JP2009526526A5 - - Google Patents
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- JP2009526526A5 JP2009526526A5 JP2008554442A JP2008554442A JP2009526526A5 JP 2009526526 A5 JP2009526526 A5 JP 2009526526A5 JP 2008554442 A JP2008554442 A JP 2008554442A JP 2008554442 A JP2008554442 A JP 2008554442A JP 2009526526 A5 JP2009526526 A5 JP 2009526526A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- domain
- integral membrane
- membrane protein
- vaccine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101710154606 Hemagglutinin Proteins 0.000 claims 66
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 66
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 66
- 101710176177 Protein A56 Proteins 0.000 claims 66
- 239000000185 hemagglutinin Substances 0.000 claims 66
- 108010006232 Neuraminidase Proteins 0.000 claims 62
- 102000005348 Neuraminidase Human genes 0.000 claims 62
- 102000018697 Membrane Proteins Human genes 0.000 claims 57
- 108010052285 Membrane Proteins Proteins 0.000 claims 57
- 235000004252 protein component Nutrition 0.000 claims 57
- 239000000203 mixture Substances 0.000 claims 50
- 229960005486 vaccine Drugs 0.000 claims 42
- 102000036639 antigens Human genes 0.000 claims 39
- 108091007433 antigens Proteins 0.000 claims 39
- 239000000427 antigen Substances 0.000 claims 34
- 108010076363 licheninase Proteins 0.000 claims 27
- 150000007523 nucleic acids Chemical class 0.000 claims 26
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 108090000623 proteins and genes Proteins 0.000 claims 23
- 241000196324 Embryophyta Species 0.000 claims 21
- 238000000034 method Methods 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 235000018102 proteins Nutrition 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 15
- 108020001507 fusion proteins Proteins 0.000 claims 15
- 102000037865 fusion proteins Human genes 0.000 claims 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 210000004899 c-terminal region Anatomy 0.000 claims 10
- 230000028993 immune response Effects 0.000 claims 10
- 208000037797 influenza A Diseases 0.000 claims 10
- 239000012528 membrane Substances 0.000 claims 10
- 241000219198 Brassica Species 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 238000003780 insertion Methods 0.000 claims 5
- 230000037431 insertion Effects 0.000 claims 5
- 235000003351 Brassica cretica Nutrition 0.000 claims 4
- 235000003343 Brassica rupestris Nutrition 0.000 claims 4
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 235000010460 mustard Nutrition 0.000 claims 4
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 3
- 240000007377 Petunia x hybrida Species 0.000 claims 3
- 229960002715 nicotine Drugs 0.000 claims 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 3
- 240000007124 Brassica oleracea Species 0.000 claims 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims 2
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims 2
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 claims 2
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims 2
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 claims 2
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims 2
- 235000010469 Glycine max Nutrition 0.000 claims 2
- 244000020551 Helianthus annuus Species 0.000 claims 2
- 235000003222 Helianthus annuus Nutrition 0.000 claims 2
- 235000014647 Lens culinaris subsp culinaris Nutrition 0.000 claims 2
- 244000043158 Lens esculenta Species 0.000 claims 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 2
- 240000004658 Medicago sativa Species 0.000 claims 2
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 244000088415 Raphanus sativus Species 0.000 claims 2
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims 2
- 241000193448 Ruminiclostridium thermocellum Species 0.000 claims 2
- 240000003768 Solanum lycopersicum Species 0.000 claims 2
- 244000061456 Solanum tuberosum Species 0.000 claims 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 2
- 244000300264 Spinacia oleracea Species 0.000 claims 2
- 235000009337 Spinacia oleracea Nutrition 0.000 claims 2
- 241000219793 Trifolium Species 0.000 claims 2
- 235000021307 Triticum Nutrition 0.000 claims 2
- 244000098338 Triticum aestivum Species 0.000 claims 2
- 240000004922 Vigna radiata Species 0.000 claims 2
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims 2
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims 2
- 108010067390 Viral Proteins Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 229940037003 alum Drugs 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 235000013399 edible fruits Nutrition 0.000 claims 2
- 239000000284 extract Substances 0.000 claims 2
- 108010051618 macrophage stimulatory lipopeptide 2 Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
- 229930182490 saponin Natural products 0.000 claims 2
- 150000007949 saponins Chemical class 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 239000012646 vaccine adjuvant Substances 0.000 claims 2
- 229940124931 vaccine adjuvant Drugs 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 235000011331 Brassica Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229940033324 influenza A vaccine Drugs 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77337806P | 2006-02-13 | 2006-02-13 | |
| US81395506P | 2006-06-15 | 2006-06-15 | |
| PCT/US2007/003969 WO2007095318A2 (en) | 2006-02-13 | 2007-02-13 | Influenza antigens, vaccine compositions, and related methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526526A JP2009526526A (ja) | 2009-07-23 |
