JP2009523421A5 - - Google Patents
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- Publication number
- JP2009523421A5 JP2009523421A5 JP2008550418A JP2008550418A JP2009523421A5 JP 2009523421 A5 JP2009523421 A5 JP 2009523421A5 JP 2008550418 A JP2008550418 A JP 2008550418A JP 2008550418 A JP2008550418 A JP 2008550418A JP 2009523421 A5 JP2009523421 A5 JP 2009523421A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- antibody
- dkk1
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75921606P | 2006-01-13 | 2006-01-13 | |
| US60/759,216 | 2006-01-13 | ||
| PCT/US2007/000777 WO2007084344A2 (en) | 2006-01-13 | 2007-01-12 | Compositions and methods of use for antibodies of dickkopf-1 and/or -4 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012274999A Division JP2013099334A (ja) | 2006-01-13 | 2012-12-17 | Ｄｉｃｋｋｏｐｆ−１および／または−４に対する抗体の組成物および製造法その使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523421A JP2009523421A (ja) | 2009-06-25 |
| JP2009523421A5 true JP2009523421A5 (https=) | 2010-02-25 |
| JP5552233B2 JP5552233B2 (ja) | 2014-07-16 |
Family
ID=38288117
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550418A Expired - Fee Related JP5552233B2 (ja) | 2006-01-13 | 2007-01-12 | Ｄｉｃｋｋｏｐｆ−１および／または−４に対する抗体の組成物および製造法その使用方法 |
| JP2012274999A Pending JP2013099334A (ja) | 2006-01-13 | 2012-12-17 | Ｄｉｃｋｋｏｐｆ−１および／または−４に対する抗体の組成物および製造法その使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012274999A Pending JP2013099334A (ja) | 2006-01-13 | 2012-12-17 | Ｄｉｃｋｋｏｐｆ−１および／または−４に対する抗体の組成物および製造法その使用方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8673306B2 (https=) |
| EP (1) | EP1976594B1 (https=) |
| JP (2) | JP5552233B2 (https=) |
| KR (1) | KR101413785B1 (https=) |
| CN (1) | CN101400406B (https=) |
| AR (1) | AR060017A1 (https=) |
| AU (1) | AU2007207787B2 (https=) |
| BR (1) | BRPI0706524A2 (https=) |
| CA (1) | CA2636579A1 (https=) |
| CR (1) | CR10128A (https=) |
| CU (1) | CU23871B1 (https=) |
| EA (1) | EA015538B1 (https=) |
| EC (1) | ECSP088618A (https=) |
| GE (1) | GEP20125476B (https=) |
| HN (1) | HN2008001104A (https=) |
| IL (1) | IL192631A (https=) |
| MA (1) | MA30158B1 (https=) |
| ME (2) | MEP1308A (https=) |
| MY (1) | MY153573A (https=) |
| NO (1) | NO20083477L (https=) |
| NZ (1) | NZ569555A (https=) |
| PE (2) | PE20071239A1 (https=) |
| SG (1) | SG169327A1 (https=) |
| SM (1) | SMP200800042B (https=) |
| SV (1) | SV2008002980A (https=) |
| TN (1) | TNSN08297A1 (https=) |
| TW (1) | TWI432450B (https=) |
| UA (1) | UA101944C2 (https=) |
| WO (1) | WO2007084344A2 (https=) |
| ZA (1) | ZA200805743B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| US8450274B2 (en) | 2006-05-24 | 2013-05-28 | Theragenetex Co., Ltd. | DKK2 protein and use thereof |
| KR101218806B1 (ko) * | 2010-04-21 | 2013-01-09 | 주식회사 테라젠이텍스 | Ｄｋｋ2 단백질 및 그의 용도 |
| JP2009065938A (ja) * | 2007-09-14 | 2009-04-02 | Matsumoto Shika Univ | タンパク質、破骨細胞分化阻害剤、炎症性骨破壊治療薬、遺伝子、組み替えベクター、及びタンパク質の製造方法 |
| TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| JP5320730B2 (ja) * | 2007-12-26 | 2013-10-23 | Ｊｎｃ株式会社 | 発光基質水溶液およびその製造方法 |
