JP2009518132A5 - - Google Patents
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- JP2009518132A5 JP2009518132A5 JP2008544482A JP2008544482A JP2009518132A5 JP 2009518132 A5 JP2009518132 A5 JP 2009518132A5 JP 2008544482 A JP2008544482 A JP 2008544482A JP 2008544482 A JP2008544482 A JP 2008544482A JP 2009518132 A5 JP2009518132 A5 JP 2009518132A5
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- acid
- polysaccharide
- polyester
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011159 matrix material Substances 0.000 claims 26
- 239000003795 chemical substances by application Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 229920000954 Polyglycolide Polymers 0.000 claims 15
- 229920000747 poly(lactic acid) Polymers 0.000 claims 15
- 229920000728 polyester Polymers 0.000 claims 15
- 239000004633 polyglycolic acid Substances 0.000 claims 15
- 239000004626 polylactic acid Substances 0.000 claims 15
- 229920001282 polysaccharide Polymers 0.000 claims 15
- 239000005017 polysaccharide Substances 0.000 claims 15
- 150000004804 polysaccharides Chemical class 0.000 claims 15
- 239000012528 membrane Substances 0.000 claims 11
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 6
- 229920002971 Heparan sulfate Polymers 0.000 claims 6
- 239000000853 adhesive Substances 0.000 claims 6
- 230000001070 adhesive effect Effects 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 6
- 229920002674 hyaluronan Polymers 0.000 claims 6
- 229960003160 hyaluronic acid Drugs 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 230000007547 defect Effects 0.000 claims 5
- 239000003102 growth factor Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- 102100027400 A disintegrin and metalloproteinase with thrombospondin motifs 4 Human genes 0.000 claims 3
- 101710100373 A disintegrin and metalloproteinase with thrombospondin motifs 4 Proteins 0.000 claims 3
- 108010059616 Activins Proteins 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 3
- 229920000045 Dermatan sulfate Polymers 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 3
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 3
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 3
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 3
- 108090000031 Hedgehog Proteins Proteins 0.000 claims 3
- 102000003693 Hedgehog Proteins Human genes 0.000 claims 3
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 3
- 102000015696 Interleukins Human genes 0.000 claims 3
- 108010063738 Interleukins Proteins 0.000 claims 3
- 229920000288 Keratan sulfate Polymers 0.000 claims 3
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 3
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 3
- 102000013275 Somatomedins Human genes 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 239000000488 activin Substances 0.000 claims 3
- 229960001126 alginic acid Drugs 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 239000000783 alginic acid Substances 0.000 claims 3
- 150000004781 alginic acids Chemical class 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 3
- 229940051593 dermatan sulfate Drugs 0.000 claims 3
- 229960002086 dextran Drugs 0.000 claims 3
- -1 dextran sulfate Polymers 0.000 claims 3
- 229960000633 dextran sulfate Drugs 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 229940126864 fibroblast growth factor Drugs 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 210000003035 hyaline cartilage Anatomy 0.000 claims 3
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 102000005755 Intercellular Signaling Peptides and Proteins Human genes 0.000 claims 2
- 108010070716 Intercellular Signaling Peptides and Proteins Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002188 osteogenic effect Effects 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74802705P | 2005-12-07 | 2005-12-07 | |
| PCT/US2006/046576 WO2007067637A2 (en) | 2005-12-07 | 2006-12-07 | Cartilage repair methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518132A JP2009518132A (ja) | 2009-05-07 |
