JP2009508902A5 - - Google Patents

Download PDF

Info

Publication number
JP2009508902A5
JP2009508902A5 JP2008531609A JP2008531609A JP2009508902A5 JP 2009508902 A5 JP2009508902 A5 JP 2009508902A5 JP 2008531609 A JP2008531609 A JP 2008531609A JP 2008531609 A JP2008531609 A JP 2008531609A JP 2009508902 A5 JP2009508902 A5 JP 2009508902A5
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound
iif
iie
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008531609A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009508902A (ja
Filing date
Publication date
Priority claimed from EP05020508A external-priority patent/EP1764095A1/en
Application filed filed Critical
Publication of JP2009508902A publication Critical patent/JP2009508902A/ja
Publication of JP2009508902A5 publication Critical patent/JP2009508902A5/ja
Pending legal-status Critical Current

Links

JP2008531609A 2005-09-20 2006-09-20 セレクチンリガンド活性を有する新規なニトロカテコール誘導体 Pending JP2009508902A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05020508A EP1764095A1 (en) 2005-09-20 2005-09-20 Novel nitrocatechol derivatives having selectin ligand activity
PCT/EP2006/009155 WO2007039114A1 (en) 2005-09-20 2006-09-20 Novel nitrocatechol derivatives having selectin ligand activity

Publications (2)

Publication Number Publication Date
JP2009508902A JP2009508902A (ja) 2009-03-05
JP2009508902A5 true JP2009508902A5 (enExample) 2009-11-12

Family

ID=35892515

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008531609A Pending JP2009508902A (ja) 2005-09-20 2006-09-20 セレクチンリガンド活性を有する新規なニトロカテコール誘導体

Country Status (10)

Country Link
US (2) US7851501B2 (enExample)
EP (2) EP1764095A1 (enExample)
JP (1) JP2009508902A (enExample)
CN (2) CN101374508B (enExample)
AU (1) AU2006299184B8 (enExample)
BR (1) BRPI0616391A2 (enExample)
CA (1) CA2622935A1 (enExample)
IL (1) IL190157A0 (enExample)
RU (1) RU2428979C2 (enExample)
WO (1) WO2007039114A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
EP1577289A1 (en) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
EP1764093A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764094A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel multi-cyclic compounds and their use
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
ES2488922T3 (es) * 2006-09-29 2014-09-01 Idenix Pharmaceuticals, Inc. Fosfoindoles enantiómeramente puros como inhibidores del HIV
DE102007018151A1 (de) 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
EA015952B1 (ru) 2007-05-03 2011-12-30 Пфайзер Лимитед 2-пиридинкарбоксамидные производные в качестве модуляторов натриевых каналов
BRPI0814441A2 (pt) * 2007-07-19 2015-07-14 Schering Corp Compostos de amida heterocíclica como inibidores de proteína cinase
TWI529165B (zh) * 2008-08-29 2016-04-11 Suntory Holdings Ltd Novel epigallocatechin gallate 3-mer, and the use of alpha-glucosidase inhibitors containing epigallocatechin gallate polymers
WO2010059529A2 (en) * 2008-11-19 2010-05-27 Merial Limited Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof
TWI432188B (zh) * 2008-12-19 2014-04-01 Merz Pharma Gmbh & Co Kgaa 供治療發炎性皮膚疾病之1-胺基-烷基環己烷衍生物類
WO2010069595A1 (en) 2008-12-19 2010-06-24 Merz Pharma Gmbh & Co. Kgaa 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases
US8557805B2 (en) * 2008-12-29 2013-10-15 Takeda Pharmaceutical Company Limited Fused ring compound and use thereof
US8366791B1 (en) 2011-09-02 2013-02-05 Warner Babcock Institute Formulation and method for hair dyeing
US8569372B2 (en) * 2011-09-27 2013-10-29 Hsiao-Ming Chao Method for preventing or treating a disease, disorder or condition induced by retina ischemia
US8828100B1 (en) 2013-10-14 2014-09-09 John C. Warner Formulation and processes for hair coloring
MX392410B (es) * 2015-01-22 2025-03-11 Mitochon Pharmaceuticals Inc Expresión inducida de factor neurotrófico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabólicas.
CN112703009B (zh) 2018-08-17 2024-06-11 宾夕法尼亚大学董事会 治疗急性肺损伤的组合物和方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4363813A (en) * 1979-07-09 1982-12-14 Kureha Kagaku Kogyo Kabushiki Kaisha 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles
JPS58156932A (ja) * 1982-03-11 1983-09-19 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
US4757084A (en) 1984-02-29 1988-07-12 Merck & Co., Inc. 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists
GB2238047B (en) 1989-11-03 1993-02-10 Orion Yhtymae Oy Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
EP0465122A1 (en) 1990-06-29 1992-01-08 Merck & Co. Inc. Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as paf antagonists
US5374772A (en) * 1992-12-08 1994-12-20 Hoffmann-Laroche Inc. Substituted benzoic acids, inhibitors of phospholipases A2
US5444050A (en) 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
HUP9801805A3 (en) 1995-06-29 2002-01-28 Novartis Ag Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a
WO1997001335A1 (en) 1995-06-29 1997-01-16 Texas Biotechnology Corporation Di- and trivalent small molecule selectin inhibitors
DE19532902A1 (de) * 1995-09-06 1997-03-13 Hoechst Ag Neuartige Glycomimetika als Selektin-Antagonisten und daraus hergestellte entzündungshemmend wirkende Arzneimittel
WO1997031864A1 (en) * 1996-03-01 1997-09-04 Dionex Corporation Anion-exchange resins with at least two different nitrogen containing ion-exchange groups
FR2761066B1 (fr) * 1997-03-24 2000-11-24 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
AU1903699A (en) 1997-12-08 1999-06-28 Glycomed Incorporated Disalicylate analog based sialyl lewisx mimetics
AU1804299A (en) 1997-12-08 1999-06-28 Glycomed Incorporated Sialyl lewis x and sialyl lewis a glycomimetics
AU2164300A (en) 1998-12-04 2000-06-26 N.V. Organon Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin
GB2344819A (en) * 1998-12-18 2000-06-21 Portela & Ca Sa 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones
US6248790B1 (en) 2000-06-29 2001-06-19 Parker Hughes Institute Treatment of inflammation with 2,4,6-trihydroxy-alpha-rho-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives
US6432957B1 (en) * 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
WO2003009807A2 (en) * 2001-07-23 2003-02-06 Galileo Laboratories, Inc. Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods
JP2003055369A (ja) 2001-08-06 2003-02-26 Univ Nihon 新規なフロログルシノール誘導体、及びこれを用いた組成物、抗アレルギー剤
AU2002246135A1 (en) 2002-03-14 2003-09-22 Bobel 246, S.L. Use of derivatives of 2,4-disubstituted phenols as inhibitors of the expression of l-selectins and of the isoform that is inducible from nitric oxide synthase
JP4266348B2 (ja) * 2002-03-27 2009-05-20 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ Ddqの媒介するジヒドロアサロンの二量体化によるネオリグナンの生成
JP5183010B2 (ja) 2002-05-16 2013-04-17 グリコミメティクス, インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
EP1527086B1 (en) 2002-08-09 2008-01-09 Astellas Pharma Europe B.V. Compounds binding to p-selectin
US20060100245A1 (en) * 2002-12-19 2006-05-11 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues
US20060188557A1 (en) 2003-05-23 2006-08-24 Hisamitsu Pharmaceutical Co., Inc. Prepartaion for external percutaneous administration containing non-steroidal anti-inflammatory drug and interleukin-1 alpha production inhibitor
EP1481669A1 (en) * 2003-05-30 2004-12-01 Yamanouchi Pharmaceutical Co. Ltd. Use of polyhydroxy phenols and polyphenols for modulating p-selectin activity
DE602004011272T2 (de) * 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
EP1577289A1 (en) * 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764093A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP1764094A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel multi-cyclic compounds and their use