| CN103002911B (zh) | 2008-09-26 | 2015-08-26 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
| WO2010100200A2 (en) * | 2009-03-05 | 2010-09-10 | Novartis Ag | Lyophilised antibody formulation |
| AR075989A1 (es) * | 2009-04-10 | 2011-05-11 | Lilly Co Eli | Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria |
| CN102421798A (zh) * | 2009-05-07 | 2012-04-18 | 诺瓦提斯公司 | 与dickkopf-1或dickkopf-4或两者的结合分子的组合物及使用方法 |
| PE20120475A1 (es) | 2009-05-12 | 2012-05-05 | Pfizer | Anticuerpos especificos para dkk-1 |
| WO2010130832A2 (en) * | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| WO2011053665A1 (en) * | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Pcsk9 immunoassay |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| SG183867A1 (en) * | 2010-03-11 | 2012-10-30 | Rinat Neuroscience Corp | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| JP6066912B2 (ja) * | 2010-10-27 | 2017-01-25 | アムジエン・インコーポレーテツド | Ｄｋｋ１抗体およびその使用方法 |
| CN103608037B (zh) * | 2011-02-01 | 2016-04-13 | 香港大学 | 抗dkk1单克隆抗体用于治疗肝癌的用途 |
| EP2681242B1 (en) | 2011-03-01 | 2018-01-24 | Amgen Inc. | Sclerostin and dkk-1 bispecific binding agents |
| CN103472226A (zh) * | 2012-06-08 | 2013-12-25 | 上海市肿瘤研究所 | 血清dkk1在制备早期肝细胞癌或小肝细胞癌的诊断试剂中的用途 |
| CN103487581A (zh) * | 2012-06-08 | 2014-01-01 | 上海市肿瘤研究所 | 血清dkk1在制备甲胎蛋白阴性肝细胞癌的诊断试剂中的用途 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| JP2016510411A (ja) * | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング |
| CN103083686B (zh) * | 2013-02-18 | 2014-09-10 | 上海交通大学医学院附属仁济医院 | Dkk4基因及其编码蛋白在制备药物中的应用 |
| WO2014144817A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Inhibitory polypeptides specific to wnt inhibitors |
| EP3978524A1 (en) | 2014-07-03 | 2022-04-06 | Yale University | Dickkopf2 (dkk2) inhibition suppresses tumor formation |
| US12428483B2 (en) | 2014-12-22 | 2025-09-30 | Systimmune, Inc. | Bispecific tetravalent antibodies and methods of making and using thereof |
| DE102016206820B4 (de) | 2015-04-22 | 2017-07-27 | BSH Hausgeräte GmbH | Weiterentwicklung eines Induktionswasserkochers, einer Kaffeemaschine und einer Suppenmaschine |
| WO2017027422A1 (en) * | 2015-08-07 | 2017-02-16 | Alexo Therapeutics Inc. | Constructs having a sirp-alpha domain or variant thereof |
| CN105203773A (zh) * | 2015-09-28 | 2015-12-30 | 成都博奥新景医学科技有限公司 | 一种人Dickkopf-1蛋白（DKK-1）定量检测试剂盒 |
| EP3368567B1 (en) * | 2015-10-28 | 2025-10-01 | Yale University | Humanized anti-dkk2 antibody and uses thereof |
| RU2656160C2 (ru) * | 2016-08-17 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Антитело или его антигенсвязывающий фрагмент, способный связываться с рецептором интерлейкина-6 человека |
| KR102701695B1 (ko) | 2016-10-26 | 2024-08-30 | 리프 테라퓨틱스 인코포레이티드 | 항-dkk-1 항체를 사용하여 암을 치료하기 위한 바이오마커로서의 베타-카테닌의 용도 |
| CN110799212A (zh) * | 2017-05-10 | 2020-02-14 | 古德T细胞有限公司 | 特异性存在于调节性t细胞中的dkk1蛋白及其用途 |
| WO2020149644A1 (ko) * | 2019-01-15 | 2020-07-23 | (주)바이오니아 | Dkk1 유전자를 표적으로 하는 이중나선 올리고뉴클레오티드, 이를 포함하는 구조체 및 이를 포함하는 탈모 예방 또는 발모용 조성물 |
| CA3128526A1 (en) | 2019-02-01 | 2020-08-06 | Board Of Regents, The University Of Texas System | Monoclonal antibodies against mhc-bound human dickkopf-1 peptides and uses thereof |
