JP2009524684A5 - - Google Patents
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- Publication number
- JP2009524684A5 JP2009524684A5 JP2008552479A JP2008552479A JP2009524684A5 JP 2009524684 A5 JP2009524684 A5 JP 2009524684A5 JP 2008552479 A JP2008552479 A JP 2008552479A JP 2008552479 A JP2008552479 A JP 2008552479A JP 2009524684 A5 JP2009524684 A5 JP 2009524684A5
- Authority
- JP
- Japan
- Prior art keywords
- saturated
- pharmaceutical composition
- lower alkyl
- cycloalkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 42
- 229920006395 saturated elastomer Polymers 0.000 claims 36
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- ILYSIVSSNXQZQG-OVSJKPMPSA-N (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-amine Chemical class NC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C ILYSIVSSNXQZQG-OVSJKPMPSA-N 0.000 claims 18
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 208000030533 eye disease Diseases 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 5
- 239000013078 crystal Substances 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 4
- 206010061323 Optic neuropathy Diseases 0.000 claims 4
- 206010057430 Retinal injury Diseases 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 201000011190 diabetic macular edema Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 208000028867 ischemia Diseases 0.000 claims 4
- 208000038015 macular disease Diseases 0.000 claims 4
- 230000002503 metabolic effect Effects 0.000 claims 4
- 208000020911 optic nerve disease Diseases 0.000 claims 4
- 208000032253 retinal ischemia Diseases 0.000 claims 4
- 230000010410 reperfusion Effects 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000004693 imidazolium salts Chemical class 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- -1 retinylamine derivative compound Chemical class 0.000 claims 2
- UNAHBDVMXZVTAI-UHFFFAOYSA-N 10-ethyl-3,7-dimethyldodeca-2,4,6,8-tetraen-1-amine Chemical compound CCC(CC)C=CC(C)=CC=CC(C)=CCN UNAHBDVMXZVTAI-UHFFFAOYSA-N 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-O Pyrrolidinium ion Chemical compound C1CC[NH2+]C1 RWRDLPDLKQPQOW-UHFFFAOYSA-O 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 210000000411 amacrine cell Anatomy 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 210000002287 horizontal cell Anatomy 0.000 claims 1
- 238000006317 isomerization reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000608 photoreceptor cell Anatomy 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 1
- 210000001116 retinal neuron Anatomy 0.000 claims 1
- 150000004492 retinoid derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76238406P | 2006-01-26 | 2006-01-26 | |
| PCT/US2007/002330 WO2007089673A2 (en) | 2006-01-26 | 2007-01-26 | Compositions and methods for treatment of ophthalmic diseases and disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009524684A JP2009524684A (ja) | 2009-07-02 |
| JP2009524684A5 true JP2009524684A5 (https=) | 2010-03-25 |
Family
ID=38327945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552479A Pending JP2009524684A (ja) | 2006-01-26 | 2007-01-26 | 眼疾患および障害の治療のための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090197967A1 (https=) |
| EP (1) | EP1988889A4 (https=) |
| JP (1) | JP2009524684A (https=) |
| CA (1) | CA2640151A1 (https=) |
| WO (1) | WO2007089673A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2681850C (en) | 2007-04-20 | 2013-07-23 | Acucela Inc. | Styrenyl derivative compounds for treating ophthalmic diseases and disorders |
| RU2470910C9 (ru) | 2007-06-29 | 2013-05-20 | Акьюсела, Инк. | Соединения, представляющие собой алкинилфенильные производные, для лечения офтальмических заболеваний и расстройств |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| CA2736229C (en) * | 2008-09-05 | 2015-06-09 | Acucela Inc. | Sulfur-linked compounds for treating opthalmic diseases and disorders |
| US10117868B2 (en) | 2011-10-25 | 2018-11-06 | Case Western Reserve University | Systems pharmacology for treating ocular disorders |
| US10471118B2 (en) * | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| US10272106B2 (en) | 2014-06-04 | 2019-04-30 | Case Western Reserve University | Compositions and methods of treating diabetic retinopathy |
| US10363231B2 (en) | 2014-11-24 | 2019-07-30 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6437003B1 (en) * | 1997-10-31 | 2002-08-20 | Jean-Baptiste Roullet | Use of retinoids to treat high blood pressure and other cardiovascular disease |
| WO2006091761A1 (en) * | 2005-02-24 | 2006-08-31 | University Of Washington | Methods for treatment of retinal degenerative disease |
-
2007
- 2007-01-26 JP JP2008552479A patent/JP2009524684A/ja active Pending
- 2007-01-26 WO PCT/US2007/002330 patent/WO2007089673A2/en not_active Ceased
- 2007-01-26 CA CA002640151A patent/CA2640151A1/en not_active Abandoned
- 2007-01-26 US US12/162,476 patent/US20090197967A1/en not_active Abandoned
- 2007-01-26 EP EP07763005A patent/EP1988889A4/en not_active Withdrawn
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