクチン | |
| Scotti et al. | Virus-like particles produced in plants as potential vaccines | |
| Naskalska et al. | Virus like particles as immunogens and universal nanocarriers | |
| WO2005055957A3 (en) | Influenza immunogen and vaccine | |
| JP2009516529A5 (OSRAM) | ||
| Wang et al. | Recombinant VP1 protein expressed in Pichia pastoris induces protective immune responses against EV71 in mice | |
| TWI479022B (zh) | 諾羅病毒衣殼與輪狀病毒ｖｐ６蛋白質做為組合疫苗的用途 | |
| JP6251273B2 (ja) | チクングニアウイルスポリペプチドを発現する組換え麻疹ウイルスおよびその適用 | |
| WO2007095320A4 (en) | Hpv antigens, vaccine compositions, and related methods | |
| JP2006504644A5 (OSRAM) | ||
| Zhang et al. | Enterovirus D68 virus-like particles expressed in Pichia pastoris potently induce neutralizing antibody responses and confer protection against lethal viral infection in mice | |
| JP2023024998A5 (OSRAM) | ||
| Gao et al. | A perspective on SARS-CoV-2 virus-like particles vaccines | |
| CN111073861B (zh) | 人呼吸道合胞病毒毒株、应用、抗体或杂交瘤细胞或抗血清 | |
| CN105462937B (zh) | 一种肠道病毒嵌合病毒样颗粒疫苗及其制备方法和应用 | |
| CN107344969B (zh) | 一种纳米流感疫苗及构建方法和应用 | |
| WO2005117983A3 (en) | Carrier conjugates of tnf-peptides | |
| CN115850398B (zh) | 新型冠状病毒奥密克戎系列变异株的多肽组合物及其应用 | |
| JP2021524273A5 (OSRAM) | ||
| CN105801704B (zh) | 一种具有抗宫颈癌细胞活性的重组疫苗构建方法及应用 | |
| CN103435690B (zh) | 一种丙型肝炎病毒的dna疫苗及其制备方法 | |
| CN114437236A (zh) | 一种重组非洲猪瘟病毒多表位融合蛋白、制备及其应用 | |
| Rosales-Mendoza et al. | The potential of plants for the production and delivery of human papillomavirus vaccines |