JP2009523139A5 - - Google Patents

Info

Publication number

JP2009523139A5

JP2009523139A5 JP2008549780A JP2008549780A JP2009523139A5 JP 2009523139 A5 JP2009523139 A5 JP 2009523139A5 JP 2008549780 A JP2008549780 A JP 2008549780A JP 2008549780 A JP2008549780 A JP 2008549780A JP 2009523139 A5 JP2009523139 A5 JP 2009523139A5

Authority

JP

Japan

Prior art keywords

alkoxy

alkyl

aryl

halogen

amino

Prior art date

2006-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003545 alkoxy group Chemical group 0.000 claims 33
• -1 Amino, hydroxyl Chemical group 0.000 claims 28
• 125000000217 alkyl group Chemical group 0.000 claims 21
• 229910052736 halogen Inorganic materials 0.000 claims 17
• 150000002367 halogens Chemical group 0.000 claims 17
• 125000006715 (C1-C5) alkylthio group Chemical group 0.000 claims 14
• 125000005914 C6-C14 aryloxy group Chemical group 0.000 claims 14
• 125000003282 alkyl amino group Chemical group 0.000 claims 14
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 14
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 14
• 125000004093 cyano group Chemical group *C#N 0.000 claims 14
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 14
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 14
• 125000005915 C6-C14 aryl group Chemical group 0.000 claims 10
• 125000003118 aryl group Chemical group 0.000 claims 8
• 125000005842 heteroatom Chemical group 0.000 claims 6
• 229910052760 oxygen Inorganic materials 0.000 claims 6
• 229910052717 sulfur Inorganic materials 0.000 claims 6
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
• 125000001072 heteroaryl group Chemical group 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 2
• 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims 2
• GFICWFZTBXUVIG-UHFFFAOYSA-N 6-n,6-n,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine Chemical compound CC1N=C(N)NC(N(C)C)=N1 GFICWFZTBXUVIG-UHFFFAOYSA-N 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000006823 (C1-C6) acyl group Chemical group 0.000 claims 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
• JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 1
• 229940122199 Insulin secretagogue Drugs 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000003367 polycyclic group Chemical group 0.000 claims 1
• 238000003419 tautomerization reaction Methods 0.000 claims 1