JP2009521908A5 - - Google Patents

Info

Publication number

JP2009521908A5

JP2009521908A5 JP2008547861A JP2008547861A JP2009521908A5 JP 2009521908 A5 JP2009521908 A5 JP 2009521908A5 JP 2008547861 A JP2008547861 A JP 2008547861A JP 2008547861 A JP2008547861 A JP 2008547861A JP 2009521908 A5 JP2009521908 A5 JP 2009521908A5

Authority

JP

Japan

Prior art keywords

seq

peptide

nucleic acid

cargo molecule

molecules

Prior art date

2006-10-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 25
• 239000000203 mixture Substances 0.000 claims description 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
• 150000007523 nucleic acids Chemical class 0.000 claims 13
• 108020004707 nucleic acids Proteins 0.000 claims 11
• 102000039446 nucleic acids Human genes 0.000 claims 11
• 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 4
• 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 4
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 125000005647 linker group Chemical group 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000011859 microparticle Substances 0.000 claims 2
• 239000002105 nanoparticle Substances 0.000 claims 2
• 238000002255 vaccination Methods 0.000 claims 2
• 108091023037 Aptamer Proteins 0.000 claims 1
• 102000053642 Catalytic RNA Human genes 0.000 claims 1
• 108090000994 Catalytic RNA Proteins 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 102000010445 Lactoferrin Human genes 0.000 claims 1
• 108010063045 Lactoferrin Proteins 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 235000014633 carbohydrates Nutrition 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 210000000170 cell membrane Anatomy 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000002131 composite material Substances 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 239000000032 diagnostic agent Substances 0.000 claims 1
• 229940039227 diagnostic agent Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 1
• 229940078795 lactoferrin Drugs 0.000 claims 1
• 235000021242 lactoferrin Nutrition 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 239000000693 micelle Substances 0.000 claims 1
• 230000000149 penetrating effect Effects 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 108091092562 ribozyme Proteins 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 150000003568 thioethers Chemical class 0.000 claims 1
• 238000001890 transfection Methods 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1
• 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 description 2
• 102000050459 human LTF Human genes 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 1
• 101000798100 Bos taurus Lactotransferrin Proteins 0.000 description 1
• 229940072440 bovine lactoferrin Drugs 0.000 description 1