JP2009524694A5 - - Google Patents
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- Publication number
- JP2009524694A5 JP2009524694A5 JP2008552602A JP2008552602A JP2009524694A5 JP 2009524694 A5 JP2009524694 A5 JP 2009524694A5 JP 2008552602 A JP2008552602 A JP 2008552602A JP 2008552602 A JP2008552602 A JP 2008552602A JP 2009524694 A5 JP2009524694 A5 JP 2009524694A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- cyano
- isoquinoline
- carbonyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(*)=O)NC(c1nc(CC2=NC2)c(c(*)c(*)c(*)c2*)c2c1O*)=* Chemical compound *C(C(*)=O)NC(c1nc(CC2=NC2)c(c(*)c(*)c(*)c2*)c2c1O*)=* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76278006P | 2006-01-27 | 2006-01-27 | |
| US60/762,780 | 2006-01-27 | ||
| PCT/US2007/061171 WO2007090068A2 (en) | 2006-01-27 | 2007-01-26 | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524694A JP2009524694A (ja) | 2009-07-02 |
| JP2009524694A5 true JP2009524694A5 (https=) | 2011-03-10 |
| JP5161793B2 JP5161793B2 (ja) | 2013-03-13 |
Family
ID=38042727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552602A Expired - Fee Related JP5161793B2 (ja) | 2006-01-27 | 2007-01-26 | 低酸素症誘導因子(hif)を安定化するシアノイソキノリン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US7928120B2 (https=) |
| EP (2) | EP2476669A1 (https=) |
| JP (1) | JP5161793B2 (https=) |
| KR (2) | KR20140089446A (https=) |
| CN (3) | CN101374815B (https=) |
| AU (1) | AU2007211077B2 (https=) |
| BR (1) | BRPI0707302B8 (https=) |
| CA (1) | CA2640435C (https=) |
| DK (1) | DK2044028T3 (https=) |
| IL (1) | IL193047A (https=) |
| MX (1) | MX2008009581A (https=) |
| NO (1) | NO342678B1 (https=) |
| RU (1) | RU2457204C2 (https=) |
| WO (1) | WO2007090068A2 (https=) |
| ZA (1) | ZA200806752B (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8614204B2 (en) * | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| WO2004108681A1 (en) | 2003-06-06 | 2004-12-16 | Fibrogen, Inc. | Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| BRPI0707302B8 (pt) * | 2006-01-27 | 2021-05-25 | Fibrogen Inc | compostos de cianoisoquinolina que atuam no dano tecidual associado com isquemia, hipóxia e anemia, bem como composição farmacêutica que os compreende |
| WO2007097929A1 (en) * | 2006-02-16 | 2007-08-30 | Fibrogen, Inc. | Compounds and methods for treatment of stroke |
| BRPI0710527B8 (pt) * | 2006-04-04 | 2021-05-25 | Fibrogen Inc | compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende |
| US8962530B2 (en) * | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
| WO2009058403A1 (en) * | 2007-11-02 | 2009-05-07 | Fibrogen, Inc. | Methods for reducing blood pressure |
| WO2009073669A1 (en) | 2007-12-03 | 2009-06-11 | Fibrogen, Inc. | Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions |
| EP2231157A1 (en) * | 2007-12-06 | 2010-09-29 | Fibrogen, Inc. | Methods for increasing endothelial progentior cells |
| WO2009075826A1 (en) * | 2007-12-07 | 2009-06-18 | Fibrogen, Inc. | Methods for increasing white blood cells |
| EP2252619B1 (en) | 2008-01-11 | 2013-10-09 | Fibrogen, Inc. | Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity |
| WO2009100250A1 (en) | 2008-02-05 | 2009-08-13 | Fibrogen, Inc. | Chromene derivatives and use thereof as hif hydroxylase activity inhibitors |
