|
US4503035B1
(en)
|
1978-11-24 |
1996-03-19 |
Hoffmann La Roche |
Protein purification process and product
|
|
US4530901A
(en)
|
1980-01-08 |
1985-07-23 |
Biogen N.V. |
Recombinant DNA molecules and their use in producing human interferon-like polypeptides
|
|
US5231176A
(en)
|
1984-08-27 |
1993-07-27 |
Genentech, Inc. |
Distinct family DNA encoding of human leukocyte interferons
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4868103A
(en)
|
1986-02-19 |
1989-09-19 |
Enzo Biochem, Inc. |
Analyte detection by means of energy transfer
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4843155A
(en)
|
1987-11-19 |
1989-06-27 |
Piotr Chomczynski |
Product and process for isolating RNA
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
CA2087413A1
(en)
|
1992-01-17 |
1993-07-18 |
Joseph R. Lakowicz |
Fluorescent energy transfer immunoassay
|
|
ATE419355T1
(de)
|
1992-02-06 |
2009-01-15 |
Novartis Vaccines & Diagnostic |
Marker für krebs und biosynthetisches bindeprotein dafür
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
JPH07133280A
(ja)
|
1993-11-09 |
1995-05-23 |
Takeda Chem Ind Ltd |
セフェム化合物、その製造法および抗菌組成物
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
CA2218503C
(en)
|
1995-04-20 |
2001-07-24 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
EP0857210B1
(en)
|
1995-10-23 |
2003-09-03 |
The Children's Medical Center Corporation |
Therapeutic antiangiogenic compositions and methods
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
EP0780386B1
(en)
|
1995-12-20 |
2002-10-02 |
F. Hoffmann-La Roche Ag |
Matrix metalloprotease inhibitors
|
|
CH690773A5
(de)
|
1996-02-01 |
2001-01-15 |
Novartis Ag |
Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
|
|
PT885198E
(pt)
|
1996-03-05 |
2002-06-28 |
Astrazeneca Ab |
Derivados de 4-anilinoquinazolina
|
|
CA2259222A1
(en)
|
1996-06-27 |
1997-12-31 |
Pfizer Inc. |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
EP0912559B1
(en)
|
1996-07-13 |
2002-11-06 |
Glaxo Group Limited |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
DE69718472T2
(de)
|
1996-07-13 |
2003-11-06 |
Glaxo Group Ltd., Greenford |
Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren
|
|
KR20000067904A
(ko)
|
1996-07-18 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
매트릭스 메탈로프로테아제의 포스피네이트계 억제제
|
|
BR9711223A
(pt)
|
1996-08-23 |
1999-08-17 |
Pfizer |
Derivados de cido arilsulfonilamino-hidrox mico
|
|
EP0950059B1
(en)
|
1997-01-06 |
2004-08-04 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
IL131042A0
(en)
|
1997-02-03 |
2001-01-28 |
Pfizer Prod Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
BR9807824A
(pt)
|
1997-02-07 |
2000-03-08 |
Pfizer |
Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
|
|
KR20000070923A
(ko)
|
1997-02-11 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
아릴설포닐 하이드록삼산 유도체
|
|
WO1998050356A1
(en)
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
AU734009B2
(en)
|
1997-05-30 |
2001-05-31 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
DE69822839T2
(de)
|
1997-08-08 |
2004-08-19 |
Pfizer Products Inc., Groton |
Derivate von aryloxyarylsulfonylamino hydroxyaminsäuren
|
|
AU8816298A
(en)
|
1997-08-22 |
1999-03-16 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
EP1017682A4
(en)
|
1997-09-26 |
2000-11-08 |
Merck & Co Inc |
NEW ANGIOGENESIS INHIBITORS
|
|
HUP0100287A3
(en)
|
1997-11-11 |
2003-04-28 |
Pfizer Prod Inc |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
JPH11236333A
(ja)
|
1997-12-30 |
1999-08-31 |
Pfizer Prod Inc |
抗ガン剤として有用なイミダゾリン−4−オン誘導体
|
|
GB9800569D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
BR9910511A
(pt)
|
1998-05-15 |
2001-11-20 |
Imclone Systems Inc |
Tratamento de tumores humanos com radiação einibidores de tirosina cinases receptoras de fatorde crescimento
|
|
CA2314156C
(en)
|
1998-05-29 |
2010-05-25 |
Sugen, Inc. |
Pyrrole substituted 2-indolinone protein kinase inhibitors
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
US6566131B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad6 expression
|
|
BR9913315A
(pt)
|
1998-08-27 |
2001-05-22 |
Pfizer Prod Inc |
Derivados de quinolin-2-ona úteis como agentes anticâncer
|
|
CA2341690C
(en)
|
1998-08-27 |
2007-04-17 |
Pfizer Products Inc. |
Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents
|
|
JP2002526500A
(ja)
|
1998-09-18 |
2002-08-20 |
ビーエーエスエフ アクチェンゲゼルシャフト |
プロテインキナーゼ阻害剤としてのピロロピリミジン
|
|
US6410323B1
(en)
|
1999-08-31 |
2002-06-25 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of human Rho family gene expression
|
|
ES2213985T3
(es)
|
1998-11-05 |
2004-09-01 |
Pfizer Products Inc. |
Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico.
