JP2009526526A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009526526A5 JP2009526526A5 JP2008554442A JP2008554442A JP2009526526A5 JP 2009526526 A5 JP2009526526 A5 JP 2009526526A5 JP 2008554442 A JP2008554442 A JP 2008554442A JP 2008554442 A JP2008554442 A JP 2008554442A JP 2009526526 A5 JP2009526526 A5 JP 2009526526A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- domain
- integral membrane
- membrane protein
- vaccine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims 66
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 66
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 66
- 101710176177 Protein A56 Proteins 0.000 claims 66
- 239000000185 hemagglutinin Substances 0.000 claims 66
- 108010006232 Neuraminidase Proteins 0.000 claims 62
- 102000005348 Neuraminidase Human genes 0.000 claims 62
- 102000018697 Membrane Proteins Human genes 0.000 claims 57
- 108010052285 Membrane Proteins Proteins 0.000 claims 57
- 235000004252 protein component Nutrition 0.000 claims 57
- 239000000203 mixture Substances 0.000 claims 50
- 229960005486 vaccine Drugs 0.000 claims 42
- 102000036639 antigens Human genes 0.000 claims 39
- 108091007433 antigens Proteins 0.000 claims 39
- 239000000427 antigen Substances 0.000 claims 34
- 108010076363 licheninase Proteins 0.000 claims 27
- 150000007523 nucleic acids Chemical class 0.000 claims 26
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 108090000623 proteins and genes Proteins 0.000 claims 23
- 241000196324 Embryophyta Species 0.000 claims 21
- 238000000034 method Methods 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 235000018102 proteins Nutrition 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 15
- 108020001507 fusion proteins Proteins 0.000 claims 15
- 102000037865 fusion proteins Human genes 0.000 claims 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 210000004899 c-terminal region Anatomy 0.000 claims 10
- 230000028993 immune response Effects 0.000 claims 10
- 208000037797 influenza A Diseases 0.000 claims 10
- 239000012528 membrane Substances 0.000 claims 10
- 241000219198 Brassica Species 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 238000003780 insertion Methods 0.000 claims 5
- 230000037431 insertion Effects 0.000 claims 5
- 235000003351 Brassica cretica Nutrition 0.000 claims 4
- 235000003343 Brassica rupestris Nutrition 0.000 claims 4
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 235000010460 mustard Nutrition 0.000 claims 4
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 3
- 240000007377 Petunia x hybrida Species 0.000 claims 3
- 229960002715 nicotine Drugs 0.000 claims 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 3
- 240000007124 Brassica oleracea Species 0.000 claims 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims 2
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims 2
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 claims 2
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims 2
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 claims 2
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims 2
- 235000010469 Glycine max Nutrition 0.000 claims 2
- 244000020551 Helianthus annuus Species 0.000 claims 2
- 235000003222 Helianthus annuus Nutrition 0.000 claims 2
- 235000014647 Lens culinaris subsp culinaris Nutrition 0.000 claims 2
- 244000043158 Lens esculenta Species 0.000 claims 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 2
- 240000004658 Medicago sativa Species 0.000 claims 2
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 244000088415 Raphanus sativus Species 0.000 claims 2
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims 2
- 241000193448 Ruminiclostridium thermocellum Species 0.000 claims 2
- 240000003768 Solanum lycopersicum Species 0.000 claims 2
- 244000061456 Solanum tuberosum Species 0.000 claims 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 2
- 244000300264 Spinacia oleracea Species 0.000 claims 2
- 235000009337 Spinacia oleracea Nutrition 0.000 claims 2
- 241000219793 Trifolium Species 0.000 claims 2
- 235000021307 Triticum Nutrition 0.000 claims 2
- 244000098338 Triticum aestivum Species 0.000 claims 2
- 240000004922 Vigna radiata Species 0.000 claims 2
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims 2
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims 2
