JP2009197002A5 - - Google Patents
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- Publication number
- JP2009197002A5 JP2009197002A5 JP2009092429A JP2009092429A JP2009197002A5 JP 2009197002 A5 JP2009197002 A5 JP 2009197002A5 JP 2009092429 A JP2009092429 A JP 2009092429A JP 2009092429 A JP2009092429 A JP 2009092429A JP 2009197002 A5 JP2009197002 A5 JP 2009197002A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding portion
- chain variable
- medicament according
- psma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 25
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 17
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 16
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 16
- 210000004408 hybridoma Anatomy 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 210000000064 prostate epithelial cell Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 238000005481 NMR spectroscopy Methods 0.000 claims 1
- 230000002280 anti-androgenic effect Effects 0.000 claims 1
- 239000000051 antiandrogen Substances 0.000 claims 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2212596P | 1996-07-18 | 1996-07-18 | |
| US60/022,125 | 1996-07-18 | ||
| US08/838,682 | 1997-04-09 | ||
| US08/838,682 US6107090A (en) | 1996-05-06 | 1997-04-09 | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50699598A Division JP4503102B2 (ja) | 1996-07-18 | 1997-07-17 | 癌の治療および診断 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009197002A JP2009197002A (ja) | 2009-09-03 |
| JP2009197002A5 true JP2009197002A5 (OSRAM) | 2009-12-10 |
| JP5627191B2 JP5627191B2 (ja) | 2014-11-19 |
Family
ID=26695548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50699598A Expired - Lifetime JP4503102B2 (ja) | 1996-07-18 | 1997-07-17 | 癌の治療および診断 |
| JP2009092429A Expired - Lifetime JP5627191B2 (ja) | 1996-07-18 | 2009-04-06 | 癌の治療および診断 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50699598A Expired - Lifetime JP4503102B2 (ja) | 1996-07-18 | 1997-07-17 | 癌の治療および診断 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US6107090A (OSRAM) |
| EP (2) | EP1655605A3 (OSRAM) |
| JP (2) | JP4503102B2 (OSRAM) |
| CN (2) | CN1165764C (OSRAM) |
| AT (1) | ATE319089T1 (OSRAM) |
| AU (1) | AU733544C (OSRAM) |
| BR (1) | BR9710487A (OSRAM) |
| CA (1) | CA2261018C (OSRAM) |
| DE (1) | DE69735368T2 (OSRAM) |
| EA (2) | EA004634B1 (OSRAM) |
| ES (1) | ES2255723T3 (OSRAM) |
| IL (2) | IL127979A0 (OSRAM) |
| NZ (2) | NZ333683A (OSRAM) |
| PT (1) | PT956506E (OSRAM) |
| WO (1) | WO1998003873A1 (OSRAM) |
Families Citing this family (146)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040253246A1 (en) * | 1996-02-23 | 2004-12-16 | Israeli Ron S. | Prostate-specific membrane antigen and uses thereof |
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- 1997-07-17 AT AT97934922T patent/ATE319089T1/de active
- 1997-07-17 IL IL12797997A patent/IL127979A0/xx not_active IP Right Cessation
- 1997-07-17 EA EA199900033A patent/EA004634B1/ru not_active IP Right Cessation
- 1997-07-17 JP JP50699598A patent/JP4503102B2/ja not_active Expired - Lifetime
- 1997-07-17 CN CNB97197912XA patent/CN1165764C/zh not_active Expired - Lifetime
- 1997-07-17 WO PCT/US1997/012035 patent/WO1998003873A1/en not_active Ceased
- 1997-07-17 CN CNB2004100544223A patent/CN100344970C/zh not_active Expired - Lifetime
- 1997-07-17 ES ES97934922T patent/ES2255723T3/es not_active Expired - Lifetime
- 1997-07-17 NZ NZ524036A patent/NZ524036A/xx not_active IP Right Cessation
- 1997-07-17 EA EA200400179A patent/EA200400179A1/ru unknown
- 1997-07-17 PT PT97934922T patent/PT956506E/pt unknown
- 1997-07-17 AU AU37976/97A patent/AU733544C/en not_active Expired
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1999
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2001
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2004
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