|
|
EP1006113A1
(en)
|
1998-12-02 |
2000-06-07 |
Pfizer Products Inc. |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
|
|
US6107091A
(en)
|
1998-12-03 |
2000-08-22 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of G-alpha-16 expression
|
|
EP1006184A1
(en)
*
|
1998-12-03 |
2000-06-07 |
F. Hoffmann-La Roche Ag |
IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
|
|
US5981732A
(en)
|
1998-12-04 |
1999-11-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-13 expression
|
|
WO2000035455A1
(en)
|
1998-12-15 |
2000-06-22 |
Telik, Inc. |
Heteroaryl-aryl ureas as igf-1 receptor antagonists
|
|
EE05627B1
(et)
|
1998-12-23 |
2013-02-15 |
Pfizer Inc. |
CTLA-4 vastased inimese monoklonaalsed antikehad
|
|
JP3270834B2
(ja)
|
1999-01-27 |
2002-04-02 |
ファイザー・プロダクツ・インク |
抗がん剤として有用なヘテロ芳香族二環式誘導体
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
ID29584A
(id)
|
1999-02-11 |
2001-09-06 |
Pfizer Prod Inc |
Turunan-turunan kuinolin-2-on tersubstitusi heteroaril yang bermanfaat sebagai zat-zat anti kanker
|
|
US6586447B1
(en)
|
1999-04-01 |
2003-07-01 |
Pfizer Inc |
3,3-disubstituted-oxindole derivatives useful as anticancer agents
|
|
US6046321A
(en)
|
1999-04-09 |
2000-04-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-i1 expression
|
|
WO2000071129A1
(en)
|
1999-05-21 |
2000-11-30 |
Bristol-Myers Squibb Company |
Pyrrolotriazine inhibitors of kinases
|
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
UA75055C2
(uk)
|
1999-11-30 |
2006-03-15 |
Пфайзер Продактс Інк. |
Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
|
|
ES2212971T3
(es)
|
1999-11-30 |
2004-08-16 |
Pfizer Products Inc. |
Derivados de quinolina utiles para la inhibicion de la farnesil protein transferasa.
|
|
US6448086B1
(en)
*
|
2000-01-18 |
2002-09-10 |
Diagnostic Systems Laboratories, Inc. |
Insulin-like growth factor system and cancer
|
|
HN2000000266A
(es)
|
2000-01-21 |
2001-05-21 |
Pfizer Prod Inc |
Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
|
|
AU2001245793A1
(en)
|
2000-03-16 |
2001-09-24 |
Cold Spring Harbor Laboratory |
Methods and compositions for rna interference
|
|
WO2001072751A1
(en)
|
2000-03-29 |
2001-10-04 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
|
US6365354B1
(en)
|
2000-07-31 |
2002-04-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of lysophospholipase I expression
|
|
US6566135B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of caspase 6 expression
|
|
AR035885A1
(es)
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
|
|
SE0102168D0
(sv)
|
2001-06-19 |
2001-06-19 |
Karolinska Innovations Ab |
New use and new compounds
|
|
US6939874B2
(en)
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
WO2003024967A2
(en)
|
2001-09-19 |
2003-03-27 |
Aventis Pharma S.A. |
Indolizines as kinase protein inhibitors
|
|
AU2002348394A1
(en)
|
2001-10-25 |
2003-05-06 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
|
WO2003035616A2
(en)
|
2001-10-25 |
2003-05-01 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
AU2002348393A1
(en)
|
2001-10-25 |
2003-05-06 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
|
WO2003035619A1
(en)
|
2001-10-25 |
2003-05-01 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
SE0104140D0
(sv)
|
2001-12-07 |
2001-12-07 |
Astrazeneca Ab |
Novel Compounds
|
|
US7241444B2
(en)
*
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
|
US20060046249A1
(en)
*
|
2002-01-18 |
2006-03-02 |
Fei Huang |
Identification of polynucleotides and polypetide for predicting activity of compounds that interact with protein tyrosine kinase and or protein tyrosine kinase pathways
