JP2009514845A - 味マスキング用多層コーティング技術 - Google Patents

味マスキング用多層コーティング技術 Download PDF

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Publication number
JP2009514845A
JP2009514845A JP2008538438A JP2008538438A JP2009514845A JP 2009514845 A JP2009514845 A JP 2009514845A JP 2008538438 A JP2008538438 A JP 2008538438A JP 2008538438 A JP2008538438 A JP 2008538438A JP 2009514845 A JP2009514845 A JP 2009514845A
Authority
JP
Japan
Prior art keywords
composition
coating layer
coating
aqueous solution
drug substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008538438A
Other languages
English (en)
Japanese (ja)
Inventor
ニコルズ・ウィリアム・マイケル
リー・ウィリー
クルカルニ・ニーマ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson Consumer Inc
Original Assignee
McNeil PPC Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeil PPC Inc filed Critical McNeil PPC Inc
Publication of JP2009514845A publication Critical patent/JP2009514845A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
JP2008538438A 2005-11-02 2006-10-23 味マスキング用多層コーティング技術 Pending JP2009514845A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/265,644 US20070098746A1 (en) 2005-11-02 2005-11-02 Multi-layered coating technology for taste masking
PCT/IB2006/003049 WO2007052121A2 (fr) 2005-11-02 2006-10-23 Technologie de revetement multicouche destinee au masquage du gout

Publications (1)

Publication Number Publication Date
JP2009514845A true JP2009514845A (ja) 2009-04-09

Family

ID=37996624

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008538438A Pending JP2009514845A (ja) 2005-11-02 2006-10-23 味マスキング用多層コーティング技術

Country Status (8)

Country Link
US (1) US20070098746A1 (fr)
EP (1) EP1951209A2 (fr)
JP (1) JP2009514845A (fr)
CN (1) CN101299999A (fr)
AU (1) AU2006310213A1 (fr)
BR (1) BRPI0618175A2 (fr)
CA (1) CA2627584A1 (fr)
WO (1) WO2007052121A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2010119851A1 (ja) * 2009-04-14 2012-10-22 ライオン株式会社 口腔内崩壊錠
JPWO2011118481A1 (ja) * 2010-03-24 2013-07-04 不二製油株式会社 不快味低減方法
WO2016117642A1 (fr) * 2015-01-22 2016-07-28 ニプロ株式会社 Préparation de film
JP2020186219A (ja) * 2019-05-13 2020-11-19 日本ジェネリック株式会社 ソリフェナシンの苦味がマスキングされた粒子状医薬組成物
JP2021104974A (ja) * 2019-12-26 2021-07-26 東和薬品株式会社 フェブキソスタット製剤

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
CA2783877A1 (fr) * 2009-12-10 2011-06-16 A. Mark Schobel Composes sensibles au ph destines a masquer le gout de bandelettes orales sous forme de film mince
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
EP2741736B1 (fr) * 2011-08-12 2017-11-22 Boehringer Ingelheim Vetmedica GmbH Composition pharmaceutique à goût masqué
CN104013606A (zh) * 2014-06-24 2014-09-03 万特制药(海南)有限公司 一种氢溴酸右美沙芬膜剂及其制备方法
FR3027802B1 (fr) * 2014-10-31 2018-03-02 Ethypharm Granules de principe actif a double masquage de gout, leur procede de preparation et comprimes orodispersibles les contenant
CA2992356C (fr) * 2015-07-17 2024-02-13 BE Pharbel Manufacturing Microparticules a liberation de compose pharmaceutiquement actif multicouche sous forme posologique liquide
CN108712900A (zh) 2015-12-19 2018-10-26 第时间美国泛型药物有限公司 软咀嚼片剂药物制剂
US20190022013A1 (en) 2015-12-19 2019-01-24 First Time Us Generics Llc Soft-chew tablet pharmaceutical formulations
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
KR20230137362A (ko) 2016-05-05 2023-10-04 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물
CN108969496A (zh) * 2018-09-07 2018-12-11 江苏恒丰强生物技术有限公司 一种宠物用盐酸贝那普利咀嚼片及其制备方法
IL262768B (en) * 2018-11-04 2020-08-31 Ambrosia Supherb Ltd Chewable tablet and method for its preparation
EP4210499A4 (fr) * 2020-09-10 2024-09-11 Coca Cola Co Film hydrosoluble pour la préparation d'une boisson