| JP2009526526A5 true JP2009526526A5 (https=) | 2009-09-03 |
Family
ID=38372128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554442A Withdrawn JP2009526526A (ja) | 2006-02-13 | 2007-02-13 | インフルエンザ抗原、ワクチン組成物、および関連する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8124103B2 (https=) |
| EP (1) | EP1984405A4 (https=) |
| JP (1) | JP2009526526A (https=) |
| KR (1) | KR20080106433A (https=) |
| CN (1) | CN101454347B (https=) |
| AU (1) | AU2007215080A1 (https=) |
| BR (1) | BRPI0707733B1 (https=) |
| CA (1) | CA2642054C (https=) |
| WO (1) | WO2007095318A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9289487B2 (en) * | 1999-09-14 | 2016-03-22 | Antigen Express, Inc. | II-key/antigenic epitope hybrid peptide vaccines |
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| WO2008048344A2 (en) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| JP2009526780A (ja) * | 2006-02-13 | 2009-07-23 | フラウンホーファー ユーエスエー， インコーポレイテッド | Ｈｐｖ抗原、ワクチン組成物、および関連する方法 |
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| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| US8470771B2 (en) | 2007-11-14 | 2013-06-25 | Institute Of Microbiology, Chinese Academy Of Sciences | Method and medicament for inhibiting the infection of influenza virus |
| EP2238253B1 (en) | 2007-11-27 | 2012-09-12 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| EP2307036A4 (en) * | 2008-06-13 | 2012-08-08 | Wisconsin Alumni Res Found | NEW PEPTIDE ADJUVANS FOR THE GRIP VACCINATION |
| EP2310030A4 (en) | 2008-06-13 | 2013-08-14 | Wisconsin Alumni Res Found | NEW ANTIVIRAL PEPTIDES AGAINST THE INFLUENZA VIRUS |
| DK2294202T3 (en) | 2008-07-08 | 2015-08-31 | Medicago Inc | SOLUBLE RECOMBINANT INFLUENZA ANTIGENES |
| MX370690B (es) | 2008-07-18 | 2019-12-19 | Medicago Inc | Epitopo de inmunizacion de nuevo virus de la influenza. |
| WO2010036970A2 (en) * | 2008-09-25 | 2010-04-01 | Fraunhofer Usa, Inc. | Influenza vaccines, antigens, compositions, and methods |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| KR101046004B1 (ko) * | 2008-11-12 | 2011-07-01 | 서울대학교산학협력단 | 돼지 인플루엔자 혈청 진단 방법 |
| US20140205619A1 (en) * | 2008-11-28 | 2014-07-24 | Biolex Therapeutics, Inc. | Recombinant avian influenza vaccine and uses thereof |
| US20100310591A1 (en) * | 2009-01-28 | 2010-12-09 | Robert Humphreys | Ii-KEY HYBRID PEPTIDES THAT MODULATE THE IMMUNE RESPONSE TO INFLUENZA |
| EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| HRP20180706T1 (hr) | 2009-06-24 | 2018-06-01 | Medicago Inc. | Kimerna gripa nalik čestici koja sadrži hemaglutinin |
| SI3998078T1 (sl) | 2009-08-28 | 2026-02-27 | Genzyme Corporation | Encimsko nadomestno zdravljenje z naraščajočim odmerkom za zdravljenje pomanjkanja kisle sfingomielinaze |
| PH12012500565B1 (en) | 2009-09-22 | 2018-01-12 | Medicago Inc | Method of preparing plant-derived proteins |
| US8784819B2 (en) | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| EP3248615A1 (en) | 2010-03-30 | 2017-11-29 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| CN102933230B (zh) | 2010-04-15 | 2016-03-02 | 株式会社新日本科学 | 用于鼻内递送的方法和组合物 |
| WO2011138032A2 (en) * | 2010-05-05 | 2011-11-10 | Artemev, Timur | Universal influenza vaccines and methods for their generation |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| IN2014CN02114A (https=) | 2011-09-20 | 2015-05-29 | Sinai School Medicine | |
| EA201591164A1 (ru) | 2012-12-18 | 2015-11-30 | Икан Скул Оф Медсин Эт Маунт Синай | Вакцины против вируса гриппа и их применение |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| CA2936350C (en) | 2014-01-10 | 2023-01-31 | Medicago Inc. | Cpmv enhancer elements |
| EP3247389A4 (en) | 2015-01-23 | 2019-10-30 | Icahn School of Medicine at Mount Sinai | INFLUENZAVIRUSSCHUTZIMPFPLÄNE |
| CA3023143A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| KR20200060969A (ko) | 2018-11-23 | 2020-06-02 | (주)셀트리온 | 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법 |
| MX2019014943A (es) | 2018-12-12 | 2020-08-06 | Cambridge Tech Llc | Vacuna universal contra la gripe. |
| EP3959216A4 (en) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
| KR102444024B1 (ko) * | 2019-06-17 | 2022-09-20 | 주식회사 바이오앱 | 아프리카 돼지열병의 진단을 위한 항원 생산용 재조합 벡터 및 이의 용도 |
| US20240009298A1 (en) * | 2020-09-03 | 2024-01-11 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
| JP2023131651A (ja) * | 2022-03-09 | 2023-09-22 | 京都府公立大学法人 | Ｒｂ活性化食品組成物 |
| CN117534738B (zh) * | 2022-07-15 | 2024-08-09 | 中山大学·深圳 | 一种季节性甲型流感通用Mosaic重组抗原及其疫苗和应用 |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
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-
2007
- 2007-02-13 AU AU2007215080A patent/AU2007215080A1/en not_active Abandoned
- 2007-02-13 KR KR1020087022551A patent/KR20080106433A/ko not_active Ceased
- 2007-02-13 BR BRPI0707733-5A patent/BRPI0707733B1/pt not_active IP Right Cessation
- 2007-02-13 WO PCT/US2007/003969 patent/WO2007095318A2/en not_active Ceased
- 2007-02-13 JP JP2008554442A patent/JP2009526526A/ja not_active Withdrawn
- 2007-02-13 CN CN2007800080983A patent/CN101454347B/zh not_active Expired - Fee Related
- 2007-02-13 CA CA2642054A patent/CA2642054C/en active Active
- 2007-02-13 EP EP07750784A patent/EP1984405A4/en not_active Withdrawn
- 2007-02-13 US US11/706,573 patent/US8124103B2/en active Active
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