JP2009500445A5 - - Google Patents
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- Publication number
- JP2009500445A5 JP2009500445A5 JP2008520987A JP2008520987A JP2009500445A5 JP 2009500445 A5 JP2009500445 A5 JP 2009500445A5 JP 2008520987 A JP2008520987 A JP 2008520987A JP 2008520987 A JP2008520987 A JP 2008520987A JP 2009500445 A5 JP2009500445 A5 JP 2009500445A5
- Authority
- JP
- Japan
- Prior art keywords
- mna
- high levels
- atherogenic effects
- dyslipidemias
- meals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000489 anti-atherogenic effect Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 208000032928 Dyslipidaemia Diseases 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69829205P | 2005-07-11 | 2005-07-11 | |
| US60/698,292 | 2005-07-11 | ||
| PCT/IB2006/004013 WO2007074406A2 (en) | 2005-07-11 | 2006-07-11 | Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500445A JP2009500445A (ja) | 2009-01-08 |
| JP2009500445A5 true JP2009500445A5 (cg-RX-API-DMAC7.html) | 2013-09-12 |
| JP5490409B2 JP5490409B2 (ja) | 2014-05-14 |
Family
ID=38218362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008520987A Expired - Fee Related JP5490409B2 (ja) | 2005-07-11 | 2006-07-11 | スタチンおよびメチルニコチンアミド誘導体を含んでなるリポ蛋白質異常の処置用調剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20070021379A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1919466B9 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5490409B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE548035T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006329564A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2614885C (cg-RX-API-DMAC7.html) |
| DK (1) | DK1919466T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2383822T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL1919466T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1919466E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007074406A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL364348A1 (en) | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Application of quaternary pyridine salts as vessel protection agent |
| EP2026651B1 (en) * | 2006-03-08 | 2013-04-17 | Cortria Corporation | Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries |
| WO2008096203A2 (en) * | 2006-10-18 | 2008-08-14 | Dermena | Food extracts containing n-methylnicotinamide for treatment of lipoprotein abnormalities and skin diseases and disorders |
| US20090118225A1 (en) * | 2007-09-28 | 2009-05-07 | Cortria Corporation | 1-Methyl Nicotinamide and Derivatives for Treatment of Gastric Injury |
| PL2211857T3 (pl) * | 2007-10-12 | 2012-11-30 | Politechnika Lodzka | Zastosowanie czwartorzędowych soli pirydyniowych do radioprotekcji |
| US8304439B1 (en) | 2007-10-12 | 2012-11-06 | Politechnika Lodzka | Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage |
| AU2009244395A1 (en) * | 2008-05-06 | 2009-11-12 | Cortria Corporation | 1-methylnicotinamide analogs |
| ES2385686B1 (es) | 2010-08-18 | 2013-06-12 | Telefónica, S.A. | Elemento de mejora de la privacidad multimedia. |
| AU2013336683A1 (en) * | 2012-10-24 | 2015-05-14 | Biocopea Limited | Drug combinations containing statins for treating cardiovascular diseases |
| RU2744615C2 (ru) * | 2016-07-18 | 2021-03-11 | Фармена С.А. | Использование 1-метилникотинамида для лечения заболеваний, связанных с c-реактивным белком |
| WO2018015862A1 (en) * | 2016-07-18 | 2018-01-25 | Pharmena S.A. | 1-methylnicotinamide salts for use in raising the blood levels of adiponectin |
| CN108478573A (zh) * | 2018-03-30 | 2018-09-04 | 浙江中医药大学 | 一种1-甲基烟酰胺在制备预防或治疗酒精性脂肪肝药物中的应用 |
| WO2020115765A1 (en) | 2018-12-05 | 2020-06-11 | Celagenex Research (India) Pvt. Ltd. | Novel synergistic composition comprising sirt1 and ampk activators for treating metabolic syndrome |
| CN111138427B (zh) | 2018-12-05 | 2021-09-17 | 江西富祥药业股份有限公司 | 黄连素及其类似物的非诺贝特酸盐、晶型、制备方法及应用 |
| US10864207B2 (en) * | 2019-01-02 | 2020-12-15 | Celagenex Research (India) Pvt. Ltd. | Method of treating endothelial dysfunction |
| WO2021205341A1 (en) | 2020-04-07 | 2021-10-14 | Pharmena S.A. | 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases |
| CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院（深圳福田） | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE840698C (de) | 1949-07-12 | 1952-06-05 | Cilag Aktiengesellschaft | Verfahren zur herstellung neuer derivate des nicotinsaureamids |
| US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5260305A (en) | 1988-12-12 | 1993-11-09 | E. R. Squibb & Sons, Inc. | Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination |
| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| HU217629B (hu) | 1991-12-12 | 2000-03-28 | Novartis Ag. | Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására |