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IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
CA2085342A1 (fr) * 1990-06-14 1991-12-15 Milton R. Kaplan Suspension aqueuse stable de medicament
US5837277A (en) * 1992-06-04 1998-11-17 Smithkline Beecham Corporation Palatable pharmaceutical compositions
US5686105A (en) * 1993-10-19 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
US5576014A (en) * 1994-01-31 1996-11-19 Yamanouchi Pharmaceutical Co., Ltd Intrabuccally dissolving compressed moldings and production process thereof
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US20010006677A1 (en) * 1996-10-29 2001-07-05 Mcginity James W. Effervescence polymeric film drug delivery system
WO1998030209A1 (fr) * 1997-01-06 1998-07-16 Pfizer Pharmaceuticals Inc. Forme galenique pharmaceutique a liberation rapide et masquant le gout
NZ503086A (en) * 1997-08-29 2002-03-01 Upjohn Co An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes
US6056977A (en) * 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6221402B1 (en) * 1997-11-20 2001-04-24 Pfizer Inc. Rapidly releasing and taste-masking pharmaceutical dosage form
US5916595A (en) * 1997-12-12 1999-06-29 Andrx Pharmaceutials, Inc. HMG co-reductase inhibitor
US6596298B2 (en) * 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US6096341A (en) * 1998-10-30 2000-08-01 Pharma Pass Llc Delayed release tablet of bupropion hydrochloride
JP2002530322A (ja) * 1998-11-25 2002-09-17 シーマ・ラブス・インコーポレイテッド 味隠蔽迅速放出コーティング系
GB9903539D0 (en) * 1999-02-16 1999-04-07 Stanford Rook Ltd Therapy using M.Vaccae
US8545880B2 (en) * 1999-02-26 2013-10-01 Andrx Pharmaceuticals, Llc Controlled release oral dosage form
US6451345B1 (en) * 2000-01-20 2002-09-17 Eurand Pharmaceuticals Ltd. Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US6499984B1 (en) * 2000-05-22 2002-12-31 Warner-Lambert Company Continuous production of pharmaceutical granulation
AU2003224890A1 (en) * 2002-04-08 2003-10-27 Lavipharm Laboratories Inc. Drug-complex microparticles and methods of making/using same
JP2004026675A (ja) * 2002-06-21 2004-01-29 Lion Corp 咀嚼型医薬製剤用粒子、それを使用した咀嚼型医薬製剤、及び咀嚼型医薬製剤の不快味抑制方法
CA2492789C (fr) * 2002-07-17 2012-07-03 Eurand Pharmaceuticals Limited Procede de preparation de microcapsules pharmaceutiques ayant un meilleur masquage du gout et une vitesse de dissolution elevee
EP1622595A1 (fr) * 2003-05-02 2006-02-08 Warner-Lambert Company LLC Films a dissolution rapide consommables dans la cavite buccale, renfermant un amidon transforme et permettant d'ameliorer la resistance a la chaleur et a l'humidite
US20050232977A1 (en) * 2004-04-20 2005-10-20 Khan Sadath U Metered mixing technology for improved taste masking

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2010119851A1 (ja) * 2009-04-14 2012-10-22 ライオン株式会社 口腔内崩壊錠
JPWO2011118481A1 (ja) * 2010-03-24 2013-07-04 不二製油株式会社 不快味低減方法
JP6024899B2 (ja) * 2010-03-24 2016-11-16 不二製油株式会社 不快味低減方法
WO2016117642A1 (fr) * 2015-01-22 2016-07-28 ニプロ株式会社 Préparation de film
JPWO2016117642A1 (ja) * 2015-01-22 2017-10-26 ニプロ株式会社 フィルム製剤
JP2020186219A (ja) * 2019-05-13 2020-11-19 日本ジェネリック株式会社 ソリフェナシンの苦味がマスキングされた粒子状医薬組成物
JP7394302B2 (ja) 2019-05-13 2023-12-08 日本ジェネリック株式会社 ソリフェナシンの苦味がマスキングされた粒子状医薬組成物
JP2021104974A (ja) * 2019-12-26 2021-07-26 東和薬品株式会社 フェブキソスタット製剤
JP7506475B2 (ja) 2019-12-26 2024-06-26 東和薬品株式会社 フェブキソスタット製剤

Also Published As

Publication number Publication date
US20070098746A1 (en) 2007-05-03
EP1951209A2 (fr) 2008-08-06
BRPI0618175A2 (pt) 2011-08-16
CN101299999A (zh) 2008-11-05
WO2007052121A3 (fr) 2007-10-18
AU2006310213A1 (en) 2007-05-10
CA2627584A1 (fr) 2007-05-10
WO2007052121A2 (fr) 2007-05-10

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