JP2009508902A5 - - Google Patents
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- Publication number
- JP2009508902A5 JP2009508902A5 JP2008531609A JP2008531609A JP2009508902A5 JP 2009508902 A5 JP2009508902 A5 JP 2009508902A5 JP 2008531609 A JP2008531609 A JP 2008531609A JP 2008531609 A JP2008531609 A JP 2008531609A JP 2009508902 A5 JP2009508902 A5 JP 2009508902A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- iif
- iie
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000034486 Multi-organ failure Diseases 0.000 claims 1
- 208000010718 Multiple Organ Failure Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010044541 Traumatic shock Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003596 drug target Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05020508A EP1764095A1 (en) | 2005-09-20 | 2005-09-20 | Novel nitrocatechol derivatives having selectin ligand activity |
| PCT/EP2006/009155 WO2007039114A1 (en) | 2005-09-20 | 2006-09-20 | Novel nitrocatechol derivatives having selectin ligand activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009508902A JP2009508902A (ja) | 2009-03-05 |
| JP2009508902A5 true JP2009508902A5 (enExample) | 2009-11-12 |
Family
ID=35892515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008531609A Pending JP2009508902A (ja) | 2005-09-20 | 2006-09-20 | セレクチンリガンド活性を有する新規なニトロカテコール誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7851501B2 (enExample) |
| EP (2) | EP1764095A1 (enExample) |
| JP (1) | JP2009508902A (enExample) |
| CN (2) | CN103230389A (enExample) |
| AU (1) | AU2006299184B8 (enExample) |
| BR (1) | BRPI0616391A2 (enExample) |
| CA (1) | CA2622935A1 (enExample) |
| IL (1) | IL190157A0 (enExample) |
| RU (1) | RU2428979C2 (enExample) |
| WO (1) | WO2007039114A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6838452B2 (en) * | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764096A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP1764094A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel multi-cyclic compounds and their use |
| NZ575831A (en) * | 2006-09-29 | 2011-12-22 | Idenix Pharmaceuticals Inc | Enantiomerically pure phosphoindoles as hiv inhibitors |
| DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| AP2516A (en) | 2007-05-03 | 2012-11-26 | Pfizer Ltd | 2-Pyridine carboxamide derivatives as sodium channel modulators |
| KR101552742B1 (ko) * | 2007-07-19 | 2015-09-11 | 머크 샤프 앤드 돔 코포레이션 | 단백질 키나제 억제제로서의 헤테로사이클릭 아미드 화합물 |
| JP5555166B2 (ja) * | 2008-08-29 | 2014-07-23 | サントリーホールディングス株式会社 | 新規エピガロカテキンガレート3量体、およびエピガロカテキンガレート重合体を含むα−グルコシダーゼ阻害剤 |
| CN102271672B (zh) * | 2008-11-19 | 2015-02-04 | 梅里亚有限公司 | 用于治疗寄生物感染的包含单独的或与甲脒组合的1-芳基吡唑的组合物 |
| TWI432188B (zh) * | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之1-胺基-烷基環己烷衍生物類 |
| KR101335118B1 (ko) | 2008-12-19 | 2013-12-05 | 메르츠 파마 게엠베하 운트 코. 카가아 | 비만 세포 매개 질환의 치료를 위한 1-아미노-알킬시클로헥산 유도체 |
| EP2371826A4 (en) * | 2008-12-29 | 2012-06-27 | Takeda Pharmaceutical | NEW CONNECTION WITH CONDENSED RINGS AND ITS USE |
| US8366791B1 (en) | 2011-09-02 | 2013-02-05 | Warner Babcock Institute | Formulation and method for hair dyeing |
| US8569372B2 (en) * | 2011-09-27 | 2013-10-29 | Hsiao-Ming Chao | Method for preventing or treating a disease, disorder or condition induced by retina ischemia |
| US8828100B1 (en) | 2013-10-14 | 2014-09-09 | John C. Warner | Formulation and processes for hair coloring |
| CN116617195A (zh) * | 2015-01-22 | 2023-08-22 | 米托充制药公司 | 脑源性神经营养因子的诱导表达 |
| CA3109798A1 (en) | 2018-08-17 | 2020-02-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of acute lung injury |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4363813A (en) * | 1979-07-09 | 1982-12-14 | Kureha Kagaku Kogyo Kabushiki Kaisha | 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles |
| JPS58156932A (ja) * | 1982-03-11 | 1983-09-19 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| US4757084A (en) | 1984-02-29 | 1988-07-12 | Merck & Co., Inc. | 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists |
| GB2238047B (en) | 1989-11-03 | 1993-02-10 | Orion Yhtymae Oy | Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation |
| CA2045863A1 (en) | 1990-06-29 | 1991-12-30 | Ichiro Shinkai | Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as paf antagonists |
