JP2009513575A - 新規なピリミジン誘導体およびそれらの治療における使用ならびにアルツハイマー病を予防および／または治療するための医薬の製造におけるピリミジン誘導体の使用 - Google Patents
新規なピリミジン誘導体およびそれらの治療における使用ならびにアルツハイマー病を予防および／または治療するための医薬の製造におけるピリミジン誘導体の使用 Download PDFInfo
- Publication number
- JP2009513575A JP2009513575A JP2008534486A JP2008534486A JP2009513575A JP 2009513575 A JP2009513575 A JP 2009513575A JP 2008534486 A JP2008534486 A JP 2008534486A JP 2008534486 A JP2008534486 A JP 2008534486A JP 2009513575 A JP2009513575 A JP 2009513575A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- imidazol
- fluoro
- alkyl
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCCC(CN=C(C)[*@@](C)CC)=CCCCCF Chemical compound CCCC(CN=C(C)[*@@](C)CC)=CCCCCF 0.000 description 7
- PKWMGIRIFQYRDG-ZEQRLZLVSA-N CCC1=C(C)N(C2CCOCC2)C(c(nc(Nc(cc2)ccc2S(N2[C@@H](C3)CN(C)[C@@H]3C2)(=O)=O)nc2)c2F)=CC1 Chemical compound CCC1=C(C)N(C2CCOCC2)C(c(nc(Nc(cc2)ccc2S(N2[C@@H](C3)CN(C)[C@@H]3C2)(=O)=O)nc2)c2F)=CC1 PKWMGIRIFQYRDG-ZEQRLZLVSA-N 0.000 description 1
- YRJGDYMGOUSKIM-UHFFFAOYSA-N CCCc(cc1)ccc1[S+](N1CCN(C)CC1)O Chemical compound CCCc(cc1)ccc1[S+](N1CCN(C)CC1)O YRJGDYMGOUSKIM-UHFFFAOYSA-N 0.000 description 1
- LNURPFMACFQLKE-UHFFFAOYSA-N Cc1ncc(C(C(C2)C2=C(Nc(cc2)ccc2C(c2ncccc2)=O)N=C2)=C2F)[n]1C Chemical compound Cc1ncc(C(C(C2)C2=C(Nc(cc2)ccc2C(c2ncccc2)=O)N=C2)=C2F)[n]1C LNURPFMACFQLKE-UHFFFAOYSA-N 0.000 description 1
- DGRDAMKKVRSHBK-UHFFFAOYSA-N O=S(CC1OCCCC1)(c(cc1)ccc1Br)=O Chemical compound O=S(CC1OCCCC1)(c(cc1)ccc1Br)=O DGRDAMKKVRSHBK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0502174 | 2005-10-03 | ||
| PCT/SE2006/001116 WO2007040440A1 (en) | 2005-10-03 | 2006-10-02 | New pyrimidine derivatives and their use in therapy as well as the use of pyrimidine derivatives in the manufacture of a medicament for prevention and/or treatment of alzheimer’s disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009513575A true JP2009513575A (ja) | 2009-04-02 |
| JP2009513575A5 JP2009513575A5 (https=) | 2010-11-11 |
Family
ID=37906403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008534486A Pending JP2009513575A (ja) | 2005-10-03 | 2006-10-02 | 新規なピリミジン誘導体およびそれらの治療における使用ならびにアルツハイマー病を予防および／または治療するための医薬の製造におけるピリミジン誘導体の使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20090105252A1 (https=) |
| EP (1) | EP1945628A4 (https=) |
| JP (1) | JP2009513575A (https=) |
| KR (1) | KR20080059423A (https=) |
| CN (1) | CN101326179A (https=) |
| AR (1) | AR058073A1 (https=) |
| AU (2) | AU2006297890B2 (https=) |
| BR (1) | BRPI0616658A2 (https=) |
| CA (1) | CA2624875A1 (https=) |
| EC (1) | ECSP088405A (https=) |
| IL (1) | IL190150A0 (https=) |
| NO (1) | NO20082067L (https=) |
| NZ (2) | NZ591316A (https=) |
| RU (2) | RU2433128C2 (https=) |
| SG (1) | SG166125A1 (https=) |
| TW (1) | TW200800957A (https=) |
| UA (1) | UA92181C2 (https=) |
| UY (1) | UY29827A1 (https=) |
| WO (1) | WO2007040440A1 (https=) |
