ATE249491T1 - Offenporige bioabbaubare matrize - Google Patents

Offenporige bioabbaubare matrize

Info

Publication number
ATE249491T1
ATE249491T1 AT98913264T AT98913264T ATE249491T1 AT E249491 T1 ATE249491 T1 AT E249491T1 AT 98913264 T AT98913264 T AT 98913264T AT 98913264 T AT98913264 T AT 98913264T AT E249491 T1 ATE249491 T1 AT E249491T1
Authority
AT
Austria
Prior art keywords
mattrice
biodegradable
pores
open
porous polymer
Prior art date
Application number
AT98913264T
Other languages
English (en)
Inventor
Leatrese Harris
David J Mooney
Lonnie Shea
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Application granted granted Critical
Publication of ATE249491T1 publication Critical patent/ATE249491T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C44/00—Shaping by internal pressure generated in the material, e.g. swelling or foaming ; Producing porous or cellular expanded plastics articles
    • B29C44/34—Auxiliary operations
    • B29C44/3442—Mixing, kneading or conveying the foamable material
    • B29C44/3446—Feeding the blowing agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
    • B29C67/20—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00 for porous or cellular articles, e.g. of foam plastics, coarse-pored
    • B29C67/202—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00 for porous or cellular articles, e.g. of foam plastics, coarse-pored comprising elimination of a solid or a liquid ingredient
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/122—Hydrogen, oxygen, CO2, nitrogen or noble gases
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/16—Making expandable particles
    • C08J9/18—Making expandable particles by impregnating polymer particles with the blowing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/02—Foams characterised by the foaming process characterised by mechanical pre- or post-treatments
    • C08J2201/032—Impregnation of a formed object with a gas
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/044—Elimination of an inorganic solid phase
    • C08J2201/0444—Salts
    • C08J2201/0446—Elimination of NaCl only
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2203/00—Foams characterized by the expanding agent
    • C08J2203/06—CO2, N2 or noble gases
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2205/00—Foams characterised by their properties
    • C08J2205/04—Foams characterised by their properties characterised by the foam pores
    • C08J2205/05—Open cells, i.e. more than 50% of the pores are open
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Materials For Medical Uses (AREA)
  • Lubricants (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Biological Depolymerization Polymers (AREA)
AT98913264T 1997-03-31 1998-03-31 Offenporige bioabbaubare matrize ATE249491T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4219897P 1997-03-31 1997-03-31
PCT/US1998/006188 WO1998044027A1 (en) 1997-03-31 1998-03-31 Open pore biodegradable matrices

Publications (1)

Publication Number Publication Date
ATE249491T1 true ATE249491T1 (de) 2003-09-15

Family

ID=21920588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98913264T ATE249491T1 (de) 1997-03-31 1998-03-31 Offenporige bioabbaubare matrize

Country Status (10)

