ATE548035T1 - Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat - Google Patents

Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat

Info

Publication number
ATE548035T1
ATE548035T1 AT06848969T AT06848969T ATE548035T1 AT E548035 T1 ATE548035 T1 AT E548035T1 AT 06848969 T AT06848969 T AT 06848969T AT 06848969 T AT06848969 T AT 06848969T AT E548035 T1 ATE548035 T1 AT E548035T1
Authority
AT
Austria
Prior art keywords
statin
methylnicotinamide
formulations
derivative
lipoprotein abnormalities
Prior art date
Application number
AT06848969T
Other languages
German (de)
English (en)
Inventor
Robert Bender
Stefan Chlopicki
Jerzy Gebicki
Original Assignee
Cortria Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortria Corp filed Critical Cortria Corp
Application granted granted Critical
Publication of ATE548035T1 publication Critical patent/ATE548035T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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AT06848969T 2005-07-11 2006-07-11 Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat ATE548035T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69829205P 2005-07-11 2005-07-11
PCT/IB2006/004013 WO2007074406A2 (en) 2005-07-11 2006-07-11 Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative

Publications (1)

Publication Number Publication Date
ATE548035T1 true ATE548035T1 (de) 2012-03-15

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AT06848969T ATE548035T1 (de) 2005-07-11 2006-07-11 Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat

Country Status (11)

Country Link
US (3) US20070021379A1 (cg-RX-API-DMAC7.html)
EP (1) EP1919466B9 (cg-RX-API-DMAC7.html)
JP (1) JP5490409B2 (cg-RX-API-DMAC7.html)
AT (1) ATE548035T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006329564A1 (cg-RX-API-DMAC7.html)
CA (1) CA2614885C (cg-RX-API-DMAC7.html)
DK (1) DK1919466T3 (cg-RX-API-DMAC7.html)
ES (1) ES2383822T3 (cg-RX-API-DMAC7.html)
PL (1) PL1919466T3 (cg-RX-API-DMAC7.html)
PT (1) PT1919466E (cg-RX-API-DMAC7.html)
WO (1) WO2007074406A2 (cg-RX-API-DMAC7.html)

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EP2026651B1 (en) * 2006-03-08 2013-04-17 Cortria Corporation Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
WO2008096203A2 (en) * 2006-10-18 2008-08-14 Dermena Food extracts containing n-methylnicotinamide for treatment of lipoprotein abnormalities and skin diseases and disorders
US20090118225A1 (en) * 2007-09-28 2009-05-07 Cortria Corporation 1-Methyl Nicotinamide and Derivatives for Treatment of Gastric Injury
PL2211857T3 (pl) * 2007-10-12 2012-11-30 Politechnika Lodzka Zastosowanie czwartorzędowych soli pirydyniowych do radioprotekcji
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AU2009244395A1 (en) * 2008-05-06 2009-11-12 Cortria Corporation 1-methylnicotinamide analogs
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AU2013336683A1 (en) * 2012-10-24 2015-05-14 Biocopea Limited Drug combinations containing statins for treating cardiovascular diseases
RU2744615C2 (ru) * 2016-07-18 2021-03-11 Фармена С.А. Использование 1-метилникотинамида для лечения заболеваний, связанных с c-реактивным белком
WO2018015862A1 (en) * 2016-07-18 2018-01-25 Pharmena S.A. 1-methylnicotinamide salts for use in raising the blood levels of adiponectin
CN108478573A (zh) * 2018-03-30 2018-09-04 浙江中医药大学 一种1-甲基烟酰胺在制备预防或治疗酒精性脂肪肝药物中的应用
WO2020115765A1 (en) 2018-12-05 2020-06-11 Celagenex Research (India) Pvt. Ltd. Novel synergistic composition comprising sirt1 and ampk activators for treating metabolic syndrome
CN111138427B (zh) 2018-12-05 2021-09-17 江西富祥药业股份有限公司 黄连素及其类似物的非诺贝特酸盐、晶型、制备方法及应用
US10864207B2 (en) * 2019-01-02 2020-12-15 Celagenex Research (India) Pvt. Ltd. Method of treating endothelial dysfunction
WO2021205341A1 (en) 2020-04-07 2021-10-14 Pharmena S.A. 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases
CN115837023B (zh) * 2023-02-20 2023-05-16 中山大学附属第八医院（深圳福田） 1-甲基烟酰胺在制备抗血管钙化药物中的应用

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WO2007074406A3 (en) 2007-11-08
US20070021379A1 (en) 2007-01-25
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JP2009500445A (ja) 2009-01-08
EP1919466B9 (en) 2012-05-16
DK1919466T3 (da) 2012-07-02
US20100120726A1 (en) 2010-05-13
US8211922B2 (en) 2012-07-03
EP1919466B1 (en) 2012-03-07
CA2614885A1 (en) 2007-07-05
ES2383822T3 (es) 2012-06-26
PT1919466E (pt) 2012-05-21
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EP1919466A2 (en) 2008-05-14
AU2006329564A1 (en) 2007-07-05

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