JP2009514894A - ジャイレース阻害剤としてのベンズイミダゾール誘導体 - Google Patents

ジャイレース阻害剤としてのベンズイミダゾール誘導体 Download PDF

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Publication number
JP2009514894A
JP2009514894A JP2008539114A JP2008539114A JP2009514894A JP 2009514894 A JP2009514894 A JP 2009514894A JP 2008539114 A JP2008539114 A JP 2008539114A JP 2008539114 A JP2008539114 A JP 2008539114A JP 2009514894 A JP2009514894 A JP 2009514894A
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JP
Japan
Prior art keywords
ring
membered
compound
cor
nitrogen
Prior art date
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Pending
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JP2008539114A
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English (en)
Japanese (ja)
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JP2009514894A5 (https=
Inventor
ポール シャーリフソン，
デイビッド デニンガー，
ジョセフ ドラム，
アン−ロール グリロー，
アルノー ルティラン，
ユーシェン リャオ，
エマニュエル ペロラ，
スティーブン ロンキン，
ディーン スタモス，
ティエンシェン ワン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2009514894A publication Critical patent/JP2009514894A/ja
Publication of JP2009514894A5 publication Critical patent/JP2009514894A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008539114A 2005-11-07 2006-11-06 ジャイレース阻害剤としてのベンズイミダゾール誘導体 Pending JP2009514894A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73413905P 2005-11-07 2005-11-07
PCT/US2006/043269 WO2007056330A1 (en) 2005-11-07 2006-11-06 Benzimidazole derivatives as gyrase inhibitors

Publications (2)

Publication Number Publication Date
JP2009514894A true JP2009514894A (ja) 2009-04-09
JP2009514894A5 JP2009514894A5 (https=) 2009-10-22

Family

ID=37894258

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008539114A Pending JP2009514894A (ja) 2005-11-07 2006-11-06 ジャイレース阻害剤としてのベンズイミダゾール誘導体

Country Status (7)

Country Link
US (1) US8394803B2 (https=)
EP (1) EP1948635A1 (https=)
JP (1) JP2009514894A (https=)
CN (1) CN101321744A (https=)
AU (1) AU2006311729A1 (https=)
CA (1) CA2626685A1 (https=)
WO (1) WO2007056330A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014503557A (ja) * 2011-01-14 2014-02-13 バーテックス ファーマシューティカルズ インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
JP2014520152A (ja) * 2011-06-20 2014-08-21 バーテックス ファーマシューティカルズ インコーポレイテッド ジャイレースおよびトポイソメラーゼ阻害剤のリン酸エステル