Country Link
US (2) US6281256B1 (de)
EP (1) EP0991705B1 (de)
JP (1) JP4085341B2 (de)
AT (1) ATE249491T1 (de)
AU (1) AU736102B2 (de)
CA (1) CA2285329A1 (de)
DE (1) DE69818052T2 (de)
DK (1) DK0991705T3 (de)
ES (1) ES2205467T3 (de)
WO (1) WO1998044027A1 (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
DE69818052T2 (de) * 1997-03-31 2004-07-08 The Regents Of The University Of Michigan, Ann Arbor Offenporige bioabbaubare matrize
US7427602B1 (en) * 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
AU3898699A (en) * 1998-05-13 1999-11-29 Regents Of The University Of Michigan, The Sustained dna delivery from structural matrices
EP1277482A3 (de) * 1999-03-19 2005-05-11 The Regents of The University of Michigan Mineralisierung und zelluläre Strukturierung von Biomaterialoberflächen
DE60003006T2 (de) * 1999-03-19 2004-04-01 The Regents Of The University Of Michigan Technology Management Wolverine Tower, Ann Arbor Mineralisierung und zelluläre strukturierung von biomaterialoberflächen
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6103255A (en) 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
MXPA01010530A (es) * 1999-04-16 2002-03-14 Univ Rutgers Andamios de polimeros porosos para ingenieria de tejidos.
WO2001035932A2 (en) * 1999-11-18 2001-05-25 The Regents Of The University Of Michigan Sustained drug delivery from structural matrices
US6702849B1 (en) * 1999-12-13 2004-03-09 Advanced Cardiovascular Systems, Inc. Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
IT1307829B1 (it) * 1999-12-21 2001-11-19 Consiglio Nazionale Ricerche Protesi dentale con mezzi per il rilascio di farmaci o fattorispecifici atti ad impedire l'insorgenza di infezioni e/o promuovere
KR100355563B1 (ko) * 2000-06-23 2002-10-11 주식회사 바이오메드랩 비등성 혼합물을 이용한 조직공학용 생분해성의 다공성고분자 지지체 및 그의 제조방법
KR20030043928A (ko) * 2000-08-08 2003-06-02 바이오아미드 인코포레이티드 조직 조작된 모발용 지지체
US7294187B2 (en) * 2001-01-24 2007-11-13 Ada Foundation Rapid-hardening calcium phosphate cement compositions
US6793725B2 (en) 2001-01-24 2004-09-21 Ada Foundation Premixed calcium phosphate cement pastes
US7709029B2 (en) * 2001-01-24 2010-05-04 Ada Foundation Calcium-containing restoration materials
JP4731044B2 (ja) * 2001-05-22 2011-07-20 独立行政法人理化学研究所 延伸フィルムおよびそれを用いた細胞培養基材
CA2460843A1 (en) * 2001-09-21 2003-03-27 Stryker Corporation Pore-forming agents for orthopedic cements
WO2003053216A2 (en) * 2001-12-06 2003-07-03 University Of Washington Biodegradable, porous structures useful for growing living tissue, and methods of manufacture
US6955716B2 (en) 2002-03-01 2005-10-18 American Dental Association Foundation Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
EP1622691B1 (de) 2003-03-14 2011-05-25 The Trustees of Columbia University in the City of New York Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid-austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
WO2004087797A1 (en) * 2003-04-03 2004-10-14 Corporation De L'ecole Polytechnique De Montreal Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof
CN100447186C (zh) * 2003-06-06 2008-12-31 人类自动化细胞有限公司 基质、细胞移植物以及制备和使用它们的方法
ATE416223T1 (de) * 2003-08-29 2008-12-15 Mayo Foundation Hydrogel-porenbildner zur herstellung von biologisch abbaubaren gerüsten
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
US7846466B2 (en) * 2004-06-10 2010-12-07 Northwestern University Biodegradable scaffolds and uses thereof
US8512730B2 (en) * 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
CA2570521C (en) * 2004-07-12 2013-06-25 Isto Technologies, Inc. Tissue matrix system
EP1804716A2 (de) * 2004-09-21 2007-07-11 The Massachusetts Institute Of Technology Gradientengerüst und verfahren zu seiner herstellung
JP4738800B2 (ja) * 2004-10-15 2011-08-03 株式会社ジーシー ブロック状細胞工学用支持体の製造方法
EP1809678B1 (de) 2004-11-12 2013-05-22 Mayo Foundation for Medical Education and Research Photovernetzbare poly-(caprolacton-fumarate)
DE102004059169A1 (de) 2004-12-08 2006-06-22 Humanautocell Gmbh Verfahren zum Testen von Substanzen an Biomatrices
US7700355B2 (en) * 2005-01-07 2010-04-20 Industrial Technology Research Institute Methods of producing a porous matrix for culturing and recovering cells
EP1877111A1 (de) * 2005-04-26 2008-01-16 Rimon Therapeutics Ltd. Proangiogene polymergerüste
AU2006242487B2 (en) * 2005-04-29 2011-12-01 Mayo Foundation For Medical Education And Research Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof
DE102005054937A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Angiogenese förderndes Substrat
AR057629A1 (es) 2005-11-22 2007-12-05 Aderans Res Inst Inc Injerto de foliculos pilosos de piel obtenida por ingenieria de tejidos
JP2009518132A (ja) * 2005-12-07 2009-05-07 イスト・テクノロジーズ・インコーポレイテッド 軟骨修復方法
ATE534415T1 (de) 2005-12-13 2011-12-15 Harvard College Gerüste zur zelltransplantation
EP1988942B1 (de) * 2006-03-01 2011-07-27 FMC Biopolymer AS Gelierte zusammensetzung
AU2007253702A1 (en) 2006-05-22 2007-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
WO2008006104A2 (en) * 2006-07-07 2008-01-10 University Of Miami Enhanced oxygen cell culture platforms
US9175254B2 (en) * 2006-07-07 2015-11-03 University Of Miami Enhanced oxygen cell culture platforms
JP4995587B2 (ja) * 2007-01-29 2012-08-08 日東電工株式会社 ポリε−カプロラクトン発泡体とその製造方法
US9770535B2 (en) 2007-06-21 2017-09-26 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US8277832B2 (en) * 2007-10-10 2012-10-02 The University Of Kansas Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals
EP2249899A4 (de) 2008-02-04 2011-05-11 Univ Columbia Fluidtrennvorrichtungen, -systeme und -verfahren
AU2009215188B2 (en) 2008-02-13 2014-09-18 Dana-Farber Cancer Institute, Inc. Continuous cell programming devices
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
