JP7457827B2 - 肝硬変の治療のための銅クラスター及び組成物 - Google Patents
肝硬変の治療のための銅クラスター及び組成物 Download PDFInfo
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- JP7457827B2 JP7457827B2 JP2022555679A JP2022555679A JP7457827B2 JP 7457827 B2 JP7457827 B2 JP 7457827B2 JP 2022555679 A JP2022555679 A JP 2022555679A JP 2022555679 A JP2022555679 A JP 2022555679A JP 7457827 B2 JP7457827 B2 JP 7457827B2
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- Prior art keywords
- cysteine
- liver
- ligand
- arginine
- copper
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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Description
参照文献
Deng H.H. et al. An ammonia-based etchant for attaining copper nanoclusters with green fluorescence emission. Nanoscale, 2018, 10, 6467.
Jia X. et al. Cu Nanoclusters with Aggregation Induced Emission Enhancement. Small, 2013, DOI: 10.1002/smll.201300896.
Wang C. and Huang Y. GREEN ROUTE TO PREPARE BIOCOMPATIBLE AND NEAR INFRARED THIOLATE-PROTECTED COPPER NANOCLUSTERS FOR CELLULAR IMAGING. NANO: Brief Reports and Reviews. 2013, 8(5): 1350054 (10 pages).
Claims (2)
- 肝硬変を治療するための医薬組成物であって、前記医薬組成物は、リガンド結合銅クラスター(CuC)を含み、前記リガンド結合CuCが、
銅コアと、
前記銅コアに結合して前記リガンド結合銅クラスター(CuC)を形成するリガンドと、
を含み、
前記銅コアは、直径が0.5~5nmであり、
前記リガンドは、L-システイン、N-イソブチリル-L-システイン(L-NIBC)、N-アセチル-L-システイン(L-NAC)、D-システイン、N-イソブチリル-D-システイン(D-NIBC)、N-アセチル-D-システイン(D-NAC)、L(D)-システイン-L(D)-アルギニンジペプチド(CR)、L(D)-アルギニン-L(D)-システインジペプチド(RC)、L(D)-ヒスチジン-L(D)-システインジペプチド(HC)、L(D)-システイン-L(D)-ヒスチジンジペプチド(CH)、グリシン-L(D)-システイン-L(D)-アルギニントリペプチド(GCR)、L(D)-プロリン-L(D)-システイン-L(D)-アルギニントリペプチド(PCR)、L(D)-リシン-L(D)-システイン-L(D)-プロリントリペプチド(KCP)、L(D)-グルタチオン(GSH)、グリシン-L(D)-セリン-L(D)-システイン-L(D)-アルギニンテトラペプチド(GSCR)、グリシン-L(D)-システイン-L(D)-セリン-L(D)-アルギニンテトラペプチド(GCSR)、1-[(2S)-2-メチル-3-チオール-1-オキソプロピル]-L(D)-プロリン、チオグリコール酸、メルカプトエタノール、チオフェノール、D-ペニシラミン、N-(2-メルカプトプロピオニル)-グリシン、およびドデシルメルカプタンからなる群より選ばれる、医薬組成物。 - 前記銅コアは、直径が0.5~3nmである、請求項1に記載の医薬組成物。
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PCT/CN2020/130028 WO2021184807A1 (en) | 2020-03-16 | 2020-11-19 | Copper clusters, composition, and method for treatment of liver cirrhosis |
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JP2003055215A (ja) | 2001-06-05 | 2003-02-26 | Ajinomoto Co Inc | 肝線維化抑制剤 |
JP2009523175A (ja) | 2006-01-10 | 2009-06-18 | パイペックス,インコーポレイテッド | 目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法 |
US20130237511A1 (en) | 2012-03-12 | 2013-09-12 | University System of Georgia | Copper Ion Delivery Platform for Pharmaceutical Agents |
CN109939243A (zh) | 2019-01-16 | 2019-06-28 | 深圳广行科学研究有限公司 | 铜团簇、胸腺嘧啶修饰的透明质酸和多聚铜团簇、其制备方法和应用 |
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WO2015057906A1 (en) * | 2013-10-16 | 2015-04-23 | Janssen Biotech, Inc. | Cd200 receptor 1 agonists |
US20180036270A1 (en) * | 2015-02-13 | 2018-02-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | A method of protecting against carbonyl stress induced ischemia-reperfusion injury in the diabetic brain via administration of n-acetylcysteine |
WO2017218004A1 (en) * | 2016-06-17 | 2017-12-21 | Michael Hudnall | Medical food for patients with chronic liver disease |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2003055215A (ja) | 2001-06-05 | 2003-02-26 | Ajinomoto Co Inc | 肝線維化抑制剤 |
JP2009523175A (ja) | 2006-01-10 | 2009-06-18 | パイペックス,インコーポレイテッド | 目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法 |
US20130237511A1 (en) | 2012-03-12 | 2013-09-12 | University System of Georgia | Copper Ion Delivery Platform for Pharmaceutical Agents |
CN109939243A (zh) | 2019-01-16 | 2019-06-28 | 深圳广行科学研究有限公司 | 铜团簇、胸腺嘧啶修饰的透明质酸和多聚铜团簇、其制备方法和应用 |
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Title |
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肝臓,1961年,Vol.2, No.3,pp.48-58 |
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