JP2009235100A5 - - Google Patents
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- Publication number
- JP2009235100A5 JP2009235100A5 JP2009169170A JP2009169170A JP2009235100A5 JP 2009235100 A5 JP2009235100 A5 JP 2009235100A5 JP 2009169170 A JP2009169170 A JP 2009169170A JP 2009169170 A JP2009169170 A JP 2009169170A JP 2009235100 A5 JP2009235100 A5 JP 2009235100A5
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- atorvastatin hemi
- organic solvent
- less
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FQCKMBLVYCEXJB-MNSAWQCASA-L atorvastatin calcium Chemical compound [Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 FQCKMBLVYCEXJB-MNSAWQCASA-L 0.000 claims 17
- 239000003960 organic solvent Substances 0.000 claims 14
- 239000012453 solvate Substances 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000000920 calcium hydroxide Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35849702P | 2002-02-19 | 2002-02-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569575A Division JP4422488B2 (ja) | 2002-02-19 | 2003-02-19 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013050939A Division JP2013136630A (ja) | 2002-02-19 | 2013-03-13 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009235100A JP2009235100A (ja) | 2009-10-15 |
| JP2009235100A5 true JP2009235100A5 (https=) | 2009-11-26 |
Family
ID=27757749
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569575A Expired - Fee Related JP4422488B2 (ja) | 2002-02-19 | 2003-02-19 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
| JP2009044173A Pending JP2009143957A (ja) | 2002-02-19 | 2009-02-26 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
| JP2009169170A Pending JP2009235100A (ja) | 2002-02-19 | 2009-07-17 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
| JP2013050939A Pending JP2013136630A (ja) | 2002-02-19 | 2013-03-13 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569575A Expired - Fee Related JP4422488B2 (ja) | 2002-02-19 | 2003-02-19 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
| JP2009044173A Pending JP2009143957A (ja) | 2002-02-19 | 2009-02-26 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013050939A Pending JP2013136630A (ja) | 2002-02-19 | 2013-03-13 | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7122681B2 (https=) |
| EP (1) | EP1465901A4 (https=) |
| JP (4) | JP4422488B2 (https=) |
| KR (3) | KR20090045419A (https=) |
| CN (1) | CN100379723C (https=) |
| AU (1) | AU2003213171A1 (https=) |
| CA (1) | CA2475123A1 (https=) |
| HR (1) | HRP20040767A2 (https=) |
| IL (1) | IL163594A0 (https=) |
| IS (1) | IS7407A (https=) |
| MX (1) | MXPA04007995A (https=) |
| NO (1) | NO20043829L (https=) |
| PL (1) | PL372241A1 (https=) |
| WO (1) | WO2003070665A2 (https=) |
| ZA (1) | ZA200406229B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7411075B1 (en) * | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
| US7501450B2 (en) | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
| US8044086B2 (en) * | 2004-07-16 | 2011-10-25 | Lek Pharmaceuticals D.D. | Oxidative degradation products of atorvastatin calcium |
| ES2262459T1 (es) * | 2004-07-22 | 2006-12-01 | Teva Pharmaceutical Industries Ltd | Nuevas formas cristalinas de atorvastatina semicalcica y procedimientos para su preparacion. |
| WO2006021882A1 (en) * | 2004-08-25 | 2006-03-02 | Pfizer Limited | Triazolobenzodiazepines and their use as vasopressin antagonists |
| KR20070106680A (ko) * | 2004-09-30 | 2007-11-05 | 닥터 레디스 레보러터리즈 리미티드 | 비정질 아토르바스타틴 칼슘 |
| CZ2007772A3 (cs) * | 2005-04-08 | 2008-02-27 | EGIS GYOGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság | Nová krystalická polymorfní forma hemivápenaté soli atorvastatinu |
| TW200745026A (en) * | 2005-12-13 | 2007-12-16 | Teva Pharma | Crystal form of atorvastatin hemi-calcium and processes for preparation thereof |
| US20070265456A1 (en) * | 2006-05-09 | 2007-11-15 | Judith Aronhime | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| IT1390848B1 (it) * | 2008-07-31 | 2011-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| KR20120011249A (ko) | 2010-07-28 | 2012-02-07 | 주식회사 경보제약 | 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법 |
| KR102043337B1 (ko) | 2014-08-28 | 2019-11-11 | 아셰뉴론 에스아 | 글리코시다제 저해제 |