| US5374772A (en) * | 1992-12-08 | 1994-12-20 | Hoffmann-Laroche Inc. | Substituted benzoic acids, inhibitors of phospholipases A2 |
| US5444050A (en) | 1994-04-29 | 1995-08-22 | Texas Biotechnology Corporation | Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa |
| CA2224346A1 (en) | 1995-06-29 | 1997-01-16 | Novartis Ag | Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a |
| WO1997001335A1 (en) | 1995-06-29 | 1997-01-16 | Texas Biotechnology Corporation | Di- and trivalent small molecule selectin inhibitors |
| DE19532902A1 (de) * | 1995-09-06 | 1997-03-13 | Hoechst Ag | Neuartige Glycomimetika als Selektin-Antagonisten und daraus hergestellte entzündungshemmend wirkende Arzneimittel |
| DE69727048T2 (de) * | 1996-03-01 | 2004-11-11 | Dionex Corp., Sunnyvale | Anionenaustauscherharze mit mindestens zwei verschiedenen nitrogenen, die ionenaustauschergruppen enthalten |
| FR2761066B1 (fr) * | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| AU1804299A (en) | 1997-12-08 | 1999-06-28 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
| AU1903699A (en) | 1997-12-08 | 1999-06-28 | Glycomed Incorporated | Disalicylate analog based sialyl lewisx mimetics |
| AU2164300A (en) | 1998-12-04 | 2000-06-26 | N.V. Organon | Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin |
| GB2344819A (en) * | 1998-12-18 | 2000-06-21 | Portela & Ca Sa | 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones |
| US6248790B1 (en) | 2000-06-29 | 2001-06-19 | Parker Hughes Institute | Treatment of inflammation with 2,4,6-trihydroxy-alpha-rho-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives |
| US6432957B1 (en) * | 2001-06-29 | 2002-08-13 | Kowa Co., Ltd. | Piperazine derivative |
| EP1435894A4 (en) * | 2001-07-23 | 2005-07-06 | Galileo Pharmaceuticals Inc | CYTOPROTECTIVE COMPOUNDS, PHARMACEUTICAL AND COSMETIC FORMULATIONS AND METHOD |
| JP2003055369A (ja) | 2001-08-06 | 2003-02-26 | Univ Nihon | 新規なフロログルシノール誘導体、及びこれを用いた組成物、抗アレルギー剤 |
| AU2002246135A1 (en) | 2002-03-14 | 2003-09-22 | Bobel 246, S.L. | Use of derivatives of 2,4-disubstituted phenols as inhibitors of the expression of l-selectins and of the isoform that is inducible from nitric oxide synthase |
| ATE380785T1 (de) * | 2002-03-27 | 2007-12-15 | Council Scient Ind Res | Herstellung eines neolignans mittels durch ddq vermittelte dimerisierung von dihydroasaron |
| US7060685B2 (en) | 2002-05-16 | 2006-06-13 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| BR0313019A (pt) | 2002-08-09 | 2005-07-12 | Yamanouchi Europ Bv | Compostos que se ligam a p-selectina |
| CA2510471A1 (en) * | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| JPWO2004112837A1 (ja) | 2003-05-23 | 2006-07-20 | 久光製薬株式会社 | 非ステロイド系消炎鎮痛剤含有外用経皮製剤およびインターロイキン−1α生成抑制剤 |
| EP1481669A1 (en) * | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | Use of polyhydroxy phenols and polyphenols for modulating p-selectin activity |
| US7361644B2 (en) * | 2003-11-19 | 2008-04-22 | Glycomimetics, Inc. | Specific antagonist for both E- and P-selectins |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| EP1764094A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel multi-cyclic compounds and their use |
| EP1764096A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764093A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
-
2005
- 2005-09-20 EP EP05020508A patent/EP1764095A1/en not_active Withdrawn
-
2006
- 2006-09-20 EP EP06805784A patent/EP1937238A1/en not_active Withdrawn
- 2006-09-20 CN CN2013100951106A patent/CN103230389A/zh active Pending
- 2006-09-20 JP JP2008531609A patent/JP2009508902A/ja active Pending
- 2006-09-20 AU AU2006299184A patent/AU2006299184B8/en not_active Ceased
- 2006-09-20 US US12/067,341 patent/US7851501B2/en not_active Expired - Fee Related
- 2006-09-20 RU RU2008115464/15A patent/RU2428979C2/ru not_active IP Right Cessation
- 2006-09-20 CA CA002622935A patent/CA2622935A1/en not_active Abandoned
- 2006-09-20 WO PCT/EP2006/009155 patent/WO2007039114A1/en not_active Ceased
- 2006-09-20 CN CN2006800387821A patent/CN101374508B/zh not_active Expired - Fee Related
- 2006-09-20 BR BRPI0616391-2A patent/BRPI0616391A2/pt not_active IP Right Cessation
-
2008
- 2008-03-13 IL IL190157A patent/IL190157A0/en unknown
-
2010
- 2010-11-08 US US12/941,369 patent/US20110053939A1/en not_active Abandoned
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