JP2005513107A5 - - Google Patents

Info

Publication number

JP2005513107A5

JP2005513107A5 JP2003554211A JP2003554211A JP2005513107A5 JP 2005513107 A5 JP2005513107 A5 JP 2005513107A5 JP 2003554211 A JP2003554211 A JP 2003554211A JP 2003554211 A JP2003554211 A JP 2003554211A JP 2005513107 A5 JP2005513107 A5 JP 2005513107A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

use according

chromium

increase

daily dose

Prior art date

2002-12-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• ZMJBYMUCKBYSCP-UHFFFAOYSA-N (+)-Erythro-hydroxycitric acid Natural products OC(=O)C(O)C(O)(C(O)=O)CC(O)=O ZMJBYMUCKBYSCP-UHFFFAOYSA-N 0.000 claims 7
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 7
• 229910052804 chromium Inorganic materials 0.000 claims 7
• 239000011651 chromium Substances 0.000 claims 7
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 6
• ZMJBYMUCKBYSCP-AWFVSMACSA-N (1s,2r)-1,2-dihydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)[C@@H](O)[C@@](O)(C(O)=O)CC(O)=O ZMJBYMUCKBYSCP-AWFVSMACSA-N 0.000 claims 5
• IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 4
• 241000196324 Embryophyta Species 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 229930183009 gymnemic acid Natural products 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 4
• 241000124008 Mammalia Species 0.000 claims 3
• 241000593508 Garcinia Species 0.000 claims 2
• 235000000885 Garcinia xanthochymus Nutrition 0.000 claims 2
• 102000016267 Leptin Human genes 0.000 claims 2
• 108010092277 Leptin Proteins 0.000 claims 2
• WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 claims 2
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
• 230000037396 body weight Effects 0.000 claims 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
• 229940089491 hydroxycitric acid Drugs 0.000 claims 2
• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 2
• 229940039781 leptin Drugs 0.000 claims 2
• 229940118019 malondialdehyde Drugs 0.000 claims 2
• 239000002207 metabolite Substances 0.000 claims 2
• WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 229960003512 nicotinic acid Drugs 0.000 claims 2
• 235000001968 nicotinic acid Nutrition 0.000 claims 2
• 239000011664 nicotinic acid Substances 0.000 claims 2
• 229940076279 serotonin Drugs 0.000 claims 2
• 230000002485 urinary effect Effects 0.000 claims 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
• 241000208251 Gymnema Species 0.000 claims 1
• 241000208253 Gymnema sylvestre Species 0.000 claims 1
• 108010028554 LDL Cholesterol Proteins 0.000 claims 1
• 238000008214 LDL Cholesterol Methods 0.000 claims 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
• 230000036528 appetite Effects 0.000 claims 1
• 235000019789 appetite Nutrition 0.000 claims 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
• 235000013361 beverage Nutrition 0.000 claims 1
• 239000011575 calcium Substances 0.000 claims 1
• 229910052791 calcium Inorganic materials 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 235000013305 food Nutrition 0.000 claims 1
• 230000037406 food intake Effects 0.000 claims 1
• 235000012631 food intake Nutrition 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 235000012054 meals Nutrition 0.000 claims 1
• 239000006186 oral dosage form Substances 0.000 claims 1
• 230000003647 oxidation Effects 0.000 claims 1
• 238000007254 oxidation reaction Methods 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 239000006187 pill Substances 0.000 claims 1
• 239000011591 potassium Chemical group 0.000 claims 1
• 229910052700 potassium Chemical group 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 239000003826 tablet Substances 0.000 claims 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
• 230000004580 weight loss Effects 0.000 claims 1