| US11261183B2 (en) * | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| CA3014572C (en) | 2016-02-25 | 2023-10-03 | Asceneuron S.A. | Acid addition salts of piperazine derivatives |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| DK3630744T3 (da) | 2017-05-23 | 2023-03-06 | H Lundbeck As | Pyrazol-magl-inhibitorer |
| JOP20190267A1 (ar) * | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
| JP7407171B2 (ja) | 2018-08-22 | 2023-12-28 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤として有用なピペラジン誘導体のコハク酸付加塩及びフマル酸付加塩 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US444129A (en) * | 1891-01-06 | Henry l | ||
| US4444129A (en) * | 1982-11-05 | 1984-04-24 | Lecorp | Method of drying fine coal particles |
| DE3306250A1 (de) * | 1983-02-23 | 1984-08-23 | Basf Ag, 6700 Ludwigshafen | Sphaerische einkristalle fuer pharmazeutische zwecke |
| JPS59167676A (ja) * | 1983-03-11 | 1984-09-21 | 株式会社 大川原製作所 | 多室型流動層乾燥機 |
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| GB8914804D0 (en) * | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| KR100389518B1 (ko) * | 1995-07-17 | 2003-11-15 | 워너-램버트 캄파니 엘엘씨 | 결정질[r-(r*,r*)]-2-(4-플루오로페닐)-베타,델타-디히드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카르보닐]-1h-피롤-1-헵탄산헤미칼슘염(아토르바스타틴) |
| HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| US6087511A (en) * | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
| TW385306B (en) * | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
| EP2206497A1 (en) | 1999-11-17 | 2010-07-14 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
| ATE320415T1 (de) | 1999-12-17 | 2006-04-15 | Pfizer Science & Tech Ltd | Verfahren zur herstellung von kristallin atorvastin kalcium |
| EP1237865B1 (en) | 1999-12-17 | 2005-11-16 | Pfizer Science and Technology Ireland Limited | A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt |
| EP1332130A4 (en) * | 2000-11-03 | 2004-01-21 | Teva Pharma | HEMICALCIC ATORVASTATIN FORM VII |
| IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| CA2622477A1 (en) | 2000-12-27 | 2002-07-04 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of atorvastatin |
| SI20814A (sl) | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
| IN190564B (https=) | 2001-04-11 | 2003-08-09 | Cadila Heathcare Ltd | |
| SK16002003A3 (sk) * | 2001-06-29 | 2004-12-01 | Warner-Lambert Company Llc | Kryštalické formy vápenatej soli (2:1) [R-(R*,R*)]-2-(4-fluóro- fenyl)-beta,delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4- [(fenylamino)karbonyl]-1H-pyrrol-1-heptánovej kyseliny (atorvastatín) |
| HRP20040077A2 (en) | 2001-07-30 | 2004-06-30 | Reddys Lab Ltd Dr | Crystalline forms vi and vii of atorvastatin-calcium |
| WO2003018547A2 (en) | 2001-08-31 | 2003-03-06 | Morepen Laboratories Ltd. | An improved process for the preparation of amorphous atorvastatin calcium salt (2:1) |
| CN100406436C (zh) | 2002-02-15 | 2008-07-30 | 特瓦制药工业有限公司 | 阿托韦兹他汀半钙结晶以及制备阿托韦兹他汀半钙形式ix的方法 |
-
2003
- 2003-02-19 CN CNB038040913A patent/CN100379723C/zh not_active Expired - Fee Related
- 2003-02-19 EP EP03709217A patent/EP1465901A4/en not_active Withdrawn
- 2003-02-19 PL PL03372241A patent/PL372241A1/xx unknown
- 2003-02-19 KR KR1020097007464A patent/KR20090045419A/ko not_active Ceased
- 2003-02-19 US US10/370,424 patent/US7122681B2/en not_active Expired - Fee Related
- 2003-02-19 MX MXPA04007995A patent/MXPA04007995A/es active IP Right Grant
- 2003-02-19 CA CA002475123A patent/CA2475123A1/en not_active Abandoned
- 2003-02-19 AU AU2003213171A patent/AU2003213171A1/en not_active Abandoned
- 2003-02-19 JP JP2003569575A patent/JP4422488B2/ja not_active Expired - Fee Related
- 2003-02-19 KR KR10-2004-7012804A patent/KR20040086397A/ko not_active Ceased
- 2003-02-19 KR KR1020097007465A patent/KR20090045420A/ko not_active Ceased
- 2003-02-19 IL IL16359403A patent/IL163594A0/xx unknown
- 2003-02-19 HR HRP20040767 patent/HRP20040767A2/hr not_active Application Discontinuation
- 2003-02-19 WO PCT/US2003/005216 patent/WO2003070665A2/en not_active Ceased
-
2004
- 2004-08-04 ZA ZA200406229A patent/ZA200406229B/en unknown
- 2004-08-17 IS IS7407A patent/IS7407A/is unknown
- 2004-09-13 NO NO20043829A patent/NO20043829L/no not_active Application Discontinuation
-
2006
- 2006-10-02 US US11/542,339 patent/US20070027328A1/en not_active Abandoned
-
2009
- 2009-02-26 JP JP2009044173A patent/JP2009143957A/ja active Pending
- 2009-07-17 JP JP2009169170A patent/JP2009235100A/ja active Pending
-
2013
- 2013-03-13 JP JP2013050939A patent/JP2013136630A/ja active Pending
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