JP2009502167A5 - - Google Patents
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- JP2009502167A5 JP2009502167A5 JP2008523951A JP2008523951A JP2009502167A5 JP 2009502167 A5 JP2009502167 A5 JP 2009502167A5 JP 2008523951 A JP2008523951 A JP 2008523951A JP 2008523951 A JP2008523951 A JP 2008523951A JP 2009502167 A5 JP2009502167 A5 JP 2009502167A5
- Authority
- JP
- Japan
- Prior art keywords
- cell line
- antibody
- protein
- inhibitor
- caspase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/187,863 | 2005-07-25 | ||
| US11/187,863 US7531327B2 (en) | 2004-07-23 | 2005-07-25 | Methods and compositions for increasing longevity and protein yield from a cell culture |
| PCT/US2006/027820 WO2007015848A2 (en) | 2005-07-25 | 2006-07-14 | Improved methods and compositions for increasing longevity and protein yield from a cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013084178A Division JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502167A JP2009502167A (ja) | 2009-01-29 |
| JP2009502167A5 true JP2009502167A5 (https=) | 2009-08-27 |
| JP5301990B2 JP5301990B2 (ja) | 2013-09-25 |
Family
ID=37709058
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008523951A Active JP5301990B2 (ja) | 2005-07-25 | 2006-07-14 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
| JP2013084178A Pending JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013084178A Pending JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7531327B2 (https=) |
| EP (1) | EP1910515B1 (https=) |
| JP (2) | JP5301990B2 (https=) |
| KR (2) | KR20130027579A (https=) |
| CN (1) | CN101273121B (https=) |
| AU (1) | AU2006276182B2 (https=) |
| CA (1) | CA2616799C (https=) |
| WO (1) | WO2007015848A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8658773B2 (en) | 2011-05-02 | 2014-02-25 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| US7608425B2 (en) * | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| US20070092947A1 (en) * | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| WO2009151591A2 (en) * | 2008-06-10 | 2009-12-17 | Sangamo Biosciences, Inc. | Methods and compositions for generation of bax- and bak-deficient cell lines |
| US20090325287A1 (en) * | 2008-06-13 | 2009-12-31 | Haimanti Dorai | Methods for Obtaining High Viable Cell Density in Mammalian Cell Culture |
| DE102008051574A1 (de) * | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
| US20160095939A1 (en) | 2014-10-07 | 2016-04-07 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| JP2012518409A (ja) | 2009-02-20 | 2012-08-16 | ベントリア・バイオサイエンス | タンパク質の組み合わせを含有する細胞培養培地 |
| CN101899471B (zh) * | 2009-05-26 | 2014-06-11 | 中国医学科学院基础医学研究所 | 同时表达抗原特异性受体和外源基因的重组逆转录病毒载体、用其修饰的b-淋巴细胞及其用途 |
| EP2478110B1 (en) | 2009-09-16 | 2016-01-06 | Immunomedics, Inc. | Class i anti-cea antibodies and uses thereof |
| ES2978177T3 (es) | 2009-12-02 | 2024-09-06 | Immunomedics Inc | Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer |
| US20120028933A1 (en) | 2010-07-28 | 2012-02-02 | Baust John M | Cell Culture Media Supplement and Method of Molecular Stress Control |
| JP5665065B2 (ja) | 2011-04-28 | 2015-02-04 | 国立大学法人大阪大学 | リソソーム病治療用医薬組成物 |
| CN103031277B (zh) * | 2011-09-29 | 2015-07-15 | 重庆大学 | 力生长因子在制备无血清培养耐受型哺乳动物工程细胞中的应用 |
| CN104379169A (zh) | 2012-08-14 | 2015-02-25 | Ibc药品公司 | 用于治疗疾病的t-细胞重定向双特异性抗体 |
| WO2017004144A1 (en) | 2015-07-01 | 2017-01-05 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| CA2898472C (en) * | 2013-02-15 | 2023-03-07 | Immunomedics, Inc. | Chimeric and humanized anti-histone antibodies |
| JP6683598B2 (ja) | 2013-03-15 | 2020-04-22 | マックスサイト インコーポレーティッド | 安定なトランスフェクトされた細胞を生成するための方法および組成物 |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| KR102243980B1 (ko) * | 2013-10-11 | 2021-04-26 | 리제너론 파마슈티칼스 인코포레이티드 | 대사적으로 최적화된 세포 배양 |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ，インコーポレイテッド | Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療 |