WO2009146456A1 (en) * 2008-05-30 2009-12-03 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
AU2009277252B2 (en) 2008-07-30 2014-01-16 Mesynthes Limited Tissue scaffolds derived from forestomach extracellular matrix
US20100203102A1 (en) * 2009-02-10 2010-08-12 Warsaw Orthopedic, Inc. Compositions and methods for treating post-operative pain using bupivacaine and an anti-onflammatory agent
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
US20110015672A1 (en) * 2009-07-17 2011-01-20 Tyco Healthcare Group Lp Method for Coating a Medical Device
US8728456B2 (en) 2009-07-31 2014-05-20 President And Fellows Of Harvard College Programming of cells for tolerogenic therapies
WO2011088229A2 (en) * 2010-01-13 2011-07-21 The Regents Of The University Of Michigan Active self-healing biomaterial system
WO2011109834A2 (en) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
JP6075732B2 (ja) * 2010-04-13 2017-02-08 ケーシーアイ ライセンシング インク 反応性成分を含む組成物ならびに創傷被覆材、装置および方法
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
SI2624873T1 (sl) 2010-10-06 2020-07-31 President And Fellows Of Harvard College Injektabilni, pore-formirajoči hidrogeli za celične terapije - na osnovi materialov
US9603894B2 (en) 2010-11-08 2017-03-28 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
WO2012148684A1 (en) 2011-04-27 2012-11-01 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
CA2833385C (en) 2011-04-28 2020-10-27 President And Fellows Of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
CA2838125A1 (en) 2011-06-03 2012-12-06 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
CN102258807B (zh) * 2011-07-15 2013-07-24 山东大学 一种组织工程用猪脱细胞真皮基质的调孔方法
EP3662896B1 (de) 2012-04-16 2024-02-28 President and Fellows of Harvard College Mesoporöse siliciumdioxidzusammensetzungen zur modulierung von immunreaktionen
KR20210096312A (ko) 2012-06-21 2021-08-04 노쓰웨스턴유니버시티 펩티드 접합된 입자
US9388312B2 (en) 2012-07-26 2016-07-12 Invista North America S.A.R.L. Thermoplastic composition for use in high impact applications
US20150203682A1 (en) 2012-07-26 2015-07-23 Invista North America S.A.R.L. Thermoplastic composition for use in high impact applications
US20140072510A1 (en) * 2012-09-13 2014-03-13 Northwestern University Synthetic Scaffolds for Metastasis Detection
US20140120152A1 (en) * 2012-10-31 2014-05-01 Northwestern University Scaffold Delivery of Immune Suppressors and Transplant Material for Control of Transplant Rejection
US9707323B2 (en) * 2012-11-12 2017-07-18 Warsaw Orthopedic, Inc. Devices and methods for inhibiting adhesion formation
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
ITTO20130284A1 (it) * 2013-04-09 2014-10-10 Fond Istituto Italiano Di Tecnologia Procedimento per la produzione di microparticelle polimeriche sagomate
HUE047329T2 (hu) 2013-08-13 2020-04-28 Univ Northwestern Peptiddel konjugált részecskék
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
WO2016164705A1 (en) * 2015-04-10 2016-10-13 Omar Abdel-Rahman Ali Immune cell trapping devices and methods for making and using the same
JP7194593B2 (ja) 2015-12-23 2022-12-22 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド 共有ポリマー抗原コンジュゲート化粒子
EP3411475B1 (de) 2016-02-06 2025-08-27 President and Fellows of Harvard College Rekapitulation der hämatopoietischen nische zur wiederherstellung der immunität
CN109789092A (zh) 2016-07-13 2019-05-21 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
CA3032505A1 (en) 2016-08-02 2018-02-08 President And Fellows Of Harvard College Biomaterials for modulating immune responses
EP3691686B1 (de) 2017-10-06 2024-12-18 The Regents Of The University Of Michigan Nachweis von metastatischer erkrankung und zugehörige verfahren
CA3083474A1 (en) * 2017-11-28 2019-06-06 Northwestern University Water-soluble salt particle containing compositions and porous materials made therefrom
US11306192B2 (en) * 2018-02-27 2022-04-19 Regents Of The University Of Minnesota Polylactide foams
WO2019194543A1 (ko) * 2018-04-02 2019-10-10 주식회사 옵티팜 세포 피막화용 알지네이트 미세캡슐 및 이의 제조방법
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
JP2022549270A (ja) 2019-09-23 2022-11-24 プレジデント アンド フェローズ オブ ハーバード カレッジ バイオマテリアルベースの無抗原ワクチンおよびその使用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2835607A (en) * 1954-08-04 1958-05-20 Goodrich Co B F Polymeric article having suede-like appearance and process of making the article
US2819981A (en) * 1955-02-23 1958-01-14 Goodrich Co B F Method for making flexible, vapor-permeable, water-resistant vinyl films and the like having improved slip and hand
DE1694529A1 (de) * 1967-03-17 1971-08-26 Kemper Charles Raymond Verfahren zur Herstellung eines poroesen Polyvinylmaterials
US3770537A (en) * 1969-10-20 1973-11-06 Minnesota Mining & Mfg Method for preparing a microporous sheet by heat-forming, annealing and leaching
US3636526A (en) * 1970-06-08 1972-01-18 Energy Conversion Devices Inc Information-recording system employing amorphous materials
US4461876A (en) * 1982-09-09 1984-07-24 Columbia University Polymeric reagents for the isolation and protection of carbonyl compounds
US4636526A (en) * 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US5567612A (en) 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5512600A (en) 1993-01-15 1996-04-30 Massachusetts Institute Of Technology Preparation of bonded fiber structures for cell implantation
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
DE4325879C3 (de) * 1993-08-02 1999-05-20 Depron Bv Folie aus einem thermoplastischen Kunststoffschaum, Verfahren zu ihrer Herstellung sowie ihre Verwendung
EP0713364A4 (de) * 1993-08-13 1996-12-27 Shalaby W Shalaby Mikroporöse polymere schäume und mikrostrukturierte oberflächen
DE69818052T2 (de) * 1997-03-31 2004-07-08 The Regents Of The University Of Michigan, Ann Arbor Offenporige bioabbaubare matrize

