JP2009517069A5 - - Google Patents
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- JP2009517069A5 JP2009517069A5 JP2008542831A JP2008542831A JP2009517069A5 JP 2009517069 A5 JP2009517069 A5 JP 2009517069A5 JP 2008542831 A JP2008542831 A JP 2008542831A JP 2008542831 A JP2008542831 A JP 2008542831A JP 2009517069 A5 JP2009517069 A5 JP 2009517069A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tar2h
- dom4
- dom7r
- dab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000178 monomer Substances 0.000 claims 45
- 239000003446 ligand Substances 0.000 claims 27
- 102000010932 Interleukin-1 receptor type 1 Human genes 0.000 claims 19
- 108050001109 Interleukin-1 receptor type 1 Proteins 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims 7
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 claims 7
- 102000000589 Interleukin-1 Human genes 0.000 claims 7
- 108010002352 Interleukin-1 Proteins 0.000 claims 7
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims 7
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 claims 7
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 6
- 102000007562 Serum Albumin Human genes 0.000 claims 6
- 108010071390 Serum Albumin Proteins 0.000 claims 6
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 claims 5
- 239000006199 nebulizer Substances 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 4
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 4
- 230000015556 catabolic process Effects 0.000 claims 4
- 238000006731 degradation reaction Methods 0.000 claims 4
- 125000003827 glycol group Chemical group 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000002685 pulmonary effect Effects 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 101100268517 Mus musculus Serpina1d gene Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000012377 drug delivery Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 102000007238 Transferrin Receptors Human genes 0.000 claims 2
- 108010033576 Transferrin Receptors Proteins 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000001361 intraarterial administration Methods 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000007912 intraperitoneal administration Methods 0.000 claims 2
- 238000007913 intrathecal administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 2
- 229920001515 polyalkylene glycol Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 230000037317 transdermal delivery Effects 0.000 claims 2
- 239000012581 transferrin Substances 0.000 claims 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000034423 Delivery Diseases 0.000 claims 1
- 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 108010057368 Interleukin-1 Type I Receptors Proteins 0.000 claims 1
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 claims 1
- 102000004125 Interleukin-1alpha Human genes 0.000 claims 1
- 108010082786 Interleukin-1alpha Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000016387 Pancreatic elastase Human genes 0.000 claims 1
- 108010067372 Pancreatic elastase Proteins 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- -1 inhaler Substances 0.000 claims 1
- 229940100601 interleukin-6 Drugs 0.000 claims 1
- 229940096397 interleukin-8 Drugs 0.000 claims 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000009677 vaginal delivery Effects 0.000 claims 1
- 238000013389 whole blood assay Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74221805P | 2005-12-01 | 2005-12-01 | |
| PCT/GB2006/004474 WO2007063311A2 (en) | 2005-12-01 | 2006-11-30 | Competitive domain antibody formats that bind interleukin 1 receptor type 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517069A JP2009517069A (ja) | 2009-04-30 |
| JP2009517069A5 true JP2009517069A5 (https=) | 2010-01-07 |
Family
ID=37814249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542831A Pending JP2009517069A (ja) | 2005-12-01 | 2006-11-30 | インターロイキン１受容体１型に結合する競合ドメイン抗体フォーマット |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080311111A1 (https=) |
| EP (1) | EP1957537A2 (https=) |
| JP (1) | JP2009517069A (https=) |
| KR (1) | KR20080077237A (https=) |
| CN (1) | CN101466734A (https=) |
| AU (1) | AU2006321367B2 (https=) |
| BR (1) | BRPI0619224A2 (https=) |
| CA (1) | CA2629850A1 (https=) |
| CR (1) | CR10025A (https=) |
| EA (1) | EA200801166A1 (https=) |
| MA (1) | MA30019B1 (https=) |
| NO (1) | NO20082387L (https=) |
| TW (1) | TW200736276A (https=) |
| WO (1) | WO2007063311A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE048024T2 (hu) * | 2006-08-10 | 2020-05-28 | Roy C Levitt | Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra |
