JP2009519329A5 - - Google Patents
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- Publication number
- JP2009519329A5 JP2009519329A5 JP2008545523A JP2008545523A JP2009519329A5 JP 2009519329 A5 JP2009519329 A5 JP 2009519329A5 JP 2008545523 A JP2008545523 A JP 2008545523A JP 2008545523 A JP2008545523 A JP 2008545523A JP 2009519329 A5 JP2009519329 A5 JP 2009519329A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- organic amine
- carboxylate
- amino compound
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 23
- 150000001412 amines Chemical class 0.000 claims 12
- -1 amino compound Chemical class 0.000 claims 12
- 150000007942 carboxylates Chemical class 0.000 claims 12
- 229910021645 metal ion Inorganic materials 0.000 claims 7
- 230000005298 paramagnetic effect Effects 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000010287 polarization Effects 0.000 claims 4
- OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical compound C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000011877 solvent mixture Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001414 amino alcohols Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052747 lanthanoid Inorganic materials 0.000 claims 1
- 150000002602 lanthanoids Chemical class 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20055983 | 2005-12-16 | ||
| NO20055983 | 2005-12-16 | ||
| PCT/NO2006/000481 WO2007069909A2 (en) | 2005-12-16 | 2006-12-15 | Method to produce hyperpolarised carboxylates of organic amines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519329A JP2009519329A (ja) | 2009-05-14 |
| JP2009519329A5 true JP2009519329A5 (enExample) | 2010-01-14 |
| JP5102221B2 JP5102221B2 (ja) | 2012-12-19 |
Family
ID=38163350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545523A Expired - Fee Related JP5102221B2 (ja) | 2005-12-16 | 2006-12-15 | 過分極カルボン酸塩の製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9272056B2 (enExample) |
| EP (1) | EP1962912B1 (enExample) |
| JP (1) | JP5102221B2 (enExample) |
| CN (1) | CN101378784B (enExample) |
| ES (1) | ES2393750T3 (enExample) |
| PL (1) | PL1962912T3 (enExample) |
| WO (1) | WO2007069909A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100233096A1 (en) * | 2006-03-29 | 2010-09-16 | Lerche Mathilde H | Method to produce hyperpolarised carboxylates and sulphonates |
| US7470813B2 (en) | 2007-03-30 | 2008-12-30 | Ge Healthcare Limited | Method for the production of pyruvic acid |
| CN101970014A (zh) * | 2007-07-26 | 2011-02-09 | 通用电气医疗集团英国有限公司 | 包含超极化的13c-乳酸盐的成像介质及其用途 |
| US20110243855A1 (en) * | 2007-08-27 | 2011-10-06 | Anna Gisselsson | Method and imaging medium for use in the method |
| EP2902041A1 (en) * | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| ATE544474T1 (de) * | 2007-12-21 | 2012-02-15 | Ge Healthcare Ltd | Magnetresonanz-abbildungsmittel, abbildungsmedium und verfahren zur abbildung, worin solch ein abbildungsmedium verwendet wird |
| CN101932340A (zh) * | 2008-02-04 | 2010-12-29 | 通用电气健康护理有限公司 | 生产超极化的氨基酸和氨基磺酸的方法 |
| MX2011010294A (es) | 2009-04-02 | 2012-01-27 | Ge Healthcare Ltd | Uso de un medio de formacion de imagenes de resonancia magnetica que comprende 13c piruvato hiperpolarizado para la deteccion de inflamacion o infeccion. |
| KR101690821B1 (ko) * | 2009-09-10 | 2016-12-28 | 지이 헬쓰케어 리미티드 | 과분극화된 １３ｃ-프럭토즈를 사용하는 １３ｃ-자기 공명 검출 방법 |
| EP2555803B1 (en) | 2010-04-08 | 2018-09-12 | Bracco Imaging S.p.A | Process for preparing hyperpolarized substrates and method for mri |
| US9511154B2 (en) * | 2011-10-12 | 2016-12-06 | Bracco Imaging S.P.A. | Process for the preparation of hyperpolarized derivatives for use in MRI analysis |
| EP2788035B1 (en) | 2011-12-05 | 2016-03-09 | Bracco Imaging S.p.A | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| MY208484A (en) | 2018-11-23 | 2025-05-13 | Bayer Pharma AG | Formulation of contrast media and process of preparation thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0515458B1 (en) | 1990-02-12 | 1995-08-23 | Nycomed Innovation AB | Triarylmethyl radicals and the use of inert carbon free radicals in mri |
| GB9024528D0 (en) * | 1990-11-12 | 1991-01-02 | Instrumentarium Corp | Improvements in and relating to magnetic resonance imaging |
| GB9704669D0 (en) * | 1997-03-06 | 1997-04-23 | Nycomed Imaging As | Free radicals |
| US5728370A (en) | 1993-04-02 | 1998-03-17 | Nycomed Imaging As | Free Radicals |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| US6958244B2 (en) * | 2002-04-12 | 2005-10-25 | Bruker Biospin Corp. | Low-conductivity buffers for magnetic resonance measurements |
| NO20023357D0 (no) * | 2002-04-19 | 2002-07-11 | Amersham Health As | Blanding |
| US7351402B2 (en) | 2003-08-21 | 2008-04-01 | Massachusetts Institute Of Technology | Polarizing agents for dynamic nuclear polarization |
| ES2545260T3 (es) * | 2004-07-30 | 2015-09-09 | Ge Healthcare As | Composición que comprende radical triarilmetilo, útil en diagnóstico por IRM |
| CN101027310B (zh) * | 2004-07-30 | 2012-08-22 | 通用电气医疗集团股份有限公司 | 基团及其在dnp方法中作为顺磁化剂的应用 |
| RU2391047C2 (ru) * | 2004-11-19 | 2010-06-10 | Джи-И Хелткер АС | Способ визуализации сердца с использованием гиперполяризованного 13c-пирувата |
| EP1954321B1 (en) * | 2005-12-01 | 2011-11-23 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
-
2006
- 2006-12-15 US US12/097,569 patent/US9272056B2/en active Active
- 2006-12-15 PL PL06835724T patent/PL1962912T3/pl unknown
- 2006-12-15 EP EP06835724A patent/EP1962912B1/en not_active Not-in-force
- 2006-12-15 WO PCT/NO2006/000481 patent/WO2007069909A2/en not_active Ceased
- 2006-12-15 JP JP2008545523A patent/JP5102221B2/ja not_active Expired - Fee Related
- 2006-12-15 CN CN2006800464616A patent/CN101378784B/zh not_active Expired - Fee Related
- 2006-12-15 ES ES06835724T patent/ES2393750T3/es active Active
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