JP2009523175A - 目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法 - Google Patents

目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法 Download PDF

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JP2009523175A
JP2009523175A JP2008550493A JP2008550493A JP2009523175A JP 2009523175 A JP2009523175 A JP 2009523175A JP 2008550493 A JP2008550493 A JP 2008550493A JP 2008550493 A JP2008550493 A JP 2008550493A JP 2009523175 A JP2009523175 A JP 2009523175A
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copper
zinc
disease
thiomolybdate
preparation
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JP2009523175A5 (OSRAM
Inventor
エイチ. カンザー,スティーブ
ジェイ. ブルーアー,ジョージ
スタージス,ニコラス
エス. アルトース,ジョン
エス. ビスゲィール,チャールズ
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Pipex Inc
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Pipex Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
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    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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  • Urology & Nephrology (AREA)
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JP2008550493A 2006-01-10 2007-01-10 目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法 Pending JP2009523175A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75767206P 2006-01-10 2006-01-10
US76581206P 2006-02-07 2006-02-07
PCT/US2007/060345 WO2007084818A2 (en) 2006-01-10 2007-01-10 Pharmaceutical compositions and methods to achieve and maintain a targeted and stable copper status and prevent and treat copper-related central nervous system diseases

Publications (2)

Publication Number Publication Date
JP2009523175A true JP2009523175A (ja) 2009-06-18
JP2009523175A5 JP2009523175A5 (OSRAM) 2010-02-25

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JP2008550493A Pending JP2009523175A (ja) 2006-01-10 2007-01-10 目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法

Country Status (6)

Country Link
US (1) US20070207191A1 (OSRAM)
EP (1) EP1993607A4 (OSRAM)
JP (1) JP2009523175A (OSRAM)
AU (1) AU2007205996A1 (OSRAM)
CA (1) CA2675230A1 (OSRAM)
WO (1) WO2007084818A2 (OSRAM)

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JP2008106006A (ja) * 2006-10-26 2008-05-08 Univ Nihon 筋萎縮性側索硬化症治療薬
JP2013509443A (ja) * 2009-11-01 2013-03-14 シンセティック バイオロジックス,インコーポレイテッド 胃保持性の経口用高用量亜鉛調製物
JP2013523709A (ja) * 2010-03-30 2013-06-17 マグナス ティーティーエム アイシー テトラチオモリブデン酸の治療的使用
JP2022525482A (ja) * 2019-03-20 2022-05-16 リンドラ セラピューティクス, インコーポレイティド 胃内滞留剤形用のコーティング
JP2022536205A (ja) * 2019-08-21 2022-08-12 ブレイン ケミストリー ラブズ 金属及びl-セリンを含む組成物、並びにその使用
KR20220130734A (ko) * 2020-03-16 2022-09-27 우한 바스트 컨덕트 사이언스 파운데이션 컴퍼니 리미티드 간경변증의 치료를 위한 구리 클러스터(CuCs) 및 조성물
WO2025173839A1 (ko) * 2024-02-14 2025-08-21 국립부경대학교 산학협력단 알부민 고정 셀룰로오스 및 이를 포함하는 알츠하이머 치료용 조성물
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WO2015100300A2 (en) * 2013-12-23 2015-07-02 Duke University Methods for diagnosing and treating copper-dependent diseases
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US10583102B2 (en) 2014-10-06 2020-03-10 The Johns Hopkins University Targeting liver nuclear receptors as a treatment for wilson disease
KR20160057500A (ko) * 2014-11-05 2016-05-24 아카데미아 시니카 클리오퀴놀을 포함하는 자폐증 스펙트럼 장애의 치료용 약학적 조성물
US20160220500A1 (en) * 2014-11-14 2016-08-04 Kent State University Targeting Intracellular Copper Ions for Inhibiting Angiogenesis Using Nanoparticles of Ternary Inorganic Metal Sulfide M1M2S4 (M1, independently, is Mg, Ca, Mn, Fe, or Zn; M2 = Mo or W) Compounds to Treat Metastatic Cancer
US10226484B2 (en) 2014-12-01 2019-03-12 Peter Y Novak Pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals and method thereof
US12527820B2 (en) 2014-12-01 2026-01-20 Vector Vitale Ip Llc Pharmaceutical composition and method for suppressing degeneration
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JP6865167B2 (ja) * 2014-12-17 2021-04-28 フンダシオン パラ ラ インベスティガシオン メディカ アプリカダ ウィルソン病の処置に使用するための核酸構築物及び遺伝子治療ベクター
ITUA20163931A1 (it) * 2016-05-30 2017-11-30 Biofordrug S R L Miscele di caffé per la neuroprotezione
US10413570B2 (en) * 2016-12-01 2019-09-17 Daniel McCaughan Method of manufacturing a zinc compound lozenge
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US10183041B2 (en) * 2017-04-12 2019-01-22 Vector Vitale Ip Llc Antibacterial composition and its use in treating bacterial infections
KR102803161B1 (ko) * 2017-12-04 2025-05-07 알렉시온 파마 인터내셔널 오퍼레이션즈 리미티드 윌슨병을 치료하기 위한 비스-콜린 테트라티오몰리브데이트
US11419832B2 (en) 2017-12-04 2022-08-23 Alexion Pharmaceuticals, Inc. Bis-choline tetrathiomolybdate for treating Wilson Disease
WO2019191270A1 (en) * 2018-03-27 2019-10-03 The Board Of Trustees Of The University Of Illinois Restoration of transmembrane copper transport
EP3820462A4 (en) * 2018-07-12 2022-04-27 The Texas A&M University System COMPOSITIONS FOR TREATMENT OF COPPER DEFICIENCY AND METHODS OF USE
CN114558029A (zh) * 2019-01-16 2022-05-31 武汉广行科学研究有限公司 铜团簇、胸腺嘧啶修饰的透明质酸和多聚铜团簇、其制备方法和应用
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
CN112138024A (zh) * 2019-06-26 2020-12-29 里弗斯Pah有限责任公司 治疗严重形式的肺动脉高压的方法
US11484610B2 (en) 2019-11-22 2022-11-01 Vector Vitale Ip Llc Method of treating melanoma
US11596650B2 (en) 2019-12-20 2023-03-07 Vector Vitale Ip Llc Composition and method for the treatment of type 2 diabetes
US10933091B1 (en) 2019-12-20 2021-03-02 Vector Vitale Ip Llc Composition and method for the treatment of type I diabetes
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GB2612210B (en) * 2020-06-24 2025-08-27 Reverspah Llc Pharmaceutical composition comprising a tetrathiomolybdate salt and a diethylcarbamazine
CN118524835A (zh) * 2021-11-10 2024-08-20 瑞沃斯帕有限责任公司 用于治疗癌症的方法和组合物
KR20240159714A (ko) * 2023-04-27 2024-11-06 국립해양생물자원관 다중구리 산화효소 활성 도메인의 개량 펩타이드를 포함하는 구리대사 관련 신경계 질환의 예방 또는 치료용 조성물
CN118252952B (zh) * 2024-05-22 2024-08-13 吉林医药学院 一种基于介孔聚多巴胺复合载药纳米粒子及其制备和应用

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