JP2009519705A5 - - Google Patents
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- JP2009519705A5 JP2009519705A5 JP2008540686A JP2008540686A JP2009519705A5 JP 2009519705 A5 JP2009519705 A5 JP 2009519705A5 JP 2008540686 A JP2008540686 A JP 2008540686A JP 2008540686 A JP2008540686 A JP 2008540686A JP 2009519705 A5 JP2009519705 A5 JP 2009519705A5
- Authority
- JP
- Japan
- Prior art keywords
- pore
- nucleotide
- individual nucleotides
- sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 15
- 125000003729 nucleotide group Chemical group 0.000 claims 15
- 239000011148 porous material Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 230000003993 interaction Effects 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 229920002477 rna polymer Polymers 0.000 claims 3
- 108091005703 transmembrane proteins Proteins 0.000 claims 3
- 102000035160 transmembrane proteins Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 108060002716 Exonuclease Proteins 0.000 claims 2
- 102000013165 exonuclease Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 150000004712 monophosphates Chemical class 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0523282.2A GB0523282D0 (en) | 2005-11-15 | 2005-11-15 | Methods using pores |
| GB0523282.2 | 2005-11-15 | ||
| PCT/GB2006/004265 WO2007057668A1 (en) | 2005-11-15 | 2006-11-15 | Methods using pores |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519705A JP2009519705A (ja) | 2009-05-21 |
| JP2009519705A5 true JP2009519705A5 (https=) | 2010-01-07 |
| JP5328362B2 JP5328362B2 (ja) | 2013-10-30 |
Family
ID=35516986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540686A Active JP5328362B2 (ja) | 2005-11-15 | 2006-11-15 | 細孔を使用する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8105846B2 (https=) |
| EP (2) | EP1951898B1 (https=) |
| JP (1) | JP5328362B2 (https=) |
| KR (1) | KR20080083281A (https=) |
| CN (1) | CN101356288B (https=) |
| AT (1) | ATE545712T1 (https=) |
| AU (1) | AU2006314296B2 (https=) |
| BR (1) | BRPI0618391A2 (https=) |
| CA (1) | CA2629009C (https=) |
| GB (1) | GB0523282D0 (https=) |
| IL (1) | IL191319A (https=) |
| MY (1) | MY149161A (https=) |
| NZ (1) | NZ568163A (https=) |
| RU (1) | RU2008123842A (https=) |
| UA (1) | UA95087C2 (https=) |
| WO (1) | WO2007057668A1 (https=) |
Families Citing this family (90)
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| GB2453377A (en) * | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
| JP2011527191A (ja) * | 2008-07-07 | 2011-10-27 | オックスフォード ナノポア テクノロジーズ リミテッド | 塩基検出細孔 |
| WO2010004265A1 (en) * | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| WO2010014235A1 (en) * | 2008-08-01 | 2010-02-04 | Brown University | System and methods for determining molecules using mass spectrometry and related techniques |
| GB0820927D0 (en) * | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| WO2010062903A2 (en) * | 2008-11-26 | 2010-06-03 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
| JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
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| US9017937B1 (en) | 2009-04-10 | 2015-04-28 | Pacific Biosciences Of California, Inc. | Nanopore sequencing using ratiometric impedance |
| AU2010301128B2 (en) | 2009-09-30 | 2014-09-18 | Quantapore, Inc. | Ultrafast sequencing of biological polymers using a labeled nanopore |
| CN102741430B (zh) | 2009-12-01 | 2016-07-13 | 牛津楠路珀尔科技有限公司 | 生化分析仪器、用于进行生化分析的第一模块以及相关方法 |
| WO2011109825A2 (en) * | 2010-03-05 | 2011-09-09 | University Of Utah Research Foundation | Detection of nucleic acid lesions and adducts using nanopores |
| US9005425B2 (en) | 2010-03-05 | 2015-04-14 | University Of Utah Research Foundation | Detection of nucleic acid lesions and adducts using nanopores |
| US8652779B2 (en) | 2010-04-09 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Nanopore sequencing using charge blockade labels |
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| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
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| US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
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| KR102168813B1 (ko) | 2013-03-08 | 2020-10-22 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 효소 정지 방법 |
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| JP2011527191A (ja) * | 2008-07-07 | 2011-10-27 | オックスフォード ナノポア テクノロジーズ リミテッド | 塩基検出細孔 |
| CA3092369C (en) | 2008-09-22 | 2025-09-23 | University Of Washington | MSP NANOPORES AND ASSOCIATED PROCESSES |
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