CA2614885C - Methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities - Google Patents

Methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities Download PDF

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Publication number
CA2614885C
CA2614885C CA2614885A CA2614885A CA2614885C CA 2614885 C CA2614885 C CA 2614885C CA 2614885 A CA2614885 A CA 2614885A CA 2614885 A CA2614885 A CA 2614885A CA 2614885 C CA2614885 C CA 2614885C
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Canada
Prior art keywords
statin
salt
subject
formula
agent
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Expired - Fee Related
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CA2614885A
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English (en)
French (fr)
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CA2614885A1 (en
Inventor
Robert Bender
Stefan Chlopicki
Jerzy Gebicki
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Cortria Corp
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Cortria Corp
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/716—Glucans
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2614885A 2005-07-11 2006-07-11 Methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities Expired - Fee Related CA2614885C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69829205P 2005-07-11 2005-07-11
US60/698,292 2005-07-11
PCT/IB2006/004013 WO2007074406A2 (en) 2005-07-11 2006-07-11 Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative

Publications (2)

Publication Number Publication Date
CA2614885A1 CA2614885A1 (en) 2007-07-05
CA2614885C true CA2614885C (en) 2015-03-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2614885A Expired - Fee Related CA2614885C (en) 2005-07-11 2006-07-11 Methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities

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Country Link
US (3) US20070021379A1 (cg-RX-API-DMAC7.html)
EP (1) EP1919466B9 (cg-RX-API-DMAC7.html)
JP (1) JP5490409B2 (cg-RX-API-DMAC7.html)
AT (1) ATE548035T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006329564A1 (cg-RX-API-DMAC7.html)
CA (1) CA2614885C (cg-RX-API-DMAC7.html)
DK (1) DK1919466T3 (cg-RX-API-DMAC7.html)
ES (1) ES2383822T3 (cg-RX-API-DMAC7.html)
PL (1) PL1919466T3 (cg-RX-API-DMAC7.html)
PT (1) PT1919466E (cg-RX-API-DMAC7.html)
WO (1) WO2007074406A2 (cg-RX-API-DMAC7.html)

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EP2026651B1 (en) * 2006-03-08 2013-04-17 Cortria Corporation Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
WO2008096203A2 (en) * 2006-10-18 2008-08-14 Dermena Food extracts containing n-methylnicotinamide for treatment of lipoprotein abnormalities and skin diseases and disorders
US20090118225A1 (en) * 2007-09-28 2009-05-07 Cortria Corporation 1-Methyl Nicotinamide and Derivatives for Treatment of Gastric Injury
PL2211857T3 (pl) * 2007-10-12 2012-11-30 Politechnika Lodzka Zastosowanie czwartorzędowych soli pirydyniowych do radioprotekcji
US8304439B1 (en) 2007-10-12 2012-11-06 Politechnika Lodzka Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage
AU2009244395A1 (en) * 2008-05-06 2009-11-12 Cortria Corporation 1-methylnicotinamide analogs
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AU2013336683A1 (en) * 2012-10-24 2015-05-14 Biocopea Limited Drug combinations containing statins for treating cardiovascular diseases
RU2744615C2 (ru) * 2016-07-18 2021-03-11 Фармена С.А. Использование 1-метилникотинамида для лечения заболеваний, связанных с c-реактивным белком
WO2018015862A1 (en) * 2016-07-18 2018-01-25 Pharmena S.A. 1-methylnicotinamide salts for use in raising the blood levels of adiponectin
CN108478573A (zh) * 2018-03-30 2018-09-04 浙江中医药大学 一种1-甲基烟酰胺在制备预防或治疗酒精性脂肪肝药物中的应用
WO2020115765A1 (en) 2018-12-05 2020-06-11 Celagenex Research (India) Pvt. Ltd. Novel synergistic composition comprising sirt1 and ampk activators for treating metabolic syndrome
CN111138427B (zh) 2018-12-05 2021-09-17 江西富祥药业股份有限公司 黄连素及其类似物的非诺贝特酸盐、晶型、制备方法及应用
US10864207B2 (en) * 2019-01-02 2020-12-15 Celagenex Research (India) Pvt. Ltd. Method of treating endothelial dysfunction
WO2021205341A1 (en) 2020-04-07 2021-10-14 Pharmena S.A. 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases
CN115837023B (zh) * 2023-02-20 2023-05-16 中山大学附属第八医院（深圳福田） 1-甲基烟酰胺在制备抗血管钙化药物中的应用

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EP1919466B9 (en) 2012-05-16
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US20100120726A1 (en) 2010-05-13
ATE548035T1 (de) 2012-03-15
US8211922B2 (en) 2012-07-03
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CA2614885A1 (en) 2007-07-05
ES2383822T3 (es) 2012-06-26
PT1919466E (pt) 2012-05-21
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