- 108010067390 Viral Proteins Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 229940037003 alum Drugs 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 235000013399 edible fruits Nutrition 0.000 claims 2
- 239000000284 extract Substances 0.000 claims 2
- 108010051618 macrophage stimulatory lipopeptide 2 Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
- 229930182490 saponin Natural products 0.000 claims 2
- 150000007949 saponins Chemical class 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 239000012646 vaccine adjuvant Substances 0.000 claims 2
- 229940124931 vaccine adjuvant Drugs 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 235000011331 Brassica Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229940033324 influenza A vaccine Drugs 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77337806P | 2006-02-13 | 2006-02-13 | |
| US81395506P | 2006-06-15 | 2006-06-15 | |
| PCT/US2007/003969 WO2007095318A2 (en) | 2006-02-13 | 2007-02-13 | Influenza antigens, vaccine compositions, and related methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526526A JP2009526526A (ja) | 2009-07-23 |
| JP2009526526A5 true JP2009526526A5 (https=) | 2009-09-03 |
Family
ID=38372128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554442A Withdrawn JP2009526526A (ja) | 2006-02-13 | 2007-02-13 | インフルエンザ抗原、ワクチン組成物、および関連する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8124103B2 (https=) |
| EP (1) | EP1984405A4 (https=) |
| JP (1) | JP2009526526A (https=) |
| KR (1) | KR20080106433A (https=) |
| CN (1) | CN101454347B (https=) |
| AU (1) | AU2007215080A1 (https=) |
| BR (1) | BRPI0707733B1 (https=) |
| CA (1) | CA2642054C (https=) |
| WO (1) | WO2007095318A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9289487B2 (en) * | 1999-09-14 | 2016-03-22 | Antigen Express, Inc. | II-key/antigenic epitope hybrid peptide vaccines |
| WO2005026375A2 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| JP2009502207A (ja) * | 2005-08-03 | 2009-01-29 | フラウンホーファー ユーエスエー， インコーポレイテッド | イムノグロブリンの産生のための組成物および方法 |
| KR20080106434A (ko) * | 2006-02-13 | 2008-12-05 | 프라운호퍼 유에스에이, 인코포레이티드 | Ｈｐｖ 항원, 백신 조성물 및 관련된 방법 |
| US8277816B2 (en) * | 2006-02-13 | 2012-10-02 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| WO2009009759A2 (en) | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| WO2009076778A1 (en) * | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| WO2009062348A1 (en) | 2007-11-14 | 2009-05-22 | Institute Of Microbiology, Chinese Academy Of Sciences | Methods for inhibiting influenza virus infection and their drugs |
| EP2310030A4 (en) | 2008-06-13 | 2013-08-14 | Wisconsin Alumni Res Found | NEW ANTIVIRAL PEPTIDES AGAINST THE INFLUENZA VIRUS |
| US9198965B2 (en) * | 2008-06-13 | 2015-12-01 | Wisconsin Alumni Research Foundation | Peptide adjuvant for influenza vaccination |
| AU2009267769B2 (en) | 2008-07-08 | 2015-07-16 | Medicago Inc. | Soluble recombinant influenza antigens |
| NZ590351A (en) | 2008-07-18 | 2012-11-30 | Medicago Inc | HA1 domain totally or partially free of N-linked glycosylation operatively linked to a regulatory region |
| WO2010036970A2 (en) * | 2008-09-25 | 2010-04-01 | Fraunhofer Usa, Inc. | Influenza vaccines, antigens, compositions, and methods |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| KR101046004B1 (ko) * | 2008-11-12 | 2011-07-01 | 서울대학교산학협력단 | 돼지 인플루엔자 혈청 진단 방법 |
| US20140205619A1 (en) * | 2008-11-28 | 2014-07-24 | Biolex Therapeutics, Inc. | Recombinant avian influenza vaccine and uses thereof |
| WO2010088393A2 (en) * | 2009-01-28 | 2010-08-05 | Antigen Express, Inc. | Li-kay hybrid peptides that modulate the immune response to influenza |
| WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
| HUE039100T2 (hu) | 2009-06-24 | 2018-12-28 | Medicago Inc | Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék |
| SI3998078T1 (sl) | 2009-08-28 | 2026-02-27 | Genzyme Corporation | Encimsko nadomestno zdravljenje z naraščajočim odmerkom za zdravljenje pomanjkanja kisle sfingomielinaze |
| KR101773431B1 (ko) | 2009-09-22 | 2017-09-12 | 메디카고 인코포레이티드 | 식물-유래 ｖｌｐ의 제조방법 |
| US8784819B2 (en) | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| CN103126996A (zh) * | 2010-04-15 | 2013-06-05 | 株式会社新日本科学 | 用于鼻内递送的方法和组合物 |
