JP2009522281A5 - - Google Patents
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- JP2009522281A5 JP2009522281A5 JP2008548731A JP2008548731A JP2009522281A5 JP 2009522281 A5 JP2009522281 A5 JP 2009522281A5 JP 2008548731 A JP2008548731 A JP 2008548731A JP 2008548731 A JP2008548731 A JP 2008548731A JP 2009522281 A5 JP2009522281 A5 JP 2009522281A5
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- JP
- Japan
- Prior art keywords
- compound
- group
- formula
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- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims description 5
- 229950006081 taribavirin Drugs 0.000 claims description 5
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 4
- 229960000329 ribavirin Drugs 0.000 claims description 3
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 12
- 230000002401 inhibitory effect Effects 0.000 claims 9
- -1 thioform acetal Chemical class 0.000 claims 9
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 3
- XESARGFCSKSFID-UHFFFAOYSA-N Pyrazofurin Natural products OC1=C(C(=O)N)NN=C1C1C(O)C(O)C(CO)O1 XESARGFCSKSFID-UHFFFAOYSA-N 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 3
- 125000003368 amide group Chemical group 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 150000004982 aromatic amines Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 150000002923 oximes Chemical class 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- XESARGFCSKSFID-FLLFQEBCSA-N pirazofurin Chemical compound OC1=C(C(=O)N)NN=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 XESARGFCSKSFID-FLLFQEBCSA-N 0.000 claims 3
- 150000003141 primary amines Chemical group 0.000 claims 3
- 150000003335 secondary amines Chemical group 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 229910052717 sulfur Chemical group 0.000 claims 3
- 239000011593 sulfur Chemical group 0.000 claims 3
- 150000003512 tertiary amines Chemical group 0.000 claims 3
- 150000003568 thioethers Chemical class 0.000 claims 3
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000003124 biologic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75446105P | 2005-12-28 | 2005-12-28 | |
| US79404806P | 2006-04-22 | 2006-04-22 | |
| US84858306P | 2006-09-29 | 2006-09-29 | |
| US85440406P | 2006-10-25 | 2006-10-25 | |
| PCT/US2006/049450 WO2007123579A2 (en) | 2005-12-28 | 2006-12-28 | Translational dysfunction based therapeutics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015182943A Division JP2016040263A (ja) | 2005-12-28 | 2015-09-16 | 翻訳機能障害に基づく治療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009522281A JP2009522281A (ja) | 2009-06-11 |
| JP2009522281A5 true JP2009522281A5 (enExample) | 2013-04-11 |
Family
ID=38625451
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548731A Pending JP2009522281A (ja) | 2005-12-28 | 2006-12-28 | 翻訳機能障害に基づく治療法 |
| JP2015182943A Pending JP2016040263A (ja) | 2005-12-28 | 2015-09-16 | 翻訳機能障害に基づく治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015182943A Pending JP2016040263A (ja) | 2005-12-28 | 2015-09-16 | 翻訳機能障害に基づく治療法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1971690B1 (enExample) |
| JP (2) | JP2009522281A (enExample) |
| AU (1) | AU2006342447B2 (enExample) |
| CA (1) | CA2633715C (enExample) |
| NZ (1) | NZ569883A (enExample) |
| WO (1) | WO2007123579A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5602349B2 (ja) * | 2007-11-20 | 2014-10-08 | 旭化成ファーマ株式会社 | ミゾリビン及び／又はリバビリンの測定方法 |
| WO2009118712A2 (en) * | 2008-03-27 | 2009-10-01 | Ecole Polytechnique Federale De Lausanne (Epfl) | Novel dihydroxypyrrolidine derivatives as anti-cancer agents |
| US8599383B2 (en) | 2009-05-06 | 2013-12-03 | The Regents Of The University Of California | Optical cytometry |
| EP2739937B1 (en) * | 2011-08-02 | 2023-03-01 | The Regents of The University of California | Rapid, massively parallel single-cell drug response measurements via live cell interferometry |
| CA2752008A1 (en) | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
| WO2014190303A1 (en) | 2013-05-24 | 2014-11-27 | The Regents Of The University Of California | Identifying desirable t lymphocytes by change in mass responses |
