JP2009518293A5 - - Google Patents
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- Publication number
- JP2009518293A5 JP2009518293A5 JP2008543435A JP2008543435A JP2009518293A5 JP 2009518293 A5 JP2009518293 A5 JP 2009518293A5 JP 2008543435 A JP2008543435 A JP 2008543435A JP 2008543435 A JP2008543435 A JP 2008543435A JP 2009518293 A5 JP2009518293 A5 JP 2009518293A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pirfenidone
- administration
- medicament
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 47
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 28
- 229960003073 pirfenidone Drugs 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 21
- 230000037406 food intake Effects 0.000 claims 13
- 239000002552 dosage form Substances 0.000 claims 11
- 235000012631 food intake Nutrition 0.000 claims 11
- 235000013305 food Nutrition 0.000 claims 7
- 239000002775 capsule Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 2
- 208000032140 Sleepiness Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 208000002173 dizziness Diseases 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74197605P | 2005-12-02 | 2005-12-02 | |
| US60/741,976 | 2005-12-02 | ||
| PCT/US2006/045750 WO2007064738A1 (en) | 2005-12-02 | 2006-11-29 | Methods of reducing adverse events associated with pirfenidone therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012187515A Division JP2012229275A (ja) | 2005-12-02 | 2012-08-28 | ピルフェニドン療法に付随する有害事象を低減する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009518293A JP2009518293A (ja) | 2009-05-07 |
| JP2009518293A5 true JP2009518293A5 (enExample) | 2009-12-17 |
| JP5175740B2 JP5175740B2 (ja) | 2013-04-03 |
Family
ID=37807840
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543435A Active JP5175740B2 (ja) | 2005-12-02 | 2006-11-29 | ピルフェニドン療法に付随する有害事象を低減する方法 |
| JP2012187515A Withdrawn JP2012229275A (ja) | 2005-12-02 | 2012-08-28 | ピルフェニドン療法に付随する有害事象を低減する方法 |
| JP2015002231A Pending JP2015061888A (ja) | 2005-12-02 | 2015-01-08 | ピルフェニドン療法に付随する有害事象を低減する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012187515A Withdrawn JP2012229275A (ja) | 2005-12-02 | 2012-08-28 | ピルフェニドン療法に付随する有害事象を低減する方法 |
| JP2015002231A Pending JP2015061888A (ja) | 2005-12-02 | 2015-01-08 | ピルフェニドン療法に付随する有害事象を低減する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070203202A1 (enExample) |
| EP (2) | EP2316453B1 (enExample) |
| JP (3) | JP5175740B2 (enExample) |
| AT (1) | ATE497766T1 (enExample) |
| CA (1) | CA2631646C (enExample) |
| CY (1) | CY1111355T1 (enExample) |
| DE (1) | DE602006020070D1 (enExample) |
| DK (1) | DK1965797T3 (enExample) |
| ES (2) | ES2385935T3 (enExample) |
| PL (1) | PL1965797T3 (enExample) |
| PT (1) | PT1965797E (enExample) |
| SI (1) | SI1965797T1 (enExample) |
| WO (1) | WO2007064738A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070203202A1 (en) | 2005-12-02 | 2007-08-30 | Robinson Cynthia Y | Methods of reducing adverse events associated with pirfenidone therapy |
| EP2124945B1 (en) * | 2006-12-18 | 2011-04-20 | Intermune, Inc. | Method of providing pirfenidone therapy to a patient |
| US20080287508A1 (en) * | 2007-05-18 | 2008-11-20 | Intermune, Inc. | Altering pharmacokinetics of pirfenidone therapy |
| KR101767849B1 (ko) | 2007-06-20 | 2017-08-11 | 오스펙스 파마슈티칼스, 인코포레이티드 | 섬유증 저해제로서의 치환된 ｎ-아릴 피리디논 |
