JP2009256374A5 - - Google Patents

Info

Publication number

JP2009256374A5

JP2009256374A5 JP2009181759A JP2009181759A JP2009256374A5 JP 2009256374 A5 JP2009256374 A5 JP 2009256374A5 JP 2009181759 A JP2009181759 A JP 2009181759A JP 2009181759 A JP2009181759 A JP 2009181759A JP 2009256374 A5 JP2009256374 A5 JP 2009256374A5

Authority

JP

Japan

Prior art keywords

pharmaceutical formulation

stem cells

nitric oxide

oxide donor

formulation according

Prior art date

2009-08-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 239000002840 nitric oxide donor Substances 0.000 claims 3
• 210000000130 stem cell Anatomy 0.000 claims 3
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 2
• 230000004766 neurogenesis Effects 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• YNRCBOXEDICOIX-CLFYSBASSA-N (Z)-[bis(2-aminoethyl)amino]-hydroxyimino-oxidoazanium Chemical group NCCN(CC[NH3+])[N+](\[O-])=N\[O-] YNRCBOXEDICOIX-CLFYSBASSA-N 0.000 claims 1
• LBQLVCJVCLTOCL-UHFFFAOYSA-N 1,3-dinitrooxypropan-2-yl nitrate;sodium Chemical compound [Na].[O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O LBQLVCJVCLTOCL-UHFFFAOYSA-N 0.000 claims 1
• WYMDDFRYORANCC-UHFFFAOYSA-N 2-[[3-[bis(carboxymethyl)amino]-2-hydroxypropyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)CN(CC(O)=O)CC(O)=O WYMDDFRYORANCC-UHFFFAOYSA-N 0.000 claims 1
• LHCXHDQPKHYQPB-UHFFFAOYSA-O CCCN(N([O-])N=O)CCC[NH3+] Chemical compound CCCN(N([O-])N=O)CCC[NH3+] LHCXHDQPKHYQPB-UHFFFAOYSA-O 0.000 claims 1
• RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 claims 1
• 241001442654 Percnon planissimum Species 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• XEYBHCRIKKKOSS-UHFFFAOYSA-N disodium;azanylidyneoxidanium;iron(2+);pentacyanide Chemical compound [Na+].[Na+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].[O+]#N XEYBHCRIKKKOSS-UHFFFAOYSA-N 0.000 claims 1
• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims 1
• GTUJJVSZIHQLHA-XPWFQUROSA-N pApA Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@@H]1O)O[C@H](COP(O)(O)=O)[C@H]1OP(O)(=O)OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N1C(N=CN=C2N)=C2N=C1 GTUJJVSZIHQLHA-XPWFQUROSA-N 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 229940083618 sodium nitroprusside Drugs 0.000 claims 1