JP2022552371A5 - - Google Patents
Info
- Publication number
- JP2022552371A5 JP2022552371A5 JP2022522628A JP2022522628A JP2022552371A5 JP 2022552371 A5 JP2022552371 A5 JP 2022552371A5 JP 2022522628 A JP2022522628 A JP 2022522628A JP 2022522628 A JP2022522628 A JP 2022522628A JP 2022552371 A5 JP2022552371 A5 JP 2022552371A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- molecule
- sequence
- lnp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962915304P | 2019-10-15 | 2019-10-15 | |
| US62/915,304 | 2019-10-15 | ||
| US202062959716P | 2020-01-10 | 2020-01-10 | |
| US62/959,716 | 2020-01-10 | ||
| US202063017040P | 2020-04-29 | 2020-04-29 | |
| US63/017,040 | 2020-04-29 | ||
| PCT/US2020/055844 WO2021076805A1 (en) | 2019-10-15 | 2020-10-15 | Mrnas encoding immune modulating polypeptides and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022552371A JP2022552371A (ja) | 2022-12-15 |
| JP2022552371A5 true JP2022552371A5 (enExample) | 2023-10-24 |
Family
ID=73402111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022522628A Pending JP2022552371A (ja) | 2019-10-15 | 2020-10-15 | 免疫調節ポリペプチドをコードするｍＲＮＡ及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240158458A1 (enExample) |
| EP (1) | EP4045527A1 (enExample) |
| JP (1) | JP2022552371A (enExample) |
| AU (1) | AU2020368447A1 (enExample) |
| CA (1) | CA3157859A1 (enExample) |
| WO (1) | WO2021076805A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116322788A (zh) | 2020-05-19 | 2023-06-23 | 奥纳治疗公司 | 环状rna组合物和方法 |
| CN117098541A (zh) | 2020-11-25 | 2023-11-21 | 阿卡格拉医药公司 | 用于递送核酸的脂质纳米粒及相关使用方法 |
| US20240277872A1 (en) * | 2021-05-12 | 2024-08-22 | The Broad Institute, Inc. | Modified mrna, modified non-coding rna, and uses thereof |
| KR20240034221A (ko) * | 2021-07-09 | 2024-03-13 | 브라이트 피크 테라퓨틱스 아게 | 염증성 질환 및 자가면역 질환의 치료를 위한 변형된 il-2 폴리펩티드 |
| WO2023155872A1 (zh) * | 2022-02-18 | 2023-08-24 | 江苏众红生物工程创药研究院有限公司 | 一种实现生物活性分子其活性控释和缓释的方法及药物应用 |
| WO2023215498A2 (en) * | 2022-05-05 | 2023-11-09 | Modernatx, Inc. | Compositions and methods for cd28 antagonism |
| WO2023230587A2 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| WO2024129826A2 (en) * | 2022-12-14 | 2024-06-20 | Grann Pharmaceuticals Inc. | Compositions and methods for modulating hsp70 activity |
| WO2024194605A1 (en) * | 2023-03-17 | 2024-09-26 | Quell Therapeutics Limited | Treg therapy |
| WO2024240962A1 (en) * | 2023-05-25 | 2024-11-28 | Ethris Gmbh | Gm-csf-encoding nucleic acids, pharmaceutical compositions, methods and uses thereof |
| WO2025024674A2 (en) * | 2023-07-26 | 2025-01-30 | Promab Biotechnologies, Inc. | Method for treating local and distant tumors |
| WO2025264765A1 (en) * | 2024-06-18 | 2025-12-26 | Grann Pharmaceuticals Inc. | Compositions and methods for modulating heat shock protein 70 activity for treatment of inflammatory diseases |
| CN120041511B (zh) * | 2025-04-24 | 2025-09-02 | 浙江大学 | IL-4受体激活剂或M-CSF受体激活剂在增强mRNA编辑巨噬细胞效率中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8613481D0 (en) | 1986-06-04 | 1986-07-09 | Diatech Ltd | Translation of mrna |
| US5723332A (en) | 1993-11-26 | 1998-03-03 | British Technology Group Limited | Translational enhancer DNA |
| US5824497A (en) | 1995-02-10 | 1998-10-20 | Mcmaster University | High efficiency translation of mRNA molecules |