| CA2688433A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
| GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| EP2220115A2 (en) * | 2007-12-13 | 2010-08-25 | Glaxo Group Limited | Polypeptides, antibody variable domains & antagonists |
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| WO2009089295A2 (en) * | 2008-01-07 | 2009-07-16 | Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Anti-hiv domain antibodies and method of making and using same |
| GB0809069D0 (en) | 2008-05-19 | 2008-06-25 | Univ Leuven Kath | Gene signatures |
| WO2009127691A1 (en) | 2008-04-17 | 2009-10-22 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| US8298533B2 (en) * | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
| CA2747206C (en) | 2008-12-22 | 2018-04-24 | The University Of Melbourne | Pain treatment |
| CN102271705A (zh) * | 2008-12-22 | 2011-12-07 | 墨尔本大学 | 骨关节炎治疗 |
| WO2011006915A2 (en) * | 2009-07-16 | 2011-01-20 | Glaxo Group Limited | Improved anti-serum albumin binding single variable domains |
| EP2531523A1 (en) | 2010-02-05 | 2012-12-12 | Ablynx N.V. | Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same |
| US8883134B2 (en) | 2010-10-20 | 2014-11-11 | Handok Pharmaceuticals, Inc. | Human interleukin-1 receptor antagonist—hybrid Fc fusion protein |
| WO2012053828A2 (ko) * | 2010-10-20 | 2012-04-26 | 주식회사 한독약품 | 인간 인터루킨-1 수용체 길항제-하이브리드 Ｆｃ 융합단백질 |
| WO2012072731A2 (en) * | 2010-12-01 | 2012-06-07 | Glaxo Group Limited | Improved anti-serum albumin binding single variable domains |
| RS55775B2 (sr) | 2011-06-23 | 2022-10-31 | Ablynx Nv | Tehnike za predviđanje, otkrivanje i smanjenje nespecifične proteinske interferencije u testovima koji uključuju pojedinačne varijabilne domene imunoglobulina |
| SG10201805064SA (en) | 2011-06-23 | 2018-07-30 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP4350345A3 (en) | 2011-06-23 | 2024-07-24 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
| PE20141522A1 (es) * | 2011-08-17 | 2014-11-17 | Glaxo Group Ltd | Proteinas y peptidos modificados |
| KR101592871B1 (ko) * | 2013-03-19 | 2016-02-11 | 부산대학교 산학협력단 | Akt에 의해 활성화되는 글리코겐 합성효소 키나아제 베타 억제용 펩타이드 |
| US11009511B2 (en) | 2014-05-16 | 2021-05-18 | Ablynx N.V. | Methods for detecting and/or measuring anti-drug antibodies, in particular treatment-emergent anti-drug antibodies |
| EP4707303A2 (en) | 2014-05-16 | 2026-03-11 | Ablynx NV | Improved immunoglobulin variable domains |
| NO2768984T3 (https=) | 2015-11-12 | 2018-06-09 | ||
| LT3374392T (lt) | 2015-11-13 | 2022-01-25 | Ablynx Nv | Patobulinti serumo albuminą surišantys imunoglobulino kintami domenai |
| AU2016357460B2 (en) | 2015-11-18 | 2023-07-27 | Ablynx Nv | Improved serum albumin binders |
| AU2016355569B2 (en) | 2015-11-18 | 2020-01-02 | Merck Sharp & Dohme Llc | CTLA4 binders |
| AU2017281421B2 (en) | 2016-06-23 | 2024-07-25 | Ablynx N.V. | Improved pharmacokinetic assays for immunoglobulin single variable domains |
| JP7626577B2 (ja) | 2016-11-28 | 2025-02-07 | 中外製薬株式会社 | リガンド結合活性が調整可能なリガンド結合分子 |
| BR112019008727A2 (pt) | 2016-11-28 | 2019-07-16 | Chugai Seiyaku Kabushiki Kaisha | domínio de ligação ao antígeno, e polipeptídeo incluindo seção de transporte |
| RU2022101604A (ru) * | 2016-12-07 | 2022-03-29 | Аблинкс Нв | Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| IL267897B2 (en) | 2017-01-17 | 2025-02-01 | Ablynx Nv | Improved serum albumin binders |
| JP7219220B2 (ja) | 2017-01-17 | 2023-02-07 | アブリンクス エン．ヴェー． | 改善された血清アルブミン結合剤 |
| US12480957B2 (en) | 2017-03-31 | 2025-11-25 | Ablynx N.V. | Method of screening for anti-drug antibodies against immunoglobulin single variable domain-based drugs |
| JP7482630B2 (ja) | 2017-11-28 | 2024-05-14 | 中外製薬株式会社 | 抗原結合ドメインおよび運搬部分を含むポリペプチド |
| JP7414736B2 (ja) | 2018-05-30 | 2024-01-16 | 中外製薬株式会社 | アグリカン結合ドメインおよび運搬部分を含むポリペプチド |
| JP7428661B2 (ja) * | 2018-05-30 | 2024-02-06 | 中外製薬株式会社 | Ｉｌ－１ｒ１結合ドメインおよび運搬部分を含むポリペプチド |
| CN110361310A (zh) * | 2019-06-18 | 2019-10-22 | 东南大学 | 一种房间换气次数的cadr测量方法 |
| CN115667307A (zh) * | 2020-05-20 | 2023-01-31 | 居里研究所 | 合成的单域文库 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2148299B (en) * | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
| USRE35450E (en) * | 1987-11-25 | 1997-02-11 | Immunex Corporation | Soluble human interleukin-1 receptors, compositions and method of use |
| US5296592A (en) * | 1987-11-25 | 1994-03-22 | Immunex Corporation | Process for purifying interleukin-1 receptors |