| US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
| US7566729B1 (en) | 2008-11-10 | 2009-07-28 | Intermune, Inc. | Modifying pirfenidone treatment for patients with atypical liver function |
| SG172981A1 (en) * | 2009-01-26 | 2011-08-29 | Intermune Inc | Methods for treating acute myocardial infarctions and associated disorders |
| US8084475B2 (en) | 2009-12-04 | 2011-12-27 | Intermune, Inc. | Pirfenidone therapy and inducers of cytochrome P450 |
| US7816383B1 (en) | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| DK2670242T3 (da) | 2011-01-31 | 2022-05-02 | Avalyn Pharma Inc | Aerosolpirfenidon- og pyridonanalogforbindelser og anvendelser deraf |
| JP2014507474A (ja) * | 2011-03-08 | 2014-03-27 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | 置換ｎ−アリールピリジノン |
| MX2011007675A (es) * | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| KR102045723B1 (ko) * | 2011-09-14 | 2019-11-18 | 시오노기 앤드 컴파니, 리미티드 | 흡입용 의약 조성물 |
| CA2819967C (en) | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Use of pirfenidone concomitantly with ciprofloxacin |
| WO2014151517A1 (en) | 2013-03-15 | 2014-09-25 | Intermune, Inc. | Methods of improving microvascular integrity |
| NZ722927A (en) | 2014-01-10 | 2022-07-29 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| TWI745396B (zh) | 2016-07-12 | 2021-11-11 | 日商鹽野義製藥股份有限公司 | 吸入用醫藥組成物 |
| WO2021107060A1 (ja) * | 2019-11-27 | 2021-06-03 | 塩野義製薬株式会社 | ピルフェニドンの副作用を軽減するための医薬 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3839346A (en) * | 1972-12-18 | 1974-10-01 | Affiliated Med Res | N-substituted pyridone and general method for preparing pyridones |
| US5310562A (en) * | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| KR100777169B1 (ko) * | 2001-01-29 | 2007-11-16 | 시오노기세이야쿠가부시키가이샤 | 5-메틸-1-페닐-2-(1ｈ)-피리돈을 활성 성분으로서함유하는 의약 제제 |
| US20070032457A1 (en) * | 2003-05-16 | 2007-02-08 | Blatt Lawrence M | Combination therapy for cancer treatment |
| US20070203202A1 (en) | 2005-12-02 | 2007-08-30 | Robinson Cynthia Y | Methods of reducing adverse events associated with pirfenidone therapy |
-
2006
- 2006-11-28 US US11/605,199 patent/US20070203202A1/en not_active Abandoned
- 2006-11-29 EP EP10075728.5A patent/EP2316453B1/en not_active Revoked
- 2006-11-29 PT PT06838621T patent/PT1965797E/pt unknown
- 2006-11-29 DK DK06838621.8T patent/DK1965797T3/da active
- 2006-11-29 WO PCT/US2006/045750 patent/WO2007064738A1/en not_active Ceased
- 2006-11-29 ES ES06838621T patent/ES2385935T3/es active Active
- 2006-11-29 CA CA2631646A patent/CA2631646C/en active Active
- 2006-11-29 SI SI200630927T patent/SI1965797T1/sl unknown
- 2006-11-29 DE DE602006020070T patent/DE602006020070D1/de active Active
- 2006-11-29 JP JP2008543435A patent/JP5175740B2/ja active Active
- 2006-11-29 EP EP06838621A patent/EP1965797B1/en active Active
- 2006-11-29 PL PL06838621T patent/PL1965797T3/pl unknown
- 2006-11-29 ES ES10075728.5T patent/ES2565190T3/es active Active
- 2006-11-29 AT AT06838621T patent/ATE497766T1/de active
-
2011
- 2011-03-21 CY CY20111100306T patent/CY1111355T1/el unknown
-
2012
- 2012-08-28 JP JP2012187515A patent/JP2012229275A/ja not_active Withdrawn
-
2015
- 2015-01-08 JP JP2015002231A patent/JP2015061888A/ja active Pending
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