Also Published As

Publication number Publication date
WO1998044027A1 (en) 1998-10-08
AU6786098A (en) 1998-10-22
DK0991705T3 (da) 2004-01-12
AU736102B2 (en) 2001-07-26
EP0991705A1 (de) 2000-04-12
EP0991705A4 (de) 2001-12-12
JP2002514253A (ja) 2002-05-14
US20020045672A1 (en) 2002-04-18
JP4085341B2 (ja) 2008-05-14
US6281256B1 (en) 2001-08-28
EP0991705B1 (de) 2003-09-10
DE69818052T2 (de) 2004-07-08
CA2285329A1 (en) 1998-10-08
US6797738B2 (en) 2004-09-28
DE69818052D1 (de) 2003-10-16
ES2205467T3 (es) 2004-05-01

Similar Documents

Publication Publication Date Title
ATE249491T1 (de) Offenporige bioabbaubare matrize
DK0696612T3 (da) Bionedbrydelige opskummede artikler og fremgangsmåde til fremstilling deraf
ATE309762T1 (de) Kombinierte medizinische vorrichtung bestehend aus einer stützstruktur und einem membran
ATE332288T1 (de) Keramischer schaumkörper
SE9601368D0 (sv) Process for the production of a porous cross-linked polysaccharide gel
ATE251196T1 (de) Verfahren zur herstellung von expandierbaren polystyrolteilchen
DE60023143D1 (de) Schraubenförmig gebildetes stent/transplantat
WO1999032204A3 (en) Permeable compositions and methods for their preparation
ES2062979T3 (es) Materiales polimericos reticulados, elasticos, porosos y de baja densidad y su preparacion.
IL147974A0 (en) Composite shaped bodies and methods for their production and use
DE69407295D1 (de) Anorganisches, poröses material und verfahren zu dessen herstellung
LV10304A (lv) Struktureti kristali ka jauna fermentu imobilizacijas forma
DE59704878D1 (de) Verfahren zur stabilisierung von sinterschaum und zur herstellung von offenzelligen sinterschaumteilen
WO2000051538A8 (en) Porous tissue scaffolding materials and uses thereof
GC0000119A (en) Improved chromate ester catalyst and method of using same to produce high performance polyethylene products.
FR2719238B1 (fr) Matériau inorganique composite poreux, notamment sous forme de membrane, et procédé d'obtention d'un tel matériau.
ATE22096T1 (de) Vinylencarbonat-polymerisate, verfahren zu ihrer herstellung und ihre anwendung.
ATE158362T1 (de) Verminderung der porosität von materialien
WO2001044141A3 (en) Porous ceramic body
WO2002024343A3 (de) Verfahren zur herstellung einer beschichtung auf porösen und/oder saugfähigen materialien
ES2063269T3 (es) Procedimiento para la preparacion de tigogenina-b-celobiosido.
NO20011320D0 (no) FremgangsmÕte for fremstilling av ekspanderte polyvinylarenpartikler
WO2003003828A1 (en) Material for improving living environment, and building material, laying material and spraying agent using the same
ATE262083T1 (de) Plattenförmiges bauelement
ATE400385T1 (de) Verfahren zur herstellung einer offenzelligen schaumstruktur

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0991705

Country of ref document: EP

REN Ceased due to non-payment of the annual fee