| BR112021024003A2 (pt) | 2019-05-31 | 2022-04-19 | Alx Oncology Inc | Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico |
| CN112121147B (zh) * | 2019-06-24 | 2023-07-04 | 中国人民解放军海军特色医学中心 | 多肽在治疗或预防骨髓瘤药物中的应用、多肽、核酸、药物及重组表达载体 |
| CN112180094A (zh) * | 2019-07-04 | 2021-01-05 | 上海东慈生物科技有限公司 | Dkk1抑制剂在预防和/或治疗肿瘤恶病质与糖尿病伴随疾病中的应用 |
| AU2020394204A1 (en) | 2019-11-27 | 2022-06-02 | ALX Oncology Inc. | Combination therapies for treating cancer |
| CN111632147A (zh) * | 2020-06-07 | 2020-09-08 | 重庆医科大学 | 骨细胞Wnt激活剂在制备骨折加速愈合、防治骨不连及不运动或失重骨丢失药物中的应用 |
| KR102494042B1 (ko) | 2020-11-20 | 2023-02-07 | 주식회사 하울바이오 | 인간모유두세포의 성장을 촉진하는 항-dkk-1 항체 및 이의 용도 |
| CN112592402B (zh) * | 2020-12-02 | 2022-04-26 | 杭州奕安济世生物药业有限公司 | 抗dkk2抗体、包含该抗dkk2抗体的组合物及其用途 |
| US20250270304A1 (en) * | 2020-12-23 | 2025-08-28 | Phenomic Ai | Anti-activin antibodies and methods of using the same |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
| CN117916377A (zh) * | 2021-09-26 | 2024-04-19 | 安沛治疗有限公司 | 针对dkk1的适体及其用途 |
| EP4471056A4 (en) * | 2022-01-28 | 2026-02-18 | Shanghai Junshi Biosciences Co Ltd | Anti-DKK1 antibodies, pharmaceutical composition and associated uses |
| WO2024216064A1 (en) * | 2023-04-14 | 2024-10-17 | Twist Bioscience Corporation | Compositions and methods related to dkk1 binders |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5597710A (en) | 1994-03-10 | 1997-01-28 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US7057017B2 (en) | 1997-04-16 | 2006-06-06 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| AU7137398A (en) | 1997-04-16 | 1998-11-11 | Millennium Pharmaceuticals, Inc. | Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor |
| DE19747418C1 (de) | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| US7446181B2 (en) | 1998-01-15 | 2008-11-04 | Millennium Pharmaceuticals, Inc. | Antibodies that bind human Dickkopf-1 proteins |
| AU5233599A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | Ddkh-3 nucleic acids, polypeptides, vectors, host cells, methods and uses thereof |
| US7041805B2 (en) | 1998-09-01 | 2006-05-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6344541B1 (en) | 1998-09-25 | 2002-02-05 | Amgen Inc. | DKR polypeptides |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| BRPI0116728B1 (pt) | 2001-01-05 | 2018-10-30 | Pfizer Inc. | anticorpos para receptor de fator de crescimento i semelhante à insulina |
| IL157328A0 (en) | 2001-02-16 | 2004-02-19 | Genentech Inc | Treatment involving dkk-1 or antagonists thereof |
| JP4406206B2 (ja) * | 2001-04-24 | 2010-01-27 | バイエル コーポレーション | ヒトｔｉｍｐ−１抗体 |
| JP2005512557A (ja) | 2001-11-07 | 2005-05-12 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ アーカンソー | 遺伝子発現プロファイリングに基づく多発性骨髄腫の診断、予後、および治療標的候補の同定 |
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| MXPA05006033A (es) | 2002-12-05 | 2006-03-08 | Univ Arkansas | Determinantes moleculares de enfermedad osea por mieloma, y usos de los mismos. |
| US20050084494A1 (en) * | 2003-05-21 | 2005-04-21 | Darwin Prockop | Inhibitors of Dkk-1 |
