JP2009519343A

JP2009519343A - エンテロスタチンの非吸湿性組成物

エンテロスタチンの非吸湿性組成物 Download PDF

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Publication number: JP2009519343A
Authority: JP; Japan
Prior art keywords: enterostatin; hygroscopic; pharmaceutical composition; acid; composition
Prior art date: 2005-12-13
Legal status : Pending

Application number

JP2008545763A

Other languages

English (en)

Japanese (ja)

Other versions

JP2009519343A5 (enExample

Inventor

ルビンブイロン

Original Assignee

ハルクネススプハルマセウティカルス，インコーポレイテッド

Priority date

2005-12-13

Filing date

2006-12-12

Publication date

2009-05-14

2006-12-12 Application filed by ハルクネススプハルマセウティカルス，インコーポレイテッド filed Critical ハルクネススプハルマセウティカルス，インコーポレイテッド

2009-05-14 Publication of JP2009519343A publication Critical patent/JP2009519343A/ja

2010-02-18 Publication of JP2009519343A5 publication Critical patent/JP2009519343A5/ja

Status Pending legal-status Critical Current

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ITZMJCSORYKOSI-AJNGGQMLSA-N APGPR Enterostatin Chemical group C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)CCC1 ITZMJCSORYKOSI-AJNGGQMLSA-N 0.000 title claims abstract description 240
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
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WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
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235000019259 sodium dehydroacetate Nutrition 0.000 description 1
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AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000012360 testing method Methods 0.000 description 1
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JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
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UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
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