| US5582837A (en) | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
| DK0632720T3 (da) | 1992-03-25 | 1999-07-26 | Depomed Inc | Hydroxyethylcellulosebaserede depotpræparat-doseringsformer |
| DK0680320T3 (da) | 1993-01-19 | 1999-10-25 | Warner Lambert Co | Stabilt oralt CI-981-præparat og fremgangsmåde til fremstilling deraf |
| AU7397094A (en) | 1993-08-30 | 1995-03-22 | Merck & Co., Inc. | Prevention and treatment of alzheimer's disease |
| US6746691B2 (en) * | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US6129930A (en) * | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6818229B1 (en) * | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US20060263428A1 (en) * | 1993-09-20 | 2006-11-23 | Eugenio Cefali | Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics |
| US6676967B1 (en) * | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6406715B1 (en) * | 1993-09-20 | 2002-06-18 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique urinary metabolite profiles |
| CN1087288C (zh) | 1995-07-17 | 2002-07-10 | 沃尼尔·朗伯公司 | 结晶[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸半钙盐 |
| AU3290397A (en) | 1996-06-10 | 1998-01-07 | Depomed, Inc. | Gastric-retentive oral controlled drug delivery system with enhanced retention properties |
| US5972389A (en) | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
| US20030161880A1 (en) * | 1997-03-06 | 2003-08-28 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| WO1998055107A1 (en) | 1997-06-06 | 1998-12-10 | Depomed, Inc. | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
| ATE359785T1 (de) * | 1997-07-31 | 2007-05-15 | Kos Life Sciences Inc | Manteltablette enthaltend nikotinsäure oder einen stoff, der zu nikotinsäure metabolisiert wird, in verzögert freigesetzter form, und einen hmg-coa reduktasehemmer im mantel zur sofortigen freisetzung |
| US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
| US6469035B1 (en) * | 1997-07-31 | 2002-10-22 | Eugenio A. Cefali | Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid |
| IE970731A1 (en) * | 1997-10-07 | 2000-10-04 | Fuisz Internat Ltd | Product and method for the treatment of hyperlipidemia |
| PL190755B1 (pl) | 1999-01-07 | 2006-01-31 | Pharmena Sp Z Oo | Preparat do leczenia i profilaktyki chorób skóry |
| MXPA02004413A (es) | 1999-11-02 | 2002-09-02 | Depomed Inc | Induccion farmacologica del modo de alimentacion, para la administracion aumentada de drogas al estomago. |
| AU767812B2 (en) | 2000-02-04 | 2003-11-27 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US6488962B1 (en) | 2000-06-20 | 2002-12-03 | Depomed, Inc. | Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms |
| US6451808B1 (en) | 2000-10-17 | 2002-09-17 | Depomed, Inc. | Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists |
| JP2004532259A (ja) | 2001-05-29 | 2004-10-21 | デポメッド ディベロップメント リミティド | 胃食道逆流症及び夜間に胃酸分泌が回復する現象の治療方法 |
| CA2357053A1 (en) * | 2001-09-04 | 2003-03-04 | Unknown | Effectiveness of a combination of antioxidant substances for the treatment of alzheimer's disease |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US20030091630A1 (en) | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| EP1438027A1 (en) | 2001-10-25 | 2004-07-21 | DepoMed, Inc. | Methods of treatment using a gastric retained losartan dosage |
| CA2409552A1 (en) | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| PL364348A1 (en) * | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Application of quaternary pyridine salts as vessel protection agent |
| US20050233013A1 (en) * | 2004-03-02 | 2005-10-20 | Lee Steve S | Methods for enhancing the transport of glucose for balancing blood sugar levels |
| EP1811996A1 (en) | 2004-11-05 | 2007-08-01 | Arena Pharmaceuticals, Inc. | Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists |
-
2006
- 2006-07-11 DK DK06848969.9T patent/DK1919466T3/da active
- 2006-07-11 AT AT06848969T patent/ATE548035T1/de active
- 2006-07-11 WO PCT/IB2006/004013 patent/WO2007074406A2/en not_active Ceased
- 2006-07-11 CA CA2614885A patent/CA2614885C/en not_active Expired - Fee Related
- 2006-07-11 JP JP2008520987A patent/JP5490409B2/ja not_active Expired - Fee Related
- 2006-07-11 EP EP06848969A patent/EP1919466B9/en active Active
- 2006-07-11 ES ES06848969T patent/ES2383822T3/es active Active
- 2006-07-11 PL PL06848969T patent/PL1919466T3/pl unknown
- 2006-07-11 US US11/484,892 patent/US20070021379A1/en not_active Abandoned
- 2006-07-11 AU AU2006329564A patent/AU2006329564A1/en not_active Abandoned
- 2006-07-11 PT PT06848969T patent/PT1919466E/pt unknown
-
2010
- 2010-01-20 US US12/690,797 patent/US8211922B2/en active Active
-
2012
- 2012-06-11 US US13/493,703 patent/US8481570B2/en active Active
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