| CA2575791A1 (en) * | 2004-08-03 | 2006-02-16 | Dyax Corp. | Hk1-binding proteins |
| MX2007001221A (es) * | 2004-08-04 | 2007-03-23 | Amgen Inc | Anticuerpos para proteina dickkopf-1 (dkk-1). |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| AU2006226060A1 (en) * | 2005-03-25 | 2006-09-28 | Glycart Biotechnology Ag | Antigen binding molecules directed to MCSP and having increased Fc receptor binding affinity and effector function |
| JP2009515516A (ja) | 2005-11-14 | 2009-04-16 | バイオレン・インク | 推定成熟ｃｄｒのブラスティングならびにコホートライブラリの作製およびスクリーニングによる抗体の超ヒト化 |
-
2007
- 2007-01-11 AR ARP070100119A patent/AR060017A1/es unknown
- 2007-01-12 NZ NZ569555A patent/NZ569555A/en not_active IP Right Cessation
- 2007-01-12 ME MEP-13/08A patent/MEP1308A/xx unknown
- 2007-01-12 SG SG201100297-9A patent/SG169327A1/en unknown
- 2007-01-12 BR BRPI0706524-8A patent/BRPI0706524A2/pt not_active IP Right Cessation
- 2007-01-12 GE GEAP200710809A patent/GEP20125476B/en unknown
- 2007-01-12 PE PE2007000031A patent/PE20071239A1/es not_active Application Discontinuation
- 2007-01-12 SM SM200800042T patent/SMP200800042B/it unknown
- 2007-01-12 TW TW096101263A patent/TWI432450B/zh not_active IP Right Cessation
- 2007-01-12 AU AU2007207787A patent/AU2007207787B2/en not_active Ceased
- 2007-01-12 UA UAA200808758A patent/UA101944C2/ru unknown
- 2007-01-12 US US12/160,875 patent/US8673306B2/en not_active Expired - Fee Related
- 2007-01-12 PE PE2011001865A patent/PE20120816A1/es not_active Application Discontinuation
- 2007-01-12 WO PCT/US2007/000777 patent/WO2007084344A2/en not_active Ceased
- 2007-01-12 ME MEP-2008-13A patent/ME00010B/me unknown
- 2007-01-12 CA CA002636579A patent/CA2636579A1/en not_active Abandoned
- 2007-01-12 MY MYPI20082536A patent/MY153573A/en unknown
- 2007-01-12 CN CN200780009135.2A patent/CN101400406B/zh active Active
- 2007-01-12 KR KR1020087019725A patent/KR101413785B1/ko not_active Expired - Fee Related
- 2007-01-12 EA EA200801679A patent/EA015538B1/ru not_active IP Right Cessation
- 2007-01-12 JP JP2008550418A patent/JP5552233B2/ja not_active Expired - Fee Related
- 2007-01-12 EP EP20070709712 patent/EP1976594B1/en active Active
-
2008
- 2008-07-01 ZA ZA200805743A patent/ZA200805743B/xx unknown
- 2008-07-03 IL IL192631A patent/IL192631A/en not_active IP Right Cessation
- 2008-07-04 CU CU20080133A patent/CU23871B1/es not_active IP Right Cessation
- 2008-07-04 CR CR10128A patent/CR10128A/es unknown
- 2008-07-11 SV SV2008002980A patent/SV2008002980A/es unknown
- 2008-07-11 EC EC2008008618A patent/ECSP088618A/es unknown
- 2008-07-11 TN TNP2008000297A patent/TNSN08297A1/en unknown
- 2008-07-11 MA MA31110A patent/MA30158B1/fr unknown
- 2008-07-14 HN HN2008001104A patent/HN2008001104A/es unknown
- 2008-08-11 NO NO20083477A patent/NO20083477L/no not_active Application Discontinuation
-
2012
- 2012-12-17 JP JP2012274999A patent/JP2013099334A/ja active Pending
-
2014
- 2014-01-24 US US14/163,230 patent/US20140341901A1/en not_active Abandoned
- 2014-02-12 US US14/178,892 patent/US9296813B2/en active Active
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