IL190157A0 - Novel nitrocatechol derivatives having selectin ligand activity - Google Patents

Novel nitrocatechol derivatives having selectin ligand activity

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Publication number
IL190157A0
IL190157A0 IL190157A IL19015708A IL190157A0 IL 190157 A0 IL190157 A0 IL 190157A0 IL 190157 A IL190157 A IL 190157A IL 19015708 A IL19015708 A IL 19015708A IL 190157 A0 IL190157 A0 IL 190157A0
Authority
IL
Israel
Prior art keywords
selectin ligand
ligand activity
nitrocatechol derivatives
novel
novel nitrocatechol
Prior art date
Application number
IL190157A
Other languages
English (en)
Original Assignee
Revotar Biopharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revotar Biopharmaceuticals Ag filed Critical Revotar Biopharmaceuticals Ag
Publication of IL190157A0 publication Critical patent/IL190157A0/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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IL190157A 2005-09-20 2008-03-13 Novel nitrocatechol derivatives having selectin ligand activity IL190157A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05020508A EP1764095A1 (en) 2005-09-20 2005-09-20 Novel nitrocatechol derivatives having selectin ligand activity
PCT/EP2006/009155 WO2007039114A1 (en) 2005-09-20 2006-09-20 Novel nitrocatechol derivatives having selectin ligand activity

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IL190157A0 true IL190157A0 (en) 2008-08-07

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IL190157A IL190157A0 (en) 2005-09-20 2008-03-13 Novel nitrocatechol derivatives having selectin ligand activity

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US (2) US7851501B2 (enExample)
EP (2) EP1764095A1 (enExample)
JP (1) JP2009508902A (enExample)
CN (2) CN103230389A (enExample)
AU (1) AU2006299184B8 (enExample)
BR (1) BRPI0616391A2 (enExample)
CA (1) CA2622935A1 (enExample)
IL (1) IL190157A0 (enExample)
RU (1) RU2428979C2 (enExample)
WO (1) WO2007039114A1 (enExample)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
EP1577289A1 (en) * 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
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