CN101378784B - 产生有机胺的超极化羧酸盐的方法 - Google Patents

产生有机胺的超极化羧酸盐的方法 Download PDF

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Publication number
CN101378784B
CN101378784B CN2006800464616A CN200680046461A CN101378784B CN 101378784 B CN101378784 B CN 101378784B CN 2006800464616 A CN2006800464616 A CN 2006800464616A CN 200680046461 A CN200680046461 A CN 200680046461A CN 101378784 B CN101378784 B CN 101378784B
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China
Prior art keywords
compositions
carboxylate
amino
compound
organic amine
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Expired - Fee Related
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CN2006800464616A
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English (en)
Chinese (zh)
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CN101378784A (zh
Inventor
M·萨宁
K·A·格拉姆
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GE Healthcare AS
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GE Healthcare AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2006800464616A 2005-12-16 2006-12-15 产生有机胺的超极化羧酸盐的方法 Expired - Fee Related CN101378784B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20055983 2005-12-16
NO20055983 2005-12-16
PCT/NO2006/000481 WO2007069909A2 (en) 2005-12-16 2006-12-15 Method to produce hyperpolarised carboxylates of organic amines

Publications (2)

Publication Number Publication Date
CN101378784A CN101378784A (zh) 2009-03-04
CN101378784B true CN101378784B (zh) 2013-06-12

Family

ID=38163350

Family Applications (1)

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CN2006800464616A Expired - Fee Related CN101378784B (zh) 2005-12-16 2006-12-15 产生有机胺的超极化羧酸盐的方法

Country Status (7)

Country Link
US (1) US9272056B2 (enExample)
EP (1) EP1962912B1 (enExample)
JP (1) JP5102221B2 (enExample)
CN (1) CN101378784B (enExample)
ES (1) ES2393750T3 (enExample)
PL (1) PL1962912T3 (enExample)
WO (1) WO2007069909A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1998813A2 (en) * 2006-03-29 2008-12-10 GE Healthcare AS Method to produce hyperpolarised carboxylates and sulphonates in the presence of inorganic cations
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
ES2375083T3 (es) * 2007-08-27 2012-02-24 Ge Healthcare Limited Medio de formación de imagen que comprende 13c-acetat-hiperpolarizado y uso del mismo.
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
ES2379143T3 (es) * 2007-12-21 2012-04-23 Ge Healthcare Limited Agente de obtención de imágenes por RM, medio de obtención de imágenes y procedimientos para la obtención de imágenes en los que se utiliza dicho medio de obtención de imágenes
US20110008261A1 (en) * 2008-02-04 2011-01-13 Ge Healthcare Limited Method to produce hyperpolarised amino acids and aminosulphonic acids
RU2543704C2 (ru) 2009-04-02 2015-03-10 ДжиИ ХЕЛТКЕР ЛИМИТЕД Применение магнитно-резонансной визуализирующей среды, содержащей гиперполяризованный 13с-пируват, для обнаружения воспаления или инфекции
KR101690821B1 (ko) * 2009-09-10 2016-12-28 지이 헬쓰케어 리미티드 과분극화된 １３ｃ-프럭토즈를 사용하는 １３ｃ-자기 공명 검출 방법
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
EP2766050B1 (en) * 2011-10-12 2018-09-05 Bracco Imaging S.p.A Process for the preparation of hyperpolarized derivatives for use in mri analysis
EP2788035B1 (en) 2011-12-05 2016-03-09 Bracco Imaging S.p.A Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
IL321215A (en) 2018-11-23 2025-07-01 Bayer Ag Formulation of contrast media and process of preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2252245A (en) * 1990-11-12 1992-08-05 Instrumentarium Corp Diagnostic composition and apparatus for use in magnetic resonance imaging
CN1285044A (zh) * 1998-01-05 2001-02-21 耐克麦德英梅金公司 磁共振研究方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI923589L (fi) * 1990-02-12 1992-08-11 Hafslund Nycomed Innovation Triarylmetylradikaler och anvaendning av inerta fria kolradikaler i mri.
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
US7351402B2 (en) 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
MX2007001035A (es) 2004-07-30 2007-07-11 Ge Healthcare As Metodo para producir una composicion, la composicion y su uso.
PL1805186T3 (pl) * 2004-07-30 2015-10-30 Ge Healthcare As Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej
JP5456256B2 (ja) * 2004-11-19 2014-03-26 ジーイー・ヘルスケア・アクスイェ・セルスカプ 心臓イメージング法
CA2628539C (en) * 2005-12-01 2014-04-29 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2252245A (en) * 1990-11-12 1992-08-05 Instrumentarium Corp Diagnostic composition and apparatus for use in magnetic resonance imaging
CN1285044A (zh) * 1998-01-05 2001-02-21 耐克麦德英梅金公司 磁共振研究方法

Also Published As

Publication number Publication date
US20080292551A1 (en) 2008-11-27
JP2009519329A (ja) 2009-05-14
CN101378784A (zh) 2009-03-04
EP1962912B1 (en) 2012-09-26
PL1962912T3 (pl) 2013-03-29
ES2393750T3 (es) 2012-12-27
EP1962912A2 (en) 2008-09-03
JP5102221B2 (ja) 2012-12-19
US9272056B2 (en) 2016-03-01
WO2007069909A2 (en) 2007-06-21
WO2007069909A3 (en) 2007-10-18

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Granted publication date: 20130612

Termination date: 20201215