JP2009524684A5 - - Google Patents
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- Publication number
- JP2009524684A5 JP2009524684A5 JP2008552479A JP2008552479A JP2009524684A5 JP 2009524684 A5 JP2009524684 A5 JP 2009524684A5 JP 2008552479 A JP2008552479 A JP 2008552479A JP 2008552479 A JP2008552479 A JP 2008552479A JP 2009524684 A5 JP2009524684 A5 JP 2009524684A5
- Authority
- JP
- Japan
- Prior art keywords
- saturated
- pharmaceutical composition
- lower alkyl
- cycloalkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 42
- 229920006395 saturated elastomer Polymers 0.000 claims 36
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- ILYSIVSSNXQZQG-OVSJKPMPSA-N (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-amine Chemical class NC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C ILYSIVSSNXQZQG-OVSJKPMPSA-N 0.000 claims 18
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 208000030533 eye disease Diseases 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 5
- 239000013078 crystal Substances 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 4
- 206010061323 Optic neuropathy Diseases 0.000 claims 4
- 206010057430 Retinal injury Diseases 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 201000011190 diabetic macular edema Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 208000028867 ischemia Diseases 0.000 claims 4
- 208000038015 macular disease Diseases 0.000 claims 4
- 230000002503 metabolic effect Effects 0.000 claims 4
- 208000020911 optic nerve disease Diseases 0.000 claims 4
- 208000032253 retinal ischemia Diseases 0.000 claims 4
- 230000010410 reperfusion Effects 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000004693 imidazolium salts Chemical class 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- -1 retinylamine derivative compound Chemical class 0.000 claims 2
- UNAHBDVMXZVTAI-UHFFFAOYSA-N 10-ethyl-3,7-dimethyldodeca-2,4,6,8-tetraen-1-amine Chemical compound CCC(CC)C=CC(C)=CC=CC(C)=CCN UNAHBDVMXZVTAI-UHFFFAOYSA-N 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-O Pyrrolidinium ion Chemical compound C1CC[NH2+]C1 RWRDLPDLKQPQOW-UHFFFAOYSA-O 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 210000000411 amacrine cell Anatomy 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 210000002287 horizontal cell Anatomy 0.000 claims 1
- 238000006317 isomerization reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000608 photoreceptor cell Anatomy 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 1
- 210000001116 retinal neuron Anatomy 0.000 claims 1
- 150000004492 retinoid derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76238406P | 2006-01-26 | 2006-01-26 | |
| PCT/US2007/002330 WO2007089673A2 (en) | 2006-01-26 | 2007-01-26 | Compositions and methods for treatment of ophthalmic diseases and disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009524684A JP2009524684A (ja) | 2009-07-02 |
| JP2009524684A5 true JP2009524684A5 (https=) | 2010-03-25 |
Family
ID=38327945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552479A Pending JP2009524684A (ja) | 2006-01-26 | 2007-01-26 | 眼疾患および障害の治療のための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090197967A1 (https=) |
| EP (1) | EP1988889A4 (https=) |
| JP (1) | JP2009524684A (https=) |
| CA (1) | CA2640151A1 (https=) |
| WO (1) | WO2007089673A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0810063A2 (pt) | 2007-04-20 | 2014-10-14 | Acucela Inc | Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina |
| NZ601866A (en) | 2007-06-29 | 2013-12-20 | Acucela Inc | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| MX2011002448A (es) * | 2008-09-05 | 2011-05-25 | Acucela Inc | Compuestos enlazados con azufre para el tratamiento de enfermedades y trastornos oftalmicos. |
| WO2015187942A1 (en) * | 2014-06-04 | 2015-12-10 | Case Western Reserve University | Compositions and methods of treating diabetic retinopathy |
| US10117868B2 (en) * | 2011-10-25 | 2018-11-06 | Case Western Reserve University | Systems pharmacology for treating ocular disorders |
| US10471118B2 (en) * | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| WO2016085939A2 (en) * | 2014-11-24 | 2016-06-02 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6437003B1 (en) * | 1997-10-31 | 2002-08-20 | Jean-Baptiste Roullet | Use of retinoids to treat high blood pressure and other cardiovascular disease |
| US20080275134A1 (en) * | 2005-02-24 | 2008-11-06 | University Of Washington | Methods for Treatment of Retinal Degenerative Disease |
-
2007
- 2007-01-26 JP JP2008552479A patent/JP2009524684A/ja active Pending
- 2007-01-26 CA CA002640151A patent/CA2640151A1/en not_active Abandoned
- 2007-01-26 US US12/162,476 patent/US20090197967A1/en not_active Abandoned
- 2007-01-26 EP EP07763005A patent/EP1988889A4/en not_active Withdrawn
- 2007-01-26 WO PCT/US2007/002330 patent/WO2007089673A2/en not_active Ceased
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