| JP2009518132A5 true JP2009518132A5 (https=) | 2010-01-28 |
Family
ID=38123465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544482A Pending JP2009518132A (ja) | 2005-12-07 | 2006-12-07 | 軟骨修復方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8444968B2 (https=) |
| EP (1) | EP1973554B1 (https=) |
| JP (1) | JP2009518132A (https=) |
| CA (1) | CA2631520A1 (https=) |
| ES (1) | ES2528272T3 (https=) |
| WO (1) | WO2007067637A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0896825B1 (en) * | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7824711B2 (en) | 2003-12-11 | 2010-11-02 | Isto Technologies, Inc. | Particulate cartilage system |
| US8192759B2 (en) * | 2004-07-12 | 2012-06-05 | Isto Technologies, Inc. | Matrix made of polyester polymers entangled with hyaluronic polymers useful for supporting tissue repair |
| US8512730B2 (en) | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| JP5292533B2 (ja) | 2005-08-26 | 2013-09-18 | ジンマー・インコーポレイテッド | インプラントおよび関節疾患の治療、置換および治療方法 |
| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| EP1764117A1 (en) * | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
| ES2528272T3 (es) | 2005-12-07 | 2015-02-06 | Isto Technologies Inc. | Métodos de reparación de cartílago |
| US20080138414A1 (en) * | 2006-12-08 | 2008-06-12 | Smith & Nephew, Inc. | Methods of Regenerating Cartilage |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| AU2008240191B2 (en) | 2007-04-12 | 2013-09-19 | Zimmer, Inc. | Compositions and methods for tissue repair |
| US8464125B2 (en) * | 2009-12-10 | 2013-06-11 | Intel Corporation | Instruction-set architecture for programmable cyclic redundancy check (CRC) computations |
| US9119605B2 (en) | 2010-05-06 | 2015-09-01 | Zimmer, Inc. | Synthetic polymer adhesives and methods for making, using and delivering the same |
| AU2012275335B2 (en) | 2011-06-29 | 2017-04-20 | Biorestorative Therapies, Inc. | Brown fat cell compositions and methods |
| AU2012323963B2 (en) * | 2011-10-13 | 2017-10-12 | Solventum Intellectual Properties Company | Stimulation of cartilage repair using reduced pressure treatment |
| US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| AU2014253920B2 (en) | 2013-04-19 | 2019-07-04 | Biorestorative Therapies, Inc. | Human brown adipose derived stem cells and uses |
| AU2015245194B2 (en) * | 2014-04-08 | 2018-07-26 | Antonio Sambusseti | Resorbable device for the reconstruction of cartilage |
| EP3197496B1 (en) | 2014-09-23 | 2021-05-26 | Cytex Therapeutics, Inc. | Articular cartilage repair |
| US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| US10524774B2 (en) | 2015-04-02 | 2020-01-07 | Arthrex, Inc. | Method of repairing cartilage defects |
| US10524775B2 (en) | 2015-07-02 | 2020-01-07 | Arthrex, Inc. | Methods of repairing cartilage defects |
| KR102355223B1 (ko) | 2016-05-16 | 2022-01-25 | 아스렉스, 인코퍼레이티드 | 무릎 관절낭 파열 및 복구 |
| US10022231B2 (en) | 2016-07-22 | 2018-07-17 | Cytex Therapeutics, Inc. | Articular cartilage repair |
| JP7480454B2 (ja) * | 2018-06-05 | 2024-05-10 | メディポスト・カンパニー・リミテッド | 有効成分として間葉系幹細胞を含む炎症性疾患の予防又は治療のための医薬組成物 |
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| US8192759B2 (en) * | 2004-07-12 | 2012-06-05 | Isto Technologies, Inc. | Matrix made of polyester polymers entangled with hyaluronic polymers useful for supporting tissue repair |
| ATE524121T1 (de) | 2004-11-24 | 2011-09-15 | Abdou Samy | Vorrichtungen zur platzierung eines orthopädischen intervertebralen implantats |
| ES2528272T3 (es) | 2005-12-07 | 2015-02-06 | Isto Technologies Inc. | Métodos de reparación de cartílago |
-
2006
- 2006-12-07 ES ES06839104.4T patent/ES2528272T3/es active Active
- 2006-12-07 CA CA002631520A patent/CA2631520A1/en not_active Abandoned
- 2006-12-07 JP JP2008544482A patent/JP2009518132A/ja active Pending
- 2006-12-07 WO PCT/US2006/046576 patent/WO2007067637A2/en not_active Ceased
- 2006-12-07 EP EP06839104.4A patent/EP1973554B1/en active Active
- 2006-12-07 US US11/635,265 patent/US8444968B2/en active Active
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