| WO2011138032A2 (en) * | 2010-05-05 | 2011-11-10 | Artemev, Timur | Universal influenza vaccines and methods for their generation |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| EP4241785B1 (en) | 2011-09-20 | 2026-01-28 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| SG11201504728RA (en) | 2012-12-18 | 2015-07-30 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| RU2699982C2 (ru) | 2014-01-10 | 2019-09-11 | Медикаго Инк. | Энхансерные элементы cpmv |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| MX2018015755A (es) | 2016-06-15 | 2019-08-29 | Icahn School Med Mount Sinai | Proteinas de hemaglutinina de virus de influenza y usos de las mismas. |
| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| CA3104297A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| KR20200060969A (ko) | 2018-11-23 | 2020-06-02 | (주)셀트리온 | 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법 |
| MX2019014943A (es) | 2018-12-12 | 2020-08-06 | Cambridge Tech Llc | Vacuna universal contra la gripe. |
| US12545718B2 (en) | 2019-04-24 | 2026-02-10 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| KR102444024B1 (ko) * | 2019-06-17 | 2022-09-20 | 주식회사 바이오앱 | 아프리카 돼지열병의 진단을 위한 항원 생산용 재조합 벡터 및 이의 용도 |
| US20240009298A1 (en) * | 2020-09-03 | 2024-01-11 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
| JP2023131651A (ja) * | 2022-03-09 | 2023-09-22 | 京都府公立大学法人 | Ｒｂ活性化食品組成物 |
| CN117534737B (zh) * | 2022-07-15 | 2024-09-06 | 中山大学·深圳 | 一种季节性甲型流感通用Mosaic重组抗原及其疫苗和应用 |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPS61176721A (ja) | 1985-01-31 | 1986-08-08 | Mochizuki Motor Kk | マンホ−ル蓋の開閉運搬装置 |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| CA2082160C (en) | 1991-03-06 | 2003-05-06 | Mary M. Bendig | Humanised and chimeric monoclonal antibodies |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| AU669124B2 (en) | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| GB9125979D0 (en) | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| CA2130436C (en) | 1992-02-19 | 2001-04-10 | John S. Abrams | Cloning and expression of humanized monoclonal antibodies against human interleukin-4 |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| PT627940E (pt) | 1992-03-05 | 2003-07-31 | Univ Texas | Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5693506A (en) | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| EP1167379A3 (en) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5705154A (en) | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US5702892A (en) | 1995-05-09 | 1997-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Phage-display of immunoglobulin heavy chain libraries |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| KR100816621B1 (ko) | 1997-04-07 | 2008-03-24 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| NZ538399A (en) | 1997-08-05 | 2007-05-31 | Nventa Biopharma Corp | Fusion protein comprising an HPV E7 protein and a stress protein wherein the E7 protein is joined directly to the amino terminus of the stress protein |
| US6037456A (en) | 1998-03-10 | 2000-03-14 | Biosource Technologies, Inc. | Process for isolating and purifying viruses, soluble proteins and peptides from plant sources |
| US6044555A (en) | 1998-05-04 | 2000-04-04 | Keystone Powered Metal Company | Method for producing fully dense powdered metal helical gear |
| IL141312A0 (en) | 1998-08-11 | 2002-03-10 | Biosource Tech Inc | Method for recovering proteins from the interstitial fluid of plant tissues |
| BR9915919A (pt) | 1998-10-07 | 2001-08-21 | Syngenta Participations Ag | Proteìnas terapeuticamente ativas em plantas |
| WO2000025574A1 (en) | 1998-10-30 | 2000-05-11 | Thomas Jefferson University | Production of biomedical peptides and proteins in plants using plant virus vectors |
| EP1147178A1 (en) | 1999-02-05 | 2001-10-24 | Thomas Jefferson University | Production of biomedical peptides and proteins in plants using transcomplementation systems |
| WO2001070663A2 (en) * | 2000-03-17 | 2001-09-27 | Corixa Corporation | Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors |
| MXPA02012254A (es) * | 2000-06-23 | 2003-04-25 | American Cyanamid Co | Montaje de particulas quimericas semejantes al virus de influenza y del tipo silvestre. |
| NZ523408A (en) | 2000-06-26 | 2006-02-24 | Stressgen Biotechnologies Corp | Human papilloma virus treatment |
| UA80809C2 (en) | 2001-11-05 | 2007-11-12 | Process for preparation of protective antigen protein of anthracis with e.coli | |
| US20040170606A1 (en) | 2002-06-07 | 2004-09-02 | Palmer Kenneth E. | Production of peptides in plants as viral coat protein fusions |
| US7683238B2 (en) | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