| ES2524883T3 (es) * | 2008-03-18 | 2014-12-15 | Merck Sharp & Dohme Corp. | 4-Hidroxipirimidina-5-carboxamidas sustituidas |
| PT2294066E (pt) | 2008-04-28 | 2014-11-21 | Janssen Pharmaceutica Nv | Benzoimidazoles como inibidores da prolil-hidroxilase |
| US8217043B2 (en) * | 2008-08-20 | 2012-07-10 | Fibrogen, Inc. | Compounds and methods for their use |
| WO2010024911A1 (en) * | 2008-08-26 | 2010-03-04 | Fibrogen, Inc. | Methods for increasing neurogenesis |
| JP5649584B2 (ja) * | 2008-11-14 | 2015-01-07 | フィブロジェン インコーポレイテッド | Hifヒドロキシラーゼ阻害剤としてのチオクロメン誘導体 |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| WO2012106472A1 (en) | 2011-02-02 | 2012-08-09 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (hif) hydroxylase |
| GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
| WO2012150221A2 (de) | 2011-05-04 | 2012-11-08 | Bayer Cropscience Ag | Neue halogenierte benzylalkoholester der cyclopropancarbonsäure als schädlingsbekämpfungsmittel |
| WO2012150208A1 (de) | 2011-05-04 | 2012-11-08 | Bayer Cropscience Ag | Verwendung von substituierten benzylalkoholestern der cyclopropancarbonsäure zur bekämpfung von insektizid-resistenten insekten |
| CN104024227B8 (zh) * | 2011-07-22 | 2025-07-29 | 北京贝美拓新药研发有限公司 | 抑制脯氨酸羟化酶活性的化合物的晶型及其应用 |
| GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
| WO2013063221A1 (en) | 2011-10-25 | 2013-05-02 | Janssen Pharmaceutica Nv | Meglumine salt formulations of 1-(5,6-dichloro-1h-benzo[d]imidazol-2-yl)-1h-pyrazole-4-carboxylic acid |
| WO2013134660A1 (en) | 2012-03-09 | 2013-09-12 | Fibrogen, Inc. | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
| AU2013290438C1 (en) | 2012-07-16 | 2019-01-03 | Kyntra Bio, Inc. | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| EP3219706A1 (en) * | 2012-07-16 | 2017-09-20 | Fibrogen, Inc. | Process for making isoquinoline compounds |
| TWI616430B (zh) * | 2012-07-27 | 2018-03-01 | 百健Ma公司 | Atx調節劑 |
| AU2014209319B2 (en) * | 2013-01-24 | 2018-04-19 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| HRP20200615T1 (hr) | 2013-06-06 | 2020-07-10 | Fibrogen, Inc. | Farmaceutske formulacije inhibitora hif hidroksilaze |
| EP2915878A1 (en) | 2014-03-07 | 2015-09-09 | Institut Pasteur | Method and device for conserving viable and functional human polymorphonuclear neutrophils |
| WO2016034108A1 (zh) | 2014-09-02 | 2016-03-10 | 广东东阳光药业有限公司 | 喹啉酮类化合物及其应用 |
| TWI699355B (zh) | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| BR112017013440A2 (pt) * | 2014-12-24 | 2018-01-09 | Gilead Sciences, Inc. | compostos de isoquinolina para o tratamento de hiv |
| SG11201705192PA (en) | 2014-12-24 | 2017-07-28 | Gilead Sciences Inc | Fused pyrimidine compounds for the treatment of hiv |
| CN106146395B (zh) | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| CN104892509B (zh) * | 2015-06-04 | 2018-03-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
| KR102333180B1 (ko) * | 2015-08-05 | 2021-11-30 | 삼성전자주식회사 | 플렉서블 디스플레이 장치를 구비한 전자 장치 |
| CN109180580B (zh) | 2016-02-28 | 2021-01-12 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的杂芳基化合物及包含该化合物的组合物及其用途 |
| CN106478503A (zh) * | 2016-09-29 | 2017-03-08 | 上海勋和医药科技有限公司 | Roxadustat中间体的制备方法 |
| CN107954931B (zh) * | 2016-10-17 | 2021-06-22 | 上海医药集团青岛国风药业股份有限公司 | 一种诺得司他的制备方法 |
| CN108017583B (zh) * | 2016-11-01 | 2021-04-06 | 徐州万邦金桥制药有限公司 | 一种可博美的制备方法 |