| US4968607A (en) * | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5081228A (en) * | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
| US6511665B1 (en) * | 1987-11-25 | 2003-01-28 | Immunex Corporation | Antibodies to interleukin-1 receptors |
| US20040101528A1 (en) * | 1988-02-25 | 2004-05-27 | Dower Steven K. | Type I IL-1 receptors |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5334380A (en) * | 1991-09-27 | 1994-08-02 | Board Of Regents, The University Of Texas System | Anti-endotoxin, interleukin-1 receptor antagonist and anti-tumor necrosis factor antibody with arginine-free formulations for the treatment of hypotension |
| WO1993008820A1 (en) * | 1991-10-31 | 1993-05-13 | The Victoria University Of Manchester | Treatment of neurological conditions by an interleukin-1 inhibiting compound |
| US5391071A (en) * | 1993-10-29 | 1995-02-21 | Eastman Kodak Company | Apparatus and method for inspecting and cleaning lips of castings die |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| ES2312179T3 (es) * | 1996-12-06 | 2009-02-16 | Amgen Inc. | Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1. |
| US6054559A (en) * | 1997-01-28 | 2000-04-25 | Smithkline Beecham Corporation | Interleukin-1 receptor antagonist beta (IL-1raβ) |
| US6294170B1 (en) * | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6326472B1 (en) * | 1997-10-15 | 2001-12-04 | Schering Corporation | Human receptor proteins; related reagents and methods |
| US6746839B1 (en) * | 1998-01-12 | 2004-06-08 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for an obstructive airway disease |
| US7115557B2 (en) * | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
| US6471961B1 (en) * | 1999-02-24 | 2002-10-29 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| US6423321B2 (en) * | 1999-02-24 | 2002-07-23 | Edward L. Tobinick | Cytokine antagonists for the treatment of sensorineural hearing loss |
| US6419944B2 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
| US6623736B2 (en) * | 2000-05-02 | 2003-09-23 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| JP2005509647A (ja) * | 2001-11-06 | 2005-04-14 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | エストロゲン応答性乳癌の治療方法 |
| SE0200667D0 (sv) * | 2002-03-05 | 2002-03-05 | A & Science Invest Ab | Novel use of cytokine inhibitors |
| AU2003244817B2 (en) * | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| US20040038874A1 (en) * | 2002-08-22 | 2004-02-26 | Osemwota Omoigui | Method of treatment of persistent pain |
| KR101317045B1 (ko) | 2002-09-06 | 2013-10-16 | 암젠 인코포레이티드 | 치료학적 인체 항-ｉｌ-1ｒ1 모노클로날 항체 |
| EP1578801A2 (en) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| US20040248158A1 (en) * | 2003-01-28 | 2004-12-09 | Loughran Thomas P | Differentially expressed genes in large granular lymphocyte leukemia |
| US20040224893A1 (en) * | 2003-05-06 | 2004-11-11 | Li-Hsien Wang | Methods of using IL-1 antagonists to treat neointimal hyperplasia |
| DE602004017726D1 (de) * | 2003-06-30 | 2008-12-24 | Domantis Ltd | Pegylierte Single-domain-antikörper (dAb) |
| AR045614A1 (es) | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
| MX2007006593A (es) * | 2004-12-02 | 2008-03-04 | Domantis Ltd | Anticuerpos de dominio simple anti-il 1r1 y sus usos terapeuticos. |
| US7103259B1 (en) * | 2005-03-21 | 2006-09-05 | Hannstar Display Corporation | Structure for affixing an optical plate on a frame in a panel display |
-
2006
- 2006-11-30 EA EA200801166A patent/EA200801166A1/ru unknown
- 2006-11-30 BR BRPI0619224A patent/BRPI0619224A2/pt not_active IP Right Cessation
- 2006-11-30 EP EP06820379A patent/EP1957537A2/en not_active Withdrawn
- 2006-11-30 AU AU2006321367A patent/AU2006321367B2/en not_active Expired - Fee Related
- 2006-11-30 CA CA002629850A patent/CA2629850A1/en not_active Abandoned
- 2006-11-30 JP JP2008542831A patent/JP2009517069A/ja active Pending
- 2006-11-30 US US12/085,919 patent/US20080311111A1/en not_active Abandoned
- 2006-11-30 KR KR1020087015943A patent/KR20080077237A/ko not_active Withdrawn
- 2006-11-30 CN CNA2006800519271A patent/CN101466734A/zh active Pending
- 2006-11-30 WO PCT/GB2006/004474 patent/WO2007063311A2/en not_active Ceased
- 2006-11-30 TW TW095144417A patent/TW200736276A/zh unknown
-
2008
- 2008-05-26 NO NO20082387A patent/NO20082387L/no unknown
- 2008-05-27 CR CR10025A patent/CR10025A/es not_active Application Discontinuation
- 2008-06-02 MA MA30988A patent/MA30019B1/fr unknown
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