NO20082597L - Karbamatforbindelser som 5-HT4 reseptoragonister - Google Patents

Karbamatforbindelser som 5-HT4 reseptoragonister

Info

Publication number
NO20082597L
NO20082597L NO20082597A NO20082597A NO20082597L NO 20082597 L NO20082597 L NO 20082597L NO 20082597 A NO20082597 A NO 20082597A NO 20082597 A NO20082597 A NO 20082597A NO 20082597 L NO20082597 L NO 20082597L
Authority
NO
Norway
Prior art keywords
compounds
receptor agonists
carbamate compounds
carbamate
receptor
Prior art date
Application number
NO20082597A
Other languages
English (en)
Inventor
Daniel Marquess
Seok-Ki Choi
Adam Goldblum
Paul R Fatheree
Daniel Long
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of NO20082597L publication Critical patent/NO20082597L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives nye benzoimidazolon-karboksamidavledede karbamat 5- HT4 reseptoragonist forbindelser med formel (1) der R', R2, R3, R4, a og b er som angitt i beskrivelsen. Det beskrives videre farmasøytiske preparater omfattende slike forbindelser, videre metoder for å bruke slike forbindelser for å behandle sykdommer assosiert med 5HT4 reseptoraktivitet, og prosesser og mellomprodukter som er nyttige for 'a fremstille slike forbindelser.
NO20082597A 2005-11-22 2008-06-10 Karbamatforbindelser som 5-HT4 reseptoragonister NO20082597L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73870205P 2005-11-22 2005-11-22
PCT/US2006/045099 WO2007062058A2 (en) 2005-11-22 2006-11-21 Carbamate compounds as 5-ht4 receptor agonists

Publications (1)

Publication Number Publication Date
NO20082597L true NO20082597L (no) 2008-06-10

Family

ID=38067868

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082597A NO20082597L (no) 2005-11-22 2008-06-10 Karbamatforbindelser som 5-HT4 reseptoragonister

Country Status (20)

Country Link
US (2) US7329752B2 (no)
EP (1) EP1960396B1 (no)
JP (1) JP2009516745A (no)
KR (1) KR20080072727A (no)
CN (1) CN101312967B (no)
AR (1) AR057627A1 (no)
AT (1) ATE448224T1 (no)
AU (1) AU2006318507A1 (no)
BR (1) BRPI0618835A2 (no)
CA (1) CA2630222A1 (no)
DE (1) DE602006010432D1 (no)
EA (1) EA014819B1 (no)
ES (1) ES2336952T3 (no)
MY (1) MY143574A (no)
NO (1) NO20082597L (no)
NZ (1) NZ567653A (no)
PE (1) PE20070954A1 (no)
TW (1) TW200804366A (no)
WO (1) WO2007062058A2 (no)
ZA (1) ZA200804010B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2523851T3 (es) * 2005-03-02 2014-12-02 Theravance Biopharma R&D Ip, Llc Compuestos de quinolinona como agonistas de los receptores 5-HT4
US7671198B2 (en) * 2006-02-16 2010-03-02 Theravance, Inc. Process for preparing intermediates to 5-HT4 receptor agonist compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231413B (it) 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
US5223511A (en) 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
JP3829879B2 (ja) * 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
US6069152A (en) 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
IT1298271B1 (it) 1998-02-18 1999-12-20 Boehringer Ingelheim Italia Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico
AU5259100A (en) 1999-04-28 2000-11-10 Respiratorius Ab Medicament
IT1313625B1 (it) 1999-09-22 2002-09-09 Boehringer Ingelheim Italia Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina.
JP4181847B2 (ja) * 2002-10-25 2008-11-19 エルピーダメモリ株式会社 タイミング調整回路、半導体装置及びタイミング調整方法
PL1664036T3 (pl) 2003-09-03 2012-04-30 Pfizer Związki benzimidazolonu wykazujące działanie agonistyczne względem receptora 5-ht4
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ATE441646T1 (de) 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
JP5042028B2 (ja) * 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
ATE469897T1 (de) 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
ES2523851T3 (es) * 2005-03-02 2014-12-02 Theravance Biopharma R&D Ip, Llc Compuestos de quinolinona como agonistas de los receptores 5-HT4
US7351304B2 (en) * 2005-05-24 2008-04-01 General Electric Company Method and apparatus for reducing surface defects
US7317022B2 (en) 2005-06-07 2008-01-08 Theravance, Inc. Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists

Also Published As

Publication number Publication date
US20070117796A1 (en) 2007-05-24
ZA200804010B (en) 2009-02-25
EA200801402A1 (ru) 2008-10-30
ATE448224T1 (de) 2009-11-15
WO2007062058A2 (en) 2007-05-31
AR057627A1 (es) 2007-12-05
CN101312967B (zh) 2011-08-24
US7329752B2 (en) 2008-02-12
CA2630222A1 (en) 2007-05-31
CN101312967A (zh) 2008-11-26
PE20070954A1 (es) 2007-09-10
US20080090811A1 (en) 2008-04-17
EP1960396A2 (en) 2008-08-27
WO2007062058A3 (en) 2007-09-07
TW200804366A (en) 2008-01-16
MY143574A (en) 2011-05-31
NZ567653A (en) 2011-06-30
KR20080072727A (ko) 2008-08-06
JP2009516745A (ja) 2009-04-23
DE602006010432D1 (de) 2009-12-24
BRPI0618835A2 (pt) 2011-09-13
ES2336952T3 (es) 2010-04-19
AU2006318507A1 (en) 2007-05-31
EA014819B1 (ru) 2011-02-28
EP1960396B1 (en) 2009-11-11
US7851467B2 (en) 2010-12-14

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