JP2009519986A - 代謝型グルタミン酸受容体のモジュレーターとしてのニコチン酸誘導体 - Google Patents

代謝型グルタミン酸受容体のモジュレーターとしてのニコチン酸誘導体 Download PDF

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JP2009519986A
JP2009519986A JP2008546217A JP2008546217A JP2009519986A JP 2009519986 A JP2009519986 A JP 2009519986A JP 2008546217 A JP2008546217 A JP 2008546217A JP 2008546217 A JP2008546217 A JP 2008546217A JP 2009519986 A JP2009519986 A JP 2009519986A
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pyridin
methanone
chloro
methyl
piperidin
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JP2009519986A5 (enExample
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ラルフ・グラットタール
ダヴィッド・オレン
カルステン・シュパンカ
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ノバルティス アクチエンゲゼルシャフト
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2008546217A 2005-12-20 2006-12-18 代謝型グルタミン酸受容体のモジュレーターとしてのニコチン酸誘導体 Pending JP2009519986A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05027934 2005-12-20
EP06120424 2006-09-11
PCT/EP2006/012181 WO2007071358A1 (en) 2005-12-20 2006-12-18 Nicotinic acid derivatives as modulators of metabotropic glutamate receptors

Publications (2)

Publication Number Publication Date
JP2009519986A true JP2009519986A (ja) 2009-05-21
JP2009519986A5 JP2009519986A5 (enExample) 2010-02-04

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JP2008546217A Pending JP2009519986A (ja) 2005-12-20 2006-12-18 代謝型グルタミン酸受容体のモジュレーターとしてのニコチン酸誘導体

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US (1) US20090005363A1 (enExample)
EP (1) EP1966144A1 (enExample)
JP (1) JP2009519986A (enExample)
KR (1) KR20080076962A (enExample)
AR (1) AR058554A1 (enExample)
AU (1) AU2006329007A1 (enExample)
BR (1) BRPI0620066A2 (enExample)
CA (1) CA2627630A1 (enExample)
PE (1) PE20071171A1 (enExample)
RU (1) RU2008129622A (enExample)
TW (1) TW200732323A (enExample)
WO (1) WO2007071358A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013505297A (ja) * 2009-09-21 2013-02-14 ヴァンダービルト ユニバーシティー ｍＧｌｕＲ５の正のアロステリック調節因子としてのＯ−ベンジルニコチンアミド類似体
JP2013526610A (ja) * 2010-05-24 2013-06-24 ヴァンダービルト ユニバーシティー Ｍｇｌｕｒ５の正のアロステリック調節剤としての置換６−メチルニコチンアミド
JP2015500872A (ja) * 2011-12-22 2015-01-08 コネクシオス ライフ サイエンシズ プライベート リミテッド アザアダマンタン誘導体およびその使用
WO2015098991A1 (ja) * 2013-12-26 2015-07-02 東レ株式会社 Ｎ－アルキルアミド誘導体及びその医薬用途

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EP2272509A1 (en) 2006-09-11 2011-01-12 Novartis AG New Uses of metabotropic glutamate receptors
CA2695331A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
WO2009047303A2 (en) * 2007-10-12 2009-04-16 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder
MX2010003913A (es) * 2007-10-12 2010-04-27 Novartis Ag Moduladores de los receptores de glutamato metabotropicos para el tratamiento de enfermedades de parkinson.
WO2010000763A2 (en) * 2008-06-30 2010-01-07 Novartis Ag Combination products
ES2551557T3 (es) * 2008-12-19 2015-11-19 Boehringer Ingelheim International Gmbh Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC
EP2942346B1 (en) 2009-02-17 2020-05-06 Syntrix Biosystems, Inc. Pyridinecarboxamides as cxcr2 modulators
EP2456438A2 (en) 2009-07-23 2012-05-30 Novartis AG Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives
SG178867A1 (en) 2009-08-24 2012-04-27 Neuralstem Inc Synthesis of a neurostimulative piperazine
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
WO2011048150A1 (en) 2009-10-20 2011-04-28 Novartis Ag Use of 1h-quinazoline-2,4-diones
PL2513093T3 (pl) 2009-12-17 2015-03-31 Centrexion Therapeutics Corp Nowi antagoniści receptora CCR2 i ich zastosowanie
CA2800970A1 (en) 2010-06-24 2011-12-29 Novartis Ag Use of 1h-quinazoline-2,4-diones
AU2011293612B2 (en) 2010-08-23 2015-11-26 Syntrix Biosystems Inc. Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators
AR084515A1 (es) * 2010-12-22 2013-05-22 Merz Pharma Gmbh & Co Kgaa Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
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