JP2009504138A - イソプレノイド修飾酵素をコードするポリヌクレオチド、およびその使用方法 - Google Patents

イソプレノイド修飾酵素をコードするポリヌクレオチド、およびその使用方法 Download PDF

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JP2009504138A
JP2009504138A JP2008519611A JP2008519611A JP2009504138A JP 2009504138 A JP2009504138 A JP 2009504138A JP 2008519611 A JP2008519611 A JP 2008519611A JP 2008519611 A JP2008519611 A JP 2008519611A JP 2009504138 A JP2009504138 A JP 2009504138A
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nucleotide sequence
isoprenoid
host cell
nucleic acid
terpene
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JP2009504138A5 (enExample
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デ−ギョン ロ
カーリン ニューマン
エリック エム． パラダイス
ジェイ ディー． キースリング
マリオ ウェレット
レイチェル エアチュス
キンバリー ホー
ティモシー ハム
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University of California
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University of California
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
JP2008519611A 2005-07-05 2006-06-29 イソプレノイド修飾酵素をコードするポリヌクレオチド、およびその使用方法 Withdrawn JP2009504138A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69706705P 2005-07-05 2005-07-05
PCT/US2006/025572 WO2007005604A2 (en) 2005-07-05 2006-06-29 Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof

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JP2009504138A true JP2009504138A (ja) 2009-02-05
JP2009504138A5 JP2009504138A5 (enExample) 2009-09-10

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JP2008519611A Withdrawn JP2009504138A (ja) 2005-07-05 2006-06-29 イソプレノイド修飾酵素をコードするポリヌクレオチド、およびその使用方法

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US (2) US8163980B2 (enExample)
EP (2) EP2489672B1 (enExample)
JP (1) JP2009504138A (enExample)
KR (2) KR101444090B1 (enExample)
CN (4) CN105950667A (enExample)
AP (1) AP3827A (enExample)
BR (1) BRPI0612411B8 (enExample)
CA (1) CA2613469C (enExample)
DK (1) DK1919514T3 (enExample)
ES (2) ES2621657T3 (enExample)
IL (1) IL188376A (enExample)
MX (1) MX2008000200A (enExample)
PL (1) PL1919514T3 (enExample)
PT (1) PT1919514E (enExample)
SG (1) SG176459A1 (enExample)
SI (1) SI1919514T1 (enExample)
WO (1) WO2007005604A2 (enExample)
ZA (1) ZA200800889B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014007285A1 (ja) * 2012-07-04 2014-01-09 住友ゴム工業株式会社 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
JP2014532418A (ja) * 2011-11-01 2014-12-08 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ シトクロムｐ４５０及びテルペンの酵素的酸化のためのそれらの使用

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JP5590769B2 (ja) 2004-07-27 2014-09-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア イソプレノイド化合物を生産するための遺伝的に修飾された宿主細胞および同宿主細胞の使用方法
ES2621657T3 (es) * 2005-07-05 2017-07-04 The Regents Of The University Of California Polinucleótidos que codifican enzimas modificadoras de isoprenoides y procedimientos de uso de los mismos
DK2024504T4 (da) 2006-05-26 2023-02-27 Amyris Inc Fremstilling af isoprenoider
WO2008039499A2 (en) * 2006-09-26 2008-04-03 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
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WO2009036087A1 (en) 2007-09-11 2009-03-19 Sapphire Energy, Inc. Methods of producing organic products with photosynthetic organisms and products and compositions thereof
EP2444415A1 (en) * 2010-10-20 2012-04-25 Genoplante-Valor 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis
BR112015004734A2 (pt) * 2012-09-07 2017-11-21 Sanofi Sa proteínas de fusão para tratar uma síndrome metabólica
PL224377B1 (pl) * 2012-11-02 2016-12-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczep Trichoderma atroviride, sposób otrzymywania i zastosowanie szczepu Trichoderma atroviride jako środka biobójczego
US9909145B2 (en) * 2013-09-19 2018-03-06 Firmenich Sa Method for producing fragrant alcohols
WO2016027943A1 (ko) * 2014-08-21 2016-02-25 중앙대학교 산학협력단 rDNA NTS 기반 유전자 다중 삽입 카세트 세트 및 이를 이용한 GRAS 등급의 재조합 효모 균주
US20180142273A1 (en) * 2015-04-15 2018-05-24 William Marsh Rice University Iterative platform for the synthesis of alpha functionalized products
US11697830B2 (en) * 2015-04-15 2023-07-11 Ramon Gonzalez Iterative platform for the synthesis of alpha functionalized products
CN105274109B (zh) * 2015-10-30 2017-12-29 上海交通大学 一种调控基因在非分泌型腺毛中表达的启动子及其应用
CN105177007B (zh) * 2015-10-30 2017-11-10 上海交通大学 一种调控基因在非分泌型腺毛中表达的启动子及其应用
CN105483236A (zh) * 2015-12-26 2016-04-13 吉林省农业科学院 转基因植物中cry1C基因的LAMP检测引物组、试剂盒及检测方法
CN105567685B (zh) * 2016-01-18 2018-07-13 上海交通大学 AaPDR3基因启动子及其应用
CN117587015A (zh) * 2016-09-20 2024-02-23 22世纪公司 用于操纵腺毛中的大麻素和其他化合物的毛状体特异性启动子
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
MX2019011323A (es) 2017-03-24 2020-01-27 Trait Biosciences Inc Biosintesis y aislamiento in vivo de alto nivel de cannabinoides solubles en agua en sistemas de plantas.
US11905543B2 (en) 2017-07-11 2024-02-20 Trait Biosceinces, Inc. In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures
US11946059B2 (en) 2017-07-11 2024-04-02 Trait Biosciences, Inc. In vivo generation of water-soluble cannabinoids in plant cell suspension cultures
EP3730145A1 (en) 2017-07-11 2020-10-28 Trait Biosciences, Inc. Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter
CN113302298B (zh) 2018-11-09 2025-02-25 银杏生物制品公司 罗汉果甙的生物合成
CN115176023A (zh) * 2020-01-23 2022-10-11 阿米瑞斯公司 紫穗槐-4,11-二烯12-单加氧酶变体及其用途
CN111621508B (zh) * 2020-06-11 2022-07-01 云南中烟工业有限责任公司 烟草萜类合成酶NtTPS7基因及其载体与应用