| WO2020214830A1 (en) * | 2019-04-16 | 2020-10-22 | The Regents Of The University Of California | Protein translational control |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1010380A (en) * | 1963-08-07 | 1965-11-17 | Shionogi & Co | Antibiotic showdomycin and a process for its production |
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| FI63596C (fi) | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| FI71768C (fi) | 1984-02-17 | 1987-02-09 | Orion Yhtymae Oy | Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning. |
| GB8432118D0 (en) | 1984-12-19 | 1985-01-30 | Malcolm A D B | Sandwich hybridisation technique |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4751177A (en) | 1985-06-13 | 1988-06-14 | Amgen | Methods and kits for performing nucleic acid hybridization assays |
| GB8800276D0 (en) * | 1988-01-07 | 1988-02-10 | Univ Liverpool | Medical treatment |
| WO1990001564A1 (en) | 1988-08-09 | 1990-02-22 | Microprobe Corporation | Methods for multiple target analyses through nucleic acid hybridization |
| US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5177198A (en) | 1989-11-30 | 1993-01-05 | University Of N.C. At Chapel Hill | Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates |
| US5130302A (en) | 1989-12-20 | 1992-07-14 | Boron Bilogicals, Inc. | Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same |
| US5457191A (en) | 1990-01-11 | 1995-10-10 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| US5459255A (en) | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| DE69126530T2 (de) | 1990-07-27 | 1998-02-05 | Isis Pharmaceutical, Inc., Carlsbad, Calif. | Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren |
| US5817491A (en) | 1990-09-21 | 1998-10-06 | The Regents Of The University Of California | VSV G pseusdotyped retroviral vectors |
| IL103059A0 (en) | 1991-09-30 | 1993-02-21 | Boehringer Ingelheim Int | Conjugates for introducing nucleic acid into higher eucaryotic cells |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
| GB9304620D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Compounds |
| JPH09510601A (ja) | 1993-11-12 | 1997-10-28 | ケース・ウエスタン・リザーブ・ユニバーシティ | ヒト遺伝子治療用のエピソーム発現ベクター |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| US5965541A (en) | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| GB9525639D0 (en) | 1995-12-15 | 1996-02-14 | Isis Innovation | Improved retroviral vectors |
| US6129705A (en) | 1997-10-01 | 2000-10-10 | Medtronic Ave, Inc. | Drug delivery and gene therapy delivery system |
| US6230802B1 (en) | 1998-07-24 | 2001-05-15 | Schlumberger Technology Corporation | Method and apparatus for gravel packing a well |
| US6135976A (en) | 1998-09-25 | 2000-10-24 | Ekos Corporation | Method, device and kit for performing gene therapy |
| US6455508B1 (en) * | 2000-02-15 | 2002-09-24 | Kanda S. Ramasamy | Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides |
| US7638496B2 (en) * | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| US6673775B2 (en) * | 2001-04-18 | 2004-01-06 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| JP2005524662A (ja) * | 2002-02-28 | 2005-08-18 | ビオタ インコーポレーティッド | ヌクレオシド５’−一リン酸模倣物およびこれらのプロドラッグ |
| WO2004012769A1 (en) * | 2002-08-02 | 2004-02-12 | The Regents Of The University Of California | Therapeutic inhibitionof protein kinases in cancer cells |
| CA2566874C (en) * | 2003-05-15 | 2014-07-08 | Hemosol Lp | Targeted delivery of anti-viral compounds through hemoglobin bioconjugation |
| JP2007516693A (ja) * | 2003-06-09 | 2007-06-28 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | 癌の治療および診断のための組成物および方法 |
-
2006
- 2006-12-28 EP EP06850026.3A patent/EP1971690B1/en active Active
- 2006-12-28 CA CA2633715A patent/CA2633715C/en active Active
- 2006-12-28 NZ NZ569883A patent/NZ569883A/en not_active IP Right Cessation
- 2006-12-28 JP JP2008548731A patent/JP2009522281A/ja active Pending
- 2006-12-28 AU AU2006342447A patent/AU2006342447B2/en not_active Ceased
- 2006-12-28 WO PCT/US2006/049450 patent/WO2007123579A2/en not_active Ceased
-
2015
- 2015-09-16 JP JP2015182943A patent/JP2016040263A/ja active Pending
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