| ZA (1) | ZA200802897B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023524935A (ja) * | 2020-03-23 | 2023-06-14 | ファニン ファーマシューティカル カンパニー リミテッド | 新規なピリミジン誘導体及びこれを含む神経退行性疾患及び癌の予防又は治療用組成物 |
| JP2023547220A (ja) * | 2020-10-29 | 2023-11-09 | 蘇州亜宝薬物研発有限公司 | 置換ジアリールアミン化合物及びその医薬組成物、製造方法と用途 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| US7442697B2 (en) | 2002-03-09 | 2008-10-28 | Astrazeneca Ab | 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity |
| GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| TW200815418A (en) * | 2006-06-27 | 2008-04-01 | Astrazeneca Ab | New compounds I |
| TW200815417A (en) * | 2006-06-27 | 2008-04-01 | Astrazeneca Ab | New compounds II |
| WO2009017453A1 (en) * | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | New therapeutic combination of an antipsychotic and a gsk3 inhibitor 958 |
| WO2009017454A1 (en) * | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | New therapeutic combination of a gsk3 inhibitor and an a7-nicotinic agonist 960 |
| WO2009017455A1 (en) * | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | A new combination of (a) an alpha-4-beta-2 -neuronal nicotinic agonist and (b) a gsk3 inhibitor |
| WO2010009166A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Oxindolyl inhibitor compounds |
| NZ602832A (en) | 2008-07-14 | 2014-04-30 | Gilead Sciences Inc | Fused heterocyclic hdac inhibitor compounds |
| JP5640005B2 (ja) * | 2008-07-14 | 2014-12-10 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物 |
| JP2011529504A (ja) | 2008-07-28 | 2011-12-08 | ギリアード サイエンシーズ， インコーポレイテッド | シクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物およびヘテロシクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物 |
| US8536185B2 (en) * | 2008-09-22 | 2013-09-17 | Cayman Chemical Company, Incorporated | Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases |
| JP2012524063A (ja) | 2009-04-15 | 2012-10-11 | アストラゼネカ・アクチエボラーグ | アルツハイマー病などのグリコーゲンシンターゼキナーゼ３関連障害の治療に有用なイミダゾール置換ピリミジン |
| GB0908772D0 (en) * | 2009-05-21 | 2009-07-01 | Astrazeneca Ab | New salts 756 |
| WO2010144378A2 (en) | 2009-06-08 | 2010-12-16 | Gilead Colorado, Inc. | Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds |
| KR20120031170A (ko) | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| WO2012050517A1 (en) * | 2010-10-14 | 2012-04-19 | Astrazeneca Ab | Imidazole substituted pyrimidine having a high gsk3 inhibiting potency as well as pan-kinase selectivity |
| CZ305457B6 (cs) | 2011-02-28 | 2015-09-30 | Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. | Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití |
| JP2017524739A (ja) | 2014-07-17 | 2017-08-31 | アンセルムＩｎｓｅｒｍ | 神経筋接合部関連疾患の処置方法 |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| KR102342803B1 (ko) * | 2020-03-23 | 2021-12-24 | 환인제약 주식회사 | 신규한 피리미딘 유도체 및 이를 포함하는 신경퇴행성 질환 및 암의 예방 또는 치료용 조성물 |
| TW202227401A (zh) * | 2020-10-23 | 2022-07-16 | 大陸商重慶兩江藥物研發中心有限公司 | 用於持續釋放治療劑的前藥及其用途 |
