ES2393750T3 - Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas - Google Patents
Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas Download PDFInfo
- Publication number
- ES2393750T3 ES2393750T3 ES06835724T ES06835724T ES2393750T3 ES 2393750 T3 ES2393750 T3 ES 2393750T3 ES 06835724 T ES06835724 T ES 06835724T ES 06835724 T ES06835724 T ES 06835724T ES 2393750 T3 ES2393750 T3 ES 2393750T3
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- Prior art keywords
- carboxylate
- composition
- polarization
- hyperpolarized
- dnp
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
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| PCT/NO2006/000481 WO2007069909A2 (en) | 2005-12-16 | 2006-12-15 | Method to produce hyperpolarised carboxylates of organic amines |
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| US20100233096A1 (en) * | 2006-03-29 | 2010-09-16 | Lerche Mathilde H | Method to produce hyperpolarised carboxylates and sulphonates |
| US7470813B2 (en) | 2007-03-30 | 2008-12-30 | Ge Healthcare Limited | Method for the production of pyruvic acid |
| CN101970014A (zh) * | 2007-07-26 | 2011-02-09 | 通用电气医疗集团英国有限公司 | 包含超极化的13c-乳酸盐的成像介质及其用途 |
| US20110243855A1 (en) * | 2007-08-27 | 2011-10-06 | Anna Gisselsson | Method and imaging medium for use in the method |
| EP2902041A1 (en) * | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| ATE544474T1 (de) * | 2007-12-21 | 2012-02-15 | Ge Healthcare Ltd | Magnetresonanz-abbildungsmittel, abbildungsmedium und verfahren zur abbildung, worin solch ein abbildungsmedium verwendet wird |
| CN101932340A (zh) * | 2008-02-04 | 2010-12-29 | 通用电气健康护理有限公司 | 生产超极化的氨基酸和氨基磺酸的方法 |
| MX2011010294A (es) | 2009-04-02 | 2012-01-27 | Ge Healthcare Ltd | Uso de un medio de formacion de imagenes de resonancia magnetica que comprende 13c piruvato hiperpolarizado para la deteccion de inflamacion o infeccion. |
| KR101690821B1 (ko) * | 2009-09-10 | 2016-12-28 | 지이 헬쓰케어 리미티드 | 과분극화된 １３ｃ-프럭토즈를 사용하는 １３ｃ-자기 공명 검출 방법 |
| EP2555803B1 (en) | 2010-04-08 | 2018-09-12 | Bracco Imaging S.p.A | Process for preparing hyperpolarized substrates and method for mri |
| US9511154B2 (en) * | 2011-10-12 | 2016-12-06 | Bracco Imaging S.P.A. | Process for the preparation of hyperpolarized derivatives for use in MRI analysis |
| EP2788035B1 (en) | 2011-12-05 | 2016-03-09 | Bracco Imaging S.p.A | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| MY208484A (en) | 2018-11-23 | 2025-05-13 | Bayer Pharma AG | Formulation of contrast media and process of preparation thereof |
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| EP0515458B1 (en) | 1990-02-12 | 1995-08-23 | Nycomed Innovation AB | Triarylmethyl radicals and the use of inert carbon free radicals in mri |
| GB9024528D0 (en) * | 1990-11-12 | 1991-01-02 | Instrumentarium Corp | Improvements in and relating to magnetic resonance imaging |
| GB9704669D0 (en) * | 1997-03-06 | 1997-04-23 | Nycomed Imaging As | Free radicals |
| US5728370A (en) | 1993-04-02 | 1998-03-17 | Nycomed Imaging As | Free Radicals |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| US6958244B2 (en) * | 2002-04-12 | 2005-10-25 | Bruker Biospin Corp. | Low-conductivity buffers for magnetic resonance measurements |
| NO20023357D0 (no) * | 2002-04-19 | 2002-07-11 | Amersham Health As | Blanding |
| US7351402B2 (en) | 2003-08-21 | 2008-04-01 | Massachusetts Institute Of Technology | Polarizing agents for dynamic nuclear polarization |
| ES2545260T3 (es) * | 2004-07-30 | 2015-09-09 | Ge Healthcare As | Composición que comprende radical triarilmetilo, útil en diagnóstico por IRM |
| CN101027310B (zh) * | 2004-07-30 | 2012-08-22 | 通用电气医疗集团股份有限公司 | 基团及其在dnp方法中作为顺磁化剂的应用 |
| RU2391047C2 (ru) * | 2004-11-19 | 2010-06-10 | Джи-И Хелткер АС | Способ визуализации сердца с использованием гиперполяризованного 13c-пирувата |
| EP1954321B1 (en) * | 2005-12-01 | 2011-11-23 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
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| WO2007069909A2 (en) | 2007-06-21 |
| EP1962912B1 (en) | 2012-09-26 |
| WO2007069909A3 (en) | 2007-10-18 |
| JP5102221B2 (ja) | 2012-12-19 |
| CN101378784A (zh) | 2009-03-04 |
| EP1962912A2 (en) | 2008-09-03 |
| CN101378784B (zh) | 2013-06-12 |
| JP2009519329A (ja) | 2009-05-14 |
| US9272056B2 (en) | 2016-03-01 |
| PL1962912T3 (pl) | 2013-03-29 |
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