| CA2841097A1 (en) * | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin and g-csf fusion proteins |
| WO2009061853A2 (en) * | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Mutant interleukin-2 (il-2) polypeptides |
| CA2953341C (en) | 2014-06-25 | 2023-01-24 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| AU2016251687C1 (en) * | 2015-04-22 | 2023-07-27 | CureVac SE | RNA containing composition for treatment of tumor diseases |
| MA46023A (fr) * | 2015-10-22 | 2019-07-03 | Modernatx Inc | Vaccin contre le virus de la grippe à large spectre |
| EP3364949A4 (en) * | 2015-10-22 | 2019-07-31 | ModernaTX, Inc. | CANCER VACCINES |
| CN108368028B (zh) | 2015-10-28 | 2021-09-03 | 爱康泰生治疗公司 | 用于递送核酸的新型脂质和脂质纳米颗粒制剂 |
| MX2019009070A (es) * | 2017-02-01 | 2019-10-30 | Modernatx Inc | Composiciones de arnm terapeuticas inmunomoduladoras que codifican peptidos de mutacion de oncogenes de activacion. |
| KR20240115352A (ko) | 2017-12-06 | 2024-07-25 | 팬디온 오퍼레이션스, 인코포레이티드 | Il-2 뮤테인 및 그 용도 |
| WO2019144309A1 (en) * | 2018-01-24 | 2019-08-01 | Beijing Percans Oncology Co. Ltd. | Cytokine Fusion Proteins |
| US20190314291A1 (en) * | 2018-01-30 | 2019-10-17 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
-
2020
- 2020-10-15 JP JP2022522628A patent/JP2022552371A/ja active Pending
- 2020-10-15 WO PCT/US2020/055844 patent/WO2021076805A1/en not_active Ceased
- 2020-10-15 CA CA3157859A patent/CA3157859A1/en active Pending
- 2020-10-15 US US17/768,513 patent/US20240158458A1/en not_active Abandoned
- 2020-10-15 EP EP20807153.0A patent/EP4045527A1/en not_active Withdrawn
- 2020-10-15 AU AU2020368447A patent/AU2020368447A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7778392B2 (ja) | 病的石灰化状態を治療するための組成物およびそれを使用する方法 | |
| JP4590033B2 (ja) | デュシェンヌ型筋ジストロフィー治療剤 | |
| US6727355B2 (en) | Pharmaceutical composition for treatment of Duchenne muscular dystrophy | |
| KR102939954B1 (ko) | 다논병 및 다른 자가포식 장애의 치료 방법 | |
| CN110325199A (zh) | 用于治疗苯丙酮尿症的基因疗法 | |
| TW201018471A (en) | Multiple exon skipping compositions for DMD | |
| JP2000325085A (ja) | デュシェンヌ型筋ジストロフィー治療剤 | |
| JP4836366B2 (ja) | デュシェンヌ型筋ジストロフィー治療剤 | |
| EP3991743A1 (en) | Immune inducer and pharmaceutical composition for preventing or treating aging-related diseases | |
| CN118421594A (zh) | 包含突变kras序列和脂质的化合物及其用途 | |
| CN1993137A (zh) | 用于治疗心血管疾病的组合物和方法 | |
| JP2025534332A (ja) | 治療用核酸及びその使用方法 | |
| JP7380670B2 (ja) | Ｉｇｆ－１－暗号化ｄｎａ作製物及びｈｇｆ－暗号化ｄｎａ作製物を用いた神経病症治療 | |
| JP2017503022A (ja) | インビボで細胞に活性型テロメラーゼを提供する組成物および方法 | |
| KR20230150836A (ko) | 파브리병 치료를 위한 조성물 및 방법 | |
| JP2025510963A5 (enExample) | ||
| JP5701747B2 (ja) | アルツハイマー病に対するｄｎａワクチン | |
| KR20230066453A (ko) | 비바이러스성 dna 벡터 및 fviii 치료제 발현을 위한 이의 용도 | |
| JP2022552378A5 (enExample) | ||
| JP2006500933A (ja) | プレｍＲＮＡのスプライシングを修飾するための方法および組成物 | |
| CN112654706B (zh) | 靶向淋巴细胞活化基因3(lag-3)的核酸适体及其用途 | |
| US20250297249A1 (en) | Antisense oligonucleotide complex | |
| EP2896399B1 (en) | Composition comprising cyclophilin a for preventing alopecia or improving hair restoration | |
| WO2024186688A2 (en) | Compositions and methods for delivery of low dose effector agents | |
| CN121064280A (zh) | 一种抗肝癌hla-a*02型疫苗及其制备方法和应用 |