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014532418A (ja) * 2011-11-01 2014-12-08 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ シトクロムｐ４５０及びテルペンの酵素的酸化のためのそれらの使用
JP2017042161A (ja) * 2011-11-01 2017-03-02 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ シトクロムｐ４５０、及びテルペンの酵素的酸化のためのそれらの使用
WO2014007285A1 (ja) * 2012-07-04 2014-01-09 住友ゴム工業株式会社 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
JP2014011972A (ja) * 2012-07-04 2014-01-23 Sumitomo Rubber Ind Ltd 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
US9834779B2 (en) 2012-07-04 2017-12-05 Sumitomo Rubber Industries, Ltd. Method for regulating expression of specific protein using photoresponsive transcriptional factor, isoprenoid-producing plant having gene encoding photoresponsive transcriptional factor introduced thereinto, and method for producing polyisoprenoid using said isoprenoid-producing plant

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CN103667370A (zh) 2014-03-26
SG176459A1 (en) 2011-12-29
SI1919514T1 (sl) 2012-08-31
MX2008000200A (es) 2008-04-07
IL188376A (en) 2012-12-31
US8163980B2 (en) 2012-04-24
EP1919514A2 (en) 2008-05-14
CN101495499B (zh) 2013-09-04
US20120288905A1 (en) 2012-11-15
WO2007005604A3 (en) 2008-12-31
ZA200800889B (en) 2009-09-30
BRPI0612411B1 (pt) 2020-05-05
CA2613469A1 (en) 2007-01-11
BRPI0612411B8 (pt) 2021-05-25
PL1919514T3 (pl) 2012-10-31
US8759632B2 (en) 2014-06-24
CA2613469C (en) 2014-08-12
KR20080031054A (ko) 2008-04-07
BRPI0612411A2 (pt) 2010-11-09
HK1134495A1 (en) 2010-04-30
EP2489672A3 (en) 2013-01-09
WO2007005604A2 (en) 2007-01-11
CN101495499A (zh) 2009-07-29
ES2621657T3 (es) 2017-07-04
IL188376A0 (en) 2008-04-13
BRPI0612411A8 (pt) 2017-12-26
CN103667370B (zh) 2016-08-10
KR101487304B1 (ko) 2015-01-28
EP2489672A2 (en) 2012-08-22
AP3827A (en) 2016-09-30
KR20130054468A (ko) 2013-05-24
KR101444090B1 (ko) 2014-09-26
AP2013006962A0 (en) 2013-07-31
EP1919514A4 (en) 2009-12-02
DK1919514T3 (da) 2012-08-20
US20100218283A1 (en) 2010-08-26
PT1919514E (pt) 2012-08-16
EP2489672B1 (en) 2017-01-18
EP1919514B1 (en) 2012-05-16
CN106939323A (zh) 2017-07-11
CN106939323B (zh) 2021-07-13
CN105950667A (zh) 2016-09-21
ES2386554T3 (es) 2012-08-22

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