Similar Documents

Publication Publication Date Title
ES2741439T3 (es) Compuestos aromáticos sustituidos
JP2009084270A5 (enExample)
NL8002370A (nl) Esters van acyl-carnitinen, werkwijzen ter bereiding ervan en farmaceutische preparaten, die dergelijke esters bevatten.
CN102079703B (zh) 一种非甾体抗炎药制备方法及其抗炎镇痛作用
JP2009536191A5 (enExample)
US9296678B2 (en) Injectable formulation for treatment and protection of patients having an Inflammatory Reaction or an Ischemia-reperfusion event
RU2008115464A (ru) Новые производные нитрокатехола, обладающие активностью в качестве лигандов селектина
JP2020529988A5 (enExample)
JP2022503890A (ja) 2-(1-アシルオキシ-n-ペンチル)安息香酸と塩基性アミノ酸またはアミノグアニジンによって形成される塩と、その製造方法及び用途
JP2014511897A5 (enExample)
JP2005526832A (ja) α−ケトアルカン酸エステルまたは−アミドおよび乳酸または乳酸塩を含有する医薬組成物
RU2008115434A (ru) Новые производные флороглюцина, обладающие активностью в отношении лиганда селектина
CN103819379A (zh) 维生素d3的胆甾烷醇共结晶及其制备方法和应用
CN102225913B (zh) 大黄酸衍生物以及它们的治疗用途
CN1475488A (zh) 含氟异黄酮衍生物、制造方法及其用途
JP6952911B2 (ja) 2−(αヒドロキシペンチル)安息香酸の有機アミンエステル誘導体薬物
CN104356038A (zh) 维生素d2与d3的共晶及其制备方法和用途
CN104098644B (zh) 闭花木酮Cleistanone的O-(哌啶基)乙基衍生物、制备方法及其用途
RU2008115491A (ru) Новые полициклические соединения
CN108218814A (zh) 靶向sirt3激动剂及其在aml治疗药物中的应用
CN103483282B (zh) 苯基取代的三唑酰胺类化合物及用途
CN101851218A (zh) 4,5-二取代芳基异硒唑类衍生物及其用途
CN119039147B (zh) 一种含氟长链化合物、其自组装结构、其制备方法及其用途
CN115594686B (zh) 一类millpuline A衍生物及其制备方法和医药用途
CN103467398B (zh) 三唑酰胺类化合物、其制备方法和其抗糖尿病用途