| ES2531125T3 (es) | 2003-02-03 | 2015-03-10 | Ibio Inc | Sistema para la expresión de genes en plantas |
| KR20060035596A (ko) * | 2003-05-05 | 2006-04-26 | 보이스 톰슨 인스터튜트 포 플랜트 리서치 | 외래유전자도입 식물로부터 유래된 면역보호성 조성물을제조하기 위한 벡터와 세포 |
| BRPI0410342A (pt) | 2003-05-05 | 2006-06-20 | Dow Agrosciences Llc | composições imunoprofiláticas e terapêuticas estáveis derivadas de células vegetais transgênicas e processos para produção |
| WO2005026375A2 (en) * | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| US7566458B2 (en) * | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US7888135B2 (en) | 2004-04-23 | 2011-02-15 | University Of Georgia Research Foundation, Inc. | Diagnostic assay for Trypanosoma cruzi infection |
| JP4980895B2 (ja) * | 2004-05-25 | 2012-07-18 | メディミューン，エルエルシー | インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体 |
| KR20080106434A (ko) | 2006-02-13 | 2008-12-05 | 프라운호퍼 유에스에이, 인코포레이티드 | Ｈｐｖ 항원, 백신 조성물 및 관련된 방법 |
| US20100150941A1 (en) | 2006-09-13 | 2010-06-17 | Dso National Laboratories | Hemagglutinin antibody and uses thereof |
| AU2007295073A1 (en) | 2006-09-15 | 2008-03-20 | Fraunhofer Usa, Inc. | Influenza antibodies, compositions, and related methods |
| EP2152301A4 (en) | 2007-04-28 | 2010-07-28 | Fraunhofer Usa Inc | TRYPANOSOMAANTIGEN, VACCINE COMPOSITIONS AND RELATED METHODS |
| WO2009009759A2 (en) | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| WO2009026397A2 (en) | 2007-08-20 | 2009-02-26 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
-
2007
- 2007-02-13 BR BRPI0707733-5A patent/BRPI0707733B1/pt not_active IP Right Cessation
- 2007-02-13 KR KR1020087022551A patent/KR20080106433A/ko not_active Ceased
- 2007-02-13 EP EP07750784A patent/EP1984405A4/en not_active Withdrawn
- 2007-02-13 CA CA2642054A patent/CA2642054C/en active Active
- 2007-02-13 WO PCT/US2007/003969 patent/WO2007095318A2/en not_active Ceased
- 2007-02-13 US US11/706,573 patent/US8124103B2/en active Active
- 2007-02-13 JP JP2008554442A patent/JP2009526526A/ja not_active Withdrawn
- 2007-02-13 AU AU2007215080A patent/AU2007215080A1/en not_active Abandoned
- 2007-02-13 CN CN2007800080983A patent/CN101454347B/zh not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009526526A5 (https=) | ||
| JP2009526780A5 (https=) | ||
| Berinstein et al. | Mucosal and systemic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens | |
| Huang et al. | Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice | |
| Zhang et al. | Advancements in the development of subunit influenza vaccines | |
| CN101454347B (zh) | 流感抗原、疫苗组合物和相关方法 | |
| JP5813505B2 (ja) | 新規インフルエンザウイルス免疫エピトープ | |
| Kerstetter et al. | Adenoviral vectors as vaccines for emerging avian influenza viruses | |
| He et al. | Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re‐emerging diseases | |
| Bouche et al. | Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: a novel antigen to protect against measles | |
| CN101820903A (zh) | 预防性和治疗性流感疫苗、抗原、组合物和方法 | |
| US7901691B2 (en) | Chimeric G protein based rabies vaccine | |
| US12257302B2 (en) | Universal vaccine platform | |
| US20130004547A1 (en) | Oral vaccines produced and administered using edible micro-organisms including lactic acid bacterial strains | |
| Zhang et al. | Recombinant baculovirus vaccine containing multiple M2e and adjuvant LTB induces T cell dependent, cross-clade protection against H5N1 influenza virus in mice | |
| US20120171230A1 (en) | Oral vaccines produced and administered using edible micro-organism | |
| Park et al. | Preparation and immunogenicity of influenza virus-like particles using nitrocellulose membrane filtration | |
| WO2003013598A2 (en) | Novel vaccine compositions and methods of vaccine preparation for veterinary and human diseases | |
| Meriç et al. | Plant-based vaccines: The future of preventive healthcare | |
| US10953086B2 (en) | Universal influenza vaccine using cold-adapted live-attenuated virus | |
| Yang et al. | A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses | |
| Abolnik | Molecular epidemiology of Newcastle disease and avian influenza in South Africa | |
| US10376574B2 (en) | Compositions and methods for vaccination against influenza A virus | |
| Gómez et al. | Developments in plant-based vaccines against diseases of concern in developing countries | |
| US20230173055A1 (en) | Influenza virus surface protein-derived recombinant hemagglutinin protein forming trimer, and use thereof |