| CA2935748A1 (en) | 2014-02-25 | 2015-09-03 | Immunomedics, Inc. | Humanized rfb4 anti-cd22 antibody |
| EP3160504B1 (en) | 2014-06-24 | 2020-09-16 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| CN107980059B (zh) | 2015-04-13 | 2022-11-11 | 美克斯细胞有限公司 | 用于修饰基因组dna的方法和组合物 |
| AU2016252771B2 (en) | 2015-04-22 | 2021-12-16 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells |
| US10745663B2 (en) * | 2015-07-17 | 2020-08-18 | Ares Trading S.A. | Methods for modulating production profiles of recombinant proteins |
| TWI784063B (zh) * | 2017-12-27 | 2022-11-21 | 財團法人生物技術開發中心 | 具有增進蛋白質表現功效的宿主細胞及其用途 |
| US12497624B2 (en) | 2018-07-13 | 2025-12-16 | Lonza Ltd | Methods for improving production of biological products by reducing the level of endogenous protein |
| CN111349615B (zh) * | 2018-12-24 | 2024-08-13 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的细胞的方法 |
| WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
| EP4455274A4 (en) * | 2021-11-26 | 2025-12-31 | Iucf Hyu | ESTABLISHMENT OF AN ERIETHROID PRECURSOR CELL LINE CAPABLE OF CONDITIONAL MATURATION USING GENE OVEREXPRESSION |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0471484A (ja) * | 1990-07-11 | 1992-03-06 | Teijin Ltd | 低凝集性細胞及びその培養方法 |
| US5550019A (en) | 1993-05-26 | 1996-08-27 | La Jolla Cancer Research Foundation | Methods of identifying compounds which alter apoptosis |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| CA2384880C (en) * | 1999-09-27 | 2010-09-21 | Genentech, Inc. | Methods for making recombinant proteins using apoptosis inhibitors |
| WO2002016590A2 (en) | 2000-08-21 | 2002-02-28 | Clonex Development, Inc. | Methods and compositions for increasing protein yield from a cell culture |
| CN1526011A (zh) | 2001-07-10 | 2004-09-01 | IDECҩ�﹫˾ | 抑制凋亡过程及改善细胞性能 |
| US6964199B2 (en) | 2001-11-02 | 2005-11-15 | Cantocor, Inc. | Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid |
| WO2003040374A1 (en) | 2001-11-02 | 2003-05-15 | Centocor, Inc. | METHODS AND COMPOSITIONS FOR ENHANCED PROTEIN EXPRESSION AND/OR GROWTH OF CULTURED CELLS USING CO-TRANSCRIPTION OF A Bcl2 ENCODING NUCLEIC ACID |
| WO2003052064A2 (en) * | 2001-12-14 | 2003-06-26 | Centocor Inc. | Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media |
| EP1348758A1 (en) | 2002-03-28 | 2003-10-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Host cells having improved cell survival properties and methods to generate such cells |
| US20030219871A1 (en) | 2002-03-28 | 2003-11-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Host cells having improved cell survival properties and methods to generate such cells |
| WO2004003151A2 (en) * | 2002-06-26 | 2004-01-08 | Biogen Idec Ma Inc. | Protein production methods and modified cells for use therein |
| WO2005035740A1 (ja) * | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | 無血清馴化したゲノム改変細胞 |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| CN1287862C (zh) * | 2004-09-29 | 2006-12-06 | 中国人民解放军第四军医大学 | MG7－Ag模拟表位构建胃癌特异性多表位基因疫苗的方法 |
| US20070092947A1 (en) | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
-
2005
- 2005-07-25 US US11/187,863 patent/US7531327B2/en active Active
-
2006
- 2006-07-14 AU AU2006276182A patent/AU2006276182B2/en active Active
- 2006-07-14 JP JP2008523951A patent/JP5301990B2/ja active Active
- 2006-07-14 CN CN2006800352269A patent/CN101273121B/zh active Active
- 2006-07-14 EP EP06787690.4A patent/EP1910515B1/en active Active
- 2006-07-14 KR KR1020137004422A patent/KR20130027579A/ko not_active Ceased
- 2006-07-14 WO PCT/US2006/027820 patent/WO2007015848A2/en not_active Ceased
- 2006-07-14 KR KR1020087002132A patent/KR101518062B1/ko active Active
- 2006-07-14 CA CA2616799A patent/CA2616799C/en active Active
-
2013
- 2013-04-12 JP JP2013084178A patent/JP2013172722A/ja active Pending
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