JP2009522334A - ストレス下にある患者の処置 - Google Patents
ストレス下にある患者の処置 Download PDFInfo
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- JP2009522334A JP2009522334A JP2008549011A JP2008549011A JP2009522334A JP 2009522334 A JP2009522334 A JP 2009522334A JP 2008549011 A JP2008549011 A JP 2008549011A JP 2008549011 A JP2008549011 A JP 2008549011A JP 2009522334 A JP2009522334 A JP 2009522334A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- Veterinary Medicine (AREA)
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- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
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| US75783506P | 2006-01-09 | 2006-01-09 | |
| PCT/EP2007/050098 WO2007080149A2 (en) | 2006-01-09 | 2007-01-04 | Treatment of stressed patients |
Publications (2)
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| JP2009522334A true JP2009522334A (ja) | 2009-06-11 |
| JP2009522334A5 JP2009522334A5 (enExample) | 2010-02-25 |
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| JP2008549011A Pending JP2009522334A (ja) | 2006-01-09 | 2007-01-04 | ストレス下にある患者の処置 |
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| EP (2) | EP2340724A3 (enExample) |
| JP (1) | JP2009522334A (enExample) |
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| CA (1) | CA2631220A1 (enExample) |
| RU (1) | RU2437655C2 (enExample) |
| WO (1) | WO2007080149A2 (enExample) |
| ZA (1) | ZA200806808B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090264520A1 (en) * | 2008-04-21 | 2009-10-22 | Asha Lipid Sciences, Inc. | Lipid-containing compositions and methods of use thereof |
| ES2544589T3 (es) | 2008-11-06 | 2015-09-01 | The Nisshin Oillio Group, Ltd. | Alimento líquido concentrado |
| EP2311486A1 (en) * | 2009-10-07 | 2011-04-20 | Nestec S.A. | GLP-2 for use in intestine and muscle recovery |
| MX2013009007A (es) | 2011-02-02 | 2013-08-29 | Nestec Sa | Composiciones nutricionales altas en proteina y metodos para elaborar y utilizar las mismas. |
| BR112014001404A2 (pt) * | 2011-07-22 | 2017-03-01 | Fresenius Kabi Deutschland Gmbh | produto para a nutrição parenteral de pacientes de tratamento intensivo obesos |
| US10568337B1 (en) * | 2014-04-30 | 2020-02-25 | Jayson Calton | Method and composition for providing liquid coconut oil |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| CN111295187A (zh) | 2017-08-14 | 2020-06-16 | 胺细拉健康公司 | 用于治疗肝脏疾病的氨基酸组合物 |
| AR115585A1 (es) | 2018-06-20 | 2021-02-03 | Axcella Health Inc | Composiciones y métodos para el tratamiento de la infiltración de grasa en músculo |
| CN111772177A (zh) * | 2020-06-04 | 2020-10-16 | 中通美雅生命健康(深圳)有限公司 | 一种短肽全营养素组合物及其制备方法 |
| CN113615832B (zh) * | 2021-09-02 | 2024-03-05 | 西安交通大学医学院第一附属医院 | 一种适用于高脂血症型急性胰腺炎患者恢复期的组合物及其制备方法 |
| CN117044952A (zh) * | 2023-08-22 | 2023-11-14 | 江中药业股份有限公司 | 一种促进伤口愈合的蛋白营养组合物 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61224939A (ja) * | 1985-03-28 | 1986-10-06 | Fuji Oil Co Ltd | 冷菓 |
| JPH09194393A (ja) * | 1996-01-22 | 1997-07-29 | Meiji Milk Prod Co Ltd | 免疫寛容を誘導する方法、免疫寛容誘導食品キットおよび免疫寛容誘導剤キット |
| JP2003520754A (ja) * | 1998-02-18 | 2003-07-08 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | カロリーの濃密な栄養組成物 |
| JP2003533436A (ja) * | 2000-02-04 | 2003-11-11 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | ムチンの合成を維持しまたは改良する方法 |
| JP2004500421A (ja) * | 2000-04-18 | 2004-01-08 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 栄養モジュール |
