JP2009516745A5 - - Google Patents
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- Publication number
- JP2009516745A5 JP2009516745A5 JP2008542415A JP2008542415A JP2009516745A5 JP 2009516745 A5 JP2009516745 A5 JP 2009516745A5 JP 2008542415 A JP2008542415 A JP 2008542415A JP 2008542415 A JP2008542415 A JP 2008542415A JP 2009516745 A5 JP2009516745 A5 JP 2009516745A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- isopropyl
- alkyl
- formula
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 15
- -1 3-isopropyl-2-oxo-2,3-dihydrobenzimidazole-1-carbonyl Chemical group 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 206010010774 Constipation Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- YPMQYIFFTKAPPZ-UHFFFAOYSA-N 1,1-dioxo-1,4-thiazinane-4-carboxylic acid Chemical compound OC(=O)N1CCS(=O)(=O)CC1 YPMQYIFFTKAPPZ-UHFFFAOYSA-N 0.000 claims 2
- 206010052105 Gastrointestinal hypomotility Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- HZWNCWJPJSKCTL-SCSAIBSYSA-N (2r)-2-carbamoylpyrrolidine-1-carboxylic acid Chemical compound NC(=O)[C@H]1CCCN1C(O)=O HZWNCWJPJSKCTL-SCSAIBSYSA-N 0.000 claims 1
- OQAQSHAJNAAFQB-UHFFFAOYSA-N 3-carbamoylpiperidine-1-carboxylic acid Chemical compound NC(=O)C1CCCN(C(O)=O)C1 OQAQSHAJNAAFQB-UHFFFAOYSA-N 0.000 claims 1
- SQIQQEFNYTXCJY-UHFFFAOYSA-N 4-(2-hydroxyethyl)piperazine-1-carboxylic acid Chemical compound OCCN1CCN(C(O)=O)CC1 SQIQQEFNYTXCJY-UHFFFAOYSA-N 0.000 claims 1
- WZQYDJOYLQVWGE-UHFFFAOYSA-N 4-(dimethylcarbamoyl)piperazine-1-carboxylic acid Chemical compound CN(C)C(=O)N1CCN(C(O)=O)CC1 WZQYDJOYLQVWGE-UHFFFAOYSA-N 0.000 claims 1
- ZGJFUGLXFFQJEI-UHFFFAOYSA-N 4-(dimethylcarbamoyloxy)piperidine-1-carboxylic acid Chemical compound CN(C)C(=O)OC1CCN(C(O)=O)CC1 ZGJFUGLXFFQJEI-UHFFFAOYSA-N 0.000 claims 1
- WFWHHKKYPPDYIB-UHFFFAOYSA-N 4-(dimethylsulfamoyl)piperazine-1-carboxylic acid Chemical compound CN(C)S(=O)(=O)N1CCN(C(O)=O)CC1 WFWHHKKYPPDYIB-UHFFFAOYSA-N 0.000 claims 1
- SYPWCPLBAKQKML-UHFFFAOYSA-N 4-(oxolane-2-carbonyl)piperazine-1-carboxylic acid Chemical compound C1CN(C(=O)O)CCN1C(=O)C1OCCC1 SYPWCPLBAKQKML-UHFFFAOYSA-N 0.000 claims 1
- WNGNAZBZESNPSG-UHFFFAOYSA-N 4-acetyl-1,4-diazepane-1-carboxylic acid Chemical compound CC(=O)N1CCCN(C(O)=O)CC1 WNGNAZBZESNPSG-UHFFFAOYSA-N 0.000 claims 1
- DDOWCQQXWQWZQD-UHFFFAOYSA-N 4-acetylpiperazine-1-carboxylic acid Chemical compound CC(=O)N1CCN(C(O)=O)CC1 DDOWCQQXWQWZQD-UHFFFAOYSA-N 0.000 claims 1
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 1
- 201000005081 Intestinal Pseudo-Obstruction Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000003243 intestinal obstruction Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- VIUHECCLPRAHMP-UHFFFAOYSA-N CC(CC1)CC1(C=O)O Chemical compound CC(CC1)CC1(C=O)O VIUHECCLPRAHMP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73870205P | 2005-11-22 | 2005-11-22 | |
| PCT/US2006/045099 WO2007062058A2 (en) | 2005-11-22 | 2006-11-21 | Carbamate compounds as 5-ht4 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009516745A JP2009516745A (ja) | 2009-04-23 |
| JP2009516745A5 true JP2009516745A5 (enExample) | 2009-12-03 |
Family
ID=38067868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542415A Pending JP2009516745A (ja) | 2005-11-22 | 2006-11-21 | ５−ｈｔ４受容体作動薬としてのカルバメート化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7329752B2 (enExample) |
| EP (1) | EP1960396B1 (enExample) |
| JP (1) | JP2009516745A (enExample) |
| KR (1) | KR20080072727A (enExample) |
| CN (1) | CN101312967B (enExample) |
| AR (1) | AR057627A1 (enExample) |
| AT (1) | ATE448224T1 (enExample) |
| AU (1) | AU2006318507A1 (enExample) |
| BR (1) | BRPI0618835A2 (enExample) |
| CA (1) | CA2630222A1 (enExample) |
| DE (1) | DE602006010432D1 (enExample) |
| EA (1) | EA014819B1 (enExample) |
| ES (1) | ES2336952T3 (enExample) |
| MY (1) | MY143574A (enExample) |