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
MX2010006237A (es) 2007-12-07 2010-12-21 Vertex Pharma Formas solidas de 1-etil-3-(5-(5-fluoropiridin-3-il)-7-(pirimidin- 2-il)-1h-benzo[d]imidazol-2-il)urea.
WO2010027583A1 (en) 2008-09-03 2010-03-11 Universal Display Corporation Phosphorescent materials
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
WO2010111058A1 (en) * 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
US9221765B2 (en) 2009-06-10 2015-12-29 North Carolina State University Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives
BR112012024705A2 (pt) 2010-03-31 2016-06-07 Actelion Pharmaceuticals Ltd derivados antibacterianos de isoquinolin-3-ilureia
WO2011151620A1 (en) 2010-06-01 2011-12-08 Summit Corporation Plc Compounds for the treatment of clostridium difficile associated disease
WO2011151618A2 (en) 2010-06-01 2011-12-08 Summit Corporation Plc Compounds for the treatment of clostridium difficile-associated disease
WO2011151617A1 (en) 2010-06-01 2011-12-08 Summit Corporation Plc Compounds for the treatment of clostridium difficile associated disease
ES2568455T3 (es) 2010-06-01 2016-04-29 Summit Therapeutics Plc Compuestos para el tratamiento de enfermedad asociada a Clostridium difficile
WO2011151619A1 (en) 2010-06-01 2011-12-08 Summit Corporation Plc Compounds for the treatment of clostridium difficile associated disease
WO2012097270A1 (en) 2011-01-14 2012-07-19 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea
US8476281B2 (en) 2011-01-14 2013-07-02 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
CN103384665B (zh) 2011-01-14 2018-01-09 斯派罗吹耐姆公司 制备促旋酶和拓扑异构酶抑制剂的方法
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
WO2014015105A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
US9079935B2 (en) 2012-08-13 2015-07-14 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Reducing risk of contracting Clostridium-difficile associated disease
MX2016010057A (es) 2014-02-03 2017-04-27 Spero Gyrase Inc Compuestos antibacterianos.
CN104945329B (zh) * 2014-03-24 2017-09-01 中国医学科学院医药生物技术研究所 抗结核药物
WO2016127102A2 (en) 2015-02-06 2016-08-11 Ernesto Abel-Santos Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
CA3057431A1 (en) 2017-03-24 2018-09-27 Taisho Pharmaceutical Co., Ltd. 2(1h)-quinolinone derivative
KR102737283B1 (ko) 2019-07-17 2024-12-03 서밋 (옥스포드) 리미티드 리디닐라졸 및 이의 결정 형태의 제조방법
CN111658646B (zh) * 2020-06-28 2021-03-02 河南工业大学 2,6-双(2-苯并咪唑基)吡啶在制备耐碳青霉烯类铜绿假单胞菌感染药物中的应用
GB202100470D0 (en) 2021-01-14 2021-03-03 Summit Oxford Ltd Solid tablet dosage for of ridinilazole
GB202100471D0 (en) 2021-01-14 2021-03-03 Summit Oxford Ltd Preparation of antibacterial compounds
EP4398890A4 (en) 2021-09-09 2025-07-30 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Univ Of Nevada Las Ve C. Difficile Spore Germination Inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004518684A (ja) * 2000-12-15 2004-06-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド 細菌性ジャイレースインヒビターおよびその使用
US20040235886A1 (en) * 2003-01-31 2004-11-25 Charifson Paul S. Gyrase inhibitors and uses thereof
US20050038247A1 (en) * 2003-01-31 2005-02-17 Charifson Paul S. Gyrase inhibitors and uses thereof
JP2005533061A (ja) * 2002-06-13 2005-11-04 バーテックス　ファーマシューティカルズ　インコーポレイテッド 細菌感染を治療するジャイレースおよび／またはトポイソメラーゼｉｖ阻害剤としての２−ウレイド−６−ヘテロアリール−３ｈ−ベンゾイミダゾール−４−カルボン酸誘導体および関連化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004518684A (ja) * 2000-12-15 2004-06-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド 細菌性ジャイレースインヒビターおよびその使用
JP2005533061A (ja) * 2002-06-13 2005-11-04 バーテックス　ファーマシューティカルズ　インコーポレイテッド 細菌感染を治療するジャイレースおよび／またはトポイソメラーゼｉｖ阻害剤としての２−ウレイド−６−ヘテロアリール−３ｈ−ベンゾイミダゾール−４−カルボン酸誘導体および関連化合物
US20040235886A1 (en) * 2003-01-31 2004-11-25 Charifson Paul S. Gyrase inhibitors and uses thereof
WO2005012292A1 (en) * 2003-01-31 2005-02-10 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20050038247A1 (en) * 2003-01-31 2005-02-17 Charifson Paul S. Gyrase inhibitors and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014503557A (ja) * 2011-01-14 2014-02-13 バーテックス ファーマシューティカルズ インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
JP2014520152A (ja) * 2011-06-20 2014-08-21 バーテックス ファーマシューティカルズ インコーポレイテッド ジャイレースおよびトポイソメラーゼ阻害剤のリン酸エステル

Also Published As

Publication number Publication date
AU2006311729A1 (en) 2007-05-18
WO2007056330A1 (en) 2007-05-18
US20130030004A1 (en) 2013-01-31
US8394803B2 (en) 2013-03-12
CA2626685A1 (en) 2007-05-18
CN101321744A (zh) 2008-12-10
EP1948635A1 (en) 2008-07-30

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