| CN110878096A (zh) * | 2018-09-05 | 2020-03-13 | 石药集团中奇制药技术(石家庄)有限公司 | 一种1,7-萘啶类衍生物及其制备方法和用途 |
| IT201800009318A1 (it) * | 2018-10-10 | 2020-04-10 | Luigi Frati | Composizioni antiossidanti |
| KR20210108367A (ko) | 2018-11-09 | 2021-09-02 | 비바체 테라퓨틱스, 인크. | 비시클릭 화합물 |
| PY2012000A (es) | 2019-02-26 | 2023-07-25 | Bayer Ag | Derivados de heterociclos bicíclicos fusionados como pesticidas |
| PY2011993A (es) | 2019-02-26 | 2021-07-05 | Bayer Ag | Derivados heterocíclos bicíclicos condensados como plaguicida |
| MX2021012638A (es) | 2019-04-16 | 2022-01-04 | Vivace Therapeutics Inc | Compuestos biciclicos. |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| CN113292494B (zh) * | 2020-02-24 | 2025-12-30 | 苏中药业集团股份有限公司 | 异喹啉羧酸化合物及其制备方法与应用 |
| US12410140B2 (en) * | 2020-06-19 | 2025-09-09 | Jumpcan (Shanghai) Medical Technology Co., Ltd | Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof |
| JP2025500888A (ja) * | 2021-12-17 | 2025-01-15 | アケビア セラピューティクス インコーポレイテッド | 選択的phd1阻害剤としてのピコリンアミド化合物、組成物、及び使用方法 |
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| BRPI0707302B8 (pt) * | 2006-01-27 | 2021-05-25 | Fibrogen Inc | compostos de cianoisoquinolina que atuam no dano tecidual associado com isquemia, hipóxia e anemia, bem como composição farmacêutica que os compreende |
| BRPI0710527B8 (pt) * | 2006-04-04 | 2021-05-25 | Fibrogen Inc | compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende |
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-
2007
- 2007-01-26 BR BRPI0707302A patent/BRPI0707302B8/pt not_active IP Right Cessation
- 2007-01-26 EP EP11194165A patent/EP2476669A1/en not_active Withdrawn
- 2007-01-26 CN CN2007800035992A patent/CN101374815B/zh not_active Expired - Fee Related
- 2007-01-26 CA CA2640435A patent/CA2640435C/en active Active
- 2007-01-26 ZA ZA200806752A patent/ZA200806752B/xx unknown
- 2007-01-26 KR KR1020147017534A patent/KR20140089446A/ko not_active Ceased
- 2007-01-26 US US11/627,906 patent/US7928120B2/en active Active
- 2007-01-26 KR KR1020087020971A patent/KR101446499B1/ko not_active Expired - Fee Related
- 2007-01-26 MX MX2008009581A patent/MX2008009581A/es active IP Right Grant
- 2007-01-26 JP JP2008552602A patent/JP5161793B2/ja not_active Expired - Fee Related
- 2007-01-26 RU RU2008134664/04A patent/RU2457204C2/ru active IP Right Revival
- 2007-01-26 CN CN201310239635.2A patent/CN103382216B/zh not_active Expired - Fee Related
- 2007-01-26 AU AU2007211077A patent/AU2007211077B2/en not_active Ceased
- 2007-01-26 CN CN201110220665.XA patent/CN102351791B/zh not_active Expired - Fee Related
- 2007-01-26 DK DK07717454.8T patent/DK2044028T3/da active
- 2007-01-26 EP EP07717454A patent/EP2044028B1/en active Active
- 2007-01-26 WO PCT/US2007/061171 patent/WO2007090068A2/en not_active Ceased
-
2008
- 2008-07-24 IL IL193047A patent/IL193047A/en active IP Right Grant
- 2008-08-25 NO NO20083658A patent/NO342678B1/no unknown
-
2011
- 2011-03-07 US US13/042,281 patent/US20110212959A1/en not_active Abandoned
-
2012
- 2012-03-26 US US13/430,568 patent/US8759373B2/en active Active
-
2014
- 2014-05-28 US US14/289,573 patent/US9174976B2/en active Active
-
2015
- 2015-09-21 US US14/860,560 patent/US20160009653A1/en not_active Abandoned
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