JP2009519895A5 - - Google Patents
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- Publication number
- JP2009519895A5 JP2009519895A5 JP2008536730A JP2008536730A JP2009519895A5 JP 2009519895 A5 JP2009519895 A5 JP 2009519895A5 JP 2008536730 A JP2008536730 A JP 2008536730A JP 2008536730 A JP2008536730 A JP 2008536730A JP 2009519895 A5 JP2009519895 A5 JP 2009519895A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- derived diffusible
- antibody
- diffusible ligand
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000002569 neuron Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 102000013498 tau Proteins Human genes 0.000 claims 1
- 108010026424 tau Proteins Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 241001529936 Murinae Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2005381125 | 2005-10-21 | ||
| USPCT/US2005/38125 | 2005-10-21 | ||
| PCT/US2006/040508 WO2007050359A2 (en) | 2005-10-21 | 2006-10-17 | Anti-addl monoclonal antibody and use thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2009519895A JP2009519895A (ja) | 2009-05-21 |
| JP2009519895A6 JP2009519895A6 (ja) | 2009-12-24 |
| JP2009519895A5 true JP2009519895A5 (enExample) | 2012-04-05 |
| JP5289963B2 JP5289963B2 (ja) | 2013-09-11 |
Family
ID=39671607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008536730A Active JP5289963B2 (ja) | 2005-10-21 | 2006-10-17 | 抗addlモノクローナル抗体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1940466B1 (enExample) |
| JP (1) | JP5289963B2 (enExample) |
| CN (1) | CN101291692A (enExample) |
| AU (1) | AU2006306553B9 (enExample) |
| CA (1) | CA2626783A1 (enExample) |
| NO (1) | NO20082288L (enExample) |
| RU (1) | RU2008120027A (enExample) |
| WO (1) | WO2007050359A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002003911A2 (en) | 2000-07-07 | 2002-01-17 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| PT1976877E (pt) | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| CN117903302A (zh) | 2005-11-30 | 2024-04-19 | Abbvie 公司 | 抗-Aβ球聚体抗体,其相关产品,生产所述抗体的方法,所述抗体的应用以及使用方法 |
| RU2429244C2 (ru) | 2006-03-23 | 2011-09-20 | Байоарктик Ньюросайенс Аб | Улучшенные селективные в отношении протофибрилл антитела и их применение |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| US7931899B2 (en) | 2007-05-14 | 2011-04-26 | Medtronic, Inc | Humanized anti-amyloid beta antibodies |
| US8323654B2 (en) | 2007-05-14 | 2012-12-04 | Medtronic, Inc. | Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| PL2170389T3 (pl) * | 2007-06-12 | 2015-03-31 | Ac Immune Sa | Humanizowane przeciwciało przeciw amyloidowi beta |
| ES2445590T3 (es) | 2007-10-05 | 2014-03-04 | Genentech, Inc. | Uso de anticuerpo anti-amiloide beta en enfermedades oculares |
| WO2009070648A2 (en) * | 2007-11-27 | 2009-06-04 | Medtronic, Inc. | Humanized anti-amyloid beta antibodies |
| US9217024B2 (en) | 2007-12-18 | 2015-12-22 | Acumen Pharmaceuticals, Inc. | ADDL receptor polypeptides, polynucleotides and host cells for recombinant production |
| EP2321338A1 (en) * | 2008-08-14 | 2011-05-18 | Merck Sharp & Dohme Corp. | Methods for purifying antibodies using protein a affinity chromatography |
| DK2510359T3 (en) | 2009-12-11 | 2015-12-07 | Araclón Biotech S L | METHODS AND REAGENTS FOR IMPROVED DETECTION OF AMYLOID-BETA PEPTIDES |
| CN104744591B (zh) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | β淀粉样蛋白结合蛋白 |
| US9320793B2 (en) | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| ES2573135T3 (es) | 2010-07-14 | 2016-06-06 | Merck Sharp & Dohme Corp. | Anticuerpo monoclonal anti-ADDL y usos del mismo |
| US9176151B2 (en) | 2010-07-14 | 2015-11-03 | Acumen Pharmaceuticals, Inc. | Antibodies, kit and method for detecting amyloid beta oligomers |
| US9221900B2 (en) | 2010-07-30 | 2015-12-29 | Ac Immune S.A. | Methods for identifying safe and functional humanized antibodies |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| EP2511296A1 (en) | 2011-04-12 | 2012-10-17 | Araclón Biotech, S. L. | Antibody, kit and method for determination of amyloid peptides |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| EP2732289B1 (en) * | 2011-07-13 | 2018-04-11 | Acumen Pharmaceuticals, Inc. | ANTIBODIES, KIT AND in vitro METHOD FOR DETECTING AMYLOID BETA OLIGOMERS |
| JP6231263B2 (ja) * | 2012-07-17 | 2017-11-15 | 株式会社島津製作所 | アフィニティ支持体及びそれを用いた物質の捕捉方法 |
| RS61717B1 (sr) | 2014-07-10 | 2021-05-31 | Bioarctic Ab | Poboljšana antitela koja vezuju a-beta protofibril |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| WO2021055670A1 (en) | 2019-09-20 | 2021-03-25 | Avx Corporation | Somatic cell-based electrical biosensor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994017197A1 (fr) * | 1993-01-25 | 1994-08-04 | Takeda Chemical Industries, Ltd. | ANTICORPS DIRIGE CONTRE LE β-AMYLOIDE OU UN DERIVE DE CE DERNIER ET SON UTILISATION |
| US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
| US20030068316A1 (en) * | 1997-02-05 | 2003-04-10 | Klein William L. | Anti-ADDL antibodies and uses thereof |
| NZ337765A (en) * | 1997-04-09 | 2001-09-28 | Mindset Biopharmaceuticals Usa | Recombinant antibodies having specificity for beta-amyloid N-terminus and C-terminus and use in treating Alzheimer's Disease |
| WO2004031400A2 (en) * | 2002-10-01 | 2004-04-15 | Northwestern University | Amyloid beta-derived diffusible ligands (addls), addl-surrogates, addl-binding molecules, and uses thereof |
| TWI374893B (en) * | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| NZ554725A (en) * | 2004-10-25 | 2009-10-30 | Merck & Co Inc | Anti-ADDL antibodies and uses thereof |
-
2006
- 2006-10-17 JP JP2008536730A patent/JP5289963B2/ja active Active
- 2006-10-17 CA CA002626783A patent/CA2626783A1/en not_active Abandoned
- 2006-10-17 CN CNA2006800392637A patent/CN101291692A/zh active Pending
- 2006-10-17 AU AU2006306553A patent/AU2006306553B9/en not_active Expired - Fee Related
- 2006-10-17 WO PCT/US2006/040508 patent/WO2007050359A2/en not_active Ceased
- 2006-10-17 EP EP06836346A patent/EP1940466B1/en active Active
- 2006-10-17 RU RU2008120027/13A patent/RU2008120027A/ru not_active Application Discontinuation
-
2008
- 2008-05-19 NO NO20082288A patent/NO20082288L/no not_active Application Discontinuation
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