PL1962912T3 - Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych - Google Patents

Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych

Info

Publication number
PL1962912T3
PL1962912T3 PL06835724T PL06835724T PL1962912T3 PL 1962912 T3 PL1962912 T3 PL 1962912T3 PL 06835724 T PL06835724 T PL 06835724T PL 06835724 T PL06835724 T PL 06835724T PL 1962912 T3 PL1962912 T3 PL 1962912T3
Authority
PL
Poland
Prior art keywords
organic amines
carboxylates
produce
produce hyperpolarised
hyperpolarised carboxylates
Prior art date
Application number
PL06835724T
Other languages
English (en)
Polish (pl)
Inventor
Mikkel Thaning
Karl Andreas Gram
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PL1962912T3 publication Critical patent/PL1962912T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
PL06835724T 2005-12-16 2006-12-15 Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych PL1962912T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20055983 2005-12-16
PCT/NO2006/000481 WO2007069909A2 (en) 2005-12-16 2006-12-15 Method to produce hyperpolarised carboxylates of organic amines
EP06835724A EP1962912B1 (en) 2005-12-16 2006-12-15 Method to produce hyperpolarised carboxylates of organic amines

Publications (1)

Publication Number Publication Date
PL1962912T3 true PL1962912T3 (pl) 2013-03-29

Family

ID=38163350

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06835724T PL1962912T3 (pl) 2005-12-16 2006-12-15 Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych

Country Status (7)

Country Link
US (1) US9272056B2 (enExample)
EP (1) EP1962912B1 (enExample)
JP (1) JP5102221B2 (enExample)
CN (1) CN101378784B (enExample)
ES (1) ES2393750T3 (enExample)
PL (1) PL1962912T3 (enExample)
WO (1) WO2007069909A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233096A1 (en) * 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
US20110243855A1 (en) * 2007-08-27 2011-10-06 Anna Gisselsson Method and imaging medium for use in the method
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
ATE544474T1 (de) * 2007-12-21 2012-02-15 Ge Healthcare Ltd Magnetresonanz-abbildungsmittel, abbildungsmedium und verfahren zur abbildung, worin solch ein abbildungsmedium verwendet wird
CN101932340A (zh) * 2008-02-04 2010-12-29 通用电气健康护理有限公司 生产超极化的氨基酸和氨基磺酸的方法
MX2011010294A (es) 2009-04-02 2012-01-27 Ge Healthcare Ltd Uso de un medio de formacion de imagenes de resonancia magnetica que comprende 13c piruvato hiperpolarizado para la deteccion de inflamacion o infeccion.
KR101690821B1 (ko) * 2009-09-10 2016-12-28 지이 헬쓰케어 리미티드 과분극화된 １３ｃ-프럭토즈를 사용하는 １３ｃ-자기 공명 검출 방법
EP2555803B1 (en) 2010-04-08 2018-09-12 Bracco Imaging S.p.A Process for preparing hyperpolarized substrates and method for mri
US9511154B2 (en) * 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
EP2788035B1 (en) 2011-12-05 2016-03-09 Bracco Imaging S.p.A Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
MY208484A (en) 2018-11-23 2025-05-13 Bayer Pharma AG Formulation of contrast media and process of preparation thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0515458B1 (en) 1990-02-12 1995-08-23 Nycomed Innovation AB Triarylmethyl radicals and the use of inert carbon free radicals in mri
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
US7351402B2 (en) 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
ES2545260T3 (es) * 2004-07-30 2015-09-09 Ge Healthcare As Composición que comprende radical triarilmetilo, útil en diagnóstico por IRM
CN101027310B (zh) * 2004-07-30 2012-08-22 通用电气医疗集团股份有限公司 基团及其在dnp方法中作为顺磁化剂的应用
RU2391047C2 (ru) * 2004-11-19 2010-06-10 Джи-И Хелткер АС Способ визуализации сердца с использованием гиперполяризованного 13c-пирувата
EP1954321B1 (en) * 2005-12-01 2011-11-23 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Also Published As

Publication number Publication date
US20080292551A1 (en) 2008-11-27
WO2007069909A2 (en) 2007-06-21
EP1962912B1 (en) 2012-09-26
WO2007069909A3 (en) 2007-10-18
ES2393750T3 (es) 2012-12-27
JP5102221B2 (ja) 2012-12-19
CN101378784A (zh) 2009-03-04
EP1962912A2 (en) 2008-09-03
CN101378784B (zh) 2013-06-12
JP2009519329A (ja) 2009-05-14
US9272056B2 (en) 2016-03-01

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