| US20240239774A1 (en) * | 2021-04-28 | 2024-07-18 | Cornell University | Soluble adenylyl cyclase (sac) inhibitors and uses thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004005283A1 (en) * | 2002-07-09 | 2004-01-15 | Vertex Pharmaceuticals Incorporated | Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities |
| JP2004508365A (ja) * | 2000-09-05 | 2004-03-18 | アストラゼネカ アクチボラグ | 抗細胞増殖薬としてのイミダゾロ−５−イル−２−アニリノ−ピリミジン類 |
| JP2004256550A (ja) * | 2002-03-09 | 2004-09-16 | Astrazeneca Ab | 化合物 |
| WO2004101549A1 (en) * | 2003-05-16 | 2004-11-25 | Astrazeneca Ab | 2-anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk (cdk2) inhibitors |
| WO2005075461A1 (en) * | 2004-02-03 | 2005-08-18 | Astrazeneca Ab | Imidazolo-5-yl-2-anilinopyrimidines as agents for the inhibition of cell proliferation |
| JP2005524672A (ja) * | 2002-03-09 | 2005-08-18 | アストラゼネカ アクチボラグ | Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体 |
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| DE3530710A1 (de) | 1985-08-28 | 1987-03-05 | Hoechst Ag | Verfahren zur herstellung von halogenphenyl-oxethyl-sulfiden und deren oxidationsprodukten |
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| EP1423388B1 (en) * | 2001-02-20 | 2008-12-03 | AstraZeneca AB | 2-arylamino-pyrimidines for the treatment of gsk3-related disorders |
| SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
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| GB0229581D0 (en) * | 2002-12-19 | 2003-01-22 | Cyclacel Ltd | Use |
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| WO2004083203A1 (en) * | 2003-03-13 | 2004-09-30 | Vertex Pharmaceuticals Incorporated | Compositions useful as protein kinase inhibitors |
| JP2007500178A (ja) * | 2003-07-30 | 2007-01-11 | サイクラセル・リミテッド | プロテインキナーゼ阻害剤としてのピリジニルアミノ−ピリミジン誘導体 |
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| TW200815418A (en) * | 2006-06-27 | 2008-04-01 | Astrazeneca Ab | New compounds I |
| JP2012524063A (ja) * | 2009-04-15 | 2012-10-11 | アストラゼネカ・アクチエボラーグ | アルツハイマー病などのグリコーゲンシンターゼキナーゼ３関連障害の治療に有用なイミダゾール置換ピリミジン |
-
2006
- 2006-09-29 UY UY29827A patent/UY29827A1/es not_active Application Discontinuation
- 2006-09-29 AR ARP060104310A patent/AR058073A1/es not_active Application Discontinuation
- 2006-10-02 US US12/089,008 patent/US20090105252A1/en not_active Abandoned
- 2006-10-02 RU RU2008110910/04A patent/RU2433128C2/ru not_active IP Right Cessation
- 2006-10-02 UA UAA200802783A patent/UA92181C2/ru unknown
- 2006-10-02 BR BRPI0616658-0A patent/BRPI0616658A2/pt not_active IP Right Cessation
- 2006-10-02 SG SG201007265-0A patent/SG166125A1/en unknown
- 2006-10-02 WO PCT/SE2006/001116 patent/WO2007040440A1/en not_active Ceased
- 2006-10-02 AU AU2006297890A patent/AU2006297890B2/en not_active Ceased
- 2006-10-02 CA CA002624875A patent/CA2624875A1/en not_active Abandoned
- 2006-10-02 KR KR1020087010755A patent/KR20080059423A/ko not_active Ceased
- 2006-10-02 NZ NZ591316A patent/NZ591316A/en not_active IP Right Cessation
