AU2006318507A1 - Carbamate compounds as 5-HT4 receptor agonists - Google Patents

Carbamate compounds as 5-HT4 receptor agonists Download PDF

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Publication number
AU2006318507A1
AU2006318507A1 AU2006318507A AU2006318507A AU2006318507A1 AU 2006318507 A1 AU2006318507 A1 AU 2006318507A1 AU 2006318507 A AU2006318507 A AU 2006318507A AU 2006318507 A AU2006318507 A AU 2006318507A AU 2006318507 A1 AU2006318507 A1 AU 2006318507A1
Authority
AU
Australia
Prior art keywords
compound
formula
isopropyl
carbonyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2006318507A
Other languages
English (en)
Inventor
Seok-Ki Choi
Paul R. Fatheree
Adam Goldblum
Daniel Long
Daniel Marquess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innoviva Inc
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of AU2006318507A1 publication Critical patent/AU2006318507A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2006318507A 2005-11-22 2006-11-21 Carbamate compounds as 5-HT4 receptor agonists Abandoned AU2006318507A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73870205P 2005-11-22 2005-11-22
US60/738,702 2005-11-22
PCT/US2006/045099 WO2007062058A2 (en) 2005-11-22 2006-11-21 Carbamate compounds as 5-ht4 receptor agonists

Publications (1)

Publication Number Publication Date
AU2006318507A1 true AU2006318507A1 (en) 2007-05-31

Family

ID=38067868

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006318507A Abandoned AU2006318507A1 (en) 2005-11-22 2006-11-21 Carbamate compounds as 5-HT4 receptor agonists

Country Status (20)

Country Link
US (2) US7329752B2 (enExample)
EP (1) EP1960396B1 (enExample)
JP (1) JP2009516745A (enExample)
KR (1) KR20080072727A (enExample)
CN (1) CN101312967B (enExample)
AR (1) AR057627A1 (enExample)
AT (1) ATE448224T1 (enExample)
AU (1) AU2006318507A1 (enExample)
BR (1) BRPI0618835A2 (enExample)
CA (1) CA2630222A1 (enExample)
DE (1) DE602006010432D1 (enExample)
EA (1) EA014819B1 (enExample)
ES (1) ES2336952T3 (enExample)
MY (1) MY143574A (enExample)
NO (1) NO20082597L (enExample)
NZ (1) NZ567653A (enExample)
PE (1) PE20070954A1 (enExample)
TW (1) TW200804366A (enExample)
WO (1) WO2007062058A2 (enExample)
ZA (1) ZA200804010B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006094063A1 (en) * 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
ATE509021T1 (de) * 2006-02-16 2011-05-15 Theravance Inc Verfahren zur herstellung von zwischenverbindungen zu 5-ht4-rezeptoragonist- verbindungen

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231413B (it) 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
US5223511A (en) * 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
JP3829879B2 (ja) * 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
IT1275903B1 (it) * 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
IT1298271B1 (it) 1998-02-18 1999-12-20 Boehringer Ingelheim Italia Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico
EP1173168A2 (en) * 1999-04-28 2002-01-23 Respiratorius AB Compound for use as a medicament for treatment of disorders involving bronchocontraction
IT1313625B1 (it) * 1999-09-22 2002-09-09 Boehringer Ingelheim Italia Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina.
JP4181847B2 (ja) * 2002-10-25 2008-11-19 エルピーダメモリ株式会社 タイミング調整回路、半導体装置及びタイミング調整方法
DK1664036T3 (da) * 2003-09-03 2012-02-13 Pfizer Benzimidazolonforbindelser med 5-HT4-receptoragonistisk virkning
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ATE441646T1 (de) * 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
ATE431824T1 (de) * 2004-11-05 2009-06-15 Theravance Inc Chinolinon-carboxamid-verbindungen
WO2006069125A1 (en) * 2004-12-22 2006-06-29 Theravance, Inc. Indazole-carboxamide compounds
WO2006094063A1 (en) * 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
US7351304B2 (en) * 2005-05-24 2008-04-01 General Electric Company Method and apparatus for reducing surface defects
ATE495171T1 (de) 2005-06-07 2011-01-15 Theravance Inc Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors

Also Published As

Publication number Publication date
US20080090811A1 (en) 2008-04-17
CA2630222A1 (en) 2007-05-31
EA200801402A1 (ru) 2008-10-30
CN101312967A (zh) 2008-11-26
WO2007062058A3 (en) 2007-09-07
EP1960396B1 (en) 2009-11-11
NO20082597L (no) 2008-06-10
MY143574A (en) 2011-05-31
US7851467B2 (en) 2010-12-14
US7329752B2 (en) 2008-02-12
WO2007062058A2 (en) 2007-05-31
DE602006010432D1 (de) 2009-12-24
BRPI0618835A2 (pt) 2011-09-13
ATE448224T1 (de) 2009-11-15
ZA200804010B (en) 2009-02-25
AR057627A1 (es) 2007-12-05
PE20070954A1 (es) 2007-09-10
NZ567653A (en) 2011-06-30
TW200804366A (en) 2008-01-16
ES2336952T3 (es) 2010-04-19
JP2009516745A (ja) 2009-04-23
CN101312967B (zh) 2011-08-24
KR20080072727A (ko) 2008-08-06
EP1960396A2 (en) 2008-08-27
US20070117796A1 (en) 2007-05-24
EA014819B1 (ru) 2011-02-28

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US7498442B2 (en) Quinolinone-carboxamide compounds
US7772239B2 (en) Benzoimidazolone-carboxamide compounds as 5-HT4 receptor agonists
US7534889B2 (en) 5-HT4 receptor agonist compounds
EP1831211A1 (en) Indazole-carboxamide compounds
EP1718643A1 (en) Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7446114B2 (en) Quinolinone compounds as 5-HT4 receptor agonists
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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application