|
|
CA2476000A1
(en)
|
2002-02-14 |
2003-08-21 |
Dana-Farber Cancer Institute Inc. |
Methods and compositions for treating hyperproliferative conditions
|
|
EP2316922B1
(en)
|
2002-05-24 |
2013-05-22 |
Merck Sharp & Dohme Corp. |
Neutralizing human anti-IGFR antibody
|
|
US20040132097A1
(en)
|
2002-06-19 |
2004-07-08 |
Bacus Sarah S. |
Method for predicting response to epidermal growth factor receptor-directed therapy
|
|
TW200501960A
(en)
*
|
2002-10-02 |
2005-01-16 |
Bristol Myers Squibb Co |
Synergistic kits and compositions for treating cancer
|
|
US20040209930A1
(en)
*
|
2002-10-02 |
2004-10-21 |
Carboni Joan M. |
Synergistic methods and compositions for treating cancer
|
|
CA2506066A1
(en)
*
|
2002-11-15 |
2004-06-03 |
Genomic Health, Inc. |
Gene expression profiling of egfr positive cancer
|
|
EP1597558A2
(en)
|
2003-01-08 |
2005-11-23 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
|
|
WO2004071572A2
(en)
|
2003-02-06 |
2004-08-26 |
Genomic Health, Inc. |
Gene expression markers for response to egfr inhibitor drugs
|
|
WO2004086038A2
(en)
|
2003-03-28 |
2004-10-07 |
Institut Curie |
A method for screening compounds having the capacity to control tumor cell invasion or metastasis using constitutively active akt
|
|
CA2527321A1
(en)
|
2003-05-30 |
2004-12-23 |
Genomic Health, Inc. |
Gene expression markers for response to egfr inhibitor drugs
|
|
KR20060031809A
(ko)
*
|
2003-06-09 |
2006-04-13 |
더 리젠츠 오브 더 유니버시티 오브 미시간 |
암 치료 및 진단용 조성물 및 방법
|
|
EP1651209A4
(en)
|
2003-07-24 |
2009-03-04 |
Merck & Co Inc |
TYROSINE KINASE INHIBITORS
|
|
EP1664716A4
(en)
|
2003-08-15 |
2008-08-13 |
Smithkline Beecham Corp |
CANCER BIOMARKERS
|
|
KR100872204B1
(ko)
|
2003-10-15 |
2008-12-09 |
오에스아이 파마슈티컬스, 인코포레이티드 |
이미다조피라진 티로신 키나제 억제제
|
|
TW200526684A
(en)
|
2003-11-21 |
2005-08-16 |
Schering Corp |
Anti-IGFR1 antibody therapeutic combinations
|
|
WO2005070020A2
(en)
*
|
2004-01-23 |
2005-08-04 |
The Regents Of The University Of Colorado |
Gefitinib sensitivity-related gene expression and products and methods related thereto
|
|
US20080113874A1
(en)
*
|
2004-01-23 |
2008-05-15 |
The Regents Of The University Of Colorado |
Gefitinib sensitivity-related gene expression and products and methods related thereto
|
|
WO2005121380A1
(en)
*
|
2004-06-04 |
2005-12-22 |
Smithkline Beecham Corporation |
Predictive biomarkers in cancer therapy
|
|
BRPI0513200A
(pt)
*
|
2004-07-16 |
2008-04-29 |
Pfizer Prod Inc |
uso de um anticorpo anti-igf-1r na preparação de um medicamento para tratamento combinado para malignidades não-hematológicas
|
|
FR2875601B1
(fr)
*
|
2004-09-17 |
2007-04-13 |
Genome Express S A Sa |
Vimentine phosphorylee comme marqueur de l'agressivite et/ou l'invasivite des tumeurs
|
|
ES2356830T3
(es)
*
|
2004-12-03 |
2011-04-13 |
Schering Corporation |
Biomarcadores para preselección de pacientes para terapia de anti-igf-1r.
|
|
WO2006101925A2
(en)
*
|
2005-03-16 |
2006-09-28 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
|
US8383357B2
(en)
*
|
2005-03-16 |
2013-02-26 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
|
AU2006292278B2
(en)
|
2005-09-20 |
2012-03-08 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
EP2027470B1
(en)
|
2006-06-02 |
2012-11-21 |
Pfizer Products Inc. |
Circulating tumor cell assay
|
|
JP2010500577A
(ja)
*
|
2006-08-07 |
2010-01-07 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
癌の予後および予測シグナチャーのプロテオミクスパターン
|
|
WO2008070460A2
(en)
|
2006-11-27 |
2008-06-12 |
The Regents Of The University Of California |
The use of soluble e-cadherin as a novel serum marker
|