| NO (1) | NO20082597L (enExample) |
| NZ (1) | NZ567653A (enExample) |
| PE (1) | PE20070954A1 (enExample) |
| TW (1) | TW200804366A (enExample) |
| WO (1) | WO2007062058A2 (enExample) |
| ZA (1) | ZA200804010B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006094063A1 (en) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
| ATE509021T1 (de) * | 2006-02-16 | 2011-05-15 | Theravance Inc | Verfahren zur herstellung von zwischenverbindungen zu 5-ht4-rezeptoragonist- verbindungen |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1231413B (it) | 1987-09-23 | 1991-12-04 | Angeli Inst Spa | Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht |
| US5223511A (en) * | 1987-09-23 | 1993-06-29 | Boehringer Ingelheim Italia S.P.A. | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists |
| JP3829879B2 (ja) * | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
| IT1275903B1 (it) * | 1995-03-14 | 1997-10-24 | Boehringer Ingelheim Italia | Esteri e ammidi della 1,4-piperidina disostituita |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| IT1298271B1 (it) | 1998-02-18 | 1999-12-20 | Boehringer Ingelheim Italia | Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico |
| EP1173168A2 (en) * | 1999-04-28 | 2002-01-23 | Respiratorius AB | Compound for use as a medicament for treatment of disorders involving bronchocontraction |
| IT1313625B1 (it) * | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
| JP4181847B2 (ja) * | 2002-10-25 | 2008-11-19 | エルピーダメモリ株式会社 | タイミング調整回路、半導体装置及びタイミング調整方法 |
| DK1664036T3 (da) * | 2003-09-03 | 2012-02-13 | Pfizer | Benzimidazolonforbindelser med 5-HT4-receptoragonistisk virkning |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| ATE441646T1 (de) * | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
| ATE431824T1 (de) * | 2004-11-05 | 2009-06-15 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
| WO2006069125A1 (en) * | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
| WO2006094063A1 (en) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
| US7351304B2 (en) * | 2005-05-24 | 2008-04-01 | General Electric Company | Method and apparatus for reducing surface defects |
| ATE495171T1 (de) | 2005-06-07 | 2011-01-15 | Theravance Inc | Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors |
-
2006
- 2006-11-09 MY MYPI20064472A patent/MY143574A/en unknown
- 2006-11-15 TW TW095142293A patent/TW200804366A/zh unknown
- 2006-11-21 JP JP2008542415A patent/JP2009516745A/ja active Pending
- 2006-11-21 EA EA200801402A patent/EA014819B1/ru not_active IP Right Cessation
- 2006-11-21 PE PE2006001486A patent/PE20070954A1/es not_active Application Discontinuation
- 2006-11-21 AU AU2006318507A patent/AU2006318507A1/en not_active Abandoned
- 2006-11-21 ES ES06838207T patent/ES2336952T3/es active Active
- 2006-11-21 AT AT06838207T patent/ATE448224T1/de not_active IP Right Cessation
- 2006-11-21 NZ NZ567653A patent/NZ567653A/en unknown
- 2006-11-21 CA CA002630222A patent/CA2630222A1/en not_active Abandoned
- 2006-11-21 WO PCT/US2006/045099 patent/WO2007062058A2/en not_active Ceased
- 2006-11-21 BR BRPI0618835-4A patent/BRPI0618835A2/pt not_active IP Right Cessation
- 2006-11-21 DE DE602006010432T patent/DE602006010432D1/de active Active
- 2006-11-21 KR KR1020087014898A patent/KR20080072727A/ko not_active Ceased
- 2006-11-21 EP EP06838207A patent/EP1960396B1/en active Active
- 2006-11-21 US US11/602,888 patent/US7329752B2/en active Active
- 2006-11-21 CN CN2006800433139A patent/CN101312967B/zh not_active Expired - Fee Related
- 2006-11-22 AR ARP060105125A patent/AR057627A1/es not_active Application Discontinuation
-
2007
- 2007-12-06 US US11/999,609 patent/US7851467B2/en not_active Expired - Fee Related
-
2008
- 2008-05-09 ZA ZA200804010A patent/ZA200804010B/xx unknown
- 2008-06-10 NO NO20082597A patent/NO20082597L/no not_active Application Discontinuation