- 2006-10-02 CN CNA2006800454648A patent/CN101326179A/zh active Pending
- 2006-10-02 JP JP2008534486A patent/JP2009513575A/ja active Pending
- 2006-10-02 EP EP06799716A patent/EP1945628A4/en not_active Withdrawn
- 2006-10-02 NZ NZ566804A patent/NZ566804A/en not_active IP Right Cessation
- 2006-10-03 TW TW095136796A patent/TW200800957A/zh unknown
-
2008
- 2008-03-13 IL IL190150A patent/IL190150A0/en not_active IP Right Cessation
- 2008-04-02 ZA ZA200802897A patent/ZA200802897B/xx unknown
- 2008-04-28 EC EC2008008405A patent/ECSP088405A/es unknown
- 2008-04-30 NO NO20082067A patent/NO20082067L/no not_active Application Discontinuation
-
2011
- 2011-03-03 AU AU2011200948A patent/AU2011200948A1/en not_active Abandoned
- 2011-04-20 RU RU2011115406/04A patent/RU2011115406A/ru not_active Application Discontinuation
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| JP2004508365A (ja) * | 2000-09-05 | 2004-03-18 | アストラゼネカ アクチボラグ | 抗細胞増殖薬としてのイミダゾロ−５−イル−２−アニリノ−ピリミジン類 |
| JP2004256550A (ja) * | 2002-03-09 | 2004-09-16 | Astrazeneca Ab | 化合物 |
| JP2005524672A (ja) * | 2002-03-09 | 2005-08-18 | アストラゼネカ アクチボラグ | Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体 |
| WO2004005283A1 (en) * | 2002-07-09 | 2004-01-15 | Vertex Pharmaceuticals Incorporated | Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities |
| WO2004101549A1 (en) * | 2003-05-16 | 2004-11-25 | Astrazeneca Ab | 2-anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk (cdk2) inhibitors |
| WO2005075461A1 (en) * | 2004-02-03 | 2005-08-18 | Astrazeneca Ab | Imidazolo-5-yl-2-anilinopyrimidines as agents for the inhibition of cell proliferation |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023524935A (ja) * | 2020-03-23 | 2023-06-14 | ファニン ファーマシューティカル カンパニー リミテッド | 新規なピリミジン誘導体及びこれを含む神経退行性疾患及び癌の予防又は治療用組成物 |
| JP7671775B2 (ja) | 2020-03-23 | 2025-05-02 | ファニン ファーマシューティカル カンパニー リミテッド | 新規なピリミジン誘導体及びこれを含む神経退行性疾患及び癌の予防又は治療用組成物 |
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Also Published As
| Publication number | Publication date |
|---|---|
| IL190150A0 (en) | 2008-08-07 |
| AU2006297890A1 (en) | 2007-04-12 |
| TW200800957A (en) | 2008-01-01 |
| RU2008110910A (ru) | 2009-11-10 |
| KR20080059423A (ko) | 2008-06-27 |
| EP1945628A4 (en) | 2010-06-02 |
| RU2011115406A (ru) | 2012-10-27 |
| BRPI0616658A2 (pt) | 2011-06-28 |
| EP1945628A1 (en) | 2008-07-23 |
| NZ591316A (en) | 2012-06-29 |
| AU2011200948A1 (en) | 2011-03-24 |
| US20090105252A1 (en) | 2009-04-23 |
| AU2006297890B2 (en) | 2011-04-28 |
| ZA200802897B (en) | 2008-12-31 |
| CA2624875A1 (en) | 2007-04-12 |
| SG166125A1 (en) | 2010-11-29 |
| WO2007040440A1 (en) | 2007-04-12 |
| ECSP088405A (es) | 2008-05-30 |
| RU2433128C2 (ru) | 2011-11-10 |
| NO20082067L (no) | 2008-07-02 |
| UY29827A1 (es) | 2007-05-31 |
| AR058073A1 (es) | 2008-01-23 |
| NZ566804A (en) | 2011-03-31 |
| UA92181C2 (ru) | 2010-10-11 |
| CN101326179A (zh) | 2008-12-17 |
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