| JP2004513912A (ja) * | 2000-11-17 | 2004-05-13 | フレセニウス・カビ・ドイチュランド・ゲーエムベーハー | 危機的状態にある患者、慢性疾患患者および栄養失調の人々の、非経口栄養補給または部分的腸内／経口栄養補給のための腸内投与サプリメント |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU682894B2 (en) * | 1993-10-28 | 1997-10-23 | Institut National De La Recherche Agronomique | Composition based on amino acids intended for the treatment of sepsis or of an attack bringing about an inflammatory reaction, in animals and man |
| US5849335A (en) * | 1997-06-02 | 1998-12-15 | Nestec S.A. | Composition and method for providing glutamine |
| US6640812B2 (en) * | 2001-02-14 | 2003-11-04 | Ilya Ayzman | Filing tool for pedicure and the like |
| EP1281325A1 (en) * | 2001-07-30 | 2003-02-05 | Societe Des Produits Nestle S.A. | Nutritional composition preventing bacterial overgrowth |
| RU2262240C1 (ru) * | 2004-01-28 | 2005-10-20 | Закрытое акционерное общество "Компания "Нутритек" (ЗАО "Компания "Нутритек") | Продукт энтерального питания "унипит" |
-
2007
- 2007-01-04 BR BRPI0706389-0A patent/BRPI0706389A2/pt not_active Application Discontinuation
- 2007-01-04 JP JP2008549011A patent/JP2009522334A/ja active Pending
- 2007-01-04 US US12/097,847 patent/US20090011077A1/en not_active Abandoned
- 2007-01-04 AU AU2007204347A patent/AU2007204347B2/en not_active Ceased
- 2007-01-04 EP EP11002915A patent/EP2340724A3/en not_active Withdrawn
- 2007-01-04 EP EP07703658A patent/EP1971230A2/en not_active Withdrawn
- 2007-01-04 CN CNA2007800021025A patent/CN101365350A/zh active Pending
- 2007-01-04 WO PCT/EP2007/050098 patent/WO2007080149A2/en not_active Ceased
- 2007-01-04 CA CA002631220A patent/CA2631220A1/en not_active Abandoned
- 2007-01-04 RU RU2008132813/15A patent/RU2437655C2/ru not_active IP Right Cessation
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2008
- 2008-08-08 ZA ZA200806808A patent/ZA200806808B/xx unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61224939A (ja) * | 1985-03-28 | 1986-10-06 | Fuji Oil Co Ltd | 冷菓 |
| JPH09194393A (ja) * | 1996-01-22 | 1997-07-29 | Meiji Milk Prod Co Ltd | 免疫寛容を誘導する方法、免疫寛容誘導食品キットおよび免疫寛容誘導剤キット |
| JP2003520754A (ja) * | 1998-02-18 | 2003-07-08 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | カロリーの濃密な栄養組成物 |
| JP2003533436A (ja) * | 2000-02-04 | 2003-11-11 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | ムチンの合成を維持しまたは改良する方法 |
| JP2004500421A (ja) * | 2000-04-18 | 2004-01-08 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 栄養モジュール |
| JP2004513912A (ja) * | 2000-11-17 | 2004-05-13 | フレセニウス・カビ・ドイチュランド・ゲーエムベーハー | 危機的状態にある患者、慢性疾患患者および栄養失調の人々の、非経口栄養補給または部分的腸内／経口栄養補給のための腸内投与サプリメント |
Non-Patent Citations (3)
| Title |
|---|
| JPN6013030822; 食品工業 Ｖｏｌ．４５， Ｎｏ．１５, 2002, ｐ．５６-６０ * |
| JPN7012000903; Ｂｒｉｔｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｅｒｙ ｖｏｌ．８４, 1997, ｐ．９２０-９３５ * |
| JPN7012000904; Ｉｎｔｅｎｓｉｖｅ Ｃａｒｅ Ｍｅｄ ｖｏｌ．２４, 1998, ｐ．８４８-８５９ * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2437655C2 (ru) | 2011-12-27 |
| EP2340724A3 (en) | 2012-02-29 |
| US20090011077A1 (en) | 2009-01-08 |
| BRPI0706389A2 (pt) | 2011-03-22 |
| CN101365350A (zh) | 2009-02-11 |
| WO2007080149A8 (en) | 2008-05-22 |
| RU2008132813A (ru) | 2010-02-20 |
| AU2007204347B2 (en) | 2012-05-17 |
| CA2631220A1 (en) | 2007-07-19 |
| WO2007080149A9 (en) | 2008-07-17 |
| WO2007080149A2 (en) | 2007-07-19 |
| ZA200806808B (en) | 2009-10-28 |
| EP1971230A2 (en) | 2008-09-24 |
| EP2340724A2 (en) | 2011-07-06 |
| AU2